JPWO2021150959A5 - - Google Patents

Info

Publication number

JPWO2021150959A5

JPWO2021150959A5 JP2022545046A JP2022545046A JPWO2021150959A5 JP WO2021150959 A5 JPWO2021150959 A5 JP WO2021150959A5 JP 2022545046 A JP2022545046 A JP 2022545046A JP 2022545046 A JP2022545046 A JP 2022545046A JP WO2021150959 A5 JPWO2021150959 A5 JP WO2021150959A5

Authority

JP

Japan

Prior art keywords

naturally occurring

occurring polypeptide

terminal truncation

amino acid

seq

Prior art date

2024-01-31

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108090000765 processed proteins & peptides Proteins 0.000 claims description 102
• 229920001184 polypeptide Polymers 0.000 claims description 98
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 98
• 210000004899 c-terminal region Anatomy 0.000 claims description 40
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 36
• 210000004027 cell Anatomy 0.000 claims description 28
• 235000001014 amino acid Nutrition 0.000 claims description 22
• 150000001413 amino acids Chemical class 0.000 claims description 22
• 239000000203 mixture Substances 0.000 claims description 17
• 102000008186 Collagen Human genes 0.000 claims description 10
• 108010035532 Collagen Proteins 0.000 claims description 10
• 229920001436 collagen Polymers 0.000 claims description 10
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 4
• 230000001580 bacterial effect Effects 0.000 claims description 4
• 230000013595 glycosylation Effects 0.000 claims description 4
• 238000006206 glycosylation reaction Methods 0.000 claims description 4
• 230000000813 microbial effect Effects 0.000 claims description 4
• 108010050451 2-oxoglutarate 3-dioxygenase proline Proteins 0.000 claims description 2
• 108090000790 Enzymes Proteins 0.000 claims description 2
• 102000004190 Enzymes Human genes 0.000 claims description 2
• 241000588724 Escherichia coli Species 0.000 claims description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 2
• 102000018399 Prolyl 3-hydroxylases Human genes 0.000 claims description 2
• 108010043005 Prolyl Hydroxylases Proteins 0.000 claims description 2
• 102000004079 Prolyl Hydroxylases Human genes 0.000 claims description 2
• 210000000988 bone and bone Anatomy 0.000 claims description 2
• 235000015872 dietary supplement Nutrition 0.000 claims description 2
• 102000013373 fibrillar collagen Human genes 0.000 claims description 2
• 108060002894 fibrillar collagen Proteins 0.000 claims description 2
• 230000033444 hydroxylation Effects 0.000 claims description 2
• 238000005805 hydroxylation reaction Methods 0.000 claims description 2
• 230000037231 joint health Effects 0.000 claims description 2
• 239000000178 monomer Substances 0.000 claims description 2
• 210000003205 muscle Anatomy 0.000 claims description 2
• 150000007523 nucleic acids Chemical group 0.000 claims description 2
• 235000013930 proline Nutrition 0.000 claims description 2
• 125000001500 prolyl group Chemical class [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 2
• 235000018102 proteins Nutrition 0.000 claims description 2
• 102000004169 proteins and genes Human genes 0.000 claims description 2
• 108090000623 proteins and genes Proteins 0.000 claims description 2
• 108010047303 von Willebrand Factor Proteins 0.000 claims description 2
• 102100036537 von Willebrand factor Human genes 0.000 claims description 2
• 229960001134 von willebrand factor Drugs 0.000 claims description 2
• 230000001815 facial effect Effects 0.000 claims 7
• 239000000047 product Substances 0.000 claims 6
• 239000006071 cream Substances 0.000 claims 4
• 210000002966 serum Anatomy 0.000 claims 3
• 239000004909 Moisturizer Substances 0.000 claims 2
• 238000003776 cleavage reaction Methods 0.000 claims 2
• 239000002537 cosmetic Substances 0.000 claims 2
• 235000013305 food Nutrition 0.000 claims 2
• 230000001333 moisturizer Effects 0.000 claims 2
• 230000007017 scission Effects 0.000 claims 2
• 239000002453 shampoo Substances 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 1
• 235000013361 beverage Nutrition 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000000839 emulsion Substances 0.000 claims 1
• 239000008266 hair spray Substances 0.000 claims 1
• 230000004054 inflammatory process Effects 0.000 claims 1
• 230000007413 intestinal health Effects 0.000 claims 1
• 239000006210 lotion Substances 0.000 claims 1
• 244000005700 microbiome Species 0.000 claims 1
• 239000003595 mist Substances 0.000 claims 1
• 210000004761 scalp Anatomy 0.000 claims 1
• 239000013589 supplement Substances 0.000 claims 1
• 230000017423 tissue regeneration Effects 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1
• 238000000034 method Methods 0.000 description 5
• 230000004048 modification Effects 0.000 description 1
• 238000012986 modification Methods 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1