JP2002500017A - 弱毒化した自殺細菌によるマクロファージの細胞質への、ポリペプチドをコードするプラスミドｄｎａの輸送 - Google Patents
弱毒化した自殺細菌によるマクロファージの細胞質への、ポリペプチドをコードするプラスミドｄｎａの輸送Info
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
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- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/999,391 | 1997-12-29 | ||
| US08/999,391 US6143551A (en) | 1997-12-29 | 1997-12-29 | Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria |
| PCT/EP1998/008345 WO1999034007A1 (en) | 1997-12-29 | 1998-12-18 | Delivery of polypeptide-encoding plasmid dna into the cytosol of macrophages by attenuated suicide bacteria |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002500017A true JP2002500017A (ja) | 2002-01-08 |
| JP2002500017A5 JP2002500017A5 (https=) | 2006-01-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2000526662A Pending JP2002500017A (ja) | 1997-12-29 | 1998-12-18 | 弱毒化した自殺細菌によるマクロファージの細胞質への、ポリペプチドをコードするプラスミドｄｎａの輸送 |
Country Status (11)
| Country | Link |
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| US (2) | US6143551A (https=) |
| EP (1) | EP1042495A1 (https=) |
| JP (1) | JP2002500017A (https=) |
| KR (1) | KR100606322B1 (https=) |
| AU (1) | AU753888B2 (https=) |
| BR (1) | BR9814546A (https=) |
| CA (1) | CA2317111A1 (https=) |
| HU (1) | HUP0100994A3 (https=) |
| IL (2) | IL136455A0 (https=) |
| PL (1) | PL194123B1 (https=) |
| WO (1) | WO1999034007A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008092956A (ja) * | 2004-12-17 | 2008-04-24 | Beth Israel Deaconess Medical Center | 細菌によって媒介される遺伝子サイレンシングのための組成物およびその使用方法 |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040242520A1 (en) * | 1997-09-06 | 2004-12-02 | Mayo Foundation For Medical Education And Research, A Minnesota Corporation | Expression of immonogenic substances |
| US6080849A (en) * | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| US6962696B1 (en) * | 1999-10-04 | 2005-11-08 | Vion Pharmaceuticals Inc. | Compositions and methods for tumor-targeted delivery of effector molecules |
| DE19949594A1 (de) * | 1999-10-14 | 2001-04-26 | Deutsches Krebsforsch | Rekombinante attenuierte Listerien zur Immuntherapie |
| AU2003240505A1 (en) * | 2002-06-05 | 2003-12-22 | Iowa State University Research Foundation, Inc. | Bacteriophage and enzymes lytic to salmonellae |
| US20050214264A1 (en) * | 2002-12-13 | 2005-09-29 | Cosenza Lawrence W | Sacromastigophoric therapeutic agent delivery system |
| US7695725B2 (en) * | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| KR101192652B1 (ko) * | 2003-02-06 | 2012-10-19 | 앤저 테라퓨틱스 인코퍼레이티드 | 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법 |
| KR101173871B1 (ko) * | 2003-02-06 | 2012-08-16 | 앤저 테라퓨틱스 인코퍼레이티드 | 변형된 독립생존 미생물, 백신 조성물 및 그것의 사용방법 |
| DE10326189A1 (de) * | 2003-06-06 | 2005-01-05 | MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH | Bakterielle Träger für Nukleotidsequenzen kodierend für Wirkstoffe |
| US7390646B2 (en) * | 2003-09-17 | 2008-06-24 | The Regents Of The University Of California | Bacterial vectors and methods of use thereof |
| US20070298012A1 (en) * | 2003-12-16 | 2007-12-27 | Ivan King | Compositions and Methods for Tumor-Targeted Delivery of Effector Molecules |
| US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| EP1799937A1 (en) | 2004-07-23 | 2007-06-27 | Henkin-Laby, LLC | Swimming pool cleaner debris container |
| WO2006137836A2 (en) * | 2004-08-17 | 2006-12-28 | Research Development Foundation | Bacterial vector systems |
| MX2007013725A (es) | 2005-05-05 | 2008-04-09 | Sensient Flavors Inc | Produccion de beta-glucanos y mananos. |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| US8241623B1 (en) | 2009-02-09 | 2012-08-14 | David Bermudes | Protease sensitivity expression system |
| US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
| US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
| WO2014043518A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use |
| US9593339B1 (en) | 2013-02-14 | 2017-03-14 | David Gordon Bermudes | Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| TWI658140B (zh) * | 2015-11-12 | 2019-05-01 | 昕穎生醫技術股份有限公司 | 表現異源基因的系統及其用途 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2255561B (en) * | 1991-04-20 | 1995-06-21 | Agricultural & Food Res | Lysins from bacteriophages |
| DE59510532D1 (de) * | 1994-09-09 | 2003-02-20 | Biotec Lab Ltd | Aufschluss von bakterienzellen durch phagenlysine |
| US5877159A (en) * | 1995-05-03 | 1999-03-02 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same |
| IL123569A (en) * | 1995-09-06 | 2006-10-05 | Dept Of The Army | Attenuated shigella strain for delivering a mamalian expression plasmid into a mammalian cell |
| DE19754938B4 (de) * | 1997-12-11 | 2006-04-20 | Christoph von Dr. Eichel-Streiber | TGC-Verfahren zur Induktion einer zielgerichteten, somatischen Transgenität |
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- 1997-12-29 US US08/999,391 patent/US6143551A/en not_active Expired - Fee Related
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1998
- 1998-12-18 IL IL13645598A patent/IL136455A0/xx not_active IP Right Cessation
- 1998-12-18 JP JP2000526662A patent/JP2002500017A/ja active Pending
- 1998-12-18 BR BR9814546-0A patent/BR9814546A/pt not_active Application Discontinuation
- 1998-12-18 WO PCT/EP1998/008345 patent/WO1999034007A1/en not_active Ceased
- 1998-12-18 PL PL98341530A patent/PL194123B1/pl unknown
- 1998-12-18 EP EP98965287A patent/EP1042495A1/en not_active Withdrawn
- 1998-12-18 HU HU0100994A patent/HUP0100994A3/hu unknown
- 1998-12-18 CA CA002317111A patent/CA2317111A1/en not_active Abandoned
- 1998-12-18 KR KR1020007007207A patent/KR100606322B1/ko not_active Expired - Fee Related
- 1998-12-18 AU AU20547/99A patent/AU753888B2/en not_active Ceased
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2000
- 2000-03-22 US US09/532,964 patent/US20020045587A1/en not_active Abandoned
- 2000-05-30 IL IL136455A patent/IL136455A/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008092956A (ja) * | 2004-12-17 | 2008-04-24 | Beth Israel Deaconess Medical Center | 細菌によって媒介される遺伝子サイレンシングのための組成物およびその使用方法 |
| JP2008523812A (ja) * | 2004-12-17 | 2008-07-10 | ベス イスラエル デアコネス メディカル センター | 細菌によって媒介される遺伝子サイレンシングのための組成物およびその使用方法 |
| JP2016138108A (ja) * | 2004-12-17 | 2016-08-04 | ベス イスラエル デアコネス メディカル センター， インコーポレイテッド | 細菌によって媒介される遺伝子サイレンシングのための組成物およびその使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0100994A2 (hu) | 2001-07-30 |
| EP1042495A1 (en) | 2000-10-11 |
| PL194123B1 (pl) | 2007-04-30 |
| US6143551A (en) | 2000-11-07 |
| AU753888B2 (en) | 2002-10-31 |
| BR9814546A (pt) | 2000-10-10 |
| PL341530A1 (en) | 2001-04-23 |
| KR100606322B1 (ko) | 2006-08-02 |
| AU2054799A (en) | 1999-07-19 |
| KR20010033684A (ko) | 2001-04-25 |
| IL136455A (en) | 2007-06-03 |
| US20020045587A1 (en) | 2002-04-18 |
| CA2317111A1 (en) | 1999-07-08 |
| HUP0100994A3 (en) | 2003-10-28 |
| WO1999034007A1 (en) | 1999-07-08 |
| IL136455A0 (en) | 2001-06-14 |
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