KR100453179B1 - 피복된 라니티딘, 비스마스 서브시트레이트 및수크랄페이트를 함유하는 경구용 위장질환 치료용 약제조성물 - Google Patents
피복된 라니티딘, 비스마스 서브시트레이트 및수크랄페이트를 함유하는 경구용 위장질환 치료용 약제조성물 Download PDFInfo
- Publication number
- KR100453179B1 KR100453179B1 KR10-2001-7016389A KR20017016389A KR100453179B1 KR 100453179 B1 KR100453179 B1 KR 100453179B1 KR 20017016389 A KR20017016389 A KR 20017016389A KR 100453179 B1 KR100453179 B1 KR 100453179B1
- Authority
- KR
- South Korea
- Prior art keywords
- ranitidine
- sucralate
- film
- subcitrate
- coated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/29—Antimony or bismuth compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Abstract
Description
시험군 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
실시예4 | 34.5 | 38.8 | 35.1 | 37.3 | 36.4 | 35.3 | 37.9 | 34.8 | 39.2 | 38.5 |
비교예 | 6.2 | 6.8 | 7.4 | 7.8 | 6.1 | 6.6 | 7.2 | 6.3 | 7.5 | 6.7 |
시험군 | 피험자수(명) | AUC(ng/hr/ml) | Cmax(ng/ml) | Tmax(hr) |
실시예1 | 6 | 2285 ±115.2* | 485.3 ±30.6* | 2.86 ±0.29 |
실시예4 | 6 | 2354 ±103.5* | 493.4 ±31.2* | 2.69 ±0.35 |
비교예 | 6 | 1623 ±98.6 | 293.7 ±34.6 | 3.23 ±0.41 |
시험군 | 피험자수(명) | 완치된 환자수(명) | 치료율(%) |
실시예1 | 5 | 4 | 80 |
실시예4 | 5 | 5 | 100 |
비교예 | 5 | 3 | 60 |
Claims (8)
- 라니티딘 중량에 대하여 0.1 내지 10.0 중량%로 포함되고 피막 파열시간이 20 내지 90분인 피막 형성 조성물로 피복된 라니티딘, 비스마스 서브시트레이트 및 수크랄페이트가 활성성분으로 함유되어 있는 것을 특징으로 하는 경구용 위장질환 치료용 약제 조성물.
- 제 1항에 있어서, 상기 라니티딘의 피막 파열시간이 30 내지 70분인 것을 특징으로 하는 약제 조성물.
- 삭제
- 제 1항에 있어서, 상기 피막 형성 조성물이 히드록시프로필 메틸셀룰로오스, 메틸셀룰로오스 및 유드라짓으로 이루어지는 군에서 선택되는 것임을 특징으로 하는 약제 조성물.
- 제 1항에 있어서, 상기 피막 형성 조성물은 장용성 피막 형성 조성물인 것을 특징으로 하는 약제 조성물.
- 제 5항에 있어서, 상기 장용성 피막 형성 조성물은 히드록시프로필 메틸셀룰로오스 프탈레이트 또는 유드라짓 E.S.인 것을 특징으로 하는 약제 조성물.
- 제 1항에 있어서, 과립제, 캅셀제, 정제 또는 피복된 핵정을 함유하는 이중정으로 제조되어짐을 특징으로 하는 약제 조성물.
- 제 7항에 있어서, 상기 피복된 핵정이 라니티딘에 약제학적으로 허용가능한 담체 또는 부형제를 첨가하여 핵정을 제조하고 상기 핵정에 피막 형성 조성물로 피복하여 제조되어짐을 특징으로 하는 약제 조성물.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/KR1999/000327 WO2000078307A1 (en) | 1999-06-21 | 1999-06-21 | Orally administrable pharmaceutical preparation having therapeutic effect on gastrointestinal disorders comprising coated ranitidine, bismuth subcitrate and sucralfate |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20020031342A KR20020031342A (ko) | 2002-05-01 |
KR100453179B1 true KR100453179B1 (ko) | 2004-10-15 |
Family
ID=19570891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR10-2001-7016389A KR100453179B1 (ko) | 1999-06-21 | 1999-06-21 | 피복된 라니티딘, 비스마스 서브시트레이트 및수크랄페이트를 함유하는 경구용 위장질환 치료용 약제조성물 |
Country Status (4)
Country | Link |
---|---|
KR (1) | KR100453179B1 (ko) |
CN (1) | CN1173698C (ko) |
AU (1) | AU4655199A (ko) |
WO (1) | WO2000078307A1 (ko) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101583452B1 (ko) | 2015-01-30 | 2016-01-11 | 주식회사 대웅제약 | 위장질환 치료용 의약 조성물 |
KR20170010510A (ko) | 2015-07-20 | 2017-02-01 | 안국약품 주식회사 | 위장질환 치료용 삼중층 정제 |
KR101794529B1 (ko) * | 2016-06-14 | 2017-11-07 | 주식회사 인트로바이오파마 | 위장질환 치료용 필름코팅정제, 및 이의 제조방법 |
KR20230156474A (ko) | 2022-05-06 | 2023-11-14 | 에니솔루션 주식회사 | 위장질환 치료용 복합정제 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006103702A2 (en) * | 2005-04-01 | 2006-10-05 | Mccullough Ricky W | Enhanced bio-adherent polymeric compositions for coating mucosal and epidermal epithelium |
CN101507717B (zh) * | 2009-03-13 | 2013-01-23 | 沈阳药科大学 | 一种治疗消化性溃疡的复方片剂及其制备方法 |
CN101607086B (zh) * | 2009-07-21 | 2011-11-02 | 山西安特生物制药股份有限公司 | 一种复方铋剂组合物及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0403048A3 (en) * | 1989-06-14 | 1991-01-30 | Warner-Lambert Company | Medicated compositions containing sucralfate and processes for their production |
JP3677376B2 (ja) * | 1996-08-13 | 2005-07-27 | 武田薬品工業株式会社 | 医薬 |
-
1999
- 1999-06-21 KR KR10-2001-7016389A patent/KR100453179B1/ko not_active IP Right Cessation
- 1999-06-21 AU AU46551/99A patent/AU4655199A/en not_active Abandoned
- 1999-06-21 CN CNB998167568A patent/CN1173698C/zh not_active Expired - Lifetime
- 1999-06-21 WO PCT/KR1999/000327 patent/WO2000078307A1/en active IP Right Grant
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101583452B1 (ko) | 2015-01-30 | 2016-01-11 | 주식회사 대웅제약 | 위장질환 치료용 의약 조성물 |
WO2016122226A2 (en) | 2015-01-30 | 2016-08-04 | Daewoong Pharmaceutical Co., Ltd. | A pharmaceutical composition for treating gastrointestinal diseases |
KR20160094268A (ko) | 2015-01-30 | 2016-08-09 | 주식회사 대웅제약 | 위장질환 치료용 의약 조성물 |
WO2016122226A3 (en) * | 2015-01-30 | 2016-09-15 | Daewoong Pharmaceutical Co., Ltd. | A pharmaceutical composition for treating gastrointestinal diseases |
EA032385B1 (ru) * | 2015-01-30 | 2019-05-31 | Дэвон Фармасьютикал Ко., Лтд. | Фармацевтическая композиция для лечения заболеваний желудочно-кишечного тракта |
KR20170010510A (ko) | 2015-07-20 | 2017-02-01 | 안국약품 주식회사 | 위장질환 치료용 삼중층 정제 |
KR101801064B1 (ko) | 2015-07-20 | 2017-11-27 | 안국약품 주식회사 | 위장질환 치료용 삼중층 정제 |
KR101794529B1 (ko) * | 2016-06-14 | 2017-11-07 | 주식회사 인트로바이오파마 | 위장질환 치료용 필름코팅정제, 및 이의 제조방법 |
KR20230156474A (ko) | 2022-05-06 | 2023-11-14 | 에니솔루션 주식회사 | 위장질환 치료용 복합정제 |
Also Published As
Publication number | Publication date |
---|---|
CN1173698C (zh) | 2004-11-03 |
AU4655199A (en) | 2001-01-09 |
CN1354660A (zh) | 2002-06-19 |
WO2000078307A1 (en) | 2000-12-28 |
KR20020031342A (ko) | 2002-05-01 |
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