ES2140703T3 - Nuevos carbamatos de fenilalquilamino-alcohol y procedimiento para su preparacion. - Google Patents
Nuevos carbamatos de fenilalquilamino-alcohol y procedimiento para su preparacion.Info
- Publication number
- ES2140703T3 ES2140703T3 ES95931444T ES95931444T ES2140703T3 ES 2140703 T3 ES2140703 T3 ES 2140703T3 ES 95931444 T ES95931444 T ES 95931444T ES 95931444 T ES95931444 T ES 95931444T ES 2140703 T3 ES2140703 T3 ES 2140703T3
- Authority
- ES
- Spain
- Prior art keywords
- phenylalaninol
- phenylalkylamino
- preparation
- new
- carbamil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
EL O-CARBAMIL-(D/L)-FENILALANINOL REPRESENTADO POR LA FORMULA ESTRUCTURAL (I) ES FARMACEUTICAMENTE UTIL PARA EL TRATAMIENTO DE ENFERMEDADES DEL SISTEMA NERVIOSO CENTRAL, Y SE PREPARA SEGUN UN PROCEDIMIENTO CARACTERISTICO QUE CONSISTE EN LOS PASOS SIGUIENTES: SE TRATA FENILALANINOL CON CLOROFORMO BENCILICO EN UN MEDIO DE SOLUCION ACUOSA BASICO PARA OBTENER NBENCILOXICARBONIL-FENILALANINOL; SE SOMETE ESTE INTERMEDIO A UNA REACCION CON FOSGENO Y A CONTINUACION, AL TRATAMIENTO CON UN EXCESO DE SOLUCION ACUOSA DE HIDROXIDO AMONICO CONCENTRADA PARA OBTENER O-CARBAMIL-N-BENCILOXICARBONIL-FENILALANINOL; DESPROTEGIENDOLO A TRAVES DE UNA REACCION DE HIDROGENOLISIS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019940022798A KR100197892B1 (ko) | 1994-09-09 | 1994-09-09 | 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2140703T3 true ES2140703T3 (es) | 2000-03-01 |
Family
ID=19392447
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95931444T Expired - Lifetime ES2140703T3 (es) | 1994-09-09 | 1995-09-06 | Nuevos carbamatos de fenilalquilamino-alcohol y procedimiento para su preparacion. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5955499A (es) |
EP (1) | EP0728129B1 (es) |
JP (1) | JP2680478B2 (es) |
KR (1) | KR100197892B1 (es) |
CN (1) | CN1069635C (es) |
AU (1) | AU700544B2 (es) |
CA (1) | CA2176012C (es) |
DE (1) | DE69513140T2 (es) |
ES (1) | ES2140703T3 (es) |
RU (1) | RU2104266C1 (es) |
WO (1) | WO1996007637A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0173862B1 (ko) * | 1995-02-11 | 1999-04-01 | 조규향 | O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
US20030069630A1 (en) * | 2001-03-02 | 2003-04-10 | Robert Burgermeister | Stent with radiopaque markers incorporated thereon |
CA2587481A1 (en) * | 2004-10-28 | 2006-05-11 | Sk Corporation | Phenylalkylamino carbamates adjunctive therapy for depression |
ES2435403T3 (es) | 2005-06-08 | 2013-12-19 | Sk Biopharmaceuticals Co., Ltd. | Tratamiento de trastornos del sueño y vigilia |
EP1893291B1 (en) * | 2005-06-22 | 2010-03-03 | SK Holdings Co., Ltd. | Treatment of sexual dysfunction |
EP2079449A2 (en) * | 2006-10-13 | 2009-07-22 | Janssen Pharmaceutica, N.V. | Phenylalkylamino carbamate compositions |
US8642772B2 (en) * | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
US8741950B2 (en) * | 2009-06-22 | 2014-06-03 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating or preventing fatigue |
US8232315B2 (en) * | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
JP5836280B2 (ja) * | 2009-11-06 | 2015-12-24 | エスケー バイオファーマスティカルズ カンパニー リミテッド | 注意欠陥/多動性障害(adhd)の治療方法 |
CN102781436B (zh) | 2009-11-06 | 2014-01-08 | 爱思开生物制药株式会社 | 纤维肌痛综合征的治疗方法 |
US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
HRP20221018T1 (hr) | 2013-03-13 | 2023-01-06 | Jazz Pharmaceuticals Ireland Limited | Liječenje katapleksije |
KR102309836B1 (ko) | 2013-07-18 | 2021-10-12 | 에스케이바이오팜 주식회사 | 비만의 치료 |
TWI698415B (zh) | 2014-02-28 | 2020-07-11 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
US10888542B2 (en) | 2014-02-28 | 2021-01-12 | Sk Biopharmaceuticals Co., Ltd. | Aminocarbonylcarbamate compounds |
US10195151B2 (en) * | 2016-09-06 | 2019-02-05 | Jazz Pharmaceuticals International Iii Limited | Formulations of (R)-2-amino-3-phenylpropyl carbamate |
CN109996540A (zh) * | 2016-09-06 | 2019-07-09 | 爵士制药国际Iii有限公司 | (r)-2-氨基-3-苯丙基氨基甲酸酯的溶剂化物形式 |
ES2964943T3 (es) | 2016-10-06 | 2024-04-10 | Axsome Malta Ltd | Compuestos de carbamoilfenilalaninol para uso médico |
WO2018133703A1 (zh) * | 2017-01-20 | 2018-07-26 | 苏州科睿思制药有限公司 | R228060 盐酸盐的晶型及其制备方法和用途 |
AU2018278332B2 (en) | 2017-06-02 | 2022-05-19 | Jazz Pharmaceuticals Ireland Limited | Methods and compositions for treating excessive sleepiness |
US11413264B2 (en) | 2017-07-31 | 2022-08-16 | Jazz Pharmaceuticals Ireland Limited | Carbamoyl phenylalaninol analogs and uses thereof |
WO2020035769A1 (en) | 2018-08-14 | 2020-02-20 | Glenmark Pharmaceuticals Limited; Glenmark Life Sciences Limited | Process for the preparation of solriamfetol and salt thereof |
WO2021001457A1 (en) | 2019-07-04 | 2021-01-07 | Sandoz Ag | Crystalline (r)-2-amino-3-phenylpropylcarbamate acid addition salts |
US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
IT202000013855A1 (it) | 2020-06-10 | 2021-12-10 | Flamma Spa | Un processo per la purificazione del (r)-2-ammino-3-fenilpropil carbammato |
KR102390194B1 (ko) | 2020-08-03 | 2022-04-25 | 셀라이온바이오메드 주식회사 | 페닐알킬 카바메이트 화합물을 포함하는 Kca3.1채널 매개질환 치료용 조성물 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1434826A (en) * | 1973-11-14 | 1976-05-05 | Gallardo Antonio Sa | Esters and carbamates of aminoalkanols |
-
1994
- 1994-09-09 KR KR1019940022798A patent/KR100197892B1/ko not_active IP Right Cessation
-
1995
- 1995-09-06 EP EP95931444A patent/EP0728129B1/en not_active Expired - Lifetime
- 1995-09-06 RU RU96113126/04A patent/RU2104266C1/ru active
- 1995-09-06 AU AU34856/95A patent/AU700544B2/en not_active Expired
- 1995-09-06 ES ES95931444T patent/ES2140703T3/es not_active Expired - Lifetime
- 1995-09-06 DE DE69513140T patent/DE69513140T2/de not_active Expired - Lifetime
- 1995-09-06 JP JP8509386A patent/JP2680478B2/ja not_active Expired - Fee Related
- 1995-09-06 CA CA002176012A patent/CA2176012C/en not_active Expired - Lifetime
- 1995-09-06 US US08/619,657 patent/US5955499A/en not_active Expired - Lifetime
- 1995-09-06 WO PCT/KR1995/000114 patent/WO1996007637A1/en active IP Right Grant
- 1995-09-06 CN CN95190875A patent/CN1069635C/zh not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0728129B1 (en) | 1999-11-03 |
KR100197892B1 (ko) | 1999-06-15 |
JPH09503231A (ja) | 1997-03-31 |
DE69513140T2 (de) | 2000-08-17 |
CN1069635C (zh) | 2001-08-15 |
DE69513140D1 (de) | 1999-12-09 |
AU3485695A (en) | 1996-03-27 |
KR960010617A (ko) | 1996-04-20 |
AU700544B2 (en) | 1999-01-07 |
WO1996007637A1 (en) | 1996-03-14 |
CA2176012C (en) | 1999-01-05 |
CN1135209A (zh) | 1996-11-06 |
US5955499A (en) | 1999-09-21 |
RU2104266C1 (ru) | 1998-02-10 |
CA2176012A1 (en) | 1996-03-14 |
JP2680478B2 (ja) | 1997-11-19 |
EP0728129A1 (en) | 1996-08-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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