KR100523201B1 - 삼투성 전달 시스템 및 그의 조립방법, 삼투성 전달 시스템 유동 조절기 어셈블리, 및 상기 삼투성 전달 시스템내로의 유익제의 전달방법 - Google Patents

삼투성 전달 시스템 및 그의 조립방법, 삼투성 전달 시스템 유동 조절기 어셈블리, 및 상기 삼투성 전달 시스템내로의 유익제의 전달방법 Download PDF

Info

Publication number
KR100523201B1
KR100523201B1 KR10-2000-7000796A KR20007000796A KR100523201B1 KR 100523201 B1 KR100523201 B1 KR 100523201B1 KR 20007000796 A KR20007000796 A KR 20007000796A KR 100523201 B1 KR100523201 B1 KR 100523201B1
Authority
KR
South Korea
Prior art keywords
delivery system
osmotic delivery
enclosure
osmotic
flow regulator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR10-2000-7000796A
Other languages
English (en)
Korean (ko)
Other versions
KR20010022223A (ko
Inventor
루이스 엘 피터슨
프레데릭 에이치 마루야마
호우딘 데흐나드
로튼 홈
케빈 에스 리
크레이그 알 데이비스
존 알 피리
Original Assignee
알자 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 알자 코포레이션 filed Critical 알자 코포레이션
Publication of KR20010022223A publication Critical patent/KR20010022223A/ko
Application granted granted Critical
Publication of KR100523201B1 publication Critical patent/KR100523201B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/141—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor with capillaries for restricting fluid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16813—Flow controllers by controlling the degree of opening of the flow line
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/494—Fluidic or fluid actuated device making

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Dicing (AREA)
  • Packages (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
KR10-2000-7000796A 1997-07-25 1998-07-24 삼투성 전달 시스템 및 그의 조립방법, 삼투성 전달 시스템 유동 조절기 어셈블리, 및 상기 삼투성 전달 시스템내로의 유익제의 전달방법 Expired - Fee Related KR100523201B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5369097P 1997-07-25 1997-07-25
US60/053,690 1997-07-25
PCT/US1998/014813 WO1999004768A2 (en) 1997-07-25 1998-07-24 Osmotic delivery system flow modulator apparatus

Publications (2)

Publication Number Publication Date
KR20010022223A KR20010022223A (ko) 2001-03-15
KR100523201B1 true KR100523201B1 (ko) 2005-10-21

Family

ID=21985903

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2000-7000796A Expired - Fee Related KR100523201B1 (ko) 1997-07-25 1998-07-24 삼투성 전달 시스템 및 그의 조립방법, 삼투성 전달 시스템 유동 조절기 어셈블리, 및 상기 삼투성 전달 시스템내로의 유익제의 전달방법

Country Status (18)

Country Link
US (4) US6524305B1 (enExample)
EP (1) EP0998273B1 (enExample)
JP (1) JP2001510792A (enExample)
KR (1) KR100523201B1 (enExample)
CN (1) CN1198601C (enExample)
AR (1) AR013255A1 (enExample)
AT (1) ATE276747T1 (enExample)
AU (1) AU8493898A (enExample)
CA (1) CA2297817C (enExample)
CO (1) CO4890860A1 (enExample)
DE (1) DE69826479T2 (enExample)
DK (1) DK0998273T3 (enExample)
ES (1) ES2226159T3 (enExample)
MY (1) MY125870A (enExample)
PT (1) PT998273E (enExample)
TW (1) TW384226B (enExample)
WO (1) WO1999004768A2 (enExample)
ZA (1) ZA986629B (enExample)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
US6764461B2 (en) * 1997-12-01 2004-07-20 Scimed Life Systems, Inc. Catheter system for the delivery of a low volume bolus
US7919109B2 (en) * 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
KR100439197B1 (ko) * 2001-08-22 2004-07-07 주식회사 꾼커뮤니케이션 다중 프로토콜을 이용한 서버 데이터 분산 방법
US20050101942A1 (en) * 2001-09-17 2005-05-12 Gillis Edward M. Device and method for accurate delivery of an active agent
WO2003105803A1 (en) * 2002-06-17 2003-12-24 Alza Corporation Osmotic delivery system with early zero order push power engine comprising an osmotic agent dispersed in the fluid vehicle
MXPA05000224A (es) * 2002-06-26 2005-06-03 Alza Corp Piston de volumen eficiente, minimamente deformable, para sistemas de suministro osmotico de farmacos.
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
CN1726008A (zh) * 2002-12-19 2006-01-25 阿尔萨公司 用于从植入装置中传递的稳定的非水单相凝胶及其制剂
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
JP2006522133A (ja) * 2003-03-31 2006-09-28 アルザ・コーポレーション 非水性単一相の媒体、及び、そのような媒体を利用するフォーミュレーション
CA2520610A1 (en) * 2003-03-31 2004-10-21 Alza Corporation Osmotic pump with means for dissipating internal pressure
MXPA05010604A (es) * 2003-03-31 2005-11-23 Alza Corp Sistema de administracion osmotica y metodo para disminuir los tiempos de arranque para sistemas de administracion osmotica.
US6976983B2 (en) * 2003-06-12 2005-12-20 Cordis Corporation Implantable device for delivering drugs using orifice mechanism capable of low fluid flow rates
US8109922B2 (en) * 2003-06-12 2012-02-07 Cordis Corporation Orifice device having multiple channels and multiple layers for drug delivery
US8491571B2 (en) * 2003-06-12 2013-07-23 Cordis Corporation Orifice device having multiple channels with varying flow rates for drug delivery
US7678103B2 (en) * 2003-06-12 2010-03-16 Cordis Corporation Orifice device for delivering drugs at low fluid flow rates
US7108762B2 (en) * 2003-06-12 2006-09-19 Cordis Corporation Method for manufacturing an orifice mechanism capable of low fluid flow rates
US7211076B2 (en) * 2003-06-12 2007-05-01 Cordis Corporation Medical device for fluid delivery having low fluid flow rate
WO2005007223A2 (en) * 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
BRPI0416094A (pt) * 2003-10-31 2007-01-02 Alza Corp bomba osmótica com plugue de membrana de inicialização rápida, de auto-retenção
MXPA06003065A (es) * 2003-11-06 2006-05-31 Alza Corp Reductor de velocidad de imbibicion modular para uso con bomba osmotica implantable.
US20050232972A1 (en) * 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
WO2006014434A2 (en) 2004-07-02 2006-02-09 Eliot Lazar Treatment medium delivery device and methods for delivery
JP2007321769A (ja) * 2005-02-01 2007-12-13 Thk Co Ltd レール取付孔の閉塞構造
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
EP2361630A1 (en) * 2005-02-03 2011-08-31 Intarcia Therapeutics, Inc Implantable drug delivery device comprising particles and an osmotic pump
US7959938B2 (en) * 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20080312587A1 (en) * 2005-06-10 2008-12-18 Gruenethal Gmbh System for the Oral Administration of Solids to Persons Suffering from Dementia
GB2442396B (en) * 2005-07-22 2011-05-11 Univ Utah Res Found Osmotically driven dispense pump and related components for use in high pressure applications
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
ES2380651T3 (es) * 2005-09-01 2012-05-17 Bristol-Myers Squibb Company Biomarcadores y procedimientos para determinar la sensibilidad a moduladores de recpetor 2 del factor de crecimiento endotelial vascular
WO2007062068A2 (en) * 2005-11-23 2007-05-31 Deon Anex, Llp Electrokinetic pump designs and drug delivery systems
US20070163968A1 (en) * 2006-01-17 2007-07-19 Johnsondiversey, Inc. Method and apparatus for providing treatment chemicals to process water systems
KR101062796B1 (ko) 2006-03-31 2011-09-06 큐엘티 인코포레이티드 약물 요법을 위한 비루관 배출계 임플란트
DK2020990T3 (da) * 2006-05-30 2010-12-13 Intarcia Therapeutics Inc Strømningsmodulator med en indre kanal til et todelt osmotisk fremføringssystem
AU2007284759B2 (en) 2006-08-09 2010-10-28 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
US7538652B2 (en) * 2006-08-29 2009-05-26 International Business Machines Corporation Electrical component tuned by conductive layer deletion
RU2440097C2 (ru) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
CA2698574A1 (en) * 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc. Insertion and extraction tools for lacrimal implants
ES2732555T3 (es) 2007-09-07 2019-11-25 Mati Therapeutics Inc Implantes lagrimales y métodos relacionados
CN101984745B (zh) 2007-09-07 2013-08-14 Qlt股份有限公司 用于持续释放治疗药物的药物核心
BRPI0817074A2 (pt) 2007-09-07 2015-03-24 Qlt Plug Delivery Inc Aparelho, método para tratar uma desordem ocular, dispositivo de detecção e sistema de detecção
ATE494919T1 (de) * 2007-11-13 2011-01-15 Acuros Gmbh Osmotische pumpe
US8343140B2 (en) * 2008-02-13 2013-01-01 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
NZ587335A (en) * 2008-02-18 2012-05-25 Quadra Logic Tech Inc Lacrimal implants and related methods with implant having drug core
CN102105137B (zh) 2008-04-30 2015-01-07 Qlt股份有限公司 复合泪管植入物及相关方法
AU2009244804A1 (en) * 2008-05-09 2009-11-12 Qlt Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
US8834446B2 (en) * 2008-06-12 2014-09-16 DePuy Synthes Products, LLC Pulsatile flux drug delivery
CN102281865B (zh) * 2008-10-15 2017-04-05 精达制药公司 高浓缩药物颗粒、制剂、混悬剂及其应用
CN105997339B (zh) * 2009-02-23 2018-09-04 马缇医疗股份有限公司 泪腺植入物
EP2429611B1 (en) * 2009-04-07 2017-03-08 Medimetrics Personalized Drug Delivery B.V. Valveless drug delivery device
FR2944292B1 (fr) 2009-04-08 2013-08-23 Sanofi Pasteur Procede de purification du virus rabique
WO2011037623A1 (en) * 2009-09-28 2011-03-31 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
EP2704759A4 (en) 2011-05-05 2015-06-03 Eksigent Technologies Llc COUPLING GEL FOR ELECTROCINETIC FLUID DISTRIBUTION SYSTEMS
DK2750660T3 (en) 2011-08-29 2016-12-12 Mati Therapeutics Inc FILING WITH PROLONGED RELEASE OF ACTIVE AGENTS to treat glaucoma and ocular hypertension
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
WO2014102741A2 (en) * 2012-12-28 2014-07-03 University Of The Witwatersrand, Johannesburg Pharmaceutical dosage form
WO2015069723A1 (en) * 2013-11-05 2015-05-14 Taris Biomedical Llc Osmotic drug delivery devices, kits, and methods
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
ES2968262T3 (es) 2015-06-03 2024-05-08 I2O Therapeutics Inc Sistemas de colocación de implantes
CA3024479A1 (en) 2016-05-16 2017-11-23 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
JP7286542B2 (ja) 2017-01-03 2023-06-05 インターシア セラピューティクス，インコーポレイティド Ｇｌｐ－１受容体アゴニストの持続的投与及び薬物の同時投与を含む方法
EP3680517B1 (en) * 2017-09-07 2025-01-08 Hiperbaric, S.A. Plug, machine and processing method under high pressure
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
CN111547366B (zh) * 2019-09-30 2025-03-11 华中科技大学同济医学院附属协和医院 一种棉球自蘸取式回缩消毒瓶
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
EP4277702A1 (en) 2021-01-12 2023-11-22 Durect Corporation Sustained release drug delivery systems and related methods
JPWO2023181996A1 (enExample) * 2022-03-25 2023-09-28

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995631A (en) 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3732865A (en) 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3995632A (en) 1973-05-04 1976-12-07 Alza Corporation Osmotic dispenser
US3831813A (en) * 1973-05-11 1974-08-27 Haemonetics Corp High-flow capacity, self-regulating bypass spike
US4111202A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4243030A (en) 1978-08-18 1981-01-06 Massachusetts Institute Of Technology Implantable programmed microinfusion apparatus
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4320758A (en) * 1979-05-07 1982-03-23 Alza Corporation Osmotically driven fluid dispenser
US4340054A (en) 1980-12-29 1982-07-20 Alza Corporation Dispenser for delivering fluids and solids
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4552561A (en) 1982-12-23 1985-11-12 Alza Corporation Body mounted pump housing and pump assembly employing the same
US4639244A (en) 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4747847A (en) * 1986-02-07 1988-05-31 Alza Corporation System for delivering potassium chloride with enhanced bioacceptability
US4865845A (en) 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
JPH0772799B2 (ja) 1986-08-13 1995-08-02 ソニー株式会社 レジスト材料
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
EP0453555B1 (fr) 1989-11-13 1993-10-06 Medicorp Holding S.A. Flacon de stockage contenant un composant d'une solution medicamenteuse
US5474785A (en) * 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5151093A (en) 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
GB9027422D0 (en) 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
US5223265A (en) 1992-01-10 1993-06-29 Alza Corporation Osmotic device with delayed activation of drug delivery
US5456679A (en) 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5308348A (en) 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
GB9223146D0 (en) 1992-11-05 1992-12-16 Scherer Corp R P Vented capsule
US5431919A (en) * 1993-06-23 1995-07-11 Alza Ruminal drug delivery device
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5690952A (en) * 1995-06-07 1997-11-25 Judy A. Magruder et al. Implantable system for delivery of fluid-sensitive agents to animals
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
EP1249229A3 (en) 1996-02-02 2005-02-02 ALZA Corporation Sustained delivery of an active agent using an implantable system
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
ZA981610B (en) * 1997-03-24 1999-08-26 Alza Corp Self adjustable exit port.
US5996586A (en) * 1997-03-26 1999-12-07 Phillips; Michael Breath test for detection of lung cancer
MY125849A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
JP4215188B2 (ja) * 1997-12-22 2009-01-28 インターシア セラピューティクス，インコーポレイティド 薬剤供給を調節するデバイスのための速度調節膜
ES2217613T3 (es) * 1997-12-29 2004-11-01 Alza Corporation Sistema de liberacion osmotica con mecanismo de retencion de tapon de membrana.
PT1736145E (pt) * 1997-12-30 2012-03-16 Intarcia Therapeutics Inc Sistema de entrega de agente benéfico com obturador de membrana
ES2196918T3 (es) * 1998-12-31 2003-12-16 Alza Corp Sistema de suministro osmotico dotado de piston con economia de espacio..
US7258869B1 (en) * 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
DK1328256T3 (da) * 1999-12-21 2006-02-20 Alza Corp Ventil til osmotiske indretninger
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
WO2003105803A1 (en) * 2002-06-17 2003-12-24 Alza Corporation Osmotic delivery system with early zero order push power engine comprising an osmotic agent dispersed in the fluid vehicle
MXPA05000224A (es) * 2002-06-26 2005-06-03 Alza Corp Piston de volumen eficiente, minimamente deformable, para sistemas de suministro osmotico de farmacos.
US7014636B2 (en) * 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
CN1726008A (zh) * 2002-12-19 2006-01-25 阿尔萨公司 用于从植入装置中传递的稳定的非水单相凝胶及其制剂
JP2006522133A (ja) * 2003-03-31 2006-09-28 アルザ・コーポレーション 非水性単一相の媒体、及び、そのような媒体を利用するフォーミュレーション
CA2520610A1 (en) * 2003-03-31 2004-10-21 Alza Corporation Osmotic pump with means for dissipating internal pressure
US20050175701A1 (en) * 2004-02-10 2005-08-11 Alza Corporation Capillary moderator for osmotic delivery system
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
US20060216242A1 (en) * 2005-02-03 2006-09-28 Rohloff Catherine M Suspending vehicles and pharmaceutical suspensions for drug dosage forms
WO2006083761A2 (en) * 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US7959938B2 (en) * 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
DK2020990T3 (da) * 2006-05-30 2010-12-13 Intarcia Therapeutics Inc Strømningsmodulator med en indre kanal til et todelt osmotisk fremføringssystem

Also Published As

Publication number Publication date
EP0998273B1 (en) 2004-09-22
US7407500B2 (en) 2008-08-05
US20080071253A1 (en) 2008-03-20
PT998273E (pt) 2004-11-30
KR20010022223A (ko) 2001-03-15
WO1999004768A3 (en) 1999-04-08
CO4890860A1 (es) 2000-02-28
AU8493898A (en) 1999-02-16
DK0998273T3 (da) 2005-01-31
JP2001510792A (ja) 2001-08-07
US20050131389A1 (en) 2005-06-16
US6524305B1 (en) 2003-02-25
ZA986629B (en) 1999-02-04
DE69826479D1 (de) 2004-10-28
ES2226159T3 (es) 2005-03-16
CA2297817A1 (en) 1999-02-04
CA2297817C (en) 2007-05-22
CN1198601C (zh) 2005-04-27
HK1027752A1 (en) 2001-01-23
CN1265030A (zh) 2000-08-30
US6840931B2 (en) 2005-01-11
AR013255A1 (es) 2000-12-13
TW384226B (en) 2000-03-11
MY125870A (en) 2006-08-30
ATE276747T1 (de) 2004-10-15
DE69826479T2 (de) 2005-09-29
EP0998273A2 (en) 2000-05-10
WO1999004768A2 (en) 1999-02-04
US20030114837A1 (en) 2003-06-19

Similar Documents

Publication Publication Date Title
KR100523201B1 (ko) 삼투성 전달 시스템 및 그의 조립방법, 삼투성 전달 시스템 유동 조절기 어셈블리, 및 상기 삼투성 전달 시스템내로의 유익제의 전달방법
CN1139411C (zh) 具有可自调节出口的可植入释放装置
KR100568917B1 (ko) 멤브레인 플러그를 갖는 익제 전달장치
JP4485945B2 (ja) 浸透圧デリバリーシステムの最小服従型で、容積効率型ピストン
KR20010022224A (ko) 반투과성 플러그를 갖춘 삼투 전달 시스템
JP2007509703A (ja) 自己保持性、迅速スタート膜プラグを有する浸透式ポンプ
CA2561784C (en) Implantable delivery device with self adjustable exit port
EP1325741B1 (en) Implantable delivery device with self adjustable exit port
AU775762B2 (en) Implantable delivery device with self adjustable exit port
HK1027752B (en) Osmotic delivery system flow modulator apparatus
MXPA99008737A (en) Implantable delivery device with self adjustable exit port
HK1025049B (en) Implantable delivery device with self adjustable exit port
HK1067077B (en) Implantable delivery device with self adjustable exit port

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R15-X000 Change to inventor requested

St.27 status event code: A-3-3-R10-R15-oth-X000

R16-X000 Change to inventor recorded

St.27 status event code: A-3-3-R10-R16-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R15-X000 Change to inventor requested

St.27 status event code: A-3-3-R10-R15-oth-X000

R16-X000 Change to inventor recorded

St.27 status event code: A-3-3-R10-R16-oth-X000

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R14-asn-PN2301

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

FPAY Annual fee payment

Payment date: 20091013

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20101015

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20101015

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000