KR100645448B1 - 세포 아폽토시스를 저해하는 설바이빈 단백질 및 이를 조절하는 방법 - Google Patents

세포 아폽토시스를 저해하는 설바이빈 단백질 및 이를 조절하는 방법 Download PDF

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KR100645448B1
KR100645448B1 KR1019997004445A KR19997004445A KR100645448B1 KR 100645448 B1 KR100645448 B1 KR 100645448B1 KR 1019997004445 A KR1019997004445 A KR 1019997004445A KR 19997004445 A KR19997004445 A KR 19997004445A KR 100645448 B1 KR100645448 B1 KR 100645448B1
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sulfabin
delete delete
nucleic acid
acid molecule
nucleotides
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KR20000057159A (ko
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다리오씨. 알티에르
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예일 유니버시티
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07—ORGANIC CHEMISTRY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
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KR1019997004445A 1996-11-20 1997-11-20 세포 아폽토시스를 저해하는 설바이빈 단백질 및 이를 조절하는 방법 Expired - Lifetime KR100645448B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3143596P 1996-11-20 1996-11-20
US60/031,435 1996-11-20
US8/975,080 1997-11-20
US08/975,080 US6245523B1 (en) 1996-11-20 1997-11-20 Survivin, a protein that inhibits cellular apoptosis, and its modulation
US08/975,080 1997-11-20

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Publication Number Publication Date
KR20000057159A KR20000057159A (ko) 2000-09-15
KR100645448B1 true KR100645448B1 (ko) 2006-11-13

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KR1019997004445A Expired - Lifetime KR100645448B1 (ko) 1996-11-20 1997-11-20 세포 아폽토시스를 저해하는 설바이빈 단백질 및 이를 조절하는 방법

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US (7) US6245523B1 (enExample)
EP (1) EP0950103B1 (enExample)
JP (2) JP4672092B2 (enExample)
KR (1) KR100645448B1 (enExample)
AT (1) ATE414149T1 (enExample)
AU (1) AU736587B2 (enExample)
CA (1) CA2271783C (enExample)
DE (1) DE69739105D1 (enExample)
IL (1) IL130036A (enExample)
WO (1) WO1998022589A2 (enExample)

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JP4368110B2 (ja) 2001-01-12 2009-11-18 エール ユニヴァーシティ 癌患者の生物学的流体中のサバイビンの検出
DE10102722A1 (de) * 2001-01-22 2002-08-14 Medinnova Ges Med Innovationen Verfahren und Testsystem zum Auffinden von Nervenzell-schützenden Substanzen
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US7332580B2 (en) * 2002-04-05 2008-02-19 The Regents Of The University Of California Bispecific single chain Fv antibody molecules and methods of use thereof
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JP2007506442A (ja) * 2003-05-30 2007-03-22 ゲノミック ヘルス， インコーポレイテッド Ｅｇｆｒ阻害薬への応答に関する遺伝子発現マーカー
JP4579911B2 (ja) * 2003-06-03 2010-11-10 アイシス・ファーマシューティカルズ・インコーポレイテッド スルビビン発現の調節
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AU736587B2 (en) 2001-08-02
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US20060069025A1 (en) 2006-03-30
US20110136743A1 (en) 2011-06-09
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US6245523B1 (en) 2001-06-12
US6800737B2 (en) 2004-10-05
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