ES8601143A1 - Un procedimiento para la preparacion de un derivado de 2, 4-dihidro-5-(fenil (substituido))-3h-pirazol-3-ona - Google Patents

Un procedimiento para la preparacion de un derivado de 2, 4-dihidro-5-(fenil (substituido))-3h-pirazol-3-ona

Info

Publication number
ES8601143A1
ES8601143A1 ES532689A ES532689A ES8601143A1 ES 8601143 A1 ES8601143 A1 ES 8601143A1 ES 532689 A ES532689 A ES 532689A ES 532689 A ES532689 A ES 532689A ES 8601143 A1 ES8601143 A1 ES 8601143A1
Authority
ES
Spain
Prior art keywords
pyrazol
disubstituted
dihydro
phenyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532689A
Other languages
English (en)
Other versions
ES532689A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/497,316 external-priority patent/US4526982A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES8601143A1 publication Critical patent/ES8601143A1/es
Publication of ES532689A0 publication Critical patent/ES532689A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACIONDE UN DERIVADO DE 24-DIHIDRO-5-FENIL(SUSTITUIDO)-3H-PIRAZOL-3-ONA DE FORMULA GENERAL (I) EN LA QUE Q ES OXIGENO O AZUFRE; R2 ES ALQUILO INFERIOR; R3 ES ALQUILO INFERIOR CIANO O TRIFLUOROMETILO; R4 ES HIDROGENO O ALQUILO INFERIOR; Y A Y B SON ALCOXI DE UNO O SEIS ATOMOS DE CARBONO Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II) EN LA QUE ALK ES ALQUILO DE 1 A 4 ATOMOS DE CARBONO CON UNA HIDRAZINA DE FORMULA: R4NHNH2 EN PRESENCIA DE UN DISOLVENTE EN ESTADO DE EBULLICION. EL PRODUCTO OBTENIDO SE TRATA CON PENTASULFURO DE FOSFORO. DE APLICACION EN MEDICINA COMO AGENTES CARDIOTONICOS Y ANTIHIPERTENSIVOS.
ES532689A 1983-05-23 1984-05-22 Un procedimiento para la preparacion de un derivado de 2, 4-dihidro-5-(fenil (substituido))-3h-pirazol-3-ona Granted ES532689A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/497,316 US4526982A (en) 1983-05-23 1983-05-23 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones
US06/586,430 US4550119A (en) 1983-05-23 1984-03-12 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones

Publications (2)

Publication Number Publication Date
ES8601143A1 true ES8601143A1 (es) 1985-10-16
ES532689A0 ES532689A0 (es) 1985-10-16

Family

ID=27052456

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532689A Granted ES532689A0 (es) 1983-05-23 1984-05-22 Un procedimiento para la preparacion de un derivado de 2, 4-dihidro-5-(fenil (substituido))-3h-pirazol-3-ona

Country Status (15)

Country Link
US (1) US4550119A (es)
EP (1) EP0126651A3 (es)
KR (1) KR840009298A (es)
AU (1) AU567345B2 (es)
CA (1) CA1215982A (es)
DK (1) DK250984A (es)
ES (1) ES532689A0 (es)
FI (1) FI842005A (es)
GR (1) GR82359B (es)
HU (1) HU192023B (es)
IL (1) IL71841A (es)
NO (1) NO842028L (es)
NZ (1) NZ208244A (es)
PH (1) PH19768A (es)
PT (1) PT78623B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3310197A1 (de) * 1983-03-21 1984-09-27 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 3-mercapto-pyridazine und deren 3-alkylthioderivate sowie verfahren zu ihrer herstellung
US4840955A (en) * 1984-12-24 1989-06-20 Warner-Lambert Company 6-substituted-2(1H)-quinolinones and related compounds having use as cardiotonic, antihypertensive, and antithrombotic agents
ZA859091B (en) * 1984-12-24 1987-07-29 Warner Lambert Co Novel 6-substituted-2 (1h)-quinolinones and related compounds having use as cardiotonic,anti-hypertensive,and anti-thrombotic agents
GB8502267D0 (en) * 1985-01-30 1985-02-27 Pfizer Ltd Quinolone inotropic agents
DK169672B1 (da) * 1985-05-20 1995-01-09 Mitsubishi Chem Ind Farmaceutiske præparater indeholdende pyrazolonderivater som aktiv bestanddel og anvendelsen af pyrazolonderivater til fremstilling af farmaceutiske præparater
USRE35801E (en) * 1985-05-20 1998-05-19 Mitsubishi Chemical Corporation Prophylactic and therapeutic composition for circulatory disorders and method of treatment
US4666913A (en) * 1985-11-22 1987-05-19 William H. Rorer, Inc. Hydroxy and aminothiazolyl-benzodiazinone compounds, cardiotonic compositions including the same, and their uses
DK40192D0 (da) * 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
WO2008138939A1 (en) 2007-05-16 2008-11-20 Nycomed Gmbh Pyrazolone derivatives as pde4 inhibitors
AR074318A1 (es) 2008-11-14 2011-01-05 Nycomed Gmbh Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL286908A (es) * 1961-12-19
GB962533A (en) * 1962-04-24 1964-07-01 Imp Chemical Industi Australia Anthelmintic compositions
DE2828529A1 (de) * 1978-06-29 1980-01-17 Kali Chemie Pharma Gmbh Neue 5-phenylpyrazol-derivate, verfahren zu deren herstellung und arzneimittel
PT71175A (fr) * 1979-05-04 1980-05-01 Continental Pharma Procede pour preparer derives de benzimidazoles
FR2479219A1 (fr) * 1980-04-01 1981-10-02 Nativelle Sa Ets Amino-alcoxy pyrazoles, procede pour leur preparation, et medicaments les contenant
FR2513996A1 (fr) * 1981-10-02 1983-04-08 Nativelle Sa Ets Derives du pyrazole, procede pour leur preparation et application en therapeutique

Also Published As

Publication number Publication date
AU2844084A (en) 1984-11-29
PH19768A (en) 1986-06-27
NO842028L (no) 1984-11-26
FI842005A0 (fi) 1984-05-18
IL71841A (en) 1987-10-20
GR82359B (es) 1984-12-13
US4550119A (en) 1985-10-29
EP0126651A3 (en) 1989-02-08
EP0126651A2 (en) 1984-11-28
FI842005A (fi) 1984-11-24
PT78623B (en) 1986-07-17
IL71841A0 (en) 1984-09-30
CA1215982A (en) 1986-12-30
ES532689A0 (es) 1985-10-16
DK250984D0 (da) 1984-05-22
PT78623A (en) 1984-06-01
AU567345B2 (en) 1987-11-19
DK250984A (da) 1984-11-24
NZ208244A (en) 1986-10-08
KR840009298A (ko) 1984-12-26
HU192023B (en) 1987-04-28
HUT34971A (en) 1985-05-28

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