JPWO2021251467A5 - - Google Patents
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- JPWO2021251467A5 JPWO2021251467A5 JP2022530623A JP2022530623A JPWO2021251467A5 JP WO2021251467 A5 JPWO2021251467 A5 JP WO2021251467A5 JP 2022530623 A JP2022530623 A JP 2022530623A JP 2022530623 A JP2022530623 A JP 2022530623A JP WO2021251467 A5 JPWO2021251467 A5 JP WO2021251467A5
- Authority
- JP
- Japan
- Prior art keywords
- months
- filtration
- impurity
- crystals
- detected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000013078 crystal Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000012535 impurity Substances 0.000 description 4
- 238000001914 filtration Methods 0.000 description 3
- LTXREWYXXSTFRX-QGZVFWFLSA-N Linagliptin Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 LTXREWYXXSTFRX-QGZVFWFLSA-N 0.000 description 1
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 1
- 229960002397 linagliptin Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000011085 pressure filtration Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025016373A JP2025069332A (ja) | 2020-06-10 | 2025-02-03 | 1-[(4-メチル-キナゾリン-2-イル)メチル]-3-メチル-7-(2-ブチン-1-イル)-8-(3-(r)-アミノ-ピペリジン-1-イル)-キサンチンの結晶形態 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020101161 | 2020-06-10 | ||
| PCT/JP2021/015338 WO2021250995A1 (ja) | 2020-06-10 | 2021-04-13 | 1-[(4-メチル-キナゾリン-2-イル)メチル]-3-メチル-7-(2-ブチン-1-イル)-8-(3-(r)-アミノ-ピペリジン-1-イル)-キサンチンの結晶形態 |
| PCT/JP2021/022157 WO2021251467A1 (ja) | 2020-06-10 | 2021-06-10 | 1-[(4-メチル-キナゾリン-2-イル)メチル]-3-メチル-7-(2-ブチン-1-イル)-8-(3-(r)-アミノ-ピペリジン-1-イル)-キサンチンの結晶形態 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025016373A Division JP2025069332A (ja) | 2020-06-10 | 2025-02-03 | 1-[(4-メチル-キナゾリン-2-イル)メチル]-3-メチル-7-(2-ブチン-1-イル)-8-(3-(r)-アミノ-ピペリジン-1-イル)-キサンチンの結晶形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2021251467A1 JPWO2021251467A1 (https=) | 2021-12-16 |
| JPWO2021251467A5 true JPWO2021251467A5 (https=) | 2023-08-23 |
Family
ID=78845537
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022530623A Pending JPWO2021251467A1 (https=) | 2020-06-10 | 2021-06-10 | |
| JP2025016373A Pending JP2025069332A (ja) | 2020-06-10 | 2025-02-03 | 1-[(4-メチル-キナゾリン-2-イル)メチル]-3-メチル-7-(2-ブチン-1-イル)-8-(3-(r)-アミノ-ピペリジン-1-イル)-キサンチンの結晶形態 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025016373A Pending JP2025069332A (ja) | 2020-06-10 | 2025-02-03 | 1-[(4-メチル-キナゾリン-2-イル)メチル]-3-メチル-7-(2-ブチン-1-イル)-8-(3-(r)-アミノ-ピペリジン-1-イル)-キサンチンの結晶形態 |
Country Status (3)
| Country | Link |
|---|---|
| JP (2) | JPWO2021251467A1 (https=) |
| CN (1) | CN115916781A (https=) |
| WO (2) | WO2021250995A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021250995A1 (ja) * | 2020-06-10 | 2021-12-16 | 有機合成薬品工業株式会社 | 1-[(4-メチル-キナゾリン-2-イル)メチル]-3-メチル-7-(2-ブチン-1-イル)-8-(3-(r)-アミノ-ピペリジン-1-イル)-キサンチンの結晶形態 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1248869A2 (en) * | 2000-01-07 | 2002-10-16 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| EP2540725A1 (de) * | 2006-05-04 | 2013-01-02 | Boehringer Ingelheim International GmbH | Polymorphe von 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin |
| US20130123282A1 (en) * | 2011-11-16 | 2013-05-16 | Leonid Metsger | Solid state forms of linagliptin |
| WO2013128379A2 (en) * | 2012-02-27 | 2013-09-06 | Dr. Reddy's Laboratories Limited | Crystalline polymorphic forms of linagliptin |
| CN103319483B (zh) * | 2012-10-19 | 2016-08-03 | 药源药物化学(上海)有限公司 | 一种利拉列汀重要中间体的制备方法 |
| KR102442536B1 (ko) * | 2015-09-17 | 2022-09-13 | 한미정밀화학주식회사 | 리나글립틴 결정형 및 이의 제조방법 |
| CN106554354B (zh) * | 2015-09-28 | 2019-03-19 | 四川科伦药物研究院有限公司 | 利格列汀或其类似物的中间体与利格列汀或其类似物的制备方法 |
| CN105272982B (zh) * | 2015-11-23 | 2017-06-16 | 齐鲁制药有限公司 | 利格列汀新晶型及其制备方法 |
| KR101804207B1 (ko) * | 2015-12-29 | 2017-12-04 | (주) 에프엔지리서치 | 무정형 리나글립틴의 제조 방법 |
| CN108017638A (zh) * | 2016-10-31 | 2018-05-11 | 江苏艾立康药业股份有限公司 | 一种利格列汀晶型的制备方法 |
| KR20180113822A (ko) * | 2017-04-07 | 2018-10-17 | 일동제약(주) | 1-[(4-메틸-퀴나졸린-2-일)메틸]-3-메틸-7-(2-부틴-1-일)-8-(3-(r)-아미노-피페리딘-1-일)-크산틴의 신규한 결정형 및 그의 제조방법 |
| CN107043376A (zh) * | 2017-05-15 | 2017-08-15 | 珠海联邦制药股份有限公司 | 一种利格列汀新晶型及其制备方法 |
| CN110964013B (zh) * | 2018-09-29 | 2023-04-07 | 甘李药业股份有限公司 | 利格列汀及其中间体的制备方法 |
| JP6947354B2 (ja) * | 2018-10-31 | 2021-10-13 | ヤマサ醤油株式会社 | リナグリプチンの製造法 |
| CN109761983B (zh) * | 2019-02-11 | 2022-03-04 | 深圳市第二人民医院 | 一种利格列汀的制备方法 |
| CN110305131B (zh) * | 2019-07-03 | 2021-12-31 | 山东百诺医药股份有限公司 | 利格列汀新晶型及其制备方法 |
| WO2021250995A1 (ja) * | 2020-06-10 | 2021-12-16 | 有機合成薬品工業株式会社 | 1-[(4-メチル-キナゾリン-2-イル)メチル]-3-メチル-7-(2-ブチン-1-イル)-8-(3-(r)-アミノ-ピペリジン-1-イル)-キサンチンの結晶形態 |
-
2021
- 2021-04-13 WO PCT/JP2021/015338 patent/WO2021250995A1/ja not_active Ceased
- 2021-06-10 CN CN202180042237.4A patent/CN115916781A/zh active Pending
- 2021-06-10 JP JP2022530623A patent/JPWO2021251467A1/ja active Pending
- 2021-06-10 WO PCT/JP2021/022157 patent/WO2021251467A1/ja not_active Ceased
-
2025
- 2025-02-03 JP JP2025016373A patent/JP2025069332A/ja active Pending
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