KR0183006B1 - 치환 아미노메틸테트랄린 및 그의 헤테로시클릭 동족체 - Google Patents
치환 아미노메틸테트랄린 및 그의 헤테로시클릭 동족체 Download PDFInfo
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- KR0183006B1 KR0183006B1 KR1019890010830A KR890010830A KR0183006B1 KR 0183006 B1 KR0183006 B1 KR 0183006B1 KR 1019890010830 A KR1019890010830 A KR 1019890010830A KR 890010830 A KR890010830 A KR 890010830A KR 0183006 B1 KR0183006 B1 KR 0183006B1
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- South Korea
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- formula
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- 0 C**(C*N)[N+]CCN Chemical compound C**(C*N)[N+]CCN 0.000 description 11
- MUSBKVWCFGRNFK-RGURZIINSA-N C([C@@H]1CCC2)NC3C1=C2CCC3 Chemical compound C([C@@H]1CCC2)NC3C1=C2CCC3 MUSBKVWCFGRNFK-RGURZIINSA-N 0.000 description 1
- JEAHUZOVGCOTHE-UHFFFAOYSA-N CC(C=C1)=CCC1F Chemical compound CC(C=C1)=CCC1F JEAHUZOVGCOTHE-UHFFFAOYSA-N 0.000 description 1
- BIZJPTBMHMULBX-UHFFFAOYSA-N CC(C=CC=CNC)=NS(=O)=O Chemical compound CC(C=CC=CNC)=NS(=O)=O BIZJPTBMHMULBX-UHFFFAOYSA-N 0.000 description 1
- NTMURWNIBPNHEZ-UHFFFAOYSA-N CC(CC=CC1)C1N(C1C=CCCC1)C(N(C)S)=O Chemical compound CC(CC=CC1)C1N(C1C=CCCC1)C(N(C)S)=O NTMURWNIBPNHEZ-UHFFFAOYSA-N 0.000 description 1
- UIFIBATXVGXHKP-UHFFFAOYSA-N CC(CCCNS(=O)=O)CC1OC(CCCC2)=C2CC1 Chemical compound CC(CCCNS(=O)=O)CC1OC(CCCC2)=C2CC1 UIFIBATXVGXHKP-UHFFFAOYSA-N 0.000 description 1
- KXWWFKKMRLQSJK-UHFFFAOYSA-N CC1(C)C(C(C)=O)=CC=CC1 Chemical compound CC1(C)C(C(C)=O)=CC=CC1 KXWWFKKMRLQSJK-UHFFFAOYSA-N 0.000 description 1
- NNXJEKXKCGHDEI-UHFFFAOYSA-N CN(C(CCC1)C2C1CC=CC21)S1(=O)=O Chemical compound CN(C(CCC1)C2C1CC=CC21)S1(=O)=O NNXJEKXKCGHDEI-UHFFFAOYSA-N 0.000 description 1
- DYIIBHYCRZLJAW-UHFFFAOYSA-N CN(CC1=C(C2C=CCCC22)C=CCC1)S2(=O)=O Chemical compound CN(CC1=C(C2C=CCCC22)C=CCC1)S2(=O)=O DYIIBHYCRZLJAW-UHFFFAOYSA-N 0.000 description 1
- NCKBSABTXUXBFS-UHFFFAOYSA-N COC1C(CC(CCCCC2C=CC=CC2)CC2)=C2C=CC1 Chemical compound COC1C(CC(CCCCC2C=CC=CC2)CC2)=C2C=CC1 NCKBSABTXUXBFS-UHFFFAOYSA-N 0.000 description 1
- URLKBWYHVLBVBO-UHFFFAOYSA-N Cc1ccc(C)cc1 Chemical compound Cc1ccc(C)cc1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP3825609.6 | 1988-07-28 | ||
DE3825609 | 1988-07-28 | ||
DEP3901814.8 | 1989-01-23 | ||
DE3901814A DE3901814A1 (de) | 1988-07-28 | 1989-01-23 | Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga |
Publications (2)
Publication Number | Publication Date |
---|---|
KR900001695A KR900001695A (ko) | 1990-02-27 |
KR0183006B1 true KR0183006B1 (ko) | 1999-05-01 |
Family
ID=25870576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890010830A KR0183006B1 (ko) | 1988-07-28 | 1989-07-28 | 치환 아미노메틸테트랄린 및 그의 헤테로시클릭 동족체 |
Country Status (19)
Country | Link |
---|---|
US (1) | US5137901A (pt) |
EP (1) | EP0352613B1 (pt) |
JP (1) | JP2963107B2 (pt) |
KR (1) | KR0183006B1 (pt) |
CN (1) | CN1024667C (pt) |
AU (1) | AU627478B2 (pt) |
CA (1) | CA1341162C (pt) |
DE (2) | DE3901814A1 (pt) |
DK (1) | DK175679B1 (pt) |
ES (1) | ES2052829T3 (pt) |
FI (1) | FI95246C (pt) |
HK (1) | HK38695A (pt) |
HU (2) | HU221296B1 (pt) |
IE (1) | IE62704B1 (pt) |
IL (1) | IL91126A (pt) |
NO (1) | NO177144C (pt) |
NZ (1) | NZ230071A (pt) |
PT (1) | PT91299B (pt) |
SG (1) | SG12595G (pt) |
Families Citing this family (69)
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CA1338012C (en) * | 1987-04-27 | 1996-01-30 | John Michael Mccall | Pharmaceutically active amines |
US5300523A (en) * | 1988-07-28 | 1994-04-05 | Bayer Aktiengesellschaft | Substituted aminomethyltetralins and their heterocyclic analogues |
JPH03173885A (ja) * | 1989-12-01 | 1991-07-29 | Mitsui Toatsu Chem Inc | ピリミジンジオン誘導体化合物、該化合物の製造法および該化合物を含む抗不整脈剤 |
US5420151A (en) * | 1989-12-22 | 1995-05-30 | Aktiebolaget Astra | Chroman derivatives |
IE65511B1 (en) * | 1989-12-29 | 1995-11-01 | Sanofi Sa | New phenylethanolaminomethyltetralins |
DE4120322A1 (de) * | 1991-06-20 | 1992-12-24 | Bayer Ag | Aminomethyl-substituierte 2,3-dihydropyrano(2,3-b)pyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
FR2678617B1 (fr) * | 1991-07-01 | 1995-01-20 | Adir | Nouveau procede de synthese d'enantiomeres de derives du 3-amino chromane. |
DE4135473A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | Triazaspirodecanon-methylchromane |
DE4135474A1 (de) * | 1991-10-28 | 1993-04-29 | Bayer Ag | 2-aminomethyl-chromane |
DE4138756A1 (de) * | 1991-11-26 | 1993-05-27 | Troponwerke Gmbh & Co Kg | Kombination mit neuroprotektiver wirkung |
DE4140540A1 (de) * | 1991-12-09 | 1993-06-17 | Bayer Ag | Neue azaheterocyclylmethyl-chromane |
DE4140542A1 (de) * | 1991-12-09 | 1993-06-17 | Bayer Ag | Piperdylmethyl substituierte chormanderivate |
FR2694557B1 (fr) * | 1992-08-05 | 1994-09-23 | Synthelabo | Dérivés de tétrahydronaphtalène, leur préparation, et leur application en thérapeutique. |
US5508306A (en) * | 1992-11-13 | 1996-04-16 | Synaptic Pharmaceutical Corporation | Aromatic amine derivatives |
RU2129556C1 (ru) * | 1993-08-19 | 1999-04-27 | Жансен Фармасетика Н.В. | Производное дигидробензопирана, обладающее сосудосуживающим действием, промежуточные соединения, способы получения, фармацевтическая композиция и способ ее получения |
ATE178330T1 (de) * | 1993-08-19 | 1999-04-15 | Janssen Pharmaceutica Nv | Gefässverengende subtituierte dihydropyranopyridine |
GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
TW281667B (pt) * | 1994-02-03 | 1996-07-21 | Synthelabo | |
FR2715658B1 (fr) * | 1994-02-03 | 1996-03-22 | Synthelabo | Dérivés de N-(3-aminopropyl)-N-phényl-5,6,7,8-tétrahydronaphtalène-2-carboxamide, leur préparation et leur application en thérapeutique. |
PT707007E (pt) * | 1994-10-14 | 2002-06-28 | Merck Patent Gmbh | Derivados amino(tio)eter como agentes activos no snc |
US5541199A (en) * | 1995-06-02 | 1996-07-30 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
DE19522088A1 (de) * | 1995-06-19 | 1997-01-02 | Bayer Ag | Benzisothiazolyl-substituierte Aminomethylchromane |
US5670667A (en) * | 1995-07-25 | 1997-09-23 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
US5663194A (en) * | 1995-07-25 | 1997-09-02 | Mewshaw; Richard E. | Chroman-2-ylmethylamino derivatives |
US5684039A (en) * | 1995-07-25 | 1997-11-04 | American Home Products Corporation | Chroman-2-ylmethylamino derivatives |
DE19543478A1 (de) * | 1995-11-22 | 1997-05-28 | Bayer Ag | Kristallines Hydrochlorid von {(R)-(-)-2- N-[4-(1,1-Dioxido-3-oxo-2,3-dihydrobenzisothiazol-2-yl)-buytl]-aminomethyl}-chroman |
WO1997019682A1 (en) | 1995-12-01 | 1997-06-05 | Synaptic Pharmaceutical Corporation | Aryl sulfonamide and sulfamide derivatives and uses thereof |
DE19604191A1 (de) * | 1996-02-06 | 1997-08-07 | Hoechst Schering Agrevo Gmbh | 2,4-Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
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GB9627006D0 (en) * | 1996-12-27 | 1997-02-12 | Knoll Ag | Therapeutic agents |
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US6133277A (en) | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
DE19754573A1 (de) * | 1997-12-09 | 1999-06-10 | Bayer Ag | Pharmazeutische Zusammensetzung zur Behandlung von Schlaganfall und Schädel-Hirn-Trauma |
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UA73123C2 (en) | 1999-06-02 | 2005-06-15 | Janssen Pharmaceutica Nv | Derivatives of benzodioxane, benzofuran or benzopyran substituted by pyrolidinyl, piperidinyl or homopiperidinyl |
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US20030207890A1 (en) | 2001-02-23 | 2003-11-06 | Collier Robert J | Compounds with 5-ht1a activity useful for treating disorders of the outer retina |
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JO2409B1 (en) * | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
DE10058119A1 (de) | 2000-11-22 | 2002-05-23 | Bayer Ag | Pepinotan-Kit |
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DE10148425A1 (de) * | 2001-10-01 | 2003-04-17 | Bayer Ag | Chromane |
DE10155075A1 (de) * | 2001-11-09 | 2003-05-22 | Merck Patent Gmbh | Cyclische Sulfonamide |
EP1445324A4 (en) * | 2001-11-09 | 2005-02-16 | Kaneka Corp | PROCESS FOR PRODUCING OPTICALLY ACTIVE CHROMAN DERIVATIVE AND INTERMEDIATE PRODUCT |
EP2266590A3 (en) | 2002-02-22 | 2011-04-20 | Shire LLC | Active agent delivery sytems and methods for protecting and administering active agents |
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DE10254596A1 (de) * | 2002-11-22 | 2004-06-03 | Merck Patent Gmbh | Indolderivate |
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ES2238015B1 (es) * | 2004-01-30 | 2006-11-01 | Cepa Schwarz Pharma, S.L. | Derivados de cicloalcanodionas con actividad neuroprotectora. |
DE102004017627A1 (de) * | 2004-04-10 | 2005-10-27 | Bayer Healthcare Ag | Verwendung von vollen 5-HT1A-Agonisten zur Hemmung der opiat/opioid-induzierten Atemdepression |
ATE458727T1 (de) * | 2004-05-05 | 2010-03-15 | Hoffmann La Roche | Zur modulation des 5-ht6-rezeptors, des 5-ht2a- rezeptors oder beider rezeptoren geeignete arylsulfonylbenzodioxane |
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CA2591793A1 (en) * | 2004-12-21 | 2006-06-29 | F. Hoffmann-La Roche Ag | Tetralin and indane derivatives and uses thereof |
PL1831152T3 (pl) * | 2004-12-21 | 2009-03-31 | Hoffmann La Roche | Pochodne tetraliny i indanu oraz ich zastosowanie jako antagonistów 5-HT |
ATE396183T1 (de) * | 2004-12-21 | 2008-06-15 | Hoffmann La Roche | Chromanderivate und ihre verwendung als liganden des 5-ht-rezeptors |
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DE3411993A1 (de) * | 1984-03-31 | 1985-10-10 | Bayer Ag, 5090 Leverkusen | Substituierte benzopyrane, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimittel |
US4748182A (en) * | 1986-03-05 | 1988-05-31 | Merrell Dow Pharmaceuticals Inc. | Aromatic 2-aminoalkyl-1,2-benzoisothiazol-3(2H)one-1,1-dioxide derivatives and their use as anti-hypertensive and anxiolytic agents |
EP0252005B1 (de) * | 1986-06-26 | 1991-07-10 | Ciba-Geigy Ag | Hydrierte 1-Benzooxacycloalkyl-pyridincarbonsäureverbindungen |
DE3718317A1 (de) * | 1986-12-10 | 1988-06-16 | Bayer Ag | Substituierte basische 2-aminotetraline |
-
1989
- 1989-01-23 DE DE3901814A patent/DE3901814A1/de not_active Withdrawn
- 1989-07-13 NO NO892892A patent/NO177144C/no unknown
- 1989-07-19 ES ES89113220T patent/ES2052829T3/es not_active Expired - Lifetime
- 1989-07-19 EP EP89113220A patent/EP0352613B1/de not_active Expired - Lifetime
- 1989-07-19 DE DE58907493T patent/DE58907493D1/de not_active Expired - Fee Related
- 1989-07-25 NZ NZ230071A patent/NZ230071A/en unknown
- 1989-07-26 FI FI893571A patent/FI95246C/fi not_active IP Right Cessation
- 1989-07-26 CA CA000606651A patent/CA1341162C/en not_active Expired - Fee Related
- 1989-07-26 AU AU38989/89A patent/AU627478B2/en not_active Ceased
- 1989-07-27 HU HU833/89A patent/HU221296B1/hu not_active IP Right Cessation
- 1989-07-27 IE IE245089A patent/IE62704B1/en not_active IP Right Cessation
- 1989-07-27 PT PT91299A patent/PT91299B/pt not_active IP Right Cessation
- 1989-07-27 DK DK198903713A patent/DK175679B1/da not_active IP Right Cessation
- 1989-07-27 IL IL9112689A patent/IL91126A/en not_active IP Right Cessation
- 1989-07-28 CN CN89105487A patent/CN1024667C/zh not_active Expired - Fee Related
- 1989-07-28 KR KR1019890010830A patent/KR0183006B1/ko not_active IP Right Cessation
- 1989-07-28 JP JP1194467A patent/JP2963107B2/ja not_active Expired - Fee Related
- 1989-09-26 US US07/412,694 patent/US5137901A/en not_active Expired - Lifetime
-
1995
- 1995-01-26 SG SG12595A patent/SG12595G/en unknown
- 1995-03-16 HK HK38695A patent/HK38695A/xx not_active IP Right Cessation
- 1995-06-28 HU HU95P/P00508P patent/HU211160A9/hu unknown
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