KR100281296B1 - 단일 4차 2,16-비스피페리디닐안드로스탄 유도체 - Google Patents

단일 4차 2,16-비스피페리디닐안드로스탄 유도체 Download PDF

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Publication number
KR100281296B1
KR100281296B1 KR1019930006536A KR930006536A KR100281296B1 KR 100281296 B1 KR100281296 B1 KR 100281296B1 KR 1019930006536 A KR1019930006536 A KR 1019930006536A KR 930006536 A KR930006536 A KR 930006536A KR 100281296 B1 KR100281296 B1 KR 100281296B1
Authority
KR
South Korea
Prior art keywords
pharmaceutically acceptable
acid
bromide
single quaternary
compounds
Prior art date
Application number
KR1019930006536A
Other languages
English (en)
Korean (ko)
Other versions
KR930021653A (ko
Inventor
토마스슬레이
얀크래이그카릴
알란윌리엄무어
Original Assignee
에프.지.엠. 헤르만스
악조 노벨 엔.브이.
이.에이치. 리링크
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프.지.엠. 헤르만스, 악조 노벨 엔.브이., 이.에이치. 리링크 filed Critical 에프.지.엠. 헤르만스
Publication of KR930021653A publication Critical patent/KR930021653A/ko
Application granted granted Critical
Publication of KR100281296B1 publication Critical patent/KR100281296B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Fats And Perfumes (AREA)
KR1019930006536A 1992-04-22 1993-04-19 단일 4차 2,16-비스피페리디닐안드로스탄 유도체 KR100281296B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92303612 1992-04-22
EP92303612.3 1992-04-22

Publications (2)

Publication Number Publication Date
KR930021653A KR930021653A (ko) 1993-11-22
KR100281296B1 true KR100281296B1 (ko) 2001-03-02

Family

ID=8211340

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930006536A KR100281296B1 (ko) 1992-04-22 1993-04-19 단일 4차 2,16-비스피페리디닐안드로스탄 유도체

Country Status (17)

Country Link
US (1) US5418226A (cs)
EP (1) EP0571012B1 (cs)
JP (1) JP3344764B2 (cs)
KR (1) KR100281296B1 (cs)
AT (1) ATE145918T1 (cs)
AU (1) AU662277B2 (cs)
CA (1) CA2094457C (cs)
CZ (1) CZ286728B6 (cs)
DE (1) DE69306303T2 (cs)
DK (1) DK0571012T3 (cs)
ES (1) ES2097435T3 (cs)
FI (1) FI111644B (cs)
GR (1) GR3022316T3 (cs)
HK (1) HK1001061A1 (cs)
HU (2) HUT64970A (cs)
MX (1) MX9302303A (cs)
NO (1) NO301931B1 (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9302455D0 (en) * 1993-02-08 1993-03-24 Lab Inpharm N V Process for preparing a pharmaceutical preparation having neuromuscular blocking activity
IT1277700B1 (it) * 1995-12-22 1997-11-11 Poli Ind Chimica Spa Processo di preparazione di 2-beta, 16-beta-diamino 3-alfa, 17-beta- diacilossi 5-alfaandrostani, bloccanti neuromuscolari a struttura
WO1999027914A1 (en) * 1997-11-27 1999-06-10 Akzo Nobel N.V. A pharmaceutical formulation of monoquaternary 2,16-bispiperidinylandrostane for intramuscular administration
HU0402017D0 (en) * 2004-10-07 2004-12-28 Richter Gedeon Vegyeszet Environment-friend process for the synthesis of quaternary ammonio-steroids
AU2014285324B2 (en) * 2013-07-01 2019-05-23 Maruishi Pharmaceutical Co., Ltd. Rocuronium preparation causing less pain, method for producing the same, and method for reducting and/or alleviating vascular pain to be induced using the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138605A (en) * 1965-02-19 1969-01-01 Organon Labor Ltd Improvements in or relating to new 2-ß,16-ß-diamino-androstanes
ATE921T1 (de) * 1978-09-05 1982-05-15 Akzo N.V. Saeureadditionssalze von 2-beta, 16-beta-bis-piperidino-an drostan-16-beta-monoquaternaeren ammoniumderivaten und diese enthaltende pharmazeutische zusammensetzungen.
IE50675B1 (en) * 1979-12-12 1986-06-11 Akzo Nv Bis-and mono-quaternary ammonium derivatives of 2beta,16beta-dipiperidino-5alpha-androstanes,processes for their preparation and pharmaceutical preparations
US4337386A (en) * 1980-01-21 1982-06-29 Caterpillar Tractor Co. Welder control

Also Published As

Publication number Publication date
FI931794A0 (fi) 1993-04-21
FI931794A (fi) 1993-10-23
EP0571012A2 (en) 1993-11-24
JP3344764B2 (ja) 2002-11-18
GR3022316T3 (en) 1997-04-30
NO931466L (no) 1993-10-25
CA2094457A1 (en) 1993-10-23
HU211859A9 (en) 1995-12-28
HU9301173D0 (en) 1993-07-28
KR930021653A (ko) 1993-11-22
FI111644B (fi) 2003-08-29
DK0571012T3 (da) 1997-05-12
JPH07267984A (ja) 1995-10-17
ATE145918T1 (de) 1996-12-15
NO931466D0 (no) 1993-04-21
ES2097435T3 (es) 1997-04-01
CA2094457C (en) 2003-12-09
DE69306303T2 (de) 1997-04-17
DE69306303D1 (de) 1997-01-16
AU662277B2 (en) 1995-08-24
CZ286728B6 (en) 2000-06-14
MX9302303A (es) 1994-03-31
EP0571012B1 (en) 1996-12-04
CZ68093A3 (en) 1994-01-19
US5418226A (en) 1995-05-23
HK1001061A1 (en) 1998-05-22
AU3703093A (en) 1993-10-28
NO301931B1 (no) 1997-12-29
EP0571012A3 (en) 1995-04-12
HUT64970A (en) 1994-03-28

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