JPWO2021202678A5 - - Google Patents
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- Publication number
- JPWO2021202678A5 JPWO2021202678A5 JP2022560206A JP2022560206A JPWO2021202678A5 JP WO2021202678 A5 JPWO2021202678 A5 JP WO2021202678A5 JP 2022560206 A JP2022560206 A JP 2022560206A JP 2022560206 A JP2022560206 A JP 2022560206A JP WO2021202678 A5 JPWO2021202678 A5 JP WO2021202678A5
- Authority
- JP
- Japan
- Prior art keywords
- cytokine
- masked
- seq
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000013462 Interleukin-12 Human genes 0.000 claims 24
- 108010065805 Interleukin-12 Proteins 0.000 claims 24
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 230000000873 masking effect Effects 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 239000000833 heterodimer Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 101001003138 Homo sapiens Interleukin-12 receptor subunit beta-2 Proteins 0.000 claims 1
- 102000014154 Interleukin-12 Subunit p35 Human genes 0.000 claims 1
- 108010011301 Interleukin-12 Subunit p35 Proteins 0.000 claims 1
- 102000014158 Interleukin-12 Subunit p40 Human genes 0.000 claims 1
- 108010011429 Interleukin-12 Subunit p40 Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102220556473 Sodium/calcium exchanger 1_L38A_mutation Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000047143 human IL12RB2 Human genes 0.000 claims 1
- 108040003610 interleukin-12 receptor activity proteins Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000006337 proteolytic cleavage Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063003842P | 2020-04-01 | 2020-04-01 | |
| US63/003,842 | 2020-04-01 | ||
| US202063118579P | 2020-11-25 | 2020-11-25 | |
| US63/118,579 | 2020-11-25 | ||
| US202063127893P | 2020-12-18 | 2020-12-18 | |
| US63/127,893 | 2020-12-18 | ||
| PCT/US2021/025107 WO2021202678A1 (en) | 2020-04-01 | 2021-03-31 | Masked il-12 cytokines and their cleavage products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023520518A JP2023520518A (ja) | 2023-05-17 |
| JPWO2021202678A5 true JPWO2021202678A5 (de) | 2024-04-10 |
Family
ID=77929928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022560206A Pending JP2023520518A (ja) | 2020-04-01 | 2021-03-31 | マスクされたｉｌ－１２サイトカイン及びその切断産物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230159603A1 (de) |
| EP (1) | EP4126249A4 (de) |
| JP (1) | JP2023520518A (de) |
| KR (1) | KR20220161405A (de) |
| CN (1) | CN115734806A (de) |
| AU (1) | AU2021248919A1 (de) |
| BR (1) | BR112022019708A2 (de) |
| CA (1) | CA3172641A1 (de) |
| IL (1) | IL296913A (de) |
| MX (1) | MX2022012312A (de) |
| TW (1) | TW202204386A (de) |
| WO (1) | WO2021202678A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021523741A (ja) | 2018-05-14 | 2021-09-09 | ウェアウルフ セラピューティクス， インコーポレイテッド | 活性化可能なインターロイキン１２ポリペプチド及びその使用方法 |
| CN113840832A (zh) | 2018-05-14 | 2021-12-24 | 狼人治疗公司 | 可活化白介素-2多肽及其使用方法 |
| EP3856764A4 (de) | 2018-09-27 | 2022-11-02 | Xilio Development, Inc. | Maskierte cytokin-polypeptide |
| KR20220023988A (ko) | 2019-05-14 | 2022-03-03 | 웨어울프 세라퓨틱스, 인크. | 분리 모이어티 및 이의 사용 방법 |
| CA3174786A1 (en) | 2020-04-10 | 2021-10-14 | Sayantan Mitra | Activatable cytokine constructs and related compositions and methods |
| JP2024511387A (ja) | 2021-03-16 | 2024-03-13 | シートムエックス セラピューティクス，インコーポレイテッド | マスクした活性化可能サイトカイン構成体ならびに関連する組成物及び方法 |
| WO2023161853A1 (en) | 2022-02-23 | 2023-08-31 | Bright Peak Therapeutics Ag | Activatable il-18 polypeptides |
| WO2023164288A2 (en) * | 2022-02-28 | 2023-08-31 | Xilio Development, Inc. | Targeted cytokines and methods of use thereof |
| US20230365635A1 (en) * | 2022-05-12 | 2023-11-16 | Massachusetts Institute Of Technology | Activatable Therapeutic Peptides and Uses Thereof |
| WO2024028347A1 (en) * | 2022-08-01 | 2024-02-08 | Ose Immunotherapeutics | Heterodimeric fc-clec-1 fusion molecule and uses thereof |
| CN117917438A (zh) * | 2022-10-21 | 2024-04-23 | 北京诺诚健华医药科技有限公司 | 抗体融合蛋白及其制备和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2312188C (en) * | 1997-12-08 | 2010-06-29 | Lexigen Pharmaceuticals Corp. | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
| JP7358047B2 (ja) * | 2016-05-16 | 2023-10-10 | チェックマブ エス．アール．エル． | 腫瘍浸潤制御性ｔ細胞において選択的に脱制御されたマーカー |
| CN111527109A (zh) * | 2017-12-26 | 2020-08-11 | 南京金斯瑞生物科技有限公司 | 以抗体Fc区为骨架的融合蛋白二聚体及其应用 |
| CN108218993B (zh) * | 2018-01-05 | 2020-11-17 | 阿思科力(苏州)生物科技有限公司 | 一种以robo1为靶点的双特异性抗体及其制备和应用 |
| JP2021515599A (ja) * | 2018-03-09 | 2021-06-24 | アスクジーン・ファーマ・インコーポレイテッドＡｓｋＧｅｎｅ Ｐｈａｒｍａ， Ｉｎｃ． | 新規のサイトカインプロドラッグ |
| JP2021523741A (ja) * | 2018-05-14 | 2021-09-09 | ウェアウルフ セラピューティクス， インコーポレイテッド | 活性化可能なインターロイキン１２ポリペプチド及びその使用方法 |
| JP7477885B2 (ja) * | 2018-06-22 | 2024-05-02 | キュージーン インコーポレイテッド | サイトカインをベースとした生理活性化薬剤およびその使用方法 |
| US20210163562A1 (en) * | 2018-07-25 | 2021-06-03 | AskGene Pharma, Inc. | Novel IL-21 Prodrugs and Methods of Use Thereof |
| EP3856764A4 (de) * | 2018-09-27 | 2022-11-02 | Xilio Development, Inc. | Maskierte cytokin-polypeptide |
| CN114401997A (zh) * | 2019-09-28 | 2022-04-26 | 奥美药业有限公司 | 细胞因子前药和双前药 |
| JP2023518518A (ja) * | 2020-03-23 | 2023-05-01 | ザイムワークス ビーシー インコーポレイテッド | マスクされたｉｌ１２融合タンパク質及びその使用方法 |
-
2021
- 2021-03-31 EP EP21781122.3A patent/EP4126249A4/de active Pending
- 2021-03-31 BR BR112022019708A patent/BR112022019708A2/pt unknown
- 2021-03-31 MX MX2022012312A patent/MX2022012312A/es unknown
- 2021-03-31 IL IL296913A patent/IL296913A/en unknown
- 2021-03-31 CA CA3172641A patent/CA3172641A1/en active Pending
- 2021-03-31 JP JP2022560206A patent/JP2023520518A/ja active Pending
- 2021-03-31 TW TW110112013A patent/TW202204386A/zh unknown
- 2021-03-31 US US17/995,162 patent/US20230159603A1/en active Pending
- 2021-03-31 WO PCT/US2021/025107 patent/WO2021202678A1/en active Application Filing
- 2021-03-31 KR KR1020227037411A patent/KR20220161405A/ko unknown
- 2021-03-31 CN CN202180038975.1A patent/CN115734806A/zh active Pending
- 2021-03-31 AU AU2021248919A patent/AU2021248919A1/en active Pending
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