JPWO2021170109A5 - - Google Patents

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Publication number
JPWO2021170109A5
JPWO2021170109A5 JP2022551553A JP2022551553A JPWO2021170109A5 JP WO2021170109 A5 JPWO2021170109 A5 JP WO2021170109A5 JP 2022551553 A JP2022551553 A JP 2022551553A JP 2022551553 A JP2022551553 A JP 2022551553A JP WO2021170109 A5 JPWO2021170109 A5 JP WO2021170109A5
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JP
Japan
Prior art keywords
amino
difluorobenzyl
indazol
benzamide
piperazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022551553A
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English (en)
Japanese (ja)
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JP2023514872A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2021/078240 external-priority patent/WO2021170109A1/en
Publication of JP2023514872A publication Critical patent/JP2023514872A/ja
Publication of JPWO2021170109A5 publication Critical patent/JPWO2021170109A5/ja
Pending legal-status Critical Current

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JP2022551553A 2020-02-26 2021-02-26 トロポミオシン受容体キナーゼ(trk)分解化合物とその使用方法 Pending JP2023514872A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020076748 2020-02-26
CNPCT/CN2020/076748 2020-02-26
PCT/CN2021/078240 WO2021170109A1 (en) 2020-02-26 2021-02-26 Tropomyosin receptor kinase (trk) degradation compounds and methods of use

Publications (2)

Publication Number Publication Date
JP2023514872A JP2023514872A (ja) 2023-04-11
JPWO2021170109A5 true JPWO2021170109A5 (ru) 2024-03-04

Family

ID=77490737

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022551553A Pending JP2023514872A (ja) 2020-02-26 2021-02-26 トロポミオシン受容体キナーゼ(trk)分解化合物とその使用方法

Country Status (11)

Country Link
US (1) US20230257380A1 (ru)
EP (1) EP4110772A4 (ru)
JP (1) JP2023514872A (ru)
KR (1) KR20230010070A (ru)
CN (1) CN115697989A (ru)
AU (1) AU2021225981A1 (ru)
BR (1) BR112022016901A2 (ru)
CA (1) CA3173262A1 (ru)
IL (1) IL295799A (ru)
MX (1) MX2022010465A (ru)
WO (1) WO2021170109A1 (ru)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11969472B2 (en) 2018-08-22 2024-04-30 Cullgen (Shanghai), Inc. Tropomyosin receptor kinase (TRK) degradation compounds and methods of use
KR20210069634A (ko) * 2018-08-22 2021-06-11 클루젠 (상하이), 인크. 트로포미오신 수용체 키나아제(trk) 분해 화합물 및 사용 방법
CN116648248A (zh) * 2021-01-26 2023-08-25 成都茵创园医药科技有限公司 芳香化合物、含其的药物组合物及其应用
CN115504963A (zh) * 2021-06-22 2022-12-23 苏州开拓药业股份有限公司 一种c-Myc蛋白降解剂
EP4400499A1 (en) * 2021-09-08 2024-07-17 Medshine Discovery Inc. Glutarimide compound and use thereof
WO2023055952A1 (en) * 2021-09-29 2023-04-06 C4 Therapeutics, Inc. Neurotrophic tyrosine receptor kinase (ntrk) degrading compounds
AU2022370021A1 (en) * 2021-10-22 2024-05-09 Gluetacs Therapeutics (Shanghai) Co., Ltd. Crbn e3 ligase ligand compound, protein degrading agent developed on the basis of ligand compound, and their applications
EP4180428A1 (en) * 2021-11-12 2023-05-17 Genzyme Corporation Crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, and their use in treating medical conditions
WO2023116835A1 (zh) * 2021-12-24 2023-06-29 苏州开拓药业股份有限公司 一种具有酰亚胺骨架的多蛋白降解剂
TW202333670A (zh) * 2022-01-04 2023-09-01 大陸商海思科醫藥集團股份有限公司 抑制並降解irak4的化合物及其藥物组合物和藥學上的應用
WO2023193760A1 (en) * 2022-04-06 2023-10-12 Cullgen (Shanghai) , Inc. Compounds and methods of treating cancers
US20230416240A1 (en) * 2022-06-16 2023-12-28 Prelude Therapeutics Incorporated Kat6 targeting compounds
TW202412851A (zh) * 2022-08-05 2024-04-01 大陸商深圳市新樾生物科技有限公司 蛋白激酶降解劑、藥物及應用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210132233A (ko) * 2014-04-14 2021-11-03 아비나스 오퍼레이션스, 인코포레이티드 단백질분해의 이미드-기초된 조절인자 및 연관된 이용 방법
WO2016096709A1 (en) * 2014-12-16 2016-06-23 Eudendron S.R.L. Heterocyclic derivatives modulating activity of certain protein kinases
EP3270917A4 (en) * 2015-03-18 2018-08-08 Arvinas, Inc. Compounds and methods for the enhanced degradation of targeted proteins
WO2017197046A1 (en) * 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
EP3455219A4 (en) * 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR THE DEGRADATION OF TARGET PROTEINS
EP3454856A4 (en) * 2016-05-10 2019-12-25 C4 Therapeutics, Inc. HETEROCYCLIC DEGRONIMERS FOR TARGET PROTEIN REDUCTION
JP2021506820A (ja) * 2017-12-13 2021-02-22 上海科技大学Shanghai Tech University Alkタンパク質分解剤及びそれらの癌療法における使用
KR20210069634A (ko) * 2018-08-22 2021-06-11 클루젠 (상하이), 인크. 트로포미오신 수용체 키나아제(trk) 분해 화합물 및 사용 방법

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