ES8203842A1 - Procedimiento para la obtencion de 4-aralquil-1,4-dihidro- pirdinas - Google Patents

Procedimiento para la obtencion de 4-aralquil-1,4-dihidro- pirdinas

Info

Publication number
ES8203842A1
ES8203842A1 ES502951A ES502951A ES8203842A1 ES 8203842 A1 ES8203842 A1 ES 8203842A1 ES 502951 A ES502951 A ES 502951A ES 502951 A ES502951 A ES 502951A ES 8203842 A1 ES8203842 A1 ES 8203842A1
Authority
ES
Spain
Prior art keywords
dihydropyridines
preparation
praparing
medicines
aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502951A
Other languages
English (en)
Other versions
ES502951A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8203842A1 publication Critical patent/ES8203842A1/es
Publication of ES502951A0 publication Critical patent/ES502951A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE 4-ARALQUIL-1,4-DIHIDROPIRIDINAS. CONSISTE EN HACER REACCIONAR UN ALDEHIDO DE FORMULA GENERAL (I) CON AMONIACO O BIEN CON ACETOACETATO (II) O CON UN ENAMINO ESTER (III). OPCIONALMENTE SE PUEDE HACER REACCIONAR EL COMPUESTO ILIDENO (IV) CON UN AMINO ESTER (III) EN UN DISOLVENTE ORGANICO. SE OBTIENE EL COMPUESTO DE FORMULA GENERAL (V), EN QUE R1 Y R2 SIGNIFICAN UN RESTO ALQUILO; R3 SIGNIFICA HIDROGENO, METILO O UN RESTO FENILO; R4 ES UN RESTO FENILO O METOXI.
ES502951A 1980-06-12 1981-06-11 Procedimiento para la obtencion de 4-aralquil-1,4-dihidro- pirdinas Granted ES502951A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3021958A DE3021958A1 (de) 1980-06-12 1980-06-12 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8203842A1 true ES8203842A1 (es) 1982-04-01
ES502951A0 ES502951A0 (es) 1982-04-01

Family

ID=6104387

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502951A Granted ES502951A0 (es) 1980-06-12 1981-06-11 Procedimiento para la obtencion de 4-aralquil-1,4-dihidro- pirdinas

Country Status (6)

Country Link
US (1) US4364952A (es)
EP (1) EP0042093A3 (es)
JP (1) JPS5728050A (es)
CA (1) CA1136631A (es)
DE (1) DE3021958A1 (es)
ES (1) ES502951A0 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60109519A (ja) * 1983-11-17 1985-06-15 Nippon Shinyaku Co Ltd ニフェジピン坐剤
JPS61180835A (ja) * 1985-02-05 1986-08-13 Matsushita Electric Ind Co Ltd 石油燃焼器
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
US5204339A (en) * 1986-01-31 1993-04-20 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
JPS62248923A (ja) * 1986-04-21 1987-10-29 Gunji Sasaki 石油スト−ブにおける防臭装置
US4920101A (en) * 1987-09-30 1990-04-24 Nelson Research & Development Co. Compositions comprising 1-oxo- or thiohydrocarbyl substituted azacycloaklkanes
US4879275A (en) * 1987-09-30 1989-11-07 Nelson Research & Development Co. Penetration enhancers for transdermal delivery of systemic agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE2003146A1 (de) * 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
DE2005116C3 (de) * 1970-02-05 1980-02-14 Bayer Ag, 5090 Leverkusen Symmetrische 1,4-Dihydropyridin-3,5-dicarbonsäureester

Also Published As

Publication number Publication date
CA1136631A (en) 1982-11-30
EP0042093A3 (en) 1982-07-14
ES502951A0 (es) 1982-04-01
DE3021958A1 (de) 1981-12-24
US4364952A (en) 1982-12-21
EP0042093A2 (de) 1981-12-23
JPS5728050A (en) 1982-02-15

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