HK1006727A1 - Protein structure of the plant toxin gelonin - Google Patents

Protein structure of the plant toxin gelonin Download PDF

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Publication number
HK1006727A1
HK1006727A1 HK98106041A HK98106041A HK1006727A1 HK 1006727 A1 HK1006727 A1 HK 1006727A1 HK 98106041 A HK98106041 A HK 98106041A HK 98106041 A HK98106041 A HK 98106041A HK 1006727 A1 HK1006727 A1 HK 1006727A1
Authority
HK
Hong Kong
Prior art keywords
gelonin
sequence
protein
amino acid
toxin
Prior art date
Application number
HK98106041A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1006727B (en
Inventor
Rosenblum Michael
Aggarwal Bharat
J. Kohr William
Original Assignee
Research Development Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Development Foundation filed Critical Research Development Foundation
Publication of HK1006727B publication Critical patent/HK1006727B/en
Publication of HK1006727A1 publication Critical patent/HK1006727A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HK98106041A 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin HK1006727A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US567220 1983-12-30
US56722090A 1990-08-14 1990-08-14
PCT/US1991/005766 WO1992003144A1 (en) 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin

Publications (2)

Publication Number Publication Date
HK1006727B HK1006727B (en) 1999-03-12
HK1006727A1 true HK1006727A1 (en) 1999-03-12

Family

ID=24266242

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98106041A HK1006727A1 (en) 1990-08-14 1991-08-14 Protein structure of the plant toxin gelonin

Country Status (22)

Country Link
US (2) US5631348A (enExample)
EP (1) EP0546087B1 (enExample)
JP (1) JPH06502847A (enExample)
KR (1) KR100220502B1 (enExample)
CN (1) CN1055123C (enExample)
AT (1) ATE150791T1 (enExample)
CA (1) CA2088068C (enExample)
DE (1) DE69125381T2 (enExample)
DK (1) DK0546087T3 (enExample)
ES (1) ES2100960T3 (enExample)
FI (1) FI112492B (enExample)
GR (1) GR3023593T3 (enExample)
HK (1) HK1006727A1 (enExample)
IE (1) IE912716A1 (enExample)
IL (1) IL99079A (enExample)
NO (1) NO309656B1 (enExample)
NZ (1) NZ239249A (enExample)
PT (1) PT98669B (enExample)
RU (1) RU2104285C1 (enExample)
SA (1) SA92130322B1 (enExample)
WO (1) WO1992003144A1 (enExample)
ZA (1) ZA916171B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62496B1 (en) * 1990-04-19 1995-02-08 Res Dev Foundation Antibody conjugates for treatment of neoplastic disease
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin
JPH06510431A (ja) * 1991-09-06 1994-11-24 リサーチ　ディベロップメント　ファンデーション ジェロニン・ポリペプチドをコードするｄｎａ配列
US5837491A (en) * 1991-11-04 1998-11-17 Xoma Corporation Polynucleotides encoding gelonin sequences
US6146850A (en) * 1991-11-04 2000-11-14 Xoma Corporation Proteins encoding gelonin sequences
US5621083A (en) * 1991-11-04 1997-04-15 Xoma Corporation Immunotoxins comprising ribosome-inactivating proteins
US6599505B1 (en) * 1992-04-10 2003-07-29 Research Development Foundation Immunotoxins directed against CD33 related surface antigens
CA2139571C (en) * 1992-07-07 2006-11-14 Eleanor N. Fish Interferon receptor binding peptides
ZA200305980B (en) * 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
CA2454048C (en) * 2001-07-17 2011-05-03 Research Development Foundation Therapeutic agents comprising pro-apoptotic proteins
JP2006506964A (ja) * 2002-06-12 2006-03-02 リサーチ　ディベロップメント　ファンデーション 治療剤としての免疫毒素及びその利用
JP2008528633A (ja) * 2005-02-01 2008-07-31 リサーチ ディベロップメント ファウンデーション Ｂｌｙｓレセプターを標的化するためのｂｌｙｓ融合タンパク質およびｂ細胞増殖性疾患の処置方法
WO2014127211A1 (en) 2013-02-15 2014-08-21 Research Development Foundation Deimmunized gelonin molecules and therapies

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US4921802A (en) * 1983-05-05 1990-05-01 Pioneer Hi-Bred International, Inc. Plant virus cDNA
US4888415A (en) * 1985-03-04 1989-12-19 Dana-Farber Cancer Institute, Inc. Gelonin immunotoxin
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
EP0341304A4 (en) 1987-11-24 1991-01-30 Genetics Institute, Inc. Improved ricin molecules and ricin toxin conjugates
GB8801877D0 (en) * 1988-01-28 1988-02-24 Erba Carlo Spa Nucleotide sequence encoding plant ribosome inactivating protein
IE62463B1 (en) * 1988-07-07 1995-02-08 Res Dev Foundation Immunoconjugates for cancer diagnosis and therapy
IE912716A1 (en) 1990-08-14 1992-02-26 Res Dev Foundation Protein Structure of the Plant Toxin Gelonin

Also Published As

Publication number Publication date
CN1055123C (zh) 2000-08-02
USRE37462E1 (en) 2001-12-04
PT98669A (pt) 1992-07-31
EP0546087A1 (en) 1993-06-16
DE69125381T2 (de) 1997-07-03
PT98669B (pt) 1999-01-29
CA2088068C (en) 1999-06-15
IE912716A1 (en) 1992-02-26
FI112492B (fi) 2003-12-15
AU8624091A (en) 1992-03-17
IL99079A (en) 1998-09-24
NO309656B1 (no) 2001-03-05
US5631348A (en) 1997-05-20
FI930626L (fi) 1993-02-12
FI930626A0 (fi) 1993-02-12
WO1992003144A1 (en) 1992-03-05
CA2088068A1 (en) 1992-02-15
ES2100960T3 (es) 1997-07-01
AU653365B2 (en) 1994-09-29
GR3023593T3 (en) 1997-08-29
KR100220502B1 (ko) 1999-10-01
EP0546087B1 (en) 1997-03-26
RU2104285C1 (ru) 1998-02-10
ATE150791T1 (de) 1997-04-15
DE69125381D1 (de) 1997-04-30
IL99079A0 (en) 1992-07-15
SA92130322B1 (ar) 2004-05-25
KR930701487A (ko) 1993-06-11
NZ239249A (en) 1992-10-28
CN1058990A (zh) 1992-02-26
EP0546087A4 (enExample) 1994-01-05
ZA916171B (en) 1992-04-29
NO930428L (no) 1993-03-29
DK0546087T3 (da) 1997-09-22
NO930428D0 (no) 1993-02-08
JPH06502847A (ja) 1994-03-31

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100814