ATE276747T1 - Ausflussregulierungsapparat für ein osmotisches verabreichungssystem - Google Patents

Ausflussregulierungsapparat für ein osmotisches verabreichungssystem

Info

Publication number
ATE276747T1
ATE276747T1 AT98935754T AT98935754T ATE276747T1 AT E276747 T1 ATE276747 T1 AT E276747T1 AT 98935754 T AT98935754 T AT 98935754T AT 98935754 T AT98935754 T AT 98935754T AT E276747 T1 ATE276747 T1 AT E276747T1
Authority
AT
Austria
Prior art keywords
outflow
administration system
osmotic administration
regulatory apparatus
regulatory
Prior art date
Application number
AT98935754T
Other languages
English (en)
Inventor
Lewis L Peterson
Frederick H Maruyama
Houdin Dehnad
Lawton Hom
Kevin S Ly
Craig R Davis
John R Peery
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ATE276747T1 publication Critical patent/ATE276747T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/141Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor with capillaries for restricting fluid flow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804Flow controllers
    • A61M5/16813Flow controllers by controlling the degree of opening of the flow line
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00Metal working
    • Y10T29/49Method of mechanical manufacture
    • Y10T29/494Fluidic or fluid actuated device making

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Dicing (AREA)
  • Packages (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
AT98935754T 1997-07-25 1998-07-24 Ausflussregulierungsapparat für ein osmotisches verabreichungssystem ATE276747T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5369097P 1997-07-25 1997-07-25
PCT/US1998/014813 WO1999004768A2 (en) 1997-07-25 1998-07-24 Osmotic delivery system flow modulator apparatus

Publications (1)

Publication Number Publication Date
ATE276747T1 true ATE276747T1 (de) 2004-10-15

Family

ID=21985903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98935754T ATE276747T1 (de) 1997-07-25 1998-07-24 Ausflussregulierungsapparat für ein osmotisches verabreichungssystem

Country Status (19)

Country Link
US (4) US6524305B1 (de)
EP (1) EP0998273B1 (de)
JP (1) JP2001510792A (de)
KR (1) KR100523201B1 (de)
CN (1) CN1198601C (de)
AR (1) AR013255A1 (de)
AT (1) ATE276747T1 (de)
AU (1) AU8493898A (de)
CA (1) CA2297817C (de)
CO (1) CO4890860A1 (de)
DE (1) DE69826479T2 (de)
DK (1) DK0998273T3 (de)
ES (1) ES2226159T3 (de)
HK (1) HK1027752A1 (de)
MY (1) MY125870A (de)
PT (1) PT998273E (de)
TW (1) TW384226B (de)
WO (1) WO1999004768A2 (de)
ZA (1) ZA986629B (de)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440457B1 (en) * 1993-05-27 2002-08-27 Alza Corporation Method of administering antidepressant dosage form
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
US6764461B2 (en) * 1997-12-01 2004-07-20 Scimed Life Systems, Inc. Catheter system for the delivery of a low volume bolus
US7919109B2 (en) * 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US6835194B2 (en) * 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
KR100439197B1 (ko) * 2001-08-22 2004-07-07 주식회사 꾼커뮤니케이션 다중 프로토콜을 이용한 서버 데이터 분산 방법
DE60233811D1 (de) * 2001-09-17 2009-11-05 Durect Corp Vorrichtung und verfahren zur genauen abgabe eines wirkstoffs
EP1536767B1 (de) * 2002-06-17 2007-08-08 Alza Corporation Osmotisches abgabesystem mit schubmotor früher nullter ordnung mit einem osmotischen mittel, das in dem flüssigen vehikel dispergiert ist
ES2295642T3 (es) * 2002-06-26 2008-04-16 Intarcia Therapeutics, Inc. Piston de volumen eficaz de ocupacion minima para sistemas de administracion de medicamentos.
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
WO2004056338A2 (en) * 2002-12-19 2004-07-08 Alza Corporation Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device
CL2004000698A1 (es) * 2003-03-31 2005-05-20 Alza Corp Comosicion farmaceutica no acuosa que comprende al menos un ingrediente activo y un vehiculo de fase unica que contiene al menos un polimero y al menos un solvente, siendo el vehiculo miscible en agua; procedimiento para su preparacion; dispositivo d
BRPI0408862A (pt) * 2003-03-31 2006-04-11 Alza Corp bomba osmótica com dispositivo para dissipar pressão interna
KR20050120767A (ko) * 2003-03-31 2005-12-23 알자 코포레이션 삼투성 전달 시스템 및 삼투성 전달 시스템의 기동 시간감소 방법
US7108762B2 (en) * 2003-06-12 2006-09-19 Cordis Corporation Method for manufacturing an orifice mechanism capable of low fluid flow rates
US6976983B2 (en) * 2003-06-12 2005-12-20 Cordis Corporation Implantable device for delivering drugs using orifice mechanism capable of low fluid flow rates
US7678103B2 (en) * 2003-06-12 2010-03-16 Cordis Corporation Orifice device for delivering drugs at low fluid flow rates
US8491571B2 (en) * 2003-06-12 2013-07-23 Cordis Corporation Orifice device having multiple channels with varying flow rates for drug delivery
US8109922B2 (en) * 2003-06-12 2012-02-07 Cordis Corporation Orifice device having multiple channels and multiple layers for drug delivery
US7211076B2 (en) * 2003-06-12 2007-05-01 Cordis Corporation Medical device for fluid delivery having low fluid flow rate
WO2005007223A2 (en) * 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
JP2007509703A (ja) * 2003-10-31 2007-04-19 アルザ・コーポレーシヨン 自己保持性、迅速スタート膜プラグを有する浸透式ポンプ
WO2005046639A2 (en) * 2003-11-06 2005-05-26 Alza Corporation Modular imbibition rate reducer for use with implantable osmotic pump
US20050232972A1 (en) 2004-04-15 2005-10-20 Steven Odrich Drug delivery via punctal plug
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
US7922702B2 (en) 2004-07-02 2011-04-12 Qlt Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device
JP2007321769A (ja) * 2005-02-01 2007-12-13 Thk Co Ltd レール取付孔の閉塞構造
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
JP2008528698A (ja) * 2005-02-03 2008-07-31 インターシア セラピューティクス,インコーポレイティド 埋め込み可能なインターフェロン含有デバイス
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US7959938B2 (en) * 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20080312587A1 (en) * 2005-06-10 2008-12-18 Gruenethal Gmbh System for the Oral Administration of Solids to Persons Suffering from Dementia
WO2007013957A2 (en) * 2005-07-22 2007-02-01 University Of Utah Research Foundation Osmotically driven dispense pump and related components for use in high pressure applications
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
EP2182078B1 (de) * 2005-09-01 2012-02-01 Bristol-Myers Squibb Company Biomarker und Verfahren zur Bestimmung der Empfindlichkeit gegen VEGFR2 modulator.
US8152477B2 (en) * 2005-11-23 2012-04-10 Eksigent Technologies, Llc Electrokinetic pump designs and drug delivery systems
US20070163968A1 (en) * 2006-01-17 2007-07-19 Johnsondiversey, Inc. Method and apparatus for providing treatment chemicals to process water systems
WO2007115261A2 (en) * 2006-03-31 2007-10-11 Qlt Plug Delivery, Inc. Drug delivery methods, structures, and compositions for nasolacrimal system
MX2008014870A (es) * 2006-05-30 2009-02-12 Intarcia Therapeutics Inc Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas.
EP2359808B1 (de) 2006-08-09 2013-05-22 Intarcia Therapeutics, Inc Osmotisches Verabreichungssystem mit Kolbenanordnung
US7538652B2 (en) * 2006-08-29 2009-05-26 International Business Machines Corporation Electrical component tuned by conductive layer deletion
CN105688191A (zh) 2007-04-23 2016-06-22 精达制药公司 促胰岛素释放肽的混悬制剂及其应用
AU2008300022A1 (en) 2007-09-07 2009-03-19 Qlt Inc. Lacrimal implant detection
SG184727A1 (en) * 2007-09-07 2012-10-30 Quadra Logic Tech Inc Insertion and extraction tools for lacrimal implants
KR101696301B1 (ko) * 2007-09-07 2017-01-13 마티 테라퓨틱스 인코포레이티드 치료 약제의 서방성 약물 코어
CA2698508C (en) * 2007-09-07 2017-06-06 Alan R. Rapacki Lacrimal implants and related methods
DE602007011946D1 (de) * 2007-11-13 2011-02-24 Acuros Gmbh Osmotische Pumpe
WO2009102467A2 (en) 2008-02-13 2009-08-20 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
EP2254536A2 (de) * 2008-02-18 2010-12-01 QLT Plug Delivery, Inc. Lakrimale implantate und relevante verfahren
JP5552482B2 (ja) 2008-04-30 2014-07-16 キュー エル ティー インク. 複合涙管挿入物および関連する方法
MX2010012022A (es) * 2008-05-09 2011-03-15 Qlt Plug Delivery Inc Suministro de liberacion sostenida de agentes activos para tratar glaucoma e hipertension ocular.
US8834446B2 (en) * 2008-06-12 2014-09-16 DePuy Synthes Products, LLC Pulsatile flux drug delivery
CA2738715C (en) * 2008-10-15 2013-07-16 Intarcia Therapeutics, Inc. Highly concentrated drug particles, formulations, suspensions and uses thereof
SG174133A1 (en) * 2009-02-23 2011-10-28 Quadra Logic Tech Inc Lacrimal implants and related methods
WO2010116304A1 (en) * 2009-04-07 2010-10-14 Koninklijke Philips Electronics N.V. Valveless drug delivery device
FR2944292B1 (fr) 2009-04-08 2013-08-23 Sanofi Pasteur Procede de purification du virus rabique
MX352878B (es) 2009-09-28 2017-12-13 Intarcia Therapeutics Inc Establecimiento y/o terminacion rapidos de suministro de estado estable sustancial de farmaco.
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
EP2704759A4 (de) 2011-05-05 2015-06-03 Eksigent Technologies Llc Gelkupplung für elektrokinetische abgabesysteme
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
EP3290024B1 (de) 2011-08-29 2019-04-17 Mati Therapeutics Inc. Verzögerte freisetzung von wirkstoffen zur behandlung von glaukom oder okularer hypertonie
WO2014102741A2 (en) * 2012-12-28 2014-07-03 University Of The Witwatersrand, Johannesburg Pharmaceutical dosage form
EP3065807A1 (de) * 2013-11-05 2016-09-14 TARIS Biomedical LLC Osmotische wirkstofffreisetzungsvorrichtung, kits und verfahren
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
JP6993235B2 (ja) 2015-06-03 2022-01-13 インターシア セラピューティクス,インコーポレイティド インプラントの設置及び撤去システム
EP3458084B1 (de) 2016-05-16 2020-04-01 Intarcia Therapeutics, Inc Für den glucagonrezeptor selektive polypeptide und verfahren zu deren verwendung
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
KR20190104039A (ko) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법
CN111148925B (zh) * 2017-09-07 2022-05-13 高压股份公司 高压下的塞子、机器及处理方法
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
WO2023181996A1 (ja) * 2022-03-25 2023-09-28 テルモ株式会社 投与装置

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732865A (en) 1971-01-13 1973-05-15 Alza Corp Osmotic dispenser
US3995631A (en) 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3995632A (en) 1973-05-04 1976-12-07 Alza Corporation Osmotic dispenser
US3831813A (en) * 1973-05-11 1974-08-27 Haemonetics Corp High-flow capacity, self-regulating bypass spike
US4111202A (en) 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4243030A (en) 1978-08-18 1981-01-06 Massachusetts Institute Of Technology Implantable programmed microinfusion apparatus
US4373527B1 (en) 1979-04-27 1995-06-27 Univ Johns Hopkins Implantable programmable medication infusion system
US4320758A (en) * 1979-05-07 1982-03-23 Alza Corporation Osmotically driven fluid dispenser
US4340054A (en) 1980-12-29 1982-07-20 Alza Corporation Dispenser for delivering fluids and solids
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4552561A (en) 1982-12-23 1985-11-12 Alza Corporation Body mounted pump housing and pump assembly employing the same
US4639244A (en) 1983-05-03 1987-01-27 Nabil I. Rizk Implantable electrophoretic pump for ionic drugs and associated methods
US4747847A (en) * 1986-02-07 1988-05-31 Alza Corporation System for delivering potassium chloride with enhanced bioacceptability
US4865845A (en) * 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
JPH0772799B2 (ja) 1986-08-13 1995-08-02 ソニー株式会社 レジスト材料
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
DK0453555T3 (da) * 1989-11-13 1994-01-31 Becton Dickinson France Flakon til opbevaring af et lægemiddelstof
US5474785A (en) * 1990-01-24 1995-12-12 Alza Corporation Delivery system comprising means for controlling internal pressure
US5151093A (en) 1990-10-29 1992-09-29 Alza Corporation Osmotically driven syringe with programmable agent delivery
GB9027422D0 (en) 1990-12-18 1991-02-06 Scras Osmotically driven infusion device
US5223265A (en) 1992-01-10 1993-06-29 Alza Corporation Osmotic device with delayed activation of drug delivery
US5308348A (en) 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5456679A (en) 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
GB9223146D0 (en) * 1992-11-05 1992-12-16 Scherer Corp R P Vented capsule
US5431919A (en) * 1993-06-23 1995-07-11 Alza Ruminal drug delivery device
US5904935A (en) * 1995-06-07 1999-05-18 Alza Corporation Peptide/protein suspending formulations
US5690952A (en) * 1995-06-07 1997-11-25 Judy A. Magruder et al. Implantable system for delivery of fluid-sensitive agents to animals
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
ES2191165T3 (es) 1996-02-02 2003-09-01 Alza Corp Liberacion prolongada de leuprolide usando un sistema implantable.
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
ZA981610B (en) * 1997-03-24 1999-08-26 Alza Corp Self adjustable exit port.
US5996586A (en) * 1997-03-26 1999-12-07 Phillips; Michael Breath test for detection of lung cancer
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
MY125849A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
ATE223208T1 (de) * 1997-12-22 2002-09-15 Alza Corp Membranen zur steuerung des durchflusses in vorrichtungen mit kontrollierter wirkstoffabgabe
EP1041968B1 (de) * 1997-12-29 2004-03-03 Alza Corporation Osmotisches verabreichungssystem mit stöpselrückhaltemechanismus
DE69836149T2 (de) * 1997-12-30 2007-08-16 Alza Corp., Mountain View Verabreichungssystem für wirkstoffe mit einem membranstöpsel
PT1140014E (pt) * 1998-12-31 2003-07-31 Alza Corp Sistema de distribuicao osmotico que possui embolo com utilizacao eficaz de espaco
US7258869B1 (en) * 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
DK1328256T3 (da) * 1999-12-21 2006-02-20 Alza Corp Ventil til osmotiske indretninger
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
EP1536767B1 (de) * 2002-06-17 2007-08-08 Alza Corporation Osmotisches abgabesystem mit schubmotor früher nullter ordnung mit einem osmotischen mittel, das in dem flüssigen vehikel dispergiert ist
ES2295642T3 (es) * 2002-06-26 2008-04-16 Intarcia Therapeutics, Inc. Piston de volumen eficaz de ocupacion minima para sistemas de administracion de medicamentos.
US7014636B2 (en) * 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
WO2004056338A2 (en) * 2002-12-19 2004-07-08 Alza Corporation Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device
BRPI0408862A (pt) * 2003-03-31 2006-04-11 Alza Corp bomba osmótica com dispositivo para dissipar pressão interna
CL2004000698A1 (es) * 2003-03-31 2005-05-20 Alza Corp Comosicion farmaceutica no acuosa que comprende al menos un ingrediente activo y un vehiculo de fase unica que contiene al menos un polimero y al menos un solvente, siendo el vehiculo miscible en agua; procedimiento para su preparacion; dispositivo d
US20050175701A1 (en) * 2004-02-10 2005-08-11 Alza Corporation Capillary moderator for osmotic delivery system
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
US20060216242A1 (en) * 2005-02-03 2006-09-28 Rohloff Catherine M Suspending vehicles and pharmaceutical suspensions for drug dosage forms
WO2006083761A2 (en) * 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US7959938B2 (en) * 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
MX2008014870A (es) * 2006-05-30 2009-02-12 Intarcia Therapeutics Inc Modulador de flujo para sistema de suministro osmotico con canal interno de dos piezas.

Also Published As

Publication number Publication date
CA2297817A1 (en) 1999-02-04
CO4890860A1 (es) 2000-02-28
CN1265030A (zh) 2000-08-30
HK1027752A1 (en) 2001-01-23
DE69826479D1 (de) 2004-10-28
EP0998273A2 (de) 2000-05-10
ES2226159T3 (es) 2005-03-16
WO1999004768A2 (en) 1999-02-04
US20030114837A1 (en) 2003-06-19
US7407500B2 (en) 2008-08-05
US20080071253A1 (en) 2008-03-20
KR100523201B1 (ko) 2005-10-21
DE69826479T2 (de) 2005-09-29
EP0998273B1 (de) 2004-09-22
KR20010022223A (ko) 2001-03-15
JP2001510792A (ja) 2001-08-07
WO1999004768A3 (en) 1999-04-08
DK0998273T3 (da) 2005-01-31
TW384226B (en) 2000-03-11
US20050131389A1 (en) 2005-06-16
CA2297817C (en) 2007-05-22
PT998273E (pt) 2004-11-30
US6840931B2 (en) 2005-01-11
CN1198601C (zh) 2005-04-27
AR013255A1 (es) 2000-12-13
MY125870A (en) 2006-08-30
US6524305B1 (en) 2003-02-25
AU8493898A (en) 1999-02-16
ZA986629B (en) 1999-02-04

Similar Documents

Publication Publication Date Title
ATE276747T1 (de) Ausflussregulierungsapparat für ein osmotisches verabreichungssystem
DE69524802D1 (de) Sicherheitssystem für ein Narkosesystem
DE69813220D1 (de) Spendesystem für flüssigkeiten
DE69327318T2 (de) Unterstützung für systementwicklung.
DE69828901D1 (de) Schauregalsystem für gondel
DE59704732D1 (de) Steuergerät für ein bordnetz
DE69500969T2 (de) Vormischung für ein Einspritzsystem
DE69723351D1 (de) Steuerungseinheit für ein Bewässerungssystem
DE69502216D1 (de) Zweikomponenten Abgabesystem
IT1268315B1 (it) Impianto antincendio per veicoli.
DE69617207T2 (de) Steuersystem für eine flugzeugflüssigkeitspumpe
DE69426535T2 (de) Docksystem für ein luftschiff
ATE301100T1 (de) Verteiltes abgabesystem für konzentrierte chemiekalien
DE69824658D1 (de) Optisches System für Projektion
DE29703758U1 (de) Schließvorrichtung für ein Schließsystem
ATE341739T1 (de) Leuchteneinheit für lichtbandsystem
DE69427251D1 (de) Verabreichungssystem für Arzneistoffe
DE59605576D1 (de) Behältersystem für briefe
DE29520565U1 (de) Sitzvorrichtung für ein Sitzmöbel
DE69529107D1 (de) Rückhaltesystem für Flugzeug
DE9403501U1 (de) Pneumatische Pumpanlage für Flüssigkeiten
DE29609388U1 (de) Scherengelenksystem für ein Sitzmöbel
ATA147697A (de) Transportanlage für langteile
DE29511630U1 (de) Aussteifungselement für Regale
DE29604142U1 (de) System zum Befüllen von Tankanlagen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0998273

Country of ref document: EP

REN Ceased due to non-payment of the annual fee