ES8203888A1 - Procedimiento para la obtencion de dihidropiridinas susti- tuidas en la posicion 4 del hetero-anillo - Google Patents

Procedimiento para la obtencion de dihidropiridinas susti- tuidas en la posicion 4 del hetero-anillo

Info

Publication number
ES8203888A1
ES8203888A1 ES502953A ES502953A ES8203888A1 ES 8203888 A1 ES8203888 A1 ES 8203888A1 ES 502953 A ES502953 A ES 502953A ES 502953 A ES502953 A ES 502953A ES 8203888 A1 ES8203888 A1 ES 8203888A1
Authority
ES
Spain
Prior art keywords
heterocylic
preparing
processes
preparation
therapeutical use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502953A
Other languages
English (en)
Other versions
ES502953A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8203888A1 publication Critical patent/ES8203888A1/es
Publication of ES502953A0 publication Critical patent/ES502953A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DIHIDROPIRIDINAS SUSTITUIDAS EN LA POSICION 4 DEL HETERO-ANILLO. CONSISTE EN HACER REACCIONAR ALDEHIDOS DE FORMULA GENERAL (I) CO AMONIACO Y CON ESTERES DE ACIDO ACETOACETICO (II), O BIEN CON ENAMINO ESTERES, EN UN DISOLVENTE ORGANICO. SE OBTIENEN COMPUESTOS DE FORMULA GENERAL (II) CON GRUPOS DE ESTER SIMETRICOS (R1,R2), OPCIONALMENTE PUEDEN HACERSE REACCIONAR COMPUESTOS DE FORMULA GENERAL (IV) CON ENIMINO-ESTERES EN UN DISOLVENTE ORGANICO-INERTE.
ES502953A 1980-06-12 1981-06-11 Procedimiento para la obtencion de dihidropiridinas susti- tuidas en la posicion 4 del hetero-anillo Granted ES502953A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3022030A DE3022030A1 (de) 1980-06-12 1980-06-12 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
ES8203888A1 true ES8203888A1 (es) 1982-04-01
ES502953A0 ES502953A0 (es) 1982-04-01

Family

ID=6104441

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502953A Granted ES502953A0 (es) 1980-06-12 1981-06-11 Procedimiento para la obtencion de dihidropiridinas susti- tuidas en la posicion 4 del hetero-anillo

Country Status (5)

Country Link
US (1) US4380547A (es)
EP (1) EP0042089A3 (es)
JP (1) JPS5728082A (es)
DE (1) DE3022030A1 (es)
ES (1) ES502953A0 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58131982A (ja) * 1982-02-01 1983-08-06 Tokyo Tanabe Co Ltd 新規なる１．４−ジヒドロピリジン誘導体
EP0080220B1 (en) * 1981-11-17 1986-02-19 FISONS plc Dihydropyridines, methods for their production and their formulation and use as pharmaceuticals
JPS58159490A (ja) * 1982-02-23 1983-09-21 Nikken Kagaku Kk １，４−ジヒドロピリジン化合物
DE3208628A1 (de) * 1982-03-10 1983-09-22 Bayer Ag, 5090 Leverkusen Neue verbindungen, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
ATE50987T1 (de) * 1982-05-10 1990-03-15 Takeda Chemical Industries Ltd Dihydropyridinderivate, deren herstellung und verwendung.
US4419518A (en) * 1982-07-26 1983-12-06 Tokyo Tanabe Co. L.T.D. 1,4-Dihydropyridine derivatives
DE3239273A1 (de) * 1982-10-23 1984-04-26 Bayer Ag, 5090 Leverkusen Tetrahydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3247118A1 (de) * 1982-12-20 1984-06-20 Cassella Ag, 6000 Frankfurt Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
PL140069B1 (en) * 1982-12-21 1987-03-31 Pfizer Method of obtaining new derivatives of dihydropiridine
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
CH663616A5 (de) * 1983-06-21 1987-12-31 Sandoz Ag 1,4-dihydropyridin-derivate und sie enthaltende pharmazeutische zubereitungen.
US4546186A (en) * 1983-12-14 1985-10-08 American Home Products Corporation 1,4,5,6,7,8-Hexahydro-2-methyl-5-oxo-4-(2-thiazolyl)-3-quinoline carboxylic acid 2-methyl(phenylmethyl)amino ethyl ester and pharmaceutically acceptable salts
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
US5364872A (en) * 1984-04-16 1994-11-15 Yamanouchi Pharmaceutical Co., Ltd. Dihydropyridine-3,5-dicarboxylic acid ester derivatives
US5326772A (en) * 1984-09-28 1994-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Diaryl compounds for their use
US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
US4659717A (en) * 1985-08-21 1987-04-21 Eli Lilly And Company Dihydropyridines useful in the treatment of angina and stroke
JPH0755955B2 (ja) * 1986-09-10 1995-06-14 日産化学工業株式会社 光学活性なジヒドロピリジン−５−ホスホン酸エステル
EP0296316B1 (de) * 1987-03-27 1993-09-01 Byk Gulden Lomberg Chemische Fabrik GmbH 1,4-Dihydropyridin-Enantiomere
DE4011106A1 (de) * 1990-04-06 1991-10-10 Bayer Ag Neue heterocyclisch substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5254692A (en) * 1990-04-06 1993-10-19 Bayer Aktiengesellschaft 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines
NZ280378A (en) * 1995-11-01 1998-04-27 Apotex Inc 4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid compounds, preparation, intermediate compounds
EP2311806A3 (en) * 1996-01-29 2011-08-10 The United States of America, Represented by the Secretary, Department of Health and Human Services Dihydropyridine-, pyridine-, benzopyranone- and triazoloquinazoline derivatives, their preparation and their use as adenosine receptor antagonists
US6316423B1 (en) 1996-04-10 2001-11-13 The United States Of America As Represented By The Departmant Of Health And Human Services Method of treating ischemic, hypoxic and anoxic brain damage
JP3296213B2 (ja) * 1996-10-30 2002-06-24 三菱電機株式会社 液体エジェクタおよび液体エジェクタを用いる印刷装置
DE102014118489A1 (de) 2014-12-12 2016-06-16 Karlsruher Institut für Technologie Verbindung zwischen zwei Fügepartnern sowie Verfahren zur Herstellung der Verbindung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670826A1 (de) * 1967-03-20 1971-03-11 Bayer Ag Verfahren zur Herstellung von 1,4-Dihydropyridinderivaten
DE1923990C3 (de) * 1969-05-10 1978-11-23 Bayer Ag Verfahren zur Herstellung von N-substituierten M-Dihydropyridin-S.S-dicarbonsäureestern
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
CH639659A5 (de) * 1978-12-18 1983-11-30 Sandoz Ag Neue 1,4-dihydropyridinderivate, deren herstellung und verwendung.
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4285955A (en) * 1978-10-31 1981-08-25 Bayer Aktiengesellschaft 1,4-Dihydropyridinecarboxylic acids
DE2949464A1 (de) * 1978-12-18 1980-06-26 Sandoz Ag Benzoxadiazole und benzothiadiazole, ihre herstellung und verwendung

Also Published As

Publication number Publication date
US4380547A (en) 1983-04-19
EP0042089A2 (de) 1981-12-23
EP0042089A3 (en) 1982-09-22
ES502953A0 (es) 1982-04-01
DE3022030A1 (de) 1981-12-17
JPS5728082A (en) 1982-02-15

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