DE602004027902D1 - Dna-vakzine gegen tumorwachstum und anwendungsverfahren dafür - Google Patents
Dna-vakzine gegen tumorwachstum und anwendungsverfahren dafürInfo
- Publication number
- DE602004027902D1 DE602004027902D1 DE602004027902T DE602004027902T DE602004027902D1 DE 602004027902 D1 DE602004027902 D1 DE 602004027902D1 DE 602004027902 T DE602004027902 T DE 602004027902T DE 602004027902 T DE602004027902 T DE 602004027902T DE 602004027902 D1 DE602004027902 D1 DE 602004027902D1
- Authority
- DE
- Germany
- Prior art keywords
- human
- protein
- tumor growth
- cancer
- apoptosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000004614 tumor growth Effects 0.000 title abstract 2
- 206010046865 Vaccinia virus infection Diseases 0.000 title 1
- 208000007089 vaccinia Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 108091007065 BIRCs Proteins 0.000 abstract 2
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 2
- 108090000695 Cytokines Proteins 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 2
- 102000055031 Inhibitor of Apoptosis Proteins Human genes 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 102000006240 membrane receptors Human genes 0.000 abstract 2
- 210000000822 natural killer cell Anatomy 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 102100027522 Baculoviral IAP repeat-containing protein 7 Human genes 0.000 abstract 1
- 101710177963 Baculoviral IAP repeat-containing protein 7 Proteins 0.000 abstract 1
- 102100036846 C-C motif chemokine 21 Human genes 0.000 abstract 1
- 108010041986 DNA Vaccines Proteins 0.000 abstract 1
- 229940021995 DNA vaccine Drugs 0.000 abstract 1
- 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 abstract 1
- 101000607306 Homo sapiens UL16-binding protein 1 Proteins 0.000 abstract 1
- 101000607320 Homo sapiens UL16-binding protein 2 Proteins 0.000 abstract 1
- 101000607318 Homo sapiens UL16-binding protein 3 Proteins 0.000 abstract 1
- 108010031034 MHC class I-related chain A Proteins 0.000 abstract 1
- 108010086911 MICB antigen Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000000763 Survivin Human genes 0.000 abstract 1
- 108010002687 Survivin Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 102000048777 human ULBP1 Human genes 0.000 abstract 1
- 102000048775 human ULBP2 Human genes 0.000 abstract 1
- 102000052075 human ULBP3 Human genes 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001136—Cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001148—Regulators of development
- A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45700903P | 2003-03-24 | 2003-03-24 | |
PCT/US2004/008932 WO2004099389A2 (en) | 2003-03-24 | 2004-03-24 | Dna vaccines against tumor growth and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004027902D1 true DE602004027902D1 (de) | 2010-08-12 |
Family
ID=33434911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004027902T Expired - Lifetime DE602004027902D1 (de) | 2003-03-24 | 2004-03-24 | Dna-vakzine gegen tumorwachstum und anwendungsverfahren dafür |
Country Status (18)
Country | Link |
---|---|
US (2) | US8716254B2 (de) |
EP (1) | EP1622648B1 (de) |
JP (1) | JP4616827B2 (de) |
KR (1) | KR101199789B1 (de) |
CN (1) | CN1791433B (de) |
AT (1) | ATE472339T1 (de) |
AU (1) | AU2004236636B2 (de) |
BR (1) | BRPI0408774A (de) |
CA (1) | CA2519953C (de) |
DE (1) | DE602004027902D1 (de) |
DK (1) | DK1622648T3 (de) |
ES (1) | ES2345200T3 (de) |
MX (1) | MXPA05010255A (de) |
PL (1) | PL1622648T3 (de) |
PT (1) | PT1622648E (de) |
RU (1) | RU2343195C2 (de) |
WO (1) | WO2004099389A2 (de) |
ZA (1) | ZA200508579B (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2005294805B2 (en) | 2004-05-28 | 2012-02-16 | Oryxe | A mixture for transdermal delivery of low and high molecular weight compounds |
US20060276423A1 (en) * | 2005-04-18 | 2006-12-07 | Rachel Altura | Survivin-directed RNA interference-compositions and methods |
US20070104689A1 (en) * | 2005-09-27 | 2007-05-10 | Merck Patent Gmbh | Compositions and methods for treating tumors presenting survivin antigens |
KR100790377B1 (ko) * | 2006-02-15 | 2008-01-02 | 고려대학교 산학협력단 | 인터페론감마를 발현하는 살모넬라 균주를 함유하는항바이러스용 조성물 |
WO2007149518A2 (en) * | 2006-06-21 | 2007-12-27 | The Scripps Research Institute | Dna composition against tumor stromal antigen fap and methods of use thereof |
EP2038417A2 (de) * | 2006-07-06 | 2009-03-25 | Merck Patent GmbH | Zusammensetzungen und verfahren zur verstärkung der wirksamkeit von il-2-vermittelten immunreaktionen |
FR2903605A1 (fr) * | 2006-07-12 | 2008-01-18 | Sanofi Pasteur Sa | Methode d'immunisation contre les quatres serotypes de la dengue |
FR2906724B1 (fr) * | 2006-10-04 | 2009-03-20 | Sanofi Pasteur Sa | Methode d'immunisation contre les 4 serotypes de la dengue. |
EP2102234A2 (de) * | 2006-11-28 | 2009-09-23 | GHC Research Development Corporation | Polypeptide mit einer intrazytoplasmischen todesdomäne und einer nkg2d-ligandendomäne |
FR2909286B1 (fr) * | 2006-12-01 | 2012-06-08 | Sanofi Pasteur | Methode d'immunisation contre les 4 serotypes de la dengue |
AU2009232774B2 (en) | 2008-03-31 | 2014-05-29 | Tella Inc. | Partial peptide of Survivin presented on MHC class II molecule and use thereof |
PT2411503T (pt) * | 2009-03-27 | 2017-11-15 | Eidgenössische Technische Hochschule Zürich | Salmonella enterica que apresenta n-glicano de c. jejuni ou derivados do mesmo |
BR112012002353A2 (pt) * | 2009-08-17 | 2018-03-13 | The Penn State Res Foudation | uso de inibidores nkg2d para tratamento de doenças cardiovasculares e metabólicas, tal como diabetes do tipo 2 |
KR101815322B1 (ko) * | 2010-01-12 | 2018-01-05 | 서울대학교산학협력단 | 항암 펩타이드 서열 |
KR102044948B1 (ko) * | 2010-06-25 | 2019-11-14 | 백시바디 에이에스 | 동종이합체 단백질 구조물 |
CN102210862B (zh) * | 2011-06-01 | 2013-06-12 | 中国人民解放军南京军区福州总医院 | 基于Livin的免疫刺激复合物及其制备方法和应用 |
IL298125A (en) * | 2013-02-26 | 2023-01-01 | Memorial Sloan Kettering Cancer Center | Preparations and methods for immunotherapy |
EP3607974A1 (de) * | 2013-03-15 | 2020-02-12 | The Trustees of The University of Pennsylvania | Krebsimpfstoffe und verfahren zur behandlung unter verwendung davon |
US20160058856A1 (en) * | 2013-04-05 | 2016-03-03 | Kyushu University, National University Corporation | Anti-tumor dna vaccine |
EP3016973A1 (de) * | 2013-07-05 | 2016-05-11 | INSERM - Institut National de la Santé et de la Recherche Médicale | Neuartige alternative splice-transkripte für ketten-alpha der mhc-klasse i (mica) und verwendungen davon |
WO2015139020A2 (en) * | 2014-03-14 | 2015-09-17 | Dana-Farber Cancer Institute, Inc. | Vaccine compositions and methods for restoring nkg2d pathway function against cancers |
MX2017002594A (es) * | 2014-08-29 | 2017-05-19 | Univ California | Vacuna para sistemas de produccion ganadera. |
US10414810B2 (en) | 2015-05-07 | 2019-09-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Double mutant survivin vaccine |
US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
WO2017048807A1 (en) | 2015-09-17 | 2017-03-23 | Jrx Biotechnology, Inc. | Approaches for improving skin hydration or moisturization |
AU2016331052B2 (en) | 2015-10-01 | 2023-08-03 | Potenza Therapeutics, Inc. | Anti-TIGIT antigen-binding proteins and methods of use thereof |
US20190359940A1 (en) * | 2017-02-07 | 2019-11-28 | Agency For Science, Technology And Research | Methods and kits for generating mimetic innate immune cells from pluripotent stem cells |
JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
CN110448689A (zh) * | 2019-08-06 | 2019-11-15 | 太仓美诺恒康生物技术有限公司 | mRNA疫苗及其试剂盒、应用 |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
AU2022208435A1 (en) | 2021-01-18 | 2023-08-10 | Conserv Bioscience Limited | Coronavirus immunogenic compositions, methods and uses thereof |
RU2770490C1 (ru) * | 2021-07-14 | 2022-04-18 | Федеральное государственное бюджетное научное учреждение "Федеральный исследовательский центр "Красноярский научный центр Сибирского отделения Российской академии наук" | Рекомбинантная плазмидная ДНК pET19b-Surv-OL, обеспечивающая синтез гибридного белка сурвивин-обелин (Surv-OL) и гибридный белок, связываемый анти-сурвивин антителами и обладающий биолюминесцентной активностью |
CN116077534A (zh) * | 2023-01-31 | 2023-05-09 | 大连工业大学 | 一种凝结芽孢杆菌的应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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US3993223A (en) * | 1974-07-25 | 1976-11-23 | American Home Products Corporation | Dispensing container |
US5733760A (en) * | 1994-08-05 | 1998-03-31 | Virus Research Institute | Salmonella vectors encoding truncated pag fusion protein, method of making, and uses thereof |
US6190657B1 (en) * | 1995-06-07 | 2001-02-20 | Yale University | Vectors for the diagnosis and treatment of solid tumors including melanoma |
DE69739105D1 (de) * | 1996-11-20 | 2008-12-24 | Univ Yale | Survivin, ein protein das zelluläre apoptosis hemmt, und dessen modulation |
KR20080009171A (ko) * | 1997-08-13 | 2008-01-24 | 더 유에이비 리서치 파운데이션 | 유전자 벡터의 국소 적용에 의한 백신접종 |
ES2251120T3 (es) * | 1997-12-17 | 2006-04-16 | Immunex Corporation | Glicoproteinas de superficie celular asociadas a los linfomas b humanos-ulbp, adn y polipeptidos. |
US20030215803A1 (en) * | 2000-12-07 | 2003-11-20 | Garcia Pablo Dominguez | Human genes and gene expression products isolated from human prostate |
AU4990999A (en) * | 1998-07-14 | 2000-02-07 | Jenner Biotherapies, Inc. | Survivin, and peptides thereof, as an anti-cancer vaccine |
US6472172B1 (en) * | 1998-07-31 | 2002-10-29 | Schering Aktiengesellschaft | DNA encoding a novel human inhibitor-of-apoptosis protein |
US6335194B1 (en) * | 1998-09-29 | 2002-01-01 | Isis Pharmaceuticals, Inc. | Antisense modulation of survivin expression |
US6838283B2 (en) * | 1998-09-29 | 2005-01-04 | Isis Pharmaceuticals Inc. | Antisense modulation of survivin expression |
IT1303683B1 (it) * | 1998-10-30 | 2001-02-23 | Menarini Ricerche Spa | Composizione farmaceutiche ad azione antitumorale contenente dnacodificante per frammenti di una proteina antigenica. |
US6413768B1 (en) * | 1998-12-02 | 2002-07-02 | University Of Maryland | Expression plasmids |
AU765160B2 (en) * | 1998-12-18 | 2003-09-11 | Symrise Gmbh & Co. Kg | Encapsulated flavour and/or fragrance preparations |
WO2002002622A2 (en) * | 2000-06-29 | 2002-01-10 | The Salk Institute For Biological Studies | Crystal structure of survivin |
EP1256354A1 (de) * | 2001-05-11 | 2002-11-13 | Schering Corporation | Verfahren zur Behandlung von Krebs |
WO2003031569A2 (en) * | 2001-10-10 | 2003-04-17 | Centocor, Inc. | Nucleic acid vaccines using tumor antigen encoding nucleic acids with cytokine adjuvant encoding nucleic acid |
US20080159957A1 (en) * | 2002-10-01 | 2008-07-03 | W Michael Kavanaugh | Anti-Cancer and Anti-Infectious Disease Compositions and Methods for Using Same |
JP2007527193A (ja) * | 2002-12-10 | 2007-09-27 | アンドキューブ ソシエタ パー アクシオン シンプリフィー | ケモカインに対する核受容体としてのthapタンパク質と、転写調節、細胞増殖、および細胞分化におけるその役割 |
-
2004
- 2004-03-24 CA CA2519953A patent/CA2519953C/en not_active Expired - Fee Related
- 2004-03-24 DE DE602004027902T patent/DE602004027902D1/de not_active Expired - Lifetime
- 2004-03-24 AT AT04749425T patent/ATE472339T1/de active
- 2004-03-24 AU AU2004236636A patent/AU2004236636B2/en not_active Ceased
- 2004-03-24 PL PL04749425T patent/PL1622648T3/pl unknown
- 2004-03-24 US US10/807,897 patent/US8716254B2/en not_active Expired - Fee Related
- 2004-03-24 WO PCT/US2004/008932 patent/WO2004099389A2/en active Application Filing
- 2004-03-24 EP EP04749425A patent/EP1622648B1/de not_active Expired - Lifetime
- 2004-03-24 DK DK04749425.7T patent/DK1622648T3/da active
- 2004-03-24 MX MXPA05010255A patent/MXPA05010255A/es active IP Right Grant
- 2004-03-24 RU RU2005132578/13A patent/RU2343195C2/ru not_active IP Right Cessation
- 2004-03-24 PT PT04749425T patent/PT1622648E/pt unknown
- 2004-03-24 JP JP2006507511A patent/JP4616827B2/ja not_active Expired - Fee Related
- 2004-03-24 KR KR1020057017978A patent/KR101199789B1/ko not_active IP Right Cessation
- 2004-03-24 CN CN2004800135569A patent/CN1791433B/zh not_active Expired - Fee Related
- 2004-03-24 BR BRPI0408774-7A patent/BRPI0408774A/pt not_active Application Discontinuation
- 2004-03-24 ES ES04749425T patent/ES2345200T3/es not_active Expired - Lifetime
-
2005
- 2005-10-21 ZA ZA200508579A patent/ZA200508579B/en unknown
-
2014
- 2014-05-05 US US14/269,998 patent/US9655815B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US8716254B2 (en) | 2014-05-06 |
PL1622648T3 (pl) | 2010-11-30 |
RU2005132578A (ru) | 2006-05-10 |
JP4616827B2 (ja) | 2011-01-19 |
KR101199789B1 (ko) | 2012-11-09 |
RU2343195C2 (ru) | 2009-01-10 |
ZA200508579B (en) | 2007-04-25 |
MXPA05010255A (es) | 2005-12-14 |
AU2004236636B2 (en) | 2010-02-04 |
JP2006523217A (ja) | 2006-10-12 |
US9655815B2 (en) | 2017-05-23 |
KR20050121694A (ko) | 2005-12-27 |
AU2004236636A1 (en) | 2004-11-18 |
EP1622648A2 (de) | 2006-02-08 |
EP1622648A4 (de) | 2007-02-14 |
CN1791433A (zh) | 2006-06-21 |
ES2345200T3 (es) | 2010-09-17 |
CA2519953A1 (en) | 2004-11-18 |
BRPI0408774A (pt) | 2006-03-28 |
CN1791433B (zh) | 2010-05-26 |
ATE472339T1 (de) | 2010-07-15 |
US20140322249A1 (en) | 2014-10-30 |
CA2519953C (en) | 2016-01-05 |
DK1622648T3 (da) | 2010-09-06 |
WO2004099389A3 (en) | 2005-09-29 |
WO2004099389A2 (en) | 2004-11-18 |
PT1622648E (pt) | 2010-08-31 |
US20040192631A1 (en) | 2004-09-30 |
EP1622648B1 (de) | 2010-06-30 |
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