KR100220502B1 - 식물성 독소 겔로닌의 단백질 구조물 - Google Patents

식물성 독소 겔로닌의 단백질 구조물 Download PDF

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Publication number
KR100220502B1
KR100220502B1 KR1019930700412A KR930700412A KR100220502B1 KR 100220502 B1 KR100220502 B1 KR 100220502B1 KR 1019930700412 A KR1019930700412 A KR 1019930700412A KR 930700412 A KR930700412 A KR 930700412A KR 100220502 B1 KR100220502 B1 KR 100220502B1
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KR
South Korea
Prior art keywords
gelonin
sequence
amino acid
protein
proteins
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Expired - Fee Related
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KR1019930700412A
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English (en)
Korean (ko)
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KR930701487A (ko
Inventor
로젠블룸 마이클
악가랄 브하라트
제이. 코어 윌리암
Original Assignee
와일러 제임스 에프.
리서치 디벨럽먼트 파운데이션
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Publication of KR930701487A publication Critical patent/KR930701487A/ko
Application granted granted Critical
Publication of KR100220502B1 publication Critical patent/KR100220502B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1019930700412A 1990-08-14 1991-08-14 식물성 독소 겔로닌의 단백질 구조물 Expired - Fee Related KR100220502B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US56722090A 1990-08-14 1990-08-14
US7/567,220 1990-08-14
US07/567,220 1990-08-14
PCT/US1991/005766 WO1992003144A1 (en) 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin

Publications (2)

Publication Number Publication Date
KR930701487A KR930701487A (ko) 1993-06-11
KR100220502B1 true KR100220502B1 (ko) 1999-10-01

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930700412A Expired - Fee Related KR100220502B1 (ko) 1990-08-14 1991-08-14 식물성 독소 겔로닌의 단백질 구조물

Country Status (22)

Country Link
US (2) US5631348A (enExample)
EP (1) EP0546087B1 (enExample)
JP (1) JPH06502847A (enExample)
KR (1) KR100220502B1 (enExample)
CN (1) CN1055123C (enExample)
AT (1) ATE150791T1 (enExample)
CA (1) CA2088068C (enExample)
DE (1) DE69125381T2 (enExample)
DK (1) DK0546087T3 (enExample)
ES (1) ES2100960T3 (enExample)
FI (1) FI112492B (enExample)
GR (1) GR3023593T3 (enExample)
HK (1) HK1006727A1 (enExample)
IE (1) IE912716A1 (enExample)
IL (1) IL99079A (enExample)
NO (1) NO309656B1 (enExample)
NZ (1) NZ239249A (enExample)
PT (1) PT98669B (enExample)
RU (1) RU2104285C1 (enExample)
SA (1) SA92130322B1 (enExample)
WO (1) WO1992003144A1 (enExample)
ZA (1) ZA916171B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97776A (en) * 1990-04-19 2000-10-31 Res Dev Foundation Composition comprising a conjugate of a ZME antibody and a biological response modifier
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
CA2115049C (en) * 1991-09-06 2003-10-21 Michael G. Rosenblum Dna sequences encoding gelonin polypeptide
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
CA2139571C (en) * 1992-07-07 2006-11-14 Eleanor N. Fish Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
CA2454048C (en) * 2001-07-17 2011-05-03 Research Development Foundation Therapeutic agents comprising pro-apoptotic proteins
JP2006506964A (ja) * 2002-06-12 2006-03-02 リサーチ　ディベロップメント　ファンデーション 治療剤としての免疫毒素及びその利用
CA2595904A1 (en) * 2005-02-01 2006-08-10 Research Development Foundation Blys fusion proteins for targeting blys receptor and methods for treatment of b-cell proliferative disorders
WO2014127211A1 (en) 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
WO1989004839A1 (en) 1987-11-24 1989-06-01 Genetics Institute, Inc. Improved ricin molecules and ricin toxin conjugates
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

Also Published As

Publication number Publication date
AU653365B2 (en) 1994-09-29
CN1058990A (zh) 1992-02-26
EP0546087B1 (en) 1997-03-26
PT98669A (pt) 1992-07-31
AU8624091A (en) 1992-03-17
CN1055123C (zh) 2000-08-02
PT98669B (pt) 1999-01-29
NO309656B1 (no) 2001-03-05
WO1992003144A1 (en) 1992-03-05
FI930626A0 (fi) 1993-02-12
NO930428D0 (no) 1993-02-08
JPH06502847A (ja) 1994-03-31
IE912716A1 (en) 1992-02-26
ES2100960T3 (es) 1997-07-01
IL99079A (en) 1998-09-24
FI112492B (fi) 2003-12-15
NZ239249A (en) 1992-10-28
DE69125381D1 (de) 1997-04-30
RU2104285C1 (ru) 1998-02-10
GR3023593T3 (en) 1997-08-29
DK0546087T3 (da) 1997-09-22
SA92130322B1 (ar) 2004-05-25
HK1006727A1 (en) 1999-03-12
EP0546087A4 (enExample) 1994-01-05
EP0546087A1 (en) 1993-06-16
FI930626L (fi) 1993-02-12
NO930428L (no) 1993-03-29
USRE37462E1 (en) 2001-12-04
DE69125381T2 (de) 1997-07-03
CA2088068C (en) 1999-06-15
KR930701487A (ko) 1993-06-11
ATE150791T1 (de) 1997-04-15
CA2088068A1 (en) 1992-02-15
ZA916171B (en) 1992-04-29
US5631348A (en) 1997-05-20
IL99079A0 (en) 1992-07-15

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