BRPI0408774A - vacinas de dna contra crescimento tumoral e seus usos - Google Patents
vacinas de dna contra crescimento tumoral e seus usosInfo
- Publication number
- BRPI0408774A BRPI0408774A BRPI0408774-7A BRPI0408774A BRPI0408774A BR PI0408774 A BRPI0408774 A BR PI0408774A BR PI0408774 A BRPI0408774 A BR PI0408774A BR PI0408774 A BRPI0408774 A BR PI0408774A
- Authority
- BR
- Brazil
- Prior art keywords
- human
- tumor growth
- protein
- cancer
- dna
- Prior art date
Links
- 230000004614 tumor growth Effects 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 229940088872 Apoptosis inhibitor Drugs 0.000 abstract 2
- 108090000695 Cytokines Proteins 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 2
- 239000000158 apoptosis inhibitor Substances 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 102100036846 C-C motif chemokine 21 Human genes 0.000 abstract 1
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 1
- 108010041986 DNA Vaccines Proteins 0.000 abstract 1
- 229940021995 DNA vaccine Drugs 0.000 abstract 1
- 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 abstract 1
- 101000607306 Homo sapiens UL16-binding protein 1 Proteins 0.000 abstract 1
- 101000607320 Homo sapiens UL16-binding protein 2 Proteins 0.000 abstract 1
- 101000607318 Homo sapiens UL16-binding protein 3 Proteins 0.000 abstract 1
- 108010031034 MHC class I-related chain A Proteins 0.000 abstract 1
- 108010086911 MICB antigen Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 102000048777 human ULBP1 Human genes 0.000 abstract 1
- 102000048775 human ULBP2 Human genes 0.000 abstract 1
- 102000052075 human ULBP3 Human genes 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 102000006240 membrane receptors Human genes 0.000 abstract 1
- 210000000822 natural killer cell Anatomy 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001136—Cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001148—Regulators of development
- A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
"VACINAS DE DNA CONTRA CRESCIMENTO TUMORAL E SEUS USOS". Uma vacina de DNA adequada para despertar uma resposta imune contra células cancerosas compreende uma construção de DNA que codifica operacionalmente uma proteína da família de inibidor de apoptose associado a câncer e um produto de gene imunoativo, como uma citocina ou um ligante para um receptor natural de superfície de célula assassina, em um veículo farmaceuticamente aceitável. Uma citocina preferida é CCL21. Ligantes preferidos para um receptor natural de superfície de célula assassina incluem MICA humana, MICB humana, ULBP1 humana, ULBP2 humana, e ULBP3 humana. A proteína da família de inibidor de apoptose associado a câncer (IAP) é preferivelmente uma proteína sobrevivente ou proteína viva. Também é descrito um método de inibição de crescimento tumoral pela administração da vacina da invenção a um mamífero.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45700903P | 2003-03-24 | 2003-03-24 | |
PCT/US2004/008932 WO2004099389A2 (en) | 2003-03-24 | 2004-03-24 | Dna vaccines against tumor growth and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0408774A true BRPI0408774A (pt) | 2006-03-28 |
Family
ID=33434911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0408774-7A BRPI0408774A (pt) | 2003-03-24 | 2004-03-24 | vacinas de dna contra crescimento tumoral e seus usos |
Country Status (18)
Country | Link |
---|---|
US (2) | US8716254B2 (pt) |
EP (1) | EP1622648B1 (pt) |
JP (1) | JP4616827B2 (pt) |
KR (1) | KR101199789B1 (pt) |
CN (1) | CN1791433B (pt) |
AT (1) | ATE472339T1 (pt) |
AU (1) | AU2004236636B2 (pt) |
BR (1) | BRPI0408774A (pt) |
CA (1) | CA2519953C (pt) |
DE (1) | DE602004027902D1 (pt) |
DK (1) | DK1622648T3 (pt) |
ES (1) | ES2345200T3 (pt) |
MX (1) | MXPA05010255A (pt) |
PL (1) | PL1622648T3 (pt) |
PT (1) | PT1622648E (pt) |
RU (1) | RU2343195C2 (pt) |
WO (1) | WO2004099389A2 (pt) |
ZA (1) | ZA200508579B (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2560449T3 (es) | 2004-05-28 | 2016-02-19 | Oryxe | Una mezcla para administración transdérmica de compuestos de peso molecular bajo y alto |
US20060276423A1 (en) * | 2005-04-18 | 2006-12-07 | Rachel Altura | Survivin-directed RNA interference-compositions and methods |
US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
KR100790377B1 (ko) * | 2006-02-15 | 2008-01-02 | 고려대학교 산학협력단 | 인터페론감마를 발현하는 살모넬라 균주를 함유하는항바이러스용 조성물 |
ES2393372T3 (es) * | 2006-06-21 | 2012-12-20 | The Scripps Research Institute | Composición de ADN contra el antígeno tumoral estromal FAP y métodos de utlización de la misma |
JP2009542592A (ja) * | 2006-07-06 | 2009-12-03 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Il−2媒介性免疫応答の有効性を高める組成物および方法 |
FR2903605A1 (fr) * | 2006-07-12 | 2008-01-18 | Sanofi Pasteur Sa | Methode d'immunisation contre les quatres serotypes de la dengue |
FR2906724B1 (fr) * | 2006-10-04 | 2009-03-20 | Sanofi Pasteur Sa | Methode d'immunisation contre les 4 serotypes de la dengue. |
EP2102234A2 (en) * | 2006-11-28 | 2009-09-23 | GHC Research Development Corporation | Polypeptides comprising intracytoplasmic death domain and nkg2d ligand domain |
FR2909286B1 (fr) * | 2006-12-01 | 2012-06-08 | Sanofi Pasteur | Methode d'immunisation contre les 4 serotypes de la dengue |
JP5546448B2 (ja) | 2008-03-31 | 2014-07-09 | 株式会社バイオイミュランス | MHCクラスII分子に提示されるサーバイビン(Survivin)の部分ペプチドとその利用法 |
RU2507253C2 (ru) * | 2009-03-27 | 2014-02-20 | Айдгенозише Технише Хохшуле Цюрих | Презентируемый в salmonella enterica n-гликан из c. jejuni и его производные |
CA2769409A1 (en) * | 2009-08-17 | 2011-02-24 | The Penn State Research Foundation | Use of nkg2d inhibitors for treating cardiovascular and metabolic diseases, such as type 2 diabetes |
KR101815322B1 (ko) * | 2010-01-12 | 2018-01-05 | 서울대학교산학협력단 | 항암 펩타이드 서열 |
WO2011161244A1 (en) * | 2010-06-25 | 2011-12-29 | Vaccibody As | Homodimeric protein constructs |
CN102210862B (zh) * | 2011-06-01 | 2013-06-12 | 中国人民解放军南京军区福州总医院 | 基于Livin的免疫刺激复合物及其制备方法和应用 |
MX2015011095A (es) * | 2013-02-26 | 2016-03-11 | Sloan Kettering Inst Cancer | Composiciones y metodos para inmunoterapia. |
EP3607974A1 (en) * | 2013-03-15 | 2020-02-12 | The Trustees of The University of Pennsylvania | Cancer vaccines and methods of treatment using the same |
WO2014163213A1 (en) * | 2013-04-05 | 2014-10-09 | Kyushu University, National University Corporation | Anti-tumor dna vaccine |
EP3016973A1 (en) * | 2013-07-05 | 2016-05-11 | INSERM - Institut National de la Santé et de la Recherche Médicale | Novel alternative splice transcripts for mhc class i related chain alpha (mica) and uses thereof |
EP3116903A2 (en) * | 2014-03-14 | 2017-01-18 | Dana-Farber Cancer Institute, Inc. | Vaccine compositions and methods for restoring nkg2d pathway function against cancers |
MX2017002594A (es) * | 2014-08-29 | 2017-05-19 | Univ California | Vacuna para sistemas de produccion ganadera. |
US10414810B2 (en) | 2015-05-07 | 2019-09-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Double mutant survivin vaccine |
US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11260018B2 (en) | 2015-09-17 | 2022-03-01 | Jrx Biotechnology, Inc. | Approaches for improving skin hydration and moisturization |
CN108368176B (zh) | 2015-10-01 | 2022-06-07 | 波滕扎治疗公司 | 抗tigit抗原结合蛋白及其使用方法 |
WO2018147801A1 (en) * | 2017-02-07 | 2018-08-16 | Agency For Science, Technology And Research | Methods and kits for generating mimetic innate immune cells from pluripotent stem cells |
JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
CN110448689A (zh) * | 2019-08-06 | 2019-11-15 | 太仓美诺恒康生物技术有限公司 | mRNA疫苗及其试剂盒、应用 |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
CA3208643A1 (en) | 2021-01-18 | 2022-07-21 | Conserv Bioscience Limited | Coronavirus immunogenic compositions, methods and uses thereof |
RU2770490C1 (ru) * | 2021-07-14 | 2022-04-18 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения Российской академии наук" | Рекомбинантная плазмидная ДНК pET19b-Surv-OL, обеспечивающая синтез гибридного белка сурвивин-обелин (Surv-OL) и гибридный белок, связываемый анти-сурвивин антителами и обладающий биолюминесцентной активностью |
CN116077534A (zh) * | 2023-01-31 | 2023-05-09 | 大连工业大学 | 一种凝结芽孢杆菌的应用 |
Family Cites Families (19)
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US3993223A (en) * | 1974-07-25 | 1976-11-23 | American Home Products Corporation | Dispensing container |
US5733760A (en) * | 1994-08-05 | 1998-03-31 | Virus Research Institute | Salmonella vectors encoding truncated pag fusion protein, method of making, and uses thereof |
US6190657B1 (en) * | 1995-06-07 | 2001-02-20 | Yale University | Vectors for the diagnosis and treatment of solid tumors including melanoma |
AU736587B2 (en) * | 1996-11-20 | 2001-08-02 | Yale University | Survivin, a protein that inhibits cellular apoptosis, and its modulation |
JP2001515052A (ja) * | 1997-08-13 | 2001-09-18 | ザ ユーエイビー リサーチ ファンデーション | 遺伝子ベクターの局所施用によるワクチン接種 |
ATE305510T1 (de) * | 1997-12-17 | 2005-10-15 | Immunex Corp | Zelloberflächenglycoproteinen zusammenhang mit menschlicher b zell lymphomen - ulbp, dns und polypeptiden |
US20030215803A1 (en) * | 2000-12-07 | 2003-11-20 | Garcia Pablo Dominguez | Human genes and gene expression products isolated from human prostate |
WO2000003693A1 (en) * | 1998-07-14 | 2000-01-27 | Jenner Biotherapies, Inc. | Survivin, and peptides thereof, as an anti-cancer vaccine |
US6472172B1 (en) * | 1998-07-31 | 2002-10-29 | Schering Aktiengesellschaft | DNA encoding a novel human inhibitor-of-apoptosis protein |
US6838283B2 (en) * | 1998-09-29 | 2005-01-04 | Isis Pharmaceuticals Inc. | Antisense modulation of survivin expression |
US6335194B1 (en) * | 1998-09-29 | 2002-01-01 | Isis Pharmaceuticals, Inc. | Antisense modulation of survivin expression |
IT1303683B1 (it) * | 1998-10-30 | 2001-02-23 | Menarini Ricerche Spa | Composizione farmaceutiche ad azione antitumorale contenente dnacodificante per frammenti di una proteina antigenica. |
US6413768B1 (en) * | 1998-12-02 | 2002-07-02 | University Of Maryland | Expression plasmids |
BR9916315A (pt) * | 1998-12-18 | 2001-08-14 | Haarmann & Reimer Gmbh | Preparados de aroma e/ou perfumes encapsulados |
WO2002002622A2 (en) * | 2000-06-29 | 2002-01-10 | The Salk Institute For Biological Studies | Crystal structure of survivin |
EP1256354A1 (en) * | 2001-05-11 | 2002-11-13 | Schering Corporation | Methods for treating cancer |
AU2002326961A1 (en) * | 2001-10-10 | 2003-04-22 | Centocor, Inc. | Nucleic acid vaccines using tumor antigen encoding nucleic acids with cytokine adjuvant encoding nucleic acid |
CA2500661A1 (en) * | 2002-10-01 | 2004-04-15 | Chiron Corporation | Anti-cancer and anti-infectious disease compositions and methods for using same |
EP1572736A2 (en) * | 2002-12-10 | 2005-09-14 | Endocube SAS | Thap proteins as nuclear receptors for chemokines and roles in transcriptional regulation, cell proliferation and cell differentiation |
-
2004
- 2004-03-24 JP JP2006507511A patent/JP4616827B2/ja not_active Expired - Fee Related
- 2004-03-24 AT AT04749425T patent/ATE472339T1/de active
- 2004-03-24 CA CA2519953A patent/CA2519953C/en not_active Expired - Fee Related
- 2004-03-24 PT PT04749425T patent/PT1622648E/pt unknown
- 2004-03-24 MX MXPA05010255A patent/MXPA05010255A/es active IP Right Grant
- 2004-03-24 WO PCT/US2004/008932 patent/WO2004099389A2/en active Application Filing
- 2004-03-24 CN CN2004800135569A patent/CN1791433B/zh not_active Expired - Fee Related
- 2004-03-24 DE DE602004027902T patent/DE602004027902D1/de not_active Expired - Lifetime
- 2004-03-24 RU RU2005132578/13A patent/RU2343195C2/ru not_active IP Right Cessation
- 2004-03-24 AU AU2004236636A patent/AU2004236636B2/en not_active Ceased
- 2004-03-24 EP EP04749425A patent/EP1622648B1/en not_active Expired - Lifetime
- 2004-03-24 BR BRPI0408774-7A patent/BRPI0408774A/pt not_active Application Discontinuation
- 2004-03-24 DK DK04749425.7T patent/DK1622648T3/da active
- 2004-03-24 US US10/807,897 patent/US8716254B2/en not_active Expired - Fee Related
- 2004-03-24 KR KR1020057017978A patent/KR101199789B1/ko not_active IP Right Cessation
- 2004-03-24 ES ES04749425T patent/ES2345200T3/es not_active Expired - Lifetime
- 2004-03-24 PL PL04749425T patent/PL1622648T3/pl unknown
-
2005
- 2005-10-21 ZA ZA200508579A patent/ZA200508579B/en unknown
-
2014
- 2014-05-05 US US14/269,998 patent/US9655815B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PL1622648T3 (pl) | 2010-11-30 |
US8716254B2 (en) | 2014-05-06 |
ZA200508579B (en) | 2007-04-25 |
CN1791433A (zh) | 2006-06-21 |
WO2004099389A2 (en) | 2004-11-18 |
ATE472339T1 (de) | 2010-07-15 |
DE602004027902D1 (de) | 2010-08-12 |
WO2004099389A3 (en) | 2005-09-29 |
RU2343195C2 (ru) | 2009-01-10 |
MXPA05010255A (es) | 2005-12-14 |
CA2519953A1 (en) | 2004-11-18 |
KR20050121694A (ko) | 2005-12-27 |
EP1622648A2 (en) | 2006-02-08 |
CA2519953C (en) | 2016-01-05 |
EP1622648B1 (en) | 2010-06-30 |
RU2005132578A (ru) | 2006-05-10 |
EP1622648A4 (en) | 2007-02-14 |
US20140322249A1 (en) | 2014-10-30 |
DK1622648T3 (da) | 2010-09-06 |
JP2006523217A (ja) | 2006-10-12 |
AU2004236636A1 (en) | 2004-11-18 |
ES2345200T3 (es) | 2010-09-17 |
US20040192631A1 (en) | 2004-09-30 |
CN1791433B (zh) | 2010-05-26 |
US9655815B2 (en) | 2017-05-23 |
JP4616827B2 (ja) | 2011-01-19 |
PT1622648E (pt) | 2010-08-31 |
KR101199789B1 (ko) | 2012-11-09 |
AU2004236636B2 (en) | 2010-02-04 |
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