DE59508973D1 - Verfahren zur Herstellung eines Decahydroisochinolino-alpha,alpha'diamino-alkohols - Google Patents

Verfahren zur Herstellung eines Decahydroisochinolino-alpha,alpha'diamino-alkohols

Info

Publication number
DE59508973D1
DE59508973D1 DE59508973T DE59508973T DE59508973D1 DE 59508973 D1 DE59508973 D1 DE 59508973D1 DE 59508973 T DE59508973 T DE 59508973T DE 59508973 T DE59508973 T DE 59508973T DE 59508973 D1 DE59508973 D1 DE 59508973D1
Authority
DE
Germany
Prior art keywords
formula
reacting
lower alkyl
alpha
r1oconhch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59508973T
Other languages
German (de)
English (en)
Inventor
Hans Hilpert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE59508973D1 publication Critical patent/DE59508973D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/18—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE59508973T 1994-09-23 1995-09-11 Verfahren zur Herstellung eines Decahydroisochinolino-alpha,alpha'diamino-alkohols Expired - Lifetime DE59508973D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH290494 1994-09-23
CH373694 1994-12-09

Publications (1)

Publication Number Publication Date
DE59508973D1 true DE59508973D1 (de) 2001-02-22

Family

ID=25691689

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59508973T Expired - Lifetime DE59508973D1 (de) 1994-09-23 1995-09-11 Verfahren zur Herstellung eines Decahydroisochinolino-alpha,alpha'diamino-alkohols

Country Status (9)

Country Link
US (5) US5591885A (enExample)
EP (1) EP0710651B1 (enExample)
JP (1) JP3819955B2 (enExample)
KR (1) KR100418237B1 (enExample)
CN (3) CN1116284C (enExample)
AT (1) ATE198740T1 (enExample)
DE (1) DE59508973D1 (enExample)
DK (1) DK0710651T3 (enExample)
ES (1) ES2154310T3 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols
DE69616446T2 (de) * 1995-02-03 2002-05-16 Kaneka Corp., Osaka Verfahren zur herstellung von alpha-haloketonen, alpha-halohydrinen und epoxiden
CA2216537A1 (en) * 1996-01-29 1997-08-07 Tadashi Sugawa Process for reduction of carbonyl compounds
ES2194145T3 (es) 1996-12-11 2003-11-16 Hoffmann La Roche Procedimiento para la obtencion de anhidridos mixtos.
WO2000044706A1 (en) 1999-01-28 2000-08-03 Ajinomoto Co., Inc. PROCESS FOR THE PREPARATION OF α-AMINOKETONES
US6605732B1 (en) * 1999-05-03 2003-08-12 Aerojet Fine Chemicals Llc Clean, high-yield preparation of S,S and R,S amino acid isosteres
JP4143787B2 (ja) * 1999-07-28 2008-09-03 味の素株式会社 α−アミノハロメチルケトン誘導体の製造方法
DE10143742A1 (de) 2001-09-06 2003-03-27 Consortium Elektrochem Ind Verfahren zur Herstellung von alpha-Halogenketonen
US7038553B2 (en) * 2002-10-03 2006-05-02 International Business Machines Corporation Scalable computer system having surface-mounted capacitive couplers for intercommunication
EP1604662A1 (en) * 2004-06-08 2005-12-14 Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft 1-[(3R)-Amino-4-(2-fluoro-phenyl)-butyl]-pyrrolidine-(2R)-carboxylic acid benzyl amine derivatives and related compounds as dipeptidyl peptidase IV (DPP-IV) inhibitors for the treatment of type 2 diabetes mellitus
US8981127B2 (en) * 2008-09-24 2015-03-17 Zach System Method for preparing nebivolol
CN102127061B (zh) * 2010-01-15 2016-02-17 浙江华海药业股份有限公司 一种制备6-氟-3，4-二氢-2h-1-苯并吡喃-2-环氧乙烷的改进方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340588C (en) * 1988-06-13 1999-06-08 Balraj Krishan Handa Amino acid derivatives
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives
GB8927915D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Novel alcohols
US5430041A (en) * 1991-05-10 1995-07-04 Hoffmann-La Roche Inc. Amino acid derivatives having antiviral activity
JP2551901B2 (ja) * 1991-07-26 1996-11-06 エフ エム シー コーポレーション 接触アルキル化方法
JPH06184069A (ja) * 1991-11-19 1994-07-05 Lonza Ag α−ヒドロキシ−β−アミノカルボン酸の製造方法
US5380849A (en) * 1992-11-09 1995-01-10 Merck & Co., Inc. Process for optically pure decahydroisoqiunolines
US5455353A (en) * 1993-03-24 1995-10-03 Hoffmann-La Roche Inc. 4-(benzyl-2-oxo-oxazolidin-5 ylmethyl)N tertbutyl-decahydroisoquinoline-3-carboxamides
EP0634410B1 (de) * 1993-07-15 1997-02-26 F. Hoffmann-La Roche Ag Verfahren zur Herstellung eines N-tert.Butylisochinolin-3-carboxamid Derivates und Zwischenprodukte in diesem Verfahren
US5523463A (en) * 1994-09-23 1996-06-04 Hoffmann-La Roche Inc. Method of producing halogenated and alpha-aminoalchohols

Also Published As

Publication number Publication date
ATE198740T1 (de) 2001-02-15
CN1275563A (zh) 2000-12-06
KR960010629A (ko) 1996-04-20
CN1116284C (zh) 2003-07-30
US5847144A (en) 1998-12-08
EP0710651A1 (de) 1996-05-08
EP0710651B1 (de) 2001-01-17
US5684176A (en) 1997-11-04
CN1133620C (zh) 2004-01-07
US5591885A (en) 1997-01-07
JPH0899959A (ja) 1996-04-16
CN1111156C (zh) 2003-06-11
US5965733A (en) 1999-10-12
US5977388A (en) 1999-11-02
KR100418237B1 (ko) 2004-07-23
JP3819955B2 (ja) 2006-09-13
ES2154310T3 (es) 2001-04-01
CN1127251A (zh) 1996-07-24
CN1275562A (zh) 2000-12-06
DK0710651T3 (da) 2001-05-14

Similar Documents

Publication Publication Date Title
DE59508973D1 (de) Verfahren zur Herstellung eines Decahydroisochinolino-alpha,alpha'diamino-alkohols
DE69029334D1 (de) Verfahren zur Herstellung von Alkoxyiminoacetamid-Derivaten und ein Zwischenproduckt dafür
FI95469C (fi) Analogiamenetelmä uusien hypoglykeemisten oksatsolidiinidionien valmistamiseksi
DE69705480D1 (de) Verwendung von Oestrogenagonisten und -antagonisten zur Herstellung eines Medikaments zur Behandlung von Atherosklerose, unabhängig von Lipidsenkung
ATE132145T1 (de) Verfahren zur herstellung von bacchatin iii und von desacetyl-10-bacchatin iii derivate
ATE115397T1 (de) Verfahren zur enzymatischen herstellung von melaninpigment und seine kosmetische verwendung.
DE3776385D1 (de) Verfahren zur herstellung von d-(+)-biotin.
SE8003822L (sv) Nya 3-vinylcefalosporiner och forfarande for framstellning derav
ES2069841T3 (es) Nuevos derivados de imidazo-(1,2-c)-quinazolina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DE69606337D1 (de) Trizyklische Derivate, ihre Herstellung, ihre Verwendung zur Herstellung von optisch aktivem oder racemischem Colchizin, Thiocolchizin, dessen Analoge oder Derivate, und Intermediate
FR2677023B1 (fr) Derives de coumarine hydrosolubles, leur preparation et leur utilisation comme substrat d'enzyme.
DE69611502D1 (de) (Oxo-1-Alkyl)amino-2-desoxy-2-glucopyranosid von Dihydroxy-2,3-propyl, Verfahren zur Herstellung und ihre Verwendungen
PT90584A (pt) Processo de preparacao de agentes diureticos de glutaramidas enantiomericas
DE3583767D1 (de) Verfahren zur herstellung von beta-(benzthiazolylthio)- und beta-(benzimidazolylthio)-carbonsaeurederivaten.
ATE150453T1 (de) Verfahren zur herstellung von trans-piperidin-2,5-dicarboxylaten
DE68903405D1 (de) Verfahren zur herstellung von 2-alpha-methyl-2-beta-(1,2,3-triazol-1-yl)methylpenam-3-alpha-carbonsaeurederivaten.
FR2664270B1 (fr) Nouveaux composes (meth)acryliques porteurs de fonction thiocyanate, leur procede de preparation et leur application a l'obtention de nouveaux polymeres.
MA24197A1 (fr) Nouvelles fungarrestines
ATE18559T1 (de) Vinyl-3-cephalosporinverbindungen und ihre herstellung.
DE3688161D1 (de) Gegebenenfalls etherifizierte oder esterifizierte in stellung 2 substituierte 4-oh-chinolincarbonsaeurederivate, verfahren und zwischenprodukte zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
DE69714749D1 (de) Verfahren zur herstellung von 3-amino-2-hydroxy-1-propylethern
ATE132863T1 (de) Verfahren zur herstellung von 6-(substituiertes aminopropionyl)-derivaten von forskolin
ATE176471T1 (de) Verfahren zu herstellung von areno(e>indole
ATE311375T1 (de) Verfahren zur herstellung antiosteoporicagenz
ATE98961T1 (de) 1,8-benzonaphthyridinderivate und ihre herstellung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition