KR100544295B1 - 에이엠피에이 수용체 활성을 증가시키는 벤조퓨란 화합물 - Google Patents

에이엠피에이 수용체 활성을 증가시키는 벤조퓨란 화합물 Download PDF

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KR100544295B1
KR100544295B1 KR1019997007369A KR19997007369A KR100544295B1 KR 100544295 B1 KR100544295 B1 KR 100544295B1 KR 1019997007369 A KR1019997007369 A KR 1019997007369A KR 19997007369 A KR19997007369 A KR 19997007369A KR 100544295 B1 KR100544295 B1 KR 100544295B1
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compound
ylcarbonyl
benzofuran
crr
hydrogen
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Korean (ko)
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KR20000071082A (ko
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개리 에이. 로저스
크리스토퍼 엠. 마스
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리전츠 오브 더 유니버시티 오브 캘리포니아
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Furan Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Luminescent Compositions (AREA)
KR1019997007369A 1997-02-13 1998-02-13 에이엠피에이 수용체 활성을 증가시키는 벤조퓨란 화합물 Expired - Fee Related KR100544295B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/800,108 US6110935A (en) 1997-02-13 1997-02-13 Benzofurazan compounds for enhancing glutamatergic synaptic responses
US08/800,108 1997-02-13
US8/800,108 1997-02-13
PCT/US1998/002713 WO1998035950A1 (en) 1997-02-13 1998-02-13 Benzofurazan compounds which enhance ampa receptor activity

Publications (2)

Publication Number Publication Date
KR20000071082A KR20000071082A (ko) 2000-11-25
KR100544295B1 true KR100544295B1 (ko) 2006-01-23

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KR1019997007369A Expired - Fee Related KR100544295B1 (ko) 1997-02-13 1998-02-13 에이엠피에이 수용체 활성을 증가시키는 벤조퓨란 화합물

Country Status (24)

Country Link
US (3) US6110935A (enExample)
EP (2) EP1428534B1 (enExample)
JP (1) JP4446023B2 (enExample)
KR (1) KR100544295B1 (enExample)
CN (1) CN1085206C (enExample)
AT (2) ATE326221T1 (enExample)
AU (1) AU737802C (enExample)
BR (1) BR9807333B1 (enExample)
CA (1) CA2279319C (enExample)
CZ (1) CZ299765B6 (enExample)
DE (2) DE69823803T2 (enExample)
DK (2) DK0960105T3 (enExample)
ES (2) ES2264078T3 (enExample)
GB (1) GB2325225B (enExample)
HU (1) HUP0002303A3 (enExample)
ID (1) ID22342A (enExample)
IL (1) IL131200A (enExample)
NO (1) NO318935B1 (enExample)
NZ (1) NZ336980A (enExample)
PL (1) PL199135B1 (enExample)
PT (2) PT960105E (enExample)
RU (1) RU2189984C2 (enExample)
TR (1) TR199901941T2 (enExample)
WO (1) WO1998035950A1 (enExample)

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* Cited by examiner, † Cited by third party
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IN188837B (enExample) 1998-05-22 2002-11-09 Torrent Pharmaceuticals Ltd
AU2002366756A1 (en) * 2001-12-20 2003-07-09 Alangudi Sankaranarayanan Use of benzofuroxan derivatives as antiplatelet agents
BRPI0406736A (pt) * 2003-01-13 2005-12-20 Cortex Pharma Inc Método de tratar declìnico cognitivo devido à privação de sono e estresse
JP4829791B2 (ja) * 2003-05-23 2011-12-07 バジリア ファルマスーチカ アーゲー フラザノベンゾイミダゾール
EP1715863B1 (en) * 2004-01-26 2012-05-09 Cortex Pharmaceuticals, Inc. Enhancement of ampakine-induced facilitation of synaptic responses by cholinesterase inhibitors
EP2061471A4 (en) * 2006-08-31 2012-02-01 Univ Alberta PROCESS FOR INHIBITING RESTRICTED DEPRESSION WITH POSITIVE ALLOSTER AMPA RECEPTOR MODULATORS
EP2114158B1 (en) * 2007-01-03 2012-08-08 Cortex Pharmaceuticals, Inc. 3-substituted-[1,2,3]benzotriazinone compounds for enhancing glutamatergic synaptic responses
CN101616592B (zh) * 2007-01-03 2013-06-05 瑟维尔实验室 用于提高谷氨酸能突触响应的3-取代的-[1,2,3]-苯并三嗪酮化合物
TW200911768A (en) * 2007-05-17 2009-03-16 Cortex Pharma Inc Di-substituted amides for enhancing glutamatergic synaptic responses
US8168632B2 (en) 2007-08-10 2012-05-01 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for the treatment of respiratory disorders
US8263591B2 (en) 2007-08-10 2012-09-11 Cortex Pharmaceuticals, Inc. Bicyclic amides for enhancing glutamatergic synaptic responses
US8071914B2 (en) * 2007-12-26 2011-12-06 Noboru Oshima Heating apparatus
US20110218190A1 (en) * 2008-11-10 2011-09-08 The Regents Of The University Of California Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
WO2010087981A2 (en) * 2009-02-02 2010-08-05 Cortex Pharmaceuticals, Inc. Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
EP2544688B1 (en) 2010-03-02 2016-09-07 President and Fellows of Harvard College Methods and compositions for treatment of angelman syndrome
US20110257186A1 (en) * 2010-04-15 2011-10-20 Staubli Ursula V Compositions and methods for treating visual disorders
CA2829006A1 (en) 2011-03-04 2012-09-13 The Regents Of The University Of California Locally released growth factors to mediate motor recovery after stroke
CN102633731B (zh) * 2012-03-13 2014-04-30 四川大学华西医院 6-喹喔啉甲酸酰胺化合物、制备方法和应用
KR101421032B1 (ko) * 2012-12-28 2014-07-22 주식회사 레고켐 바이오사이언스 (2-메틸-1-(3-메틸벤질)-1Ｈ-벤조[d]이미다졸-5일)(피페리딘-5-일)메탄온의 제조방법
CA2915405A1 (en) 2013-06-13 2014-12-18 Veroscience Llc Compositions and methods for treating metabolic disorders
CN107286114B (zh) 2016-04-13 2020-08-18 中国人民解放军军事医学科学院毒物药物研究所 Ampa受体增效剂的脑靶向前药及其医药用途

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US3981864A (en) * 1973-09-08 1976-09-21 Eisai Co., Ltd. 1,3-Benzodioxol derivatives
FR2499991A1 (fr) * 1981-02-19 1982-08-20 Sandoz Sa Nouveaux 2,1,3-benzothiadiazoles et 2,1,3-benzoxadiazoles, leur preparation et leur application comme medicaments
US4420485A (en) * 1982-09-29 1983-12-13 Hoechst-Roussel Pharmaceuticals Inc. 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines]
SU1657189A1 (ru) * 1988-05-23 1991-06-23 Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср Способ коррекции апато-абулических состо ний при шизофрении
SU1587050A1 (ru) * 1988-12-23 1990-08-23 Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского Производные (7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амина в качестве промежуточных продуктов в синтезе 2-[(7-бромбензо-2,1,3-тиадиазол-4-сульфонил)амино]-5-бром-N-(4-хлорфенил)бензамида, обладающего антигельминтной активностью
US5112824A (en) * 1989-12-08 1992-05-12 Merck & Co., Inc. Benzofuran compounds as class III antiarrhythmic agents
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
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ATE174915T1 (de) * 1994-10-31 1999-01-15 Merck Patent Gmbh Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren
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Publication number Publication date
ATE326221T1 (de) 2006-06-15
EP0960105A1 (en) 1999-12-01
AU6159998A (en) 1998-09-08
GB2325225A (en) 1998-11-18
NO993768L (no) 1999-09-23
NZ336980A (en) 2000-08-25
WO1998035950A1 (en) 1998-08-20
CA2279319A1 (en) 1998-08-20
DK0960105T3 (da) 2004-08-30
DE69834590D1 (de) 2006-06-22
GB9809221D0 (enExample) 1998-07-01
EP1428534A1 (en) 2004-06-16
NO318935B1 (no) 2005-05-30
AU737802B2 (en) 2001-08-30
CA2279319C (en) 2008-08-05
DE69823803D1 (de) 2004-06-17
BR9807333B1 (pt) 2011-10-18
AU737802C (en) 2005-05-12
CZ279599A3 (cs) 2000-01-12
IL131200A0 (en) 2001-01-28
DK1428534T3 (da) 2006-06-12
GB2325225A8 (en) 1999-02-17
CZ299765B6 (cs) 2008-11-19
US6730677B2 (en) 2004-05-04
IL131200A (en) 2005-06-19
CN1085206C (zh) 2002-05-22
ID22342A (id) 1999-09-30
HUP0002303A3 (en) 2002-09-30
JP4446023B2 (ja) 2010-04-07
EP1428534B1 (en) 2006-05-17
US6313115B1 (en) 2001-11-06
CN1247534A (zh) 2000-03-15
NO993768D0 (no) 1999-08-04
RU2189984C2 (ru) 2002-09-27
ES2264078T3 (es) 2006-12-16
GB2325225B (en) 1999-03-03
BR9807333A (pt) 2000-04-18
JP2001512459A (ja) 2001-08-21
DE69823803T2 (de) 2005-04-14
US20020055508A1 (en) 2002-05-09
KR20000071082A (ko) 2000-11-25
PT1428534E (pt) 2006-07-31
TR199901941T2 (xx) 1999-12-21
PL335058A1 (en) 2000-03-27
HUP0002303A2 (hu) 2001-04-28
EP0960105B1 (en) 2004-05-12
ES2221152T3 (es) 2004-12-16
ATE266649T1 (de) 2004-05-15
PL199135B1 (pl) 2008-08-29
DE69834590T2 (de) 2007-04-26
US6110935A (en) 2000-08-29
PT960105E (pt) 2004-09-30

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