JPWO2021170109A5 - - Google Patents

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Publication number
JPWO2021170109A5
JPWO2021170109A5 JP2022551553A JP2022551553A JPWO2021170109A5 JP WO2021170109 A5 JPWO2021170109 A5 JP WO2021170109A5 JP 2022551553 A JP2022551553 A JP 2022551553A JP 2022551553 A JP2022551553 A JP 2022551553A JP WO2021170109 A5 JPWO2021170109 A5 JP WO2021170109A5
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JP
Japan
Prior art keywords
amino
difluorobenzyl
indazol
benzamide
piperazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022551553A
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English (en)
Japanese (ja)
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JP2023514872A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2021/078240 external-priority patent/WO2021170109A1/en
Publication of JP2023514872A publication Critical patent/JP2023514872A/ja
Publication of JPWO2021170109A5 publication Critical patent/JPWO2021170109A5/ja
Pending legal-status Critical Current

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JP2022551553A 2020-02-26 2021-02-26 トロポミオシン受容体キナーゼ(trk)分解化合物とその使用方法 Pending JP2023514872A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020076748 2020-02-26
CNPCT/CN2020/076748 2020-02-26
PCT/CN2021/078240 WO2021170109A1 (en) 2020-02-26 2021-02-26 Tropomyosin receptor kinase (trk) degradation compounds and methods of use

Publications (2)

Publication Number Publication Date
JP2023514872A JP2023514872A (ja) 2023-04-11
JPWO2021170109A5 true JPWO2021170109A5 (ru) 2024-03-04

Family

ID=77490737

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022551553A Pending JP2023514872A (ja) 2020-02-26 2021-02-26 トロポミオシン受容体キナーゼ(trk)分解化合物とその使用方法

Country Status (11)

Country Link
US (1) US20230257380A1 (ru)
EP (1) EP4110772A4 (ru)
JP (1) JP2023514872A (ru)
KR (1) KR20230010070A (ru)
CN (1) CN115697989A (ru)
AU (1) AU2021225981A1 (ru)
BR (1) BR112022016901A2 (ru)
CA (1) CA3173262A1 (ru)
IL (1) IL295799A (ru)
MX (1) MX2022010465A (ru)
WO (1) WO2021170109A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11969472B2 (en) 2018-08-22 2024-04-30 Cullgen (Shanghai), Inc. Tropomyosin receptor kinase (TRK) degradation compounds and methods of use
CA3110267A1 (en) * 2018-08-22 2020-02-27 Cullgen (Shanghai), Inc. Tropomyosin receptor kinase (trk) degradation compounds and methods of use
WO2022161414A1 (zh) * 2021-01-26 2022-08-04 成都茵创园医药科技有限公司 芳香化合物、含其的药物组合物及其应用
CN115504963A (zh) * 2021-06-22 2022-12-23 苏州开拓药业股份有限公司 一种c-Myc蛋白降解剂
WO2023036175A1 (zh) * 2021-09-08 2023-03-16 南京明德新药研发有限公司 戊二酰亚胺类化合物与其应用
WO2023055952A1 (en) * 2021-09-29 2023-04-06 C4 Therapeutics, Inc. Neurotrophic tyrosine receptor kinase (ntrk) degrading compounds
WO2023066350A1 (zh) * 2021-10-22 2023-04-27 标新生物医药科技(上海)有限公司 Crbn e3连接酶配体化合物、基于该配体化合物开发的蛋白降解剂及它们的应用
EP4180428A1 (en) 2021-11-12 2023-05-17 Genzyme Corporation Crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, and their use in treating medical conditions
WO2023116835A1 (zh) * 2021-12-24 2023-06-29 苏州开拓药业股份有限公司 一种具有酰亚胺骨架的多蛋白降解剂
TW202333670A (zh) * 2022-01-04 2023-09-01 大陸商海思科醫藥集團股份有限公司 抑制並降解irak4的化合物及其藥物组合物和藥學上的應用
WO2023193760A1 (en) * 2022-04-06 2023-10-12 Cullgen (Shanghai) , Inc. Compounds and methods of treating cancers
US20230416240A1 (en) * 2022-06-16 2023-12-28 Prelude Therapeutics Incorporated Kat6 targeting compounds
CN117510504A (zh) * 2022-08-05 2024-02-06 深圳市新樾生物科技有限公司 蛋白激酶降解剂、药物及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015247817C1 (en) * 2014-04-14 2022-02-10 Arvinas Operations, Inc. Imide-based modulators of proteolysis and associated methods of use
EP3233840B1 (en) * 2014-12-16 2018-11-21 Eudendron S.r.l. Heterocyclic derivatives modulating activity of certain protein kinases
CA2979070A1 (en) * 2015-03-18 2016-09-22 Arvinas, Inc. Compounds and methods for the enhanced degradation of targeted proteins
WO2017197046A1 (en) * 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
WO2017197051A1 (en) * 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
WO2017197055A1 (en) * 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
KR102538307B1 (ko) * 2017-12-13 2023-05-31 상하이테크 유니버시티 Alk 단백질 분해제 및 암 치료에서의 이의 용도
CA3110267A1 (en) * 2018-08-22 2020-02-27 Cullgen (Shanghai), Inc. Tropomyosin receptor kinase (trk) degradation compounds and methods of use

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