AU753888B2 - Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide bacteria - Google Patents
Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated suicide bacteria Download PDFInfo
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- AU753888B2 AU753888B2 AU20547/99A AU2054799A AU753888B2 AU 753888 B2 AU753888 B2 AU 753888B2 AU 20547/99 A AU20547/99 A AU 20547/99A AU 2054799 A AU2054799 A AU 2054799A AU 753888 B2 AU753888 B2 AU 753888B2
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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| US08/999391 | 1997-12-29 | ||
| US08/999,391 US6143551A (en) | 1997-12-29 | 1997-12-29 | Delivery of polypeptide-encoding plasmid DNA into the cytosol of macrophages by attenuated listeria suicide bacteria |
| PCT/EP1998/008345 WO1999034007A1 (en) | 1997-12-29 | 1998-12-18 | Delivery of polypeptide-encoding plasmid dna into the cytosol of macrophages by attenuated suicide bacteria |
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| AU2054799A AU2054799A (en) | 1999-07-19 |
| AU753888B2 true AU753888B2 (en) | 2002-10-31 |
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| US20040242520A1 (en) * | 1997-09-06 | 2004-12-02 | Mayo Foundation For Medical Education And Research, A Minnesota Corporation | Expression of immonogenic substances |
| US6080849A (en) * | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| US6962696B1 (en) * | 1999-10-04 | 2005-11-08 | Vion Pharmaceuticals Inc. | Compositions and methods for tumor-targeted delivery of effector molecules |
| DE19949594A1 (de) * | 1999-10-14 | 2001-04-26 | Deutsches Krebsforsch | Rekombinante attenuierte Listerien zur Immuntherapie |
| AU2003240505A1 (en) * | 2002-06-05 | 2003-12-22 | Iowa State University Research Foundation, Inc. | Bacteriophage and enzymes lytic to salmonellae |
| US20050214264A1 (en) * | 2002-12-13 | 2005-09-29 | Cosenza Lawrence W | Sacromastigophoric therapeutic agent delivery system |
| US7695725B2 (en) * | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| KR101192652B1 (ko) * | 2003-02-06 | 2012-10-19 | 앤저 테라퓨틱스 인코퍼레이티드 | 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법 |
| KR101173871B1 (ko) * | 2003-02-06 | 2012-08-16 | 앤저 테라퓨틱스 인코퍼레이티드 | 변형된 독립생존 미생물, 백신 조성물 및 그것의 사용방법 |
| DE10326189A1 (de) * | 2003-06-06 | 2005-01-05 | MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH | Bakterielle Träger für Nukleotidsequenzen kodierend für Wirkstoffe |
| US7390646B2 (en) * | 2003-09-17 | 2008-06-24 | The Regents Of The University Of California | Bacterial vectors and methods of use thereof |
| US20070298012A1 (en) * | 2003-12-16 | 2007-12-27 | Ivan King | Compositions and Methods for Tumor-Targeted Delivery of Effector Molecules |
| US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| EP1799937A1 (en) | 2004-07-23 | 2007-06-27 | Henkin-Laby, LLC | Swimming pool cleaner debris container |
| WO2006137836A2 (en) * | 2004-08-17 | 2006-12-28 | Research Development Foundation | Bacterial vector systems |
| US20090123426A1 (en) | 2004-12-17 | 2009-05-14 | Chiang Li | Compositions for Bacterial Mediated Gene Silencing and Methods of Using the Same |
| MX2007013725A (es) | 2005-05-05 | 2008-04-09 | Sensient Flavors Inc | Produccion de beta-glucanos y mananos. |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| US8241623B1 (en) | 2009-02-09 | 2012-08-14 | David Bermudes | Protease sensitivity expression system |
| US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
| US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
| WO2014043518A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use |
| US9593339B1 (en) | 2013-02-14 | 2017-03-14 | David Gordon Bermudes | Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| TWI658140B (zh) * | 2015-11-12 | 2019-05-01 | 昕穎生醫技術股份有限公司 | 表現異源基因的系統及其用途 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996034631A1 (en) * | 1995-05-03 | 1996-11-07 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells |
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| GB2255561B (en) * | 1991-04-20 | 1995-06-21 | Agricultural & Food Res | Lysins from bacteriophages |
| DE59510532D1 (de) * | 1994-09-09 | 2003-02-20 | Biotec Lab Ltd | Aufschluss von bakterienzellen durch phagenlysine |
| IL123569A (en) * | 1995-09-06 | 2006-10-05 | Dept Of The Army | Attenuated shigella strain for delivering a mamalian expression plasmid into a mammalian cell |
| DE19754938B4 (de) * | 1997-12-11 | 2006-04-20 | Christoph von Dr. Eichel-Streiber | TGC-Verfahren zur Induktion einer zielgerichteten, somatischen Transgenität |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996034631A1 (en) * | 1995-05-03 | 1996-11-07 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells |
Non-Patent Citations (1)
| Title |
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| CELL, VOL.68, PP521-31,1991 * |
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| HUP0100994A2 (hu) | 2001-07-30 |
| EP1042495A1 (en) | 2000-10-11 |
| PL194123B1 (pl) | 2007-04-30 |
| US6143551A (en) | 2000-11-07 |
| BR9814546A (pt) | 2000-10-10 |
| PL341530A1 (en) | 2001-04-23 |
| KR100606322B1 (ko) | 2006-08-02 |
| AU2054799A (en) | 1999-07-19 |
| KR20010033684A (ko) | 2001-04-25 |
| IL136455A (en) | 2007-06-03 |
| US20020045587A1 (en) | 2002-04-18 |
| CA2317111A1 (en) | 1999-07-08 |
| HUP0100994A3 (en) | 2003-10-28 |
| WO1999034007A1 (en) | 1999-07-08 |
| IL136455A0 (en) | 2001-06-14 |
| JP2002500017A (ja) | 2002-01-08 |
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