KR100333149B1 - 담즙산의테트라졸유도체및이를포함하는약제 - Google Patents

담즙산의테트라졸유도체및이를포함하는약제 Download PDF

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Publication number
KR100333149B1
KR100333149B1 KR1019940009971A KR19940009971A KR100333149B1 KR 100333149 B1 KR100333149 B1 KR 100333149B1 KR 1019940009971 A KR1019940009971 A KR 1019940009971A KR 19940009971 A KR19940009971 A KR 19940009971A KR 100333149 B1 KR100333149 B1 KR 100333149B1
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KR
South Korea
Prior art keywords
compound
bile acid
radical
mmol
formula
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Expired - Fee Related
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KR1019940009971A
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English (en)
Korean (ko)
Inventor
알폰스엔젠
하이너글롬빅
베르너크라머
귄터베스
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훽스트 악티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019940009971A 1993-05-08 1994-05-07 담즙산의테트라졸유도체및이를포함하는약제 Expired - Fee Related KR100333149B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4315368 1993-05-08
DEP4315368.2 1993-05-08

Publications (1)

Publication Number Publication Date
KR100333149B1 true KR100333149B1 (ko) 2002-09-19

Family

ID=6487579

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940009971A Expired - Fee Related KR100333149B1 (ko) 1993-05-08 1994-05-07 담즙산의테트라졸유도체및이를포함하는약제

Country Status (19)

Country Link
US (1) US5466815A (https=)
EP (1) EP0624596B1 (https=)
JP (1) JP3476157B2 (https=)
KR (1) KR100333149B1 (https=)
AT (1) ATE163938T1 (https=)
AU (1) AU666440B2 (https=)
CA (1) CA2123048C (https=)
CY (1) CY2119B1 (https=)
CZ (1) CZ289515B6 (https=)
DE (1) DE59405410D1 (https=)
DK (1) DK0624596T3 (https=)
ES (1) ES2115096T3 (https=)
FI (1) FI942075A7 (https=)
GR (1) GR3026496T3 (https=)
HU (1) HU217439B (https=)
IL (1) IL109581A (https=)
NO (1) NO304795B1 (https=)
NZ (1) NZ260469A (https=)
TW (1) TW289757B (https=)

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US6323190B1 (en) 1998-07-31 2001-11-27 The Univeristy Of Georgia Research Foundation, Inc. Estrogen mimetics lacking reproductive tract effects
CN1187364C (zh) 1999-04-30 2005-02-02 亚其发展公司 类固醇衍生物
US7086134B2 (en) * 2000-08-07 2006-08-08 Shipley Company, L.L.C. Alignment apparatus and method for aligning stacked devices
EP1385868A4 (en) * 2001-02-08 2004-12-08 Univ Chicago STEROID DERIVATIVE
JP4309661B2 (ja) * 2001-05-03 2009-08-05 ザ ユニバーシティー オブ シカゴ 肝臓ｘ受容体
US20070197484A1 (en) * 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
US7078396B2 (en) * 2001-05-03 2006-07-18 Arch Development Corporation Method of treating disorder related to high cholesterol concentration
US6816317B2 (en) * 2002-01-31 2004-11-09 Lightel Technologies Inc. Collimator for ready fitting to an optical device with precise optical alignment without need for adjusting positions or angles to compensate for offsets or deviations during optical device assembly and method of making same
WO2003086303A2 (en) * 2002-04-12 2003-10-23 The University Of Chicago Farnesoid x-activated receptor agonists
CA2572770A1 (en) 2004-07-08 2006-01-19 Novo-Nordisk A/S Polypeptide protracting tags comprising a tetrazole moiety
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US8829213B2 (en) * 2009-07-29 2014-09-09 The University Of Chicago Liver X receptor agonists
ES2687027T3 (es) 2010-11-04 2018-10-23 Albireo Ab Inhibidores de ibat para el tratamiento de enfermedades hepáticas
DK2637646T3 (en) 2010-11-08 2016-08-29 Albireo Ab PHARMACEUTICAL COMBINATION CONTAINING AN IBAT inhibitor and a bile acid binder
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CN106659726A (zh) 2014-06-25 2017-05-10 Ea制药株式会社 固体制剂及其着色防止或着色减少方法
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WO2016073767A1 (en) 2014-11-06 2016-05-12 Enanta Pharmaceuticals, Inc. Bile acid analogs an fxr/tgr5 agonists and methods of use thereof
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JP2017535570A (ja) 2014-11-26 2017-11-30 エナンタ ファーマシューティカルズ インコーポレイテッド Ｆｘｒ／ｔｇｒ５アゴニストとしての胆汁酸類似体およびその使用方法
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CA2981503C (en) 2015-03-31 2023-09-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
CN111116699B (zh) * 2015-04-28 2023-02-28 江苏豪森药业集团有限公司 胆酸衍生物及其制备方法和医药用途
WO2017138878A1 (en) 2016-02-09 2017-08-17 Albireo Ab Oral cholestyramine formulation and use thereof
CN108601739B (zh) 2016-02-09 2022-01-04 阿尔比里奥公司 考来烯胺丸剂及其制备方法
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417725A2 (de) * 1989-09-14 1991-03-20 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung, Verwendung als Arzneimittel
EP0489423A1 (de) * 1990-12-06 1992-06-10 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindung als Arzneimittel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0417725A2 (de) * 1989-09-14 1991-03-20 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung, Verwendung als Arzneimittel
EP0489423A1 (de) * 1990-12-06 1992-06-10 Hoechst Aktiengesellschaft Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindung als Arzneimittel

Also Published As

Publication number Publication date
AU666440B2 (en) 1996-02-08
NO941677L (no) 1994-11-09
DE59405410D1 (de) 1998-04-16
JP3476157B2 (ja) 2003-12-10
EP0624596B1 (de) 1998-03-11
FI942075L (fi) 1994-11-09
EP0624596A3 (de) 1995-06-07
FI942075A7 (fi) 1994-11-09
HU217439B (hu) 2000-01-28
NZ260469A (en) 1995-03-28
ES2115096T3 (es) 1998-06-16
FI942075A0 (fi) 1994-05-05
CY2119B1 (en) 2002-04-26
HUT67390A (en) 1995-04-28
ATE163938T1 (de) 1998-03-15
DK0624596T3 (da) 1998-10-07
EP0624596A2 (de) 1994-11-17
NO941677D0 (no) 1994-05-06
IL109581A (en) 1998-03-10
TW289757B (https=) 1996-11-01
CZ113594A3 (en) 1994-12-15
US5466815A (en) 1995-11-14
CA2123048A1 (en) 1994-11-09
JPH06329695A (ja) 1994-11-29
AU6194794A (en) 1994-11-10
HU9401443D0 (en) 1994-08-29
NO304795B1 (no) 1999-02-15
CZ289515B6 (cs) 2002-02-13
IL109581A0 (en) 1994-08-26
CA2123048C (en) 2005-11-29
GR3026496T3 (en) 1998-07-31

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P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000