KR100606322B1 - 약독화된 자멸 박테리아에 의한 마크로파지의 세포질로폴리펩티드-암호화 플라스미드 ｄｎａ의 전달 - Google Patents

약독화된 자멸 박테리아에 의한 마크로파지의 세포질로폴리펩티드-암호화 플라스미드 ｄｎａ의 전달 Download PDF

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KR100606322B1
KR100606322B1 KR1020007007207A KR20007007207A KR100606322B1 KR 100606322 B1 KR100606322 B1 KR 100606322B1 KR 1020007007207 A KR1020007007207 A KR 1020007007207A KR 20007007207 A KR20007007207 A KR 20007007207A KR 100606322 B1 KR100606322 B1 KR 100606322B1
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bacterium
bacteria
promoter
attenuated
plasmid
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KR20010033684A (ko
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베르너 괴벨
기도 디트리히
이바일로 겐트쉐브
슈테판 카우프만
위르겐 헤스
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쉐링 악티엔게젤샤프트
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
    • C12N15/877—Techniques for producing new mammalian cloned embryos
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

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  • Developmental Biology & Embryology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020007007207A 1997-12-29 1998-12-18 약독화된 자멸 박테리아에 의한 마크로파지의 세포질로폴리펩티드-암호화 플라스미드 ｄｎａ의 전달 Expired - Fee Related KR100606322B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/999,391 1997-12-29
US08/999,391 US6143551A (en) 1997-12-29 1997-12-29 Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria
PCT/EP1998/008345 WO1999034007A1 (en) 1997-12-29 1998-12-18 Delivery of polypeptide-encoding plasmid dna into the cytosol of macrophages by attenuated suicide bacteria

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KR20010033684A KR20010033684A (ko) 2001-04-25
KR100606322B1 true KR100606322B1 (ko) 2006-08-02

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KR1020007007207A Expired - Fee Related KR100606322B1 (ko) 1997-12-29 1998-12-18 약독화된 자멸 박테리아에 의한 마크로파지의 세포질로폴리펩티드-암호화 플라스미드 ｄｎａ의 전달

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US (2) US6143551A (https=)
EP (1) EP1042495A1 (https=)
JP (1) JP2002500017A (https=)
KR (1) KR100606322B1 (https=)
AU (1) AU753888B2 (https=)
BR (1) BR9814546A (https=)
CA (1) CA2317111A1 (https=)
HU (1) HUP0100994A3 (https=)
IL (2) IL136455A0 (https=)
PL (1) PL194123B1 (https=)
WO (1) WO1999034007A1 (https=)

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US20040242520A1 (en) * 1997-09-06 2004-12-02 Mayo Foundation For Medical Education And Research, A Minnesota Corporation Expression of immonogenic substances
US6080849A (en) * 1997-09-10 2000-06-27 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
US6962696B1 (en) * 1999-10-04 2005-11-08 Vion Pharmaceuticals Inc. Compositions and methods for tumor-targeted delivery of effector molecules
DE19949594A1 (de) * 1999-10-14 2001-04-26 Deutsches Krebsforsch Rekombinante attenuierte Listerien zur Immuntherapie
AU2003240505A1 (en) * 2002-06-05 2003-12-22 Iowa State University Research Foundation, Inc. Bacteriophage and enzymes lytic to salmonellae
US20050214264A1 (en) * 2002-12-13 2005-09-29 Cosenza Lawrence W Sacromastigophoric therapeutic agent delivery system
US7695725B2 (en) * 2003-02-06 2010-04-13 Aduro Biotech Modified free-living microbes, vaccine compositions and methods of use thereof
KR101192652B1 (ko) * 2003-02-06 2012-10-19 앤저 테라퓨틱스 인코퍼레이티드 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법
KR101173871B1 (ko) * 2003-02-06 2012-08-16 앤저 테라퓨틱스 인코퍼레이티드 변형된 독립생존 미생물, 백신 조성물 및 그것의 사용방법
DE10326189A1 (de) * 2003-06-06 2005-01-05 MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH Bakterielle Träger für Nukleotidsequenzen kodierend für Wirkstoffe
US7390646B2 (en) * 2003-09-17 2008-06-24 The Regents Of The University Of California Bacterial vectors and methods of use thereof
US20070298012A1 (en) * 2003-12-16 2007-12-27 Ivan King Compositions and Methods for Tumor-Targeted Delivery of Effector Molecules
US7842289B2 (en) 2003-12-24 2010-11-30 Aduro Biotech Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof
EP1799937A1 (en) 2004-07-23 2007-06-27 Henkin-Laby, LLC Swimming pool cleaner debris container
WO2006137836A2 (en) * 2004-08-17 2006-12-28 Research Development Foundation Bacterial vector systems
US20090123426A1 (en) 2004-12-17 2009-05-14 Chiang Li Compositions for Bacterial Mediated Gene Silencing and Methods of Using the Same
MX2007013725A (es) 2005-05-05 2008-04-09 Sensient Flavors Inc Produccion de beta-glucanos y mananos.
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
US8241623B1 (en) 2009-02-09 2012-08-14 David Bermudes Protease sensitivity expression system
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
WO2014043518A1 (en) 2012-09-14 2014-03-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use
US9593339B1 (en) 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
TWI658140B (zh) * 2015-11-12 2019-05-01 昕穎生醫技術股份有限公司 表現異源基因的系統及其用途
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO1996034631A1 (en) * 1995-05-03 1996-11-07 University Of Maryland At Baltimore Method for introducing and expressing genes in animal cells

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GB2255561B (en) * 1991-04-20 1995-06-21 Agricultural & Food Res Lysins from bacteriophages
DE59510532D1 (de) * 1994-09-09 2003-02-20 Biotec Lab Ltd Aufschluss von bakterienzellen durch phagenlysine
IL123569A (en) * 1995-09-06 2006-10-05 Dept Of The Army Attenuated shigella strain for delivering a mamalian expression plasmid into a mammalian cell
DE19754938B4 (de) * 1997-12-11 2006-04-20 Christoph von Dr. Eichel-Streiber TGC-Verfahren zur Induktion einer zielgerichteten, somatischen Transgenität

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO1996034631A1 (en) * 1995-05-03 1996-11-07 University Of Maryland At Baltimore Method for introducing and expressing genes in animal cells

Non-Patent Citations (1)

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Title
Cell, Vol.68:521-531 (1992.02.07) *

Also Published As

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HUP0100994A2 (hu) 2001-07-30
EP1042495A1 (en) 2000-10-11
PL194123B1 (pl) 2007-04-30
US6143551A (en) 2000-11-07
AU753888B2 (en) 2002-10-31
BR9814546A (pt) 2000-10-10
PL341530A1 (en) 2001-04-23
AU2054799A (en) 1999-07-19
KR20010033684A (ko) 2001-04-25
IL136455A (en) 2007-06-03
US20020045587A1 (en) 2002-04-18
CA2317111A1 (en) 1999-07-08
HUP0100994A3 (en) 2003-10-28
WO1999034007A1 (en) 1999-07-08
IL136455A0 (en) 2001-06-14
JP2002500017A (ja) 2002-01-08

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