KR100523409B1 - 9,11-에폭시 스테로이드의 제조방법 및 이 제조방법에유용한 중간체 - Google Patents

9,11-에폭시 스테로이드의 제조방법 및 이 제조방법에유용한 중간체 Download PDF

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Publication number
KR100523409B1
KR100523409B1 KR10-2004-7021389A KR20047021389A KR100523409B1 KR 100523409 B1 KR100523409 B1 KR 100523409B1 KR 20047021389 A KR20047021389 A KR 20047021389A KR 100523409 B1 KR100523409 B1 KR 100523409B1
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South Korea
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formula
group
compounds
compound
reaction
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KR10-2004-7021389A
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Korean (ko)
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KR20050009765A (ko
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엔지존에스
류친
앤더슨데니스케이.
로손존피.
위엑조렉죠셉
쿤다사스트리
레텐드레레오제이.
포쪼마크제이.
싱유엔-룽엘.
왕핑티.
요난에드워드이.
위어리처드엠.
코와르토마스알.
바에즈쥴리오에이.
이알비베르나르트
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지.디. 썰 엘엘씨
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Application filed by 지.디. 썰 엘엘씨 filed Critical 지.디. 썰 엘엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C12P33/08—Hydroxylating at 11 position
    • C12P33/10—Hydroxylating at 11 position at 11 alpha-position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/03—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds
    • C07D301/12—Synthesis of the oxirane ring by oxidation of unsaturated compounds, or of mixtures of unsaturated and saturated compounds with hydrogen peroxide or inorganic peroxides or peracids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Inorganic Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epoxy Compounds (AREA)
  • Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR10-2004-7021389A 1996-12-11 1997-12-11 9,11-에폭시 스테로이드의 제조방법 및 이 제조방법에유용한 중간체 KR100523409B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3331596P 1996-12-11 1996-12-11
US60/033315 1996-12-11
US4938897P 1997-06-11 1997-06-11
US60/049388 1997-06-11
PCT/US1997/023090 WO1998025948A2 (fr) 1996-12-11 1997-12-11 Procedes de production de 9,11-epoxy steroides et intermediaires appropries a cet effet

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR10-1999-7005270A Division KR100506007B1 (ko) 1996-12-11 1997-12-11 9,11-에폭시 스테로이드의 제조방법 및 이 제조방법에 유용한 중간체

Publications (2)

Publication Number Publication Date
KR20050009765A KR20050009765A (ko) 2005-01-25
KR100523409B1 true KR100523409B1 (ko) 2005-10-24

Family

ID=26709541

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2004-7021389A KR100523409B1 (ko) 1996-12-11 1997-12-11 9,11-에폭시 스테로이드의 제조방법 및 이 제조방법에유용한 중간체

Country Status (21)

Country Link
US (1) US6610844B2 (fr)
EP (1) EP0944644B1 (fr)
JP (1) JP2001509792A (fr)
KR (1) KR100523409B1 (fr)
CN (1) CN100369927C (fr)
AT (2) ATE375992T1 (fr)
AU (1) AU733559B2 (fr)
BR (1) BR9714510A (fr)
CA (1) CA2273343C (fr)
DE (2) DE69738225T2 (fr)
DK (1) DK0944644T3 (fr)
ES (2) ES2293944T3 (fr)
HK (1) HK1043370B (fr)
IL (1) IL130182A0 (fr)
NO (1) NO314149B1 (fr)
NZ (1) NZ336004A (fr)
PL (1) PL189459B1 (fr)
PT (1) PT944644E (fr)
RO (1) RO120710B1 (fr)
RU (1) RU2005121439A (fr)
WO (1) WO1998025948A2 (fr)

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WO2010068500A2 (fr) * 2008-11-25 2010-06-17 Evestra, Inc. Γ-lactones d'acide 3-(6,6-éthylène-17β-hydroxy-3-oxo-17α-prégna-4-ène-17α-yl)propionique progestatives
WO2011141456A1 (fr) 2010-05-10 2011-11-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédés et compositions pour le traitement de l'accumulation de fluides dans et/ou sous la rétine
US9241944B2 (en) 2010-06-16 2016-01-26 Institut National De La Santé Et De La Recherche Médicale (Inserm) Methods and compositions for stimulating reepithelialisation during wound healing
CN104844681B (zh) * 2014-02-13 2016-06-01 合肥久诺医药科技有限公司 一种l晶型依普利酮的精制方法
ES2699923T3 (es) 2014-10-17 2019-02-13 Ind Chimica Srl Proceso para la preparación de 7alfa-(metoxicarbonil)-3-oxo-17alfa-pregn-4,9(11)-dien-21,17-carbolactona, un intermedio útil para la síntesis de moléculas con actividad farmacológica
WO2017055248A1 (fr) 2015-09-28 2017-04-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour le traitement d'une insuffisance cardiaque
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WO2018019843A1 (fr) 2016-07-26 2018-02-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonistes du récepteur des minéralocorticoïdes pour le traitement de l'arthrose
CN106349326A (zh) * 2016-07-29 2017-01-25 北京万全德众医药生物技术有限公司 依普利酮杂质a的制备方法
CN107602652A (zh) * 2017-10-11 2018-01-19 浙江仙琚制药股份有限公司 制备6β‑甲基泼尼松龙的方法
CN108445236B (zh) * 2018-02-07 2021-04-20 深圳市新产业生物医学工程股份有限公司 甾体类衍生物和其保存液以及其应用
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Also Published As

Publication number Publication date
HK1043370B (zh) 2008-08-01
JP2001509792A (ja) 2001-07-24
DE69716116T2 (de) 2003-09-04
DE69738225T2 (de) 2008-07-17
US6610844B2 (en) 2003-08-26
CN1253564A (zh) 2000-05-17
AU733559B2 (en) 2001-05-17
RO120710B1 (ro) 2006-06-30
KR20050009765A (ko) 2005-01-25
RU2005121439A (ru) 2007-01-20
NZ336004A (en) 2001-04-27
CN100369927C (zh) 2008-02-20
DE69738225D1 (de) 2007-11-29
BR9714510A (pt) 2000-11-28
DK0944644T3 (da) 2003-02-03
PL334084A1 (en) 2000-01-31
NO992825L (no) 1999-07-29
PL189459B1 (pl) 2005-08-31
ES2293944T3 (es) 2008-04-01
EP0944644B1 (fr) 2002-10-02
CA2273343C (fr) 2006-10-10
ATE225367T1 (de) 2002-10-15
US20030055274A1 (en) 2003-03-20
NO314149B1 (no) 2003-02-03
HK1043370A1 (en) 2002-09-13
WO1998025948A3 (fr) 1998-10-15
PT944644E (pt) 2003-02-28
DE69716116D1 (de) 2002-11-07
IL130182A0 (en) 2000-06-01
NO992825D0 (no) 1999-06-10
CA2273343A1 (fr) 1998-06-18
ES2186017T3 (es) 2003-05-01
AU5798398A (en) 1998-07-03
EP0944644A2 (fr) 1999-09-29
ATE375992T1 (de) 2007-11-15
WO1998025948A2 (fr) 1998-06-18

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