KR100190730B1 - 부신피질 호르몬 유리인자(crf) 길항물질로서 치환된 피라졸 - Google Patents

부신피질 호르몬 유리인자(crf) 길항물질로서 치환된 피라졸 Download PDF

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Publication number
KR100190730B1
KR100190730B1 KR1019950702479A KR19950702479A KR100190730B1 KR 100190730 B1 KR100190730 B1 KR 100190730B1 KR 1019950702479 A KR1019950702479 A KR 1019950702479A KR 19950702479 A KR19950702479 A KR 19950702479A KR 100190730 B1 KR100190730 B1 KR 100190730B1
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alkyl
ylmethyl
methyl
pyrazol
phenyl
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Expired - Fee Related
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Korean (ko)
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KR950704299A (ko
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진엠. 브라이트
윌라드엠.쥬니어 웰치
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디. 제이. 우드, 스피겔 알렌 제이
화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019950702479A 1992-12-17 1993-09-30 부신피질 호르몬 유리인자(crf) 길항물질로서 치환된 피라졸 Expired - Fee Related KR100190730B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US99222892A 1992-12-17 1992-12-17
US07/992228 1992-12-17
US7/992228 1992-12-17
PCT/US1993/009170 WO1994013661A1 (en) 1992-12-17 1993-09-30 Substituted pyrazoles as crf antagonists

Publications (2)

Publication Number Publication Date
KR950704299A KR950704299A (ko) 1995-11-17
KR100190730B1 true KR100190730B1 (ko) 1999-06-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950702479A Expired - Fee Related KR100190730B1 (ko) 1992-12-17 1993-09-30 부신피질 호르몬 유리인자(crf) 길항물질로서 치환된 피라졸

Country Status (26)

Country Link
EP (2) EP0674631B1 (enExample)
JP (1) JP2781661B2 (enExample)
KR (1) KR100190730B1 (enExample)
CN (1) CN1045293C (enExample)
AT (1) ATE187451T1 (enExample)
AU (1) AU690079B2 (enExample)
BR (1) BR9307664A (enExample)
CA (1) CA2150703C (enExample)
CZ (1) CZ287925B6 (enExample)
DE (1) DE69327254T2 (enExample)
DK (1) DK0674631T3 (enExample)
EG (1) EG20440A (enExample)
ES (1) ES2139676T3 (enExample)
FI (1) FI111254B (enExample)
GR (1) GR3032461T3 (enExample)
HU (1) HUT65822A (enExample)
IL (1) IL107947A (enExample)
MY (1) MY109522A (enExample)
NO (1) NO307884B1 (enExample)
NZ (1) NZ256620A (enExample)
PL (1) PL175982B1 (enExample)
PT (1) PT674631E (enExample)
RU (1) RU2130453C1 (enExample)
TW (1) TW237455B (enExample)
WO (1) WO1994013661A1 (enExample)
ZA (1) ZA939406B (enExample)

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NO952397D0 (no) 1995-06-16
EP0674631A1 (en) 1995-10-04
WO1994013661A1 (en) 1994-06-23
DK0674631T3 (da) 2000-04-10
HUT65822A (en) 1994-07-28
BR9307664A (pt) 1999-06-29
PL175982B1 (pl) 1999-03-31
NO952397L (no) 1995-08-14
AU690079B2 (en) 1998-04-23
FI935672L (fi) 1994-06-18
FI935672A0 (fi) 1993-12-16
CA2150703A1 (en) 1994-06-23
JPH08500121A (ja) 1996-01-09
JP2781661B2 (ja) 1998-07-30
CN1093363A (zh) 1994-10-12
NZ256620A (en) 1996-05-28
ATE187451T1 (de) 1999-12-15
CA2150703C (en) 2002-01-08
IL107947A (en) 1998-08-16
DE69327254T2 (de) 2000-03-30
DE69327254D1 (de) 2000-01-13
AU5141393A (en) 1994-07-04
KR950704299A (ko) 1995-11-17
EP0674631B1 (en) 1999-12-08
EP0959074A3 (en) 2000-06-07
EP0959074A2 (en) 1999-11-24
CN1045293C (zh) 1999-09-29
GR3032461T3 (en) 2000-05-31
IL107947A0 (en) 1994-04-12
FI111254B (fi) 2003-06-30
EG20440A (en) 1999-04-29
CZ287925B6 (cs) 2001-03-14
MY109522A (en) 1997-02-28
NO307884B1 (no) 2000-06-13
ZA939406B (en) 1995-06-15
PT674631E (pt) 2000-04-28
CZ158295A3 (en) 1995-12-13
ES2139676T3 (es) 2000-02-16
PL309355A1 (en) 1995-10-02
TW237455B (enExample) 1995-01-01
RU2130453C1 (ru) 1999-05-20

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