KR100299734B1 - 1,4-(디페닐알킬)피페라진유도체 - Google Patents

1,4-(디페닐알킬)피페라진유도체 Download PDF

Info

Publication number
KR100299734B1
KR100299734B1 KR1019960700394A KR19960700394A KR100299734B1 KR 100299734 B1 KR100299734 B1 KR 100299734B1 KR 1019960700394 A KR1019960700394 A KR 1019960700394A KR 19960700394 A KR19960700394 A KR 19960700394A KR 100299734 B1 KR100299734 B1 KR 100299734B1
Authority
KR
South Korea
Prior art keywords
compound
salts
therapeutic agent
brain
amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019960700394A
Other languages
English (en)
Korean (ko)
Inventor
요이치 가와시마
쥰조 마츠모토
기요시 마츠노
도시히코 센다
게이코 히라노
Original Assignee
모리타 다카카즈
산텐 세이야꾸 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 모리타 다카카즈, 산텐 세이야꾸 가부시키가이샤 filed Critical 모리타 다카카즈
Application granted granted Critical
Publication of KR100299734B1 publication Critical patent/KR100299734B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019960700394A 1993-07-28 1994-07-25 1,4-(디페닐알킬)피페라진유도체 Expired - Fee Related KR100299734B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP93-185839 1993-07-28
JP18583993 1993-07-28
PCT/JP1994/001220 WO1995004050A1 (en) 1993-07-28 1994-07-25 Novel 1,4-di(phenylalkyl)piperazine derivative

Publications (1)

Publication Number Publication Date
KR100299734B1 true KR100299734B1 (ko) 2002-01-09

Family

ID=16177784

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960700394A Expired - Fee Related KR100299734B1 (ko) 1993-07-28 1994-07-25 1,4-(디페닐알킬)피페라진유도체

Country Status (11)

Country Link
US (1) US5736546A (enExample)
EP (1) EP0711763B1 (enExample)
KR (1) KR100299734B1 (enExample)
CN (1) CN1042029C (enExample)
AT (1) ATE197047T1 (enExample)
CA (1) CA2168264A1 (enExample)
DE (1) DE69426157T2 (enExample)
ES (1) ES2151930T3 (enExample)
FI (1) FI960364A0 (enExample)
NO (1) NO960270D0 (enExample)
WO (1) WO1995004050A1 (enExample)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859295A (en) * 1994-12-05 1999-01-12 University Of Kentucky Research Foundation Canavanine analogs and their use as chemotherapeutic agents
IL117149A0 (en) * 1995-02-23 1996-06-18 Schering Corp Muscarinic antagonists
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
HUP9601331A3 (en) * 1996-05-17 2000-06-28 Egyt Gyogyszervegyeszeti Gyar Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them
EP0912515B1 (en) * 1996-07-10 2002-11-13 Schering Corporation 1,4-di-substituted piperidines as muscarinic antagonists
US5952349A (en) * 1996-07-10 1999-09-14 Schering Corporation Muscarinic antagonists for treating memory loss
US5860391A (en) * 1996-08-06 1999-01-19 First Brands Corporation Absorbents containing activated carbons
US6713651B1 (en) * 1999-06-07 2004-03-30 Theravance, Inc. β2-adrenergic receptor agonists
EP1130018B1 (en) * 1998-11-09 2007-01-17 Santen Pharmaceutical Co., Ltd. Drug dependence remedy
AU5569800A (en) * 1999-06-30 2001-01-31 Santen Pharmaceutical Co. Ltd. Brain sigma-1 receptor-binding ligand
DE10050236A1 (de) * 2000-10-11 2002-04-25 Merck Patent Gmbh Verwendung bestimmter Substanzen, die an den Sigma-Rezeptor binden, zur Behandlung von Sarkomen und Karzinomen
CN1181065C (zh) 2002-05-08 2004-12-22 上海医药工业研究院 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用
CN1172919C (zh) * 2002-06-03 2004-10-27 上海医药工业研究院 芳烷醇哌嗪衍生物及其在制备抗抑郁症药物中的应用
US7863272B2 (en) * 2003-06-12 2011-01-04 M's Science Corporation Sigma ligands for neuronal regeneration and functional recovery
WO2005028457A1 (en) * 2003-09-23 2005-03-31 Fermion Oy Preparation of quetiapine
DE102004061593A1 (de) 2004-12-21 2006-06-22 Abbott Gmbh & Co. Kg Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung
CN101263127A (zh) * 2005-08-09 2008-09-10 株式会社爱慕知科学 哌嗪衍生物
NZ567629A (en) * 2005-09-23 2011-08-26 Ms Science Corp Piperazine derivatives useful in the treatment of discorders of the central nervous system
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
JP2009513672A (ja) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド 神経発生のｇａｂａ受容体媒介調節
CN101448503B (zh) * 2006-01-27 2011-04-13 株式会社爱慕知科学 哌啶和哌嗪衍生物
CN101384260A (zh) * 2006-02-15 2009-03-11 株式会社爱慕知科学 哌嗪衍生物
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008060271A1 (en) * 2006-11-13 2008-05-22 M's Science Corporation Sigma ligands for neuronal regeneration and functional recovery
US8461389B2 (en) 2008-04-18 2013-06-11 University College Dublin, National University Of Ireland, Dublin Psycho-pharmaceuticals
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8673920B2 (en) * 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9073882B2 (en) 2010-10-27 2015-07-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9056859B2 (en) 2010-10-29 2015-06-16 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
ES2605164T3 (es) 2011-08-19 2017-03-13 Merck Sharp & Dohme Corp. Inhibidores del canal de potasio de la médula renal externa
EP2755656B1 (en) 2011-09-16 2016-09-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US8999991B2 (en) 2011-10-25 2015-04-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US8999990B2 (en) 2011-10-25 2015-04-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013066714A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2013066717A1 (en) 2011-10-31 2013-05-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9493474B2 (en) 2011-10-31 2016-11-15 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9206199B2 (en) 2011-12-16 2015-12-08 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
US9777002B2 (en) 2012-11-29 2017-10-03 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014099633A2 (en) 2012-12-19 2014-06-26 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9604998B2 (en) 2013-02-18 2017-03-28 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2968288B1 (en) 2013-03-15 2018-07-04 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP3027625B1 (en) 2013-07-31 2018-05-30 Merck Sharp & Dohme Corp. Spiro-fused derivatives of piperidine useful for the treatment of inter alia hypertension and acute or chronic heart failure
WO2015065866A1 (en) 2013-10-31 2015-05-07 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2016127358A1 (en) 2015-02-12 2016-08-18 Merck Sharp & Dohme Corp. Inhibitors of renal outer medullary potassium channel

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009594A1 (en) * 1989-12-28 1991-07-11 Virginia Commonwealth University Sigma receptor ligands and the use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5583771A (en) * 1978-12-20 1980-06-24 Kanebo Ltd N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt
JPS60155171A (ja) * 1983-12-10 1985-08-15 Wako Pure Chem Ind Ltd ポリメトキシベンジルピペラジン誘導体
JPS6133827A (ja) * 1984-07-27 1986-02-17 Mitsubishi Electric Corp 放電加工装置
JP2722250B2 (ja) * 1989-05-30 1998-03-04 興和株式会社 新規なジアミン化合物及びこれを含有する脳機能障害改善剤
EP0566189A1 (en) * 1992-04-13 1993-10-20 Akzo N.V. Psychotropic piperazine derivative
US5428037A (en) * 1993-04-09 1995-06-27 Syntex Pharmaceuticals, Ltd. Heterocyclic derivatives in the treatment of Ischaemia and related diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009594A1 (en) * 1989-12-28 1991-07-11 Virginia Commonwealth University Sigma receptor ligands and the use thereof

Also Published As

Publication number Publication date
ES2151930T3 (es) 2001-01-16
CN1042029C (zh) 1999-02-10
ATE197047T1 (de) 2000-11-15
EP0711763B1 (en) 2000-10-18
EP0711763A1 (en) 1996-05-15
NO960270L (no) 1996-01-23
DE69426157D1 (de) 2000-11-23
CN1128026A (zh) 1996-07-31
DE69426157T2 (de) 2001-05-17
FI960364A7 (fi) 1996-01-26
EP0711763A4 (enExample) 1996-06-12
NO960270D0 (no) 1996-01-23
WO1995004050A1 (en) 1995-02-09
FI960364L (fi) 1996-01-26
CA2168264A1 (en) 1995-02-09
US5736546A (en) 1998-04-07
FI960364A0 (fi) 1996-01-26

Similar Documents

Publication Publication Date Title
KR100299734B1 (ko) 1,4-(디페닐알킬)피페라진유도체
AU642836B1 (en) Process for preparing aryl piperazinyl-heterocyclic compounds
US5478941A (en) Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl) sulfonyl]piperazine
JP3346562B2 (ja) Ｐｃｐレセプター・リガンドおよびそれらを含む薬剤
KR100214905B1 (ko) 퀴누클리딘 유도체
US5143916A (en) Naphthylpiperazines useful as 5-ht1a receptor ligands
KR100192833B1 (ko) 4-이실아미노피리딘 유도체 및 그의 제조방법
US4806547A (en) Isoquinoline derivatives, analgesic compounds thereof and method of treating pain
EP0319429A2 (en) 9-Acylamino-tetrahydroacridine derivatives and memory enhancing agent containing said derivative as active ingredient
US4735944A (en) Spiro-dioxolanes, -dithiolanes and -oxothiolanes, and their use in mental therapy
DE69517936T2 (de) Substituierte 4-Phenyl-Thiazole Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammenstellungen die sie enthalten
US5910586A (en) Tricyclic aminoalkylcarboxamides; dopamine D3 receptor subtype specific ligands
JPH09510706A (ja) ドパミン作動性活性を有するベンゾイミダゾール誘導体
US4727072A (en) 3-alkoxy-2-aminopropylamines compositions and use as cardiovascular agents
JP2883970B2 (ja) 新規１，４−（ジフェニルアルキル）ピペラジン誘導体
US5071864A (en) Aminoalkyl-substituted 2-aminothiazoles and therapeutic agents containing them
CZ290711B6 (cs) 1-Arylcykloalkylsulfidy, -sulfoxidy a -sulfony, způsob jejich přípravy, farmaceutický prostředek s jejich obsahem a použití
JP3077047B2 (ja) 新規ピペラジン誘導体
US5096900A (en) (4-piperidyl)methyl-2,3-dihydro-1h-isoindole and -2,3,4,5-tetrahydro-1h-benzazepine derivatives, their preparation and their application in therapy
US5053409A (en) Aminobenzenesulfonic acid derivatives
FR2753970A1 (fr) Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique
US5418235A (en) Aminoalkyl-substituted 5-mercaptothiazoles, the preparation and use thereof
US6211204B1 (en) Muscarinic receptor agonists
JP4216337B2 (ja) ベンゾ［ｇ］キノリン誘導体
AU618648B2 (en) New indole derivatives, process for preparing them and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

FPAY Annual fee payment

Payment date: 20120521

Year of fee payment: 12

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 12

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20130613

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20130613

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000