KR100418237B1 - 알파,알파'-디아미노알콜의제조방법 - Google Patents

알파,알파'-디아미노알콜의제조방법 Download PDF

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Publication number
KR100418237B1
KR100418237B1 KR1019950031290A KR19950031290A KR100418237B1 KR 100418237 B1 KR100418237 B1 KR 100418237B1 KR 1019950031290 A KR1019950031290 A KR 1019950031290A KR 19950031290 A KR19950031290 A KR 19950031290A KR 100418237 B1 KR100418237 B1 KR 100418237B1
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South Korea
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formula
methyl
benzyl
alkyl
general formula
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Expired - Lifetime
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KR1019950031290A
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English (en)
Korean (ko)
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KR960010629A (ko
Inventor
한스힐페르트
Original Assignee
에프. 호프만-라 로슈 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019950031290A 1994-09-23 1995-09-22 알파,알파'-디아미노알콜의제조방법 Expired - Lifetime KR100418237B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH2904/94 1994-09-23
CH290494 1994-09-23
CH373694 1994-12-09
CH3736/94 1994-12-09

Publications (2)

Publication Number Publication Date
KR960010629A KR960010629A (ko) 1996-04-20
KR100418237B1 true KR100418237B1 (ko) 2004-07-23

Family

ID=25691689

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950031290A Expired - Lifetime KR100418237B1 (ko) 1994-09-23 1995-09-22 알파,알파'-디아미노알콜의제조방법

Country Status (9)

Country Link
US (5) US5591885A (enExample)
EP (1) EP0710651B1 (enExample)
JP (1) JP3819955B2 (enExample)
KR (1) KR100418237B1 (enExample)
CN (3) CN1116284C (enExample)
AT (1) ATE198740T1 (enExample)
DE (1) DE59508973D1 (enExample)
DK (1) DK0710651T3 (enExample)
ES (1) ES2154310T3 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
ES2167541T3 (es) * 1995-02-03 2002-05-16 Kaneka Corp Procedimientos de produccion de alfa-halocetonas, de alfa-halohidrinas y de epoxidos.
EP0827943B1 (en) * 1996-01-29 2003-05-21 Kaneka Corporation Processes for the reduction of carbonyl compounds
ES2194145T3 (es) 1996-12-11 2003-11-16 Hoffmann La Roche Procedimiento para la obtencion de anhidridos mixtos.
ATE411978T1 (de) 1999-01-28 2008-11-15 Ajinomoto Kk Verfahren zur herstellung von alpha-aminoketonen
US6605732B1 (en) 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres
JP4143787B2 (ja) * 1999-07-28 2008-09-03 味の素株式会社 α−アミノハロメチルケトン誘導体の製造方法
DE10143742A1 (de) 2001-09-06 2003-03-27 Consortium Elektrochem Ind Verfahren zur Herstellung von alpha-Halogenketonen
US7038553B2 (en) * 2002-10-03 2006-05-02 International Business Machines Corporation Scalable computer system having surface-mounted capacitive couplers for intercommunication
EP1604662A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
CN102164906A (zh) * 2008-09-24 2011-08-24 Zach系统股份公司 用于制备奈必洛尔的方法
CN102127061B (zh) * 2010-01-15 2016-02-17 浙江华海药业股份有限公司 一种制备6-氟-3，4-二氢-2h-1-苯并吡喃-2-环氧乙烷的改进方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0432695A2 (en) * 1989-12-11 1991-06-19 F. Hoffmann-La Roche Ag Amino acid derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
US5430041A (en) * 1991-05-10 1995-07-04 Hoffmann-La Roche Inc. Amino acid derivatives having antiviral activity
JP2551901B2 (ja) * 1991-07-26 1996-11-06 エフ エム シー コーポレーション 接触アルキル化方法
JPH06184069A (ja) * 1991-11-19 1994-07-05 Lonza Ag α−ヒドロキシ−β−アミノカルボン酸の製造方法
US5380849A (en) * 1992-11-09 1995-01-10 Merck & Co., Inc. Process for optically pure decahydroisoqiunolines
US5455353A (en) * 1993-03-24 1995-10-03 Hoffmann-La Roche Inc. 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
EP0738724B1 (de) * 1993-07-15 1998-11-04 F. Hoffmann-La Roche Ag Verfahren zur Herstellung eines N-tert.Butylamids
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0432695A2 (en) * 1989-12-11 1991-06-19 F. Hoffmann-La Roche Ag Amino acid derivatives

Also Published As

Publication number Publication date
CN1275562A (zh) 2000-12-06
US5684176A (en) 1997-11-04
JPH0899959A (ja) 1996-04-16
DE59508973D1 (de) 2001-02-22
CN1133620C (zh) 2004-01-07
US5965733A (en) 1999-10-12
US5977388A (en) 1999-11-02
CN1275563A (zh) 2000-12-06
EP0710651B1 (de) 2001-01-17
US5591885A (en) 1997-01-07
CN1111156C (zh) 2003-06-11
EP0710651A1 (de) 1996-05-08
CN1127251A (zh) 1996-07-24
JP3819955B2 (ja) 2006-09-13
US5847144A (en) 1998-12-08
ATE198740T1 (de) 2001-02-15
ES2154310T3 (es) 2001-04-01
KR960010629A (ko) 1996-04-20
CN1116284C (zh) 2003-07-30
DK0710651T3 (da) 2001-05-14

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