KR100197892B1 - 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법 - Google Patents

신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법 Download PDF

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Publication number
KR100197892B1
KR100197892B1 KR1019940022798A KR19940022798A KR100197892B1 KR 100197892 B1 KR100197892 B1 KR 100197892B1 KR 1019940022798 A KR1019940022798 A KR 1019940022798A KR 19940022798 A KR19940022798 A KR 19940022798A KR 100197892 B1 KR100197892 B1 KR 100197892B1
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KR
South Korea
Prior art keywords
represented
structural formula
following structural
phenylalaninol
carbamoyl
Prior art date
Application number
KR1019940022798A
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English (en)
Korean (ko)
Other versions
KR960010617A (ko
Inventor
변재국
최용문
Original Assignee
남창우
에스케이주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR1019940022798A priority Critical patent/KR100197892B1/ko
Application filed by 남창우, 에스케이주식회사 filed Critical 남창우
Priority to US08/619,657 priority patent/US5955499A/en
Priority to CA002176012A priority patent/CA2176012C/en
Priority to EP95931444A priority patent/EP0728129B1/en
Priority to JP8509386A priority patent/JP2680478B2/ja
Priority to AU34856/95A priority patent/AU700544B2/en
Priority to RU96113126/04A priority patent/RU2104266C1/ru
Priority to DE69513140T priority patent/DE69513140T2/de
Priority to CN95190875A priority patent/CN1069635C/zh
Priority to PCT/KR1995/000114 priority patent/WO1996007637A1/en
Priority to ES95931444T priority patent/ES2140703T3/es
Publication of KR960010617A publication Critical patent/KR960010617A/ko
Application granted granted Critical
Publication of KR100197892B1 publication Critical patent/KR100197892B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019940022798A 1994-09-09 1994-09-09 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법 KR100197892B1 (ko)

Priority Applications (11)

Application Number Priority Date Filing Date Title
KR1019940022798A KR100197892B1 (ko) 1994-09-09 1994-09-09 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법
CA002176012A CA2176012C (en) 1994-09-09 1995-09-06 Novel phenylalkylaminoalcohol carbamates and process for preparing the same
EP95931444A EP0728129B1 (en) 1994-09-09 1995-09-06 Novel phenylalkylaminoalcohol carbamates and process for preparing the same
JP8509386A JP2680478B2 (ja) 1994-09-09 1995-09-06 新規のフェニルアルキルアミノアルコールカルバメートとその製造方法
US08/619,657 US5955499A (en) 1994-09-09 1995-09-06 Phenylalkylaminoalcohol carbamates and process for preparing the same
AU34856/95A AU700544B2 (en) 1994-09-09 1995-09-06 Novel phenylalkylaminoalcohol carbamates and process for preparing the same
RU96113126/04A RU2104266C1 (ru) 1994-09-09 1995-09-06 Карбаматы фенилалкиламиноспиртов и способы их получения
DE69513140T DE69513140T2 (de) 1994-09-09 1995-09-06 Neue phenylalkylaminoalkohol-carbamate und ein verfahren zu ihrer herstellung
CN95190875A CN1069635C (zh) 1994-09-09 1995-09-06 新的氨基甲酸苯基烷基氨基醇酯及其制备方法
PCT/KR1995/000114 WO1996007637A1 (en) 1994-09-09 1995-09-06 Novel phenylalkylaminoalcohol carbamates and process for preparing the same
ES95931444T ES2140703T3 (es) 1994-09-09 1995-09-06 Nuevos carbamatos de fenilalquilamino-alcohol y procedimiento para su preparacion.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019940022798A KR100197892B1 (ko) 1994-09-09 1994-09-09 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법

Publications (2)

Publication Number Publication Date
KR960010617A KR960010617A (ko) 1996-04-20
KR100197892B1 true KR100197892B1 (ko) 1999-06-15

Family

ID=19392447

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940022798A KR100197892B1 (ko) 1994-09-09 1994-09-09 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법

Country Status (11)

Country Link
US (1) US5955499A (e)
EP (1) EP0728129B1 (e)
JP (1) JP2680478B2 (e)
KR (1) KR100197892B1 (e)
CN (1) CN1069635C (e)
AU (1) AU700544B2 (e)
CA (1) CA2176012C (e)
DE (1) DE69513140T2 (e)
ES (1) ES2140703T3 (e)
RU (1) RU2104266C1 (e)
WO (1) WO1996007637A1 (e)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9907777B2 (en) 2010-06-30 2018-03-06 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
KR20190065311A (ko) * 2016-09-06 2019-06-11 에스케이바이오팜 주식회사 (r)-2-아미노-3-페닐프로필 카바메이트의 용매화물 폼
WO2022030879A1 (ko) 2020-08-03 2022-02-10 셀라이온바이오메드 주식회사 페닐알킬 카바메이트 화합물을 포함하는 kca3.1채널 매개질환 치료용 조성물

Families Citing this family (25)

* Cited by examiner, † Cited by third party
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KR0173862B1 (ko) * 1995-02-11 1999-04-01 조규향 O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법
US20030069630A1 (en) * 2001-03-02 2003-04-10 Robert Burgermeister Stent with radiopaque markers incorporated thereon
JP2008518921A (ja) * 2004-10-28 2008-06-05 エスケー ホルディングス カンパニー リミテッド うつ病のための補助療法
PL1890684T3 (pl) 2005-06-08 2014-05-30 Sk Biopharmaceuticals Co Ltd Leczenie zaburzeń snu i czuwania
JP5298334B2 (ja) * 2005-06-22 2013-09-25 エスケー ホルディングス カンパニー リミテッド 性機能障害を治療する方法
JP2010506845A (ja) * 2006-10-13 2010-03-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ フェニルアルキルアミノカルバメート組成物
US8642772B2 (en) * 2008-10-14 2014-02-04 Sk Biopharmaceuticals Co., Ltd. Piperidine compounds, pharmaceutical composition comprising the same and its use
EP2445490B1 (en) * 2009-06-22 2023-02-08 SK Biopharmaceuticals Co., Ltd. Methods for treating or preventing fatigue
US8232315B2 (en) * 2009-06-26 2012-07-31 Sk Biopharmaceuticals Co., Ltd. Methods for treating drug addiction and improving addiction-related behavior
AU2010316106B2 (en) 2009-11-06 2015-10-22 Sk Biopharmaceuticals Co., Ltd. Methods for treating attention-deficit/hyperactivity disorder
MX350745B (es) * 2009-11-06 2017-09-14 Sk Biopharmaceuticals Co Ltd * El uso de un compuesto de carbamoilo para el tratamiento del sindrome de fibromialgia.
US8623913B2 (en) * 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome
PT2968208T (pt) 2013-03-13 2022-10-28 Aerial Biopharma Llc Tratamento da cataplexia
PL3021838T3 (pl) 2013-07-18 2021-03-08 Jazz Pharmaceuticals Ireland Limited Leczenie otyłości
TWI698415B (zh) 2014-02-28 2020-07-11 南韓商愛思開生物製藥股份有限公司 胺基羰基胺基甲酸酯化合物
US10888542B2 (en) 2014-02-28 2021-01-12 Sk Biopharmaceuticals Co., Ltd. Aminocarbonylcarbamate compounds
US10195151B2 (en) 2016-09-06 2019-02-05 Jazz Pharmaceuticals International Iii Limited Formulations of (R)-2-amino-3-phenylpropyl carbamate
WO2018067971A1 (en) 2016-10-06 2018-04-12 Jazz Pharmaceuticals International Iii Limited Carbamoyl phenylalaninol compounds and uses therof
WO2018133703A1 (zh) * 2017-01-20 2018-07-26 苏州科睿思制药有限公司 R228060 盐酸盐的晶型及其制备方法和用途
MX2019014409A (es) 2017-06-02 2022-03-17 Jazz Pharmaceuticals Ireland Ltd Métodos y composiciones para tratar somnolencia excesiva.
EP3661911A4 (en) 2017-07-31 2021-04-14 Jazz Pharmaceuticals Ireland Limited CARBAMOYL-PHENYLALANINOL ANALOGS AND USES THEREOF
EP3837239A4 (en) 2018-08-14 2022-05-18 Glenmark Life Sciences Limited PROCESS FOR THE PREPARATION OF SOLRIAMFETOL AND SALT THEREOF
WO2021001457A1 (en) 2019-07-04 2021-01-07 Sandoz Ag Crystalline (r)-2-amino-3-phenylpropylcarbamate acid addition salts
US10940133B1 (en) 2020-03-19 2021-03-09 Jazz Pharmaceuticals Ireland Limited Methods of providing solriamfetol therapy to subjects with impaired renal function
IT202000013855A1 (it) 2020-06-10 2021-12-10 Flamma Spa Un processo per la purificazione del (r)-2-ammino-3-fenilpropil carbammato

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1434826A (en) * 1973-11-14 1976-05-05 Gallardo Antonio Sa Esters and carbamates of aminoalkanols

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9907777B2 (en) 2010-06-30 2018-03-06 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
KR101828934B1 (ko) 2010-06-30 2018-03-29 에스케이바이오팜 주식회사 양극성 장애의 치료방법
KR20190065311A (ko) * 2016-09-06 2019-06-11 에스케이바이오팜 주식회사 (r)-2-아미노-3-페닐프로필 카바메이트의 용매화물 폼
US11560354B2 (en) 2016-09-06 2023-01-24 Axsome Malta Ltd. Compositions comprising (R)-2-amino-3-phenylpropyl carbamate and uses thereof
KR102513800B1 (ko) * 2016-09-06 2023-03-24 에스케이바이오팜 주식회사 (r)-2-아미노-3-페닐프로필 카바메이트의 용매화물 폼
WO2022030879A1 (ko) 2020-08-03 2022-02-10 셀라이온바이오메드 주식회사 페닐알킬 카바메이트 화합물을 포함하는 kca3.1채널 매개질환 치료용 조성물

Also Published As

Publication number Publication date
US5955499A (en) 1999-09-21
KR960010617A (ko) 1996-04-20
RU2104266C1 (ru) 1998-02-10
CN1069635C (zh) 2001-08-15
ES2140703T3 (es) 2000-03-01
CN1135209A (zh) 1996-11-06
WO1996007637A1 (en) 1996-03-14
JP2680478B2 (ja) 1997-11-19
JPH09503231A (ja) 1997-03-31
AU3485695A (en) 1996-03-27
EP0728129B1 (en) 1999-11-03
CA2176012A1 (en) 1996-03-14
CA2176012C (en) 1999-01-05
DE69513140D1 (de) 1999-12-09
EP0728129A1 (en) 1996-08-28
DE69513140T2 (de) 2000-08-17
AU700544B2 (en) 1999-01-07

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