KE3758A - Novel antihistamines,process for their preparation and pharmaceutical compositions containing them - Google Patents

Novel antihistamines,process for their preparation and pharmaceutical compositions containing them

Info

Publication number
KE3758A
KE3758A KE3758A KE375887A KE3758A KE 3758 A KE3758 A KE 3758A KE 3758 A KE3758 A KE 3758A KE 375887 A KE375887 A KE 375887A KE 3758 A KE3758 A KE 3758A
Authority
KE
Kenya
Prior art keywords
antihistamines
novel
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
KE3758A
Other languages
English (en)
Inventor
Frank J Villani
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22578489&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KE3758(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of KE3758A publication Critical patent/KE3758A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KE3758A 1980-06-19 1987-08-24 Novel antihistamines,process for their preparation and pharmaceutical compositions containing them KE3758A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06160795 US4282233B1 (en) 1980-06-19 1980-06-19 Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
EP81104480A EP0042544B1 (en) 1980-06-19 1981-06-11 Novel antihistamines, process for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
KE3758A true KE3758A (en) 1987-10-02

Family

ID=22578489

Family Applications (1)

Application Number Title Priority Date Filing Date
KE3758A KE3758A (en) 1980-06-19 1987-08-24 Novel antihistamines,process for their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US4282233B1 (ru)
EP (1) EP0042544B1 (ru)
JP (1) JPS5735586A (ru)
KR (1) KR850000744B1 (ru)
AT (1) ATE9695T1 (ru)
AU (1) AU543054B2 (ru)
CA (1) CA1160230A (ru)
CY (1) CY1405A (ru)
DE (1) DE3166441D1 (ru)
DK (1) DK169817B1 (ru)
ES (1) ES8300779A1 (ru)
FI (1) FI70213C (ru)
HK (1) HK94387A (ru)
HU (1) HU186774B (ru)
IE (1) IE51303B1 (ru)
IL (1) IL63122A (ru)
KE (1) KE3758A (ru)
LU (1) LU88359I2 (ru)
MY (1) MY8700761A (ru)
NL (1) NL930094I2 (ru)
NZ (1) NZ197435A (ru)
PH (1) PH19252A (ru)
PT (1) PT73200B (ru)
SG (1) SG70587G (ru)
ZA (1) ZA814062B (ru)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU195800B (en) * 1983-10-13 1988-07-28 Sandoz Ltd Process for producing 4h-benzo/4,5/cylopenta/1,2-b/ thiofene derivatives and pharmaceutical compositions containing them
AU570306B2 (en) * 1984-02-15 1988-03-10 Schering Corporation 8-chloro-6, 11-dihydro-11-(4-piperidylidene)-5h-benzo (5,6) cyclohepta (1,2-b) pyridine and its salts.
DE3677842D1 (de) * 1985-05-13 1991-04-11 Schering Corp Verfahren zur herstellung von piperidyliden-dihydrodibenzo(a,d)zykloheptenen und deren azoderivate, so hergestellte verbindungen und ihre anwendung zur vorbereitung von heilmitteln.
US4804666A (en) * 1985-08-14 1989-02-14 Schering Corporation Antiallergic 6,11-dihydro-11-(4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
AU635400B2 (en) * 1986-10-31 1993-03-18 Schering Corporation Intermediates for producing benzo(5,6)cycloheptapyridines
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US5438062A (en) * 1986-10-31 1995-08-01 Schering Corporation Benzo(5,6)cycloheptapyridines, compositions and methods of use
US5665726A (en) * 1986-10-31 1997-09-09 Schering Corporation Benzo[5,6]cycloheptapyridines, compositions and methods of use
ES2056214T3 (es) * 1988-04-28 1994-10-01 Schering Corp Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso.
US4912222A (en) * 1988-06-17 1990-03-27 Fisons Corporation Antihistamines related to cyproheptadine
US4863931A (en) * 1988-09-15 1989-09-05 Schering Corporation Antihistaminic fluoro substituted benzocycloheptapyridines
US4990535A (en) 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
CA2038417A1 (en) * 1990-04-11 1991-10-12 Yasuo Ito Piperidine compounds, method for preparation thereof, and a pharmaceutical composition comprising the same
IE68935B1 (en) * 1990-06-22 1996-07-24 Schering Corp Bis-benzo or benzopyrido cyclohepta piperidene piperidylidene and piperazine compounds compositions and methods of use
EP0552245A1 (en) * 1990-10-10 1993-07-28 Schering Corporation Bis-benzo cyclohepta piperidylidene, piperidine and piperazine compounds, compositions and methods of use
US5393753A (en) * 1990-10-10 1995-02-28 Schering Corporation Substituted imidazobenzazepines
CA2098198A1 (en) * 1990-12-18 1992-06-18 Ann Christie King Agents for potentiating the effects of antitumour agents and combating multiple drug resistance
JPH0676403B2 (ja) * 1991-01-18 1994-09-28 エスエス製薬株式会社 新規なベンゾ［５，６ シクロヘプタ［１，２−ｂ ピリジン誘導体及びこれを含有する抗アレルギー剤
WO1992020681A1 (en) * 1991-05-23 1992-11-26 Schering Corporation Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use
EP0595989A1 (en) * 1991-07-23 1994-05-11 Schering Corporation Benzopyrido piperylidene compounds, compositions, methods of manufacture and methods of use
ES2040177B1 (es) * 1992-03-06 1994-05-16 S A Tamarang Procedimiento para la sintesis de la 8-cloro-6, 11-dihidro-11, (1-etoxicarbonil-4-piperidiliden) -5h-benzo (5,6) ciclohepta-(1,2-b) piridina.
JPH07505394A (ja) * 1992-03-27 1995-06-15 シェリング・コーポレーション 橋渡しビスアリールカルビノール誘導体，組成物および使用法
ES2089815T3 (es) * 1992-03-27 1996-10-01 Schering Corp Derivados de bis-aril-carbinol sin enlaces de puente, composiciones y metodos de uso.
ES2042421B1 (es) * 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
US5314697A (en) * 1992-10-23 1994-05-24 Schering Corporation Stable extended release oral dosage composition comprising loratadine and pseudoephedrine
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6080428A (en) * 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US6075025A (en) 1993-10-15 2000-06-13 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5661152A (en) * 1993-10-15 1997-08-26 Schering Corporation Tricyclic sulfonamide compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
ES2164716T3 (es) * 1993-10-15 2002-03-01 Schering Corp Compuestos triciclicos de carbamato utiles para inhibir la funcion de la proteina-g y para el tratamiento de enfermedades proliferativas.
US6365588B1 (en) 1993-10-15 2002-04-02 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
DE69429440T2 (de) * 1993-10-15 2002-08-08 Schering Corp., Kenilworth Tricyclische sulfonamide-derivate zur inhibierung der g-protein funktion und fur die bekandlung von proliferativen erkrantungen
US5595997A (en) 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
US7211582B1 (en) * 1994-12-30 2007-05-01 Sepracor Inc. Methods for treating urticaria using descarboethoxyloratadine
US7214683B1 (en) 1994-12-30 2007-05-08 Sepracor Inc. Compositions of descarboethoxyloratadine
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5684013A (en) * 1995-03-24 1997-11-04 Schering Corporation Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5891872A (en) * 1995-04-07 1999-04-06 Schering Corporation Tricyclic compounds
US5712280A (en) * 1995-04-07 1998-01-27 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
JP3779349B2 (ja) * 1995-04-24 2006-05-24 興和株式会社 ピペリジン誘導体
JP3383499B2 (ja) 1995-11-30 2003-03-04 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料
JPH09152696A (ja) 1995-11-30 1997-06-10 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
US5874442A (en) 1995-12-22 1999-02-23 Schering-Plough Corporation Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
EP1014972A4 (en) * 1996-02-08 2004-12-08 Merck & Co Inc TREATMENT METHOD AND PHARMACEUTICAL COMPOSITION
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
ATE247106T1 (de) * 1996-09-13 2003-08-15 Schering Corp Substituierte benzocycloheptapyridine derivate verwendbar als farnesyl protein transferase inhibitoren
US5945429A (en) * 1996-09-13 1999-08-31 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US5900421A (en) * 1997-02-11 1999-05-04 Sepracor Inc. Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
US5939426A (en) * 1997-02-28 1999-08-17 Sepracor Inc. Methods for treating urinary incontinence using descarboethoxyloratadine
SE509618C2 (sv) 1997-03-06 1999-02-15 Goeran Blomqvist Farmaceutisk komposition för behandling av s k restless legs
US5998620A (en) * 1997-03-25 1999-12-07 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6506767B1 (en) 1997-07-02 2003-01-14 Schering Corporation 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine
US5869479A (en) * 1997-08-14 1999-02-09 Schering Corporation Treatment of upper airway allergic responses
US6335347B1 (en) * 1997-10-10 2002-01-01 Schering Corporation Ethyl 4-(8-chloro-5,6-dihydro-11 H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidene carboxylate polymorph
WO1999019322A1 (en) * 1997-10-10 1999-04-22 Schering Corporation ETHYL 4-(8-CHLORO-5, 6-DIHYDRO-11H- BENZO[5,6]CYCLOHEPTA [1,2-b]PYRIDIN -11-YLIDENE)-1- PIPERIDENE CARBOXYLATE POLYMORPH
ES2226289T3 (es) * 1998-06-30 2005-03-16 Pfizer Products Inc. Loratadina para uso como antiarritmico.
US6423721B1 (en) 1998-09-10 2002-07-23 Schering Corporation Methods and compositions for treating sinusitis, otitis media and other related disorders using antihistamines
WO2000030589A2 (en) 1998-11-20 2000-06-02 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6372909B1 (en) 1998-11-20 2002-04-16 Schering Corporation Synthesis of intermediates useful in preparing tricyclic compounds
US6271378B1 (en) 1998-12-18 2001-08-07 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
AU2157100A (en) * 1998-12-18 2000-07-12 Schering Corporation Process for preparing tricyclic compounds having antihistaminic activity
US6686502B1 (en) 1999-03-26 2004-02-03 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
PE20001566A1 (es) 1999-03-26 2001-02-05 Ucb Sa Piperazinas 1,4-sustituidas, piperidinas 1,4-sustituidas y 4-alquilidenilpiperidinas 1-sustituidas
US6894059B1 (en) 1999-03-26 2005-05-17 Ucb S.A. Compounds and methods for treatment of asthma, allergy and inflammatory disorders
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US6100274A (en) * 1999-07-07 2000-08-08 Schering Corporation 8-chloro-6,11-dihydro-11- ](4-piperidylidine)-5H-benzo[5,6]cyclohepta[1,2-bpyridine oral compositions
PT1207860E (pt) 1999-09-02 2008-01-24 Nostrum Pharmaceuticals Inc Formulação de peletes de libertação controlada
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US6114346A (en) * 1999-10-22 2000-09-05 Schering Corporation Treating sleep disorders using desloratadine
AU2277101A (en) * 1999-12-20 2001-07-03 Schering Corporation Stable extended release oral dosage composition
SK287105B6 (sk) 1999-12-20 2009-12-07 Schering Corporation Dvojvrstvový orálny dávkový prostriedok s predĺženým uvoľňovaním
US7405223B2 (en) 2000-02-03 2008-07-29 Schering Corporation Treating allergic and inflammatory conditions
DE60125343T2 (de) 2000-04-18 2007-06-14 Schering Corp. Synthese von zwischenprodukten zur herstellung von tricyclischen verbindungen
WO2002036077A2 (en) * 2000-11-06 2002-05-10 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
HU226998B1 (en) * 2000-11-23 2010-04-28 Richter Gedeon Nyrt Desloratadine hemisulphate, process for the preparation thereof and pharmaceutical compositions containing the same
US6599913B1 (en) * 2001-06-29 2003-07-29 Schering Corporation Treating allergic and inflammatory conditions
US6720002B2 (en) 2001-07-20 2004-04-13 R.P. Scherer Technologies, Inc. Antihistamine formulations for soft capsule dosage forms
US20030004179A1 (en) * 2002-05-21 2003-01-02 Affrime Melton B Treating allergic and inflammatory conditions
US20040033257A1 (en) * 2002-05-30 2004-02-19 Strides Inc. Pharmaceutical formulation in a drug delivery system and process for preparing the same
TW200400816A (en) * 2002-06-26 2004-01-16 Lilly Co Eli Tricyclic steroid hormone nuclear receptor modulators
US20040001885A1 (en) * 2002-06-27 2004-01-01 Unchalee Kositprapa Rapidly disintegrating antihistamine formulation
US20040101563A1 (en) * 2002-07-18 2004-05-27 Kundu Subhas C. Storage stable antihistaminic syrup formulations
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
US6635654B1 (en) 2003-01-09 2003-10-21 Allergan, Inc. Ophthalmic compositions containing loratadine
DE602004004453T2 (de) * 2003-03-12 2007-11-08 Teva Pharmaceutical Industries Ltd. Stabile pharmazeutische zusammensetzungen mit desloratadin
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
JP3881640B2 (ja) * 2003-08-08 2007-02-14 塩野義製薬株式会社 ロラタジンを含むドライシロップ剤
MX2007001561A (es) * 2004-08-04 2007-04-16 Schering Corp Formulacion farmaceutica que comprende pleconaril para tratamiento de enfermedades de vias aereas.
US20060154948A1 (en) * 2005-01-12 2006-07-13 Schering Corporation Treating allergic and inflammatory conditions
BRPI0610780A2 (pt) * 2005-04-22 2016-09-06 Teva Pharma formulação farmacéutica em tablete desintegrante, e, métodos para tratar um paciente em necessidade de tratamento com olanzapina, e para produzir a formulação farmacêutica em tablete
ES2398960T3 (es) * 2005-06-17 2013-03-22 Aft Pharmaceuticals Limited Composición farmacéutica novedosa y su uso en un método para el tratamiento de pacientes con cangestión mucosa de las vías respiratorias altas
US20080194823A1 (en) * 2006-04-04 2008-08-14 Mayur Devjibhai Khunt Preparation of loratadine form i
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
KR101464771B1 (ko) * 2006-06-01 2014-11-26 머크 샤프 앤드 돔 코포레이션 페닐에프린의 지속 방출용 약제학적 조성물
WO2007143158A2 (en) * 2006-06-01 2007-12-13 Schering-Plough Healthcare Products, Inc. Sustained release pharmaceutical formulation comprising phenylephrine
EP2023957A2 (en) * 2006-06-07 2009-02-18 Morton Grove Pharmaceuticals, Inc. Oral liquid loratadine formulations and methods
CA2679070C (en) 2007-03-12 2016-04-26 Nektar Therapeutics Oligomer-antihistamine conjugates
US20090082385A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched desloratidine
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
MX2011013679A (es) 2009-06-16 2012-01-20 Schering Corp Esteroides de heteroarilo [3.2-c] novedosos como agonistas de receptor de glucocorticoide composiciones y uso de los mismos.
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
CA2690490C (en) 2010-01-19 2012-06-26 Accucaps Industries Limited Pharmaceutical formulations of loratadine for encapsulation and combinations thereof
EP2762141A4 (en) 2011-09-29 2015-03-25 Shionogi & Co THERAPEUTIC PHARMACEUTICAL PRODUCT AGAINST ALLERGIC RHINITIS COMPRISING A PGD2 ANTAGONIST AND A HISTAMINE ANTAGONIST
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
CN106478595B (zh) * 2016-09-18 2019-05-21 西安交通大学 氯雷他定晶型及其制备方法和用途
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WO2022106923A1 (en) 2020-11-18 2022-05-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
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Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (ru) * 1963-04-24
US3419565A (en) * 1963-04-24 1968-12-31 Schering Corp Aza-dibenzocycloheptenes
US3264342A (en) * 1963-05-24 1966-08-02 Geigy Chem Corp Derivatives of 5h-dibenzo[a, d] cycloheptene
US3491103A (en) * 1963-12-19 1970-01-20 Sandoz Ag Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
US3464983A (en) * 1964-02-04 1969-09-02 Sandoz Ag 4h-benzo(4,5)cyclohepta(1,2-b)thiophenes
US3435073A (en) * 1966-04-19 1969-03-25 Colgate Palmolive Co 5-(n-benzyl-n-lower alkylaminoalkylene)-5h-dibenzo(a,d)cycloheptenes
US3513201A (en) * 1966-10-25 1970-05-19 Merck & Co Inc Process for preparing 5-(3-alkylaminopropyl)-5h-dibenzo(a,d)cycloheptenes
US3917669A (en) * 1966-11-08 1975-11-04 Hoffmann La Roche Intermediates for tricyclic amines
ES356805A1 (es) * 1967-08-03 1970-05-01 Hoffmann La Roche Procedimiento para la preparacion de compuestos tricicli- cos.
US3952017A (en) * 1968-05-03 1976-04-20 Hoffmann-La Roche Inc. Tricyclic compounds
CH531000A (de) * 1970-03-11 1972-11-30 Sandoz Ag Verfahren zur Herstellung neuer Benzocycloheptathiophene
GB1329733A (en) * 1970-12-02 1973-09-12 Science Union & Cie Derivatives of isonipecotic acid and a process for their prepa- ration

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Publication number Publication date
DK169817B1 (da) 1995-03-06
FI811878L (fi) 1981-12-20
IL63122A (en) 1985-06-30
FI70213C (fi) 1986-09-15
ATE9695T1 (de) 1984-10-15
ZA814062B (en) 1982-07-28
NL930094I2 (nl) 1994-12-01
DE3166441D1 (en) 1984-11-08
HK94387A (en) 1987-12-18
JPS5735586A (en) 1982-02-26
EP0042544A3 (en) 1982-04-07
ES503085A0 (es) 1982-11-01
IE51303B1 (en) 1986-11-26
PH19252A (en) 1986-02-17
DK263481A (da) 1981-12-20
PT73200B (en) 1983-04-26
SG70587G (en) 1988-02-19
KR830006218A (ko) 1983-09-20
US4282233B1 (en) 2000-09-05
EP0042544B1 (en) 1984-10-03
ES8300779A1 (es) 1982-11-01
KR850000744B1 (ko) 1985-05-24
NL930094I1 (nl) 1993-10-01
EP0042544A2 (en) 1981-12-30
AU543054B2 (en) 1985-03-28
FI70213B (fi) 1986-02-28
LU88359I2 (fr) 1994-05-04
US4282233A (en) 1981-08-04
HU186774B (en) 1985-09-30
JPS6355513B2 (ru) 1988-11-02
MY8700761A (en) 1987-12-31
AU7186281A (en) 1981-12-24
NZ197435A (en) 1984-03-30
PT73200A (en) 1981-07-01
IE811328L (en) 1981-12-19
CA1160230A (en) 1984-01-10
CY1405A (en) 1988-04-22

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