KR100432587B1 - 레보설피리드의 제조방법 및 이에 사용되는 중간체 - Google Patents
레보설피리드의 제조방법 및 이에 사용되는 중간체 Download PDFInfo
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- KR100432587B1 KR100432587B1 KR10-2001-0031027A KR20010031027A KR100432587B1 KR 100432587 B1 KR100432587 B1 KR 100432587B1 KR 20010031027 A KR20010031027 A KR 20010031027A KR 100432587 B1 KR100432587 B1 KR 100432587B1
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- Prior art keywords
- preparing
- compound
- ethyl
- methoxy
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/402—1-aryl substituted, e.g. piretanide
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
Abstract
Description
Claims (5)
- 다음의 일반구조식 (V)의 화합물을 트리풀루오로아세트산으로 처리하여 다음 구조식 (I)의 화합물을 제조하는 방법.상기식에서 R1및 R2는 각각 수소원자 또는 탄소수 1 ∼ 4의 저급알킬 또는 페닐이며, R3는 다음 구조식 (VIII)의 페닐유도체 또는 다음 구조식 (IX)의 나프틸유도체이며(구조식 [V]은 키랄탄소(*)를 포함하므로 라세믹체, (S) 및 (R)체가 존재한다.)여기에서 X는 수소원자 또는 할로겐원자를 나타낸다.
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2001-0031027A KR100432587B1 (ko) | 2001-06-02 | 2001-06-02 | 레보설피리드의 제조방법 및 이에 사용되는 중간체 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2001-0031027A KR100432587B1 (ko) | 2001-06-02 | 2001-06-02 | 레보설피리드의 제조방법 및 이에 사용되는 중간체 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR10-2003-0069901A Division KR100450485B1 (ko) | 2003-10-08 | 2003-10-08 | 레보설피리드 제조용 중간체 및 그 제조방법 |
KR10-2003-0069903A Division KR100468314B1 (ko) | 2003-10-08 | 2003-10-08 | 레보설피리드 제조용 중간체 및 그 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20020092123A KR20020092123A (ko) | 2002-12-11 |
KR100432587B1 true KR100432587B1 (ko) | 2004-05-24 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR10-2001-0031027A KR100432587B1 (ko) | 2001-06-02 | 2001-06-02 | 레보설피리드의 제조방법 및 이에 사용되는 중간체 |
Country Status (1)
Country | Link |
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KR (1) | KR100432587B1 (ko) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102442935A (zh) * | 2010-11-16 | 2012-05-09 | 江苏恒祥化工有限责任公司 | 一种(s)-n-乙基-2-氨甲基吡咯烷的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS565458A (en) * | 1979-06-27 | 1981-01-20 | Sanyo Kagaku Kenkyusho:Kk | Preparation of 1-ethyl-2- 2-methoxy-5- sulfamoylbenzamidemethyl pyrrolidine |
JPS5663953A (en) * | 1979-10-30 | 1981-05-30 | Fujimoto Seiyaku Kk | Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide |
JPS5695165A (en) * | 1979-12-28 | 1981-08-01 | Sato Yoshio | Preparation of substituted benzoic acid amide |
JPS572266A (en) * | 1980-06-05 | 1982-01-07 | Yamanouchi Pharmaceut Co Ltd | Novel benzamide derivative |
JPS5762255A (en) * | 1980-05-08 | 1982-04-15 | Shionogi & Co Ltd | Preparation of benzamide derivative, and intermediate of benzamide derivative |
-
2001
- 2001-06-02 KR KR10-2001-0031027A patent/KR100432587B1/ko active IP Right Grant
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS565458A (en) * | 1979-06-27 | 1981-01-20 | Sanyo Kagaku Kenkyusho:Kk | Preparation of 1-ethyl-2- 2-methoxy-5- sulfamoylbenzamidemethyl pyrrolidine |
JPS5663953A (en) * | 1979-10-30 | 1981-05-30 | Fujimoto Seiyaku Kk | Novel preparation of n- 1-ethyl-2-pyrrolidinylmethyl -2- methoxy-5-sulfamoylbenzamide |
JPS5695165A (en) * | 1979-12-28 | 1981-08-01 | Sato Yoshio | Preparation of substituted benzoic acid amide |
JPS5762255A (en) * | 1980-05-08 | 1982-04-15 | Shionogi & Co Ltd | Preparation of benzamide derivative, and intermediate of benzamide derivative |
JPS572266A (en) * | 1980-06-05 | 1982-01-07 | Yamanouchi Pharmaceut Co Ltd | Novel benzamide derivative |
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Publication number | Publication date |
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KR20020092123A (ko) | 2002-12-11 |
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