KR100730440B1 - 주사가능한 부프레노르핀 미세 입자 조성물 및 이의 용도 - Google Patents

주사가능한 부프레노르핀 미세 입자 조성물 및 이의 용도 Download PDF

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Publication number
KR100730440B1
KR100730440B1 KR1020027002567A KR20027002567A KR100730440B1 KR 100730440 B1 KR100730440 B1 KR 100730440B1 KR 1020027002567 A KR1020027002567 A KR 1020027002567A KR 20027002567 A KR20027002567 A KR 20027002567A KR 100730440 B1 KR100730440 B1 KR 100730440B1
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South Korea
Prior art keywords
microparticles
buprenorphine
microparticle composition
weight
ethyl acetate
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Expired - Fee Related
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KR1020027002567A
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English (en)
Korean (ko)
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KR20020053057A (ko
Inventor
토마스 알. 타이스
제이 케이. 스타스
테레사 엠. 페렐
피터 마크랜드
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브룩우드 파마슈티컬스, 인코포레이티드
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Publication of KR20020053057A publication Critical patent/KR20020053057A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020027002567A 1999-08-27 2000-08-25 주사가능한 부프레노르핀 미세 입자 조성물 및 이의 용도 Expired - Fee Related KR100730440B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15111299P 1999-08-27 1999-08-27
US60/151,112 1999-08-27

Publications (2)

Publication Number Publication Date
KR20020053057A KR20020053057A (ko) 2002-07-04
KR100730440B1 true KR100730440B1 (ko) 2007-06-19

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KR1020027002567A Expired - Fee Related KR100730440B1 (ko) 1999-08-27 2000-08-25 주사가능한 부프레노르핀 미세 입자 조성물 및 이의 용도

Country Status (24)

Country Link
US (2) US6495155B1 (https=)
EP (1) EP1212061B1 (https=)
JP (1) JP4913298B2 (https=)
KR (1) KR100730440B1 (https=)
CN (2) CN100387228C (https=)
AT (1) ATE280579T1 (https=)
AU (1) AU765496C (https=)
BR (1) BR0013650A (https=)
CA (1) CA2382577C (https=)
CY (1) CY1106043T1 (https=)
CZ (1) CZ2002728A3 (https=)
DE (1) DE60015370T2 (https=)
EA (1) EA009080B1 (https=)
ES (1) ES2230154T3 (https=)
HK (1) HK1046858B (https=)
HU (1) HUP0203613A3 (https=)
IL (2) IL148343A0 (https=)
MX (1) MXPA02002105A (https=)
NO (2) NO322650B1 (https=)
NZ (1) NZ517997A (https=)
PL (1) PL198334B1 (https=)
PT (1) PT1212061E (https=)
RO (1) RO121631B1 (https=)
WO (1) WO2001015699A1 (https=)

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US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
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US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US7041320B1 (en) * 2002-05-31 2006-05-09 Biotek, Inc. High drug loaded injectable microparticle compositions and methods of treating opioid drug dependence
CA2487577C (en) 2002-05-31 2014-11-18 Titan Pharmaceuticals, Inc. Implantable polymeric device for sustained release of buprenorphine
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
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Publication number Publication date
CA2382577C (en) 2008-01-22
ES2230154T3 (es) 2005-05-01
PL354977A1 (en) 2004-03-22
CN100387228C (zh) 2008-05-14
US20030152638A1 (en) 2003-08-14
NO20020924L (no) 2002-04-03
DE60015370D1 (de) 2004-12-02
US6495155B1 (en) 2002-12-17
CA2382577A1 (en) 2001-03-08
NZ517997A (en) 2002-11-26
JP2003508439A (ja) 2003-03-04
BR0013650A (pt) 2002-05-07
CN1788721A (zh) 2006-06-21
WO2001015699A1 (en) 2001-03-08
PL198334B1 (pl) 2008-06-30
CN1382051A (zh) 2002-11-27
HUP0203613A2 (hu) 2003-02-28
EA200200295A1 (ru) 2002-08-29
EP1212061A1 (en) 2002-06-12
KR20020053057A (ko) 2002-07-04
EA009080B1 (ru) 2007-10-26
CZ2002728A3 (cs) 2002-08-14
DE60015370T2 (de) 2006-03-09
US7473431B2 (en) 2009-01-06
PT1212061E (pt) 2005-01-31
AU7075100A (en) 2001-03-26
ATE280579T1 (de) 2004-11-15
NO322650B1 (no) 2006-11-13
MXPA02002105A (es) 2003-12-11
NO20020924D0 (no) 2002-02-26
HK1046858B (en) 2005-03-24
AU765496B2 (en) 2003-09-18
NO20063239L (no) 2002-04-03
CN1248689C (zh) 2006-04-05
EP1212061B1 (en) 2004-10-27
CY1106043T1 (el) 2011-04-06
AU765496C (en) 2005-08-25
HUP0203613A3 (en) 2005-01-28
JP4913298B2 (ja) 2012-04-11
RO121631B1 (ro) 2008-01-30
IL148343A (en) 2008-03-20
IL148343A0 (en) 2002-09-12
HK1046858A1 (en) 2003-01-30

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