KR100544041B1 - 결정형태의n-(4-트리플루오로메틸페닐)-5-메틸이소옥사졸-4-카복스아미드 - Google Patents
결정형태의n-(4-트리플루오로메틸페닐)-5-메틸이소옥사졸-4-카복스아미드 Download PDFInfo
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- KR100544041B1 KR100544041B1 KR1019980032110A KR19980032110A KR100544041B1 KR 100544041 B1 KR100544041 B1 KR 100544041B1 KR 1019980032110 A KR1019980032110 A KR 1019980032110A KR 19980032110 A KR19980032110 A KR 19980032110A KR 100544041 B1 KR100544041 B1 KR 100544041B1
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Classifications
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- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050056044A KR100588254B1 (ko) | 1997-08-08 | 2005-06-28 | 결정 형태의ｎ-(4-트리플루오로메틸페닐)-5-메틸이속사졸-4-카복스아미드 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19734438.0 | 1997-08-08 | ||
| DE19734438A DE19734438A1 (de) | 1997-08-08 | 1997-08-08 | Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid |
| DE19756093.8 | 1997-12-17 | ||
| DE1997156093 DE19756093A1 (de) | 1997-12-17 | 1997-12-17 | Verfahren zur Herstellung einer Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid |
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| KR1020050056044A Division KR100588254B1 (ko) | 1997-08-08 | 2005-06-28 | 결정 형태의ｎ-(4-트리플루오로메틸페닐)-5-메틸이속사졸-4-카복스아미드 |
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| KR19990023433A KR19990023433A (ko) | 1999-03-25 |
| KR100544041B1 true KR100544041B1 (ko) | 2006-09-18 |
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| KR1020050056044A Expired - Lifetime KR100588254B1 (ko) | 1997-08-08 | 2005-06-28 | 결정 형태의ｎ-(4-트리플루오로메틸페닐)-5-메틸이속사졸-4-카복스아미드 |
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| KR1020050056044A Expired - Lifetime KR100588254B1 (ko) | 1997-08-08 | 2005-06-28 | 결정 형태의ｎ-(4-트리플루오로메틸페닐)-5-메틸이속사졸-4-카복스아미드 |
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| EP (2) | EP0903345B1 (https=) |
| JP (2) | JPH11124372A (https=) |
| KR (2) | KR100544041B1 (https=) |
| CN (2) | CN1089759C (https=) |
| AR (1) | AR015418A1 (https=) |
| AT (2) | ATE196764T1 (https=) |
| AU (1) | AU752764B2 (https=) |
| BR (1) | BR9806568A (https=) |
| CA (1) | CA2245267C (https=) |
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| NZ (1) | NZ331270A (https=) |
| PL (1) | PL192126B1 (https=) |
| PT (2) | PT987256E (https=) |
| RU (1) | RU2224753C2 (https=) |
| SK (2) | SK285216B6 (https=) |
| TR (2) | TR199801513A2 (https=) |
| TW (1) | TW593288B (https=) |
| UA (1) | UA54411C2 (https=) |
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| ATE196764T1 (de) * | 1997-08-08 | 2000-10-15 | Aventis Pharma Gmbh | Kristallform von 5-methylisoxazol-4-carbonsäure- (4-trifluormethyl)-anilid |
| DE19908527C2 (de) | 1999-02-26 | 2001-08-30 | Aventis Pharma Gmbh | Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid |
| CN1411373A (zh) * | 1999-12-16 | 2003-04-16 | 特瓦制药工业有限公司 | 制备来氟米特的新方法和新晶形的来氟米特 |
| CA2400290A1 (en) * | 2000-02-15 | 2001-08-23 | Teva Pharmaceutical Industries Ltd. | A method for synthesizing leflunomide |
| CA2429426A1 (en) * | 2000-11-17 | 2002-05-23 | Takeda Chemical Industries, Ltd. | Isoxazole derivatives |
| GB0123571D0 (en) | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| US7429593B2 (en) | 2001-09-14 | 2008-09-30 | Shionogi & Co., Ltd. | Utilities of amide compounds |
| AU2003207055A1 (en) * | 2002-02-12 | 2003-09-04 | Sumitomo Pharmaceuticals Co., Ltd. | Novel drugs for external use |
| US20050158371A1 (en) * | 2002-02-12 | 2005-07-21 | Sumitomo Pharmaceuticals Co., Ltd. | Novel external agent |
| US20060135547A1 (en) * | 2003-03-12 | 2006-06-22 | Toth Zoltan G | Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine |
| WO2004080461A2 (en) * | 2003-03-12 | 2004-09-23 | TEVA Gyógyszergyár Részvénytársaság | Stable pharmaceutical compositions of desloratadine |
| JP4223428B2 (ja) * | 2004-03-31 | 2009-02-12 | 富士通メディアデバイス株式会社 | フィルタおよびその製造方法 |
| WO2007067710A1 (en) * | 2005-12-08 | 2007-06-14 | Amphora Discovery Corporation | Certain chemical entities, compositions, and methods for modulating trpv1 |
| CN101143834B (zh) * | 2006-09-15 | 2010-09-08 | 欣凯医药化工中间体（上海）有限公司 | N-(4-三氟甲基苯)-2-氰基-3-羟基丁烯酰胺钠盐的多晶型及其制备方法 |
| JP2011513202A (ja) * | 2008-03-10 | 2011-04-28 | 武田薬品工業株式会社 | ベンズイミダゾール化合物の結晶 |
| US20120172427A1 (en) | 2009-09-18 | 2012-07-05 | Sanofi | (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide tablet formulations with improved stability |
| CN103977594B (zh) * | 2014-06-03 | 2016-02-17 | 江苏九九久科技股份有限公司 | 一种结晶方法 |
| US9895370B2 (en) * | 2015-11-19 | 2018-02-20 | Pharmedix.Co., Ltd | Pharmaceutical composition for preventing or treating of cirrhosis of liver comprising G protein coupled receptor 119 ligand as an active ingredient |
| CN109180599A (zh) * | 2018-09-03 | 2019-01-11 | 深圳市新阳唯康科技有限公司 | 一种来氟米特新晶型化合物及其制备方法 |
| CN112898215B (zh) * | 2021-02-04 | 2022-11-08 | 美罗药业股份有限公司 | 一种来氟米特晶型i的制备方法 |
| CN114716388B (zh) * | 2021-11-04 | 2024-02-13 | 江苏冠军科技集团股份有限公司 | 一种磺胺-银化合物及其制备方法 |
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| NL178596C (nl) * | 1975-06-05 | 1986-04-16 | Hoechst Ag | Werkwijze voor het bereiden van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor het bereiden van daarin als geneeskrachtige verbindingen te gebruiken 5-methylisoxazool-4-carbonzuuraniliden. |
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| DE2854439A1 (de) * | 1978-12-16 | 1980-07-03 | Hoechst Ag | Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung |
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| DE59407414D1 (de) * | 1993-01-08 | 1999-01-21 | Hoechst Ag | Verwendung von Leflunomid zur Hemmung von Tumornekrosefaktor alpha |
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1998
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