JPWO2021101919A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2021101919A5
JPWO2021101919A5 JP2022529017A JP2022529017A JPWO2021101919A5 JP WO2021101919 A5 JPWO2021101919 A5 JP WO2021101919A5 JP 2022529017 A JP2022529017 A JP 2022529017A JP 2022529017 A JP2022529017 A JP 2022529017A JP WO2021101919 A5 JPWO2021101919 A5 JP WO2021101919A5
Authority
JP
Japan
Prior art keywords
methyl
pyridin
piperidine
dione
oxoisoindolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022529017A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023503052A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/060937 external-priority patent/WO2021101919A1/en
Publication of JP2023503052A publication Critical patent/JP2023503052A/ja
Publication of JPWO2021101919A5 publication Critical patent/JPWO2021101919A5/ja
Pending legal-status Critical Current

Links

JP2022529017A 2019-11-19 2020-11-18 Heliosタンパク質の阻害剤として有用な化合物 Pending JP2023503052A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962937350P 2019-11-19 2019-11-19
US62/937,350 2019-11-19
PCT/US2020/060937 WO2021101919A1 (en) 2019-11-19 2020-11-18 Compounds useful as inhibitors of helios protein

Publications (2)

Publication Number Publication Date
JP2023503052A JP2023503052A (ja) 2023-01-26
JPWO2021101919A5 true JPWO2021101919A5 (he) 2023-11-14

Family

ID=73834595

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022529017A Pending JP2023503052A (ja) 2019-11-19 2020-11-18 Heliosタンパク質の阻害剤として有用な化合物

Country Status (13)

Country Link
US (1) US11548870B2 (he)
EP (1) EP4061812A1 (he)
JP (1) JP2023503052A (he)
KR (1) KR20220103753A (he)
CN (1) CN114728950B (he)
AR (1) AR120481A1 (he)
AU (1) AU2020387392A1 (he)
BR (1) BR112022009514A2 (he)
CA (1) CA3158976A1 (he)
IL (1) IL293027A (he)
MX (1) MX2022005839A (he)
TW (1) TWI836159B (he)
WO (1) WO2021101919A1 (he)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202140441A (zh) * 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 經取代之側氧基異吲哚啉化合物
JP2023536164A (ja) * 2020-08-03 2023-08-23 ノバルティス アーゲー ヘテロアリール置換3-(1-オキソイソインドリン-2-イル)ピペリジン-2,6-ジオン誘導体及びその使用
AU2022253450A1 (en) * 2021-04-05 2023-11-16 Bristol-Myers Squibb Company Pyridinyl substituted oxoisoindoline compounds for the treatment of cancer
CN115504963A (zh) * 2021-06-22 2022-12-23 苏州开拓药业股份有限公司 一种c-Myc蛋白降解剂
EP4367112A1 (en) 2021-07-09 2024-05-15 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2
CN118139858A (zh) 2021-10-28 2024-06-04 吉利德科学公司 吡地嗪-3(2h)-酮衍生物
KR20240097895A (ko) 2021-10-29 2024-06-27 길리애드 사이언시즈, 인코포레이티드 Cd73 화합물
CA3237577A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
CA3239528A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
MX2024009897A (es) * 2022-02-09 2024-08-20 C4 Therapeutics Inc Formas morficas de cft7455 y sus metodos de fabricacion.
AU2023233730A1 (en) 2022-03-17 2024-09-26 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
WO2023205719A1 (en) 2022-04-21 2023-10-26 Gilead Sciences, Inc. Kras g12d modulating compounds
US20240116928A1 (en) 2022-07-01 2024-04-11 Gilead Sciences, Inc. Cd73 compounds
WO2024064358A1 (en) 2022-09-23 2024-03-28 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
WO2024137852A1 (en) 2022-12-22 2024-06-27 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
US20240327381A1 (en) * 2023-02-08 2024-10-03 Celgene Corporation Compounds and Compositions for Selective Degradation of Engineered Proteins

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ304569B6 (cs) 1996-07-24 2014-07-09 Celgene Corporation 1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindolin pro použití pro snížení nežádoucí hladiny TNFα u savce
US20030045552A1 (en) 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
ATE428419T1 (de) 2001-08-06 2009-05-15 Childrens Medical Center Antiangiogenese wirkung von stickstoffsubstituierten thalidomid-analoga
TWI380996B (zh) 2004-09-17 2013-01-01 Hoffmann La Roche 抗ox40l抗體
WO2006105021A2 (en) 2005-03-25 2006-10-05 Tolerrx, Inc. Gitr binding molecules and uses therefor
WO2006122150A1 (en) 2005-05-10 2006-11-16 Incyte Corporation Modulators of indoleamine 2,3-dioxygenase and methods of using the same
KR101888321B1 (ko) 2005-07-01 2018-08-13 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체
EP1971583B1 (en) 2005-12-20 2015-03-25 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
JP5319532B2 (ja) 2006-09-19 2013-10-16 インサイト・コーポレイション インドールアミン2,3−ジオキシゲナーゼのモジュレーターとしてのn−ヒドロキシアミジノヘテロサイクル
EP1987839A1 (en) 2007-04-30 2008-11-05 I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
JP5932217B2 (ja) 2007-07-12 2016-06-08 ジーアイティーアール, インコーポレイテッド Gitr結合分子を使用する併用療法
EP2044949A1 (en) 2007-10-05 2009-04-08 Immutep Use of recombinant lag-3 or the derivatives thereof for eliciting monocyte immune response
JP5583592B2 (ja) 2007-11-30 2014-09-03 ニューリンク ジェネティクス コーポレイション Ido阻害剤
AU2008353145B2 (en) 2008-01-03 2013-09-12 Universite D' Aix-Marseille Bitherapy and tritherapy used for treating an HIV-positive patient
WO2009137095A2 (en) 2008-05-08 2009-11-12 The Johns Hopkins University Compositions and methods for modulating an immune response
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
CN102245640B (zh) 2008-12-09 2014-12-31 霍夫曼-拉罗奇有限公司 抗-pd-l1抗体及它们用于增强t细胞功能的用途
JP5561577B2 (ja) 2009-07-01 2014-07-30 国立大学法人 名古屋工業大学 光学活性3’−フルオロサリドマイド誘導体の製造方法
SG178991A1 (en) 2009-09-03 2012-04-27 Schering Corp Anti-gitr antibodies
WO2011056652A1 (en) 2009-10-28 2011-05-12 Newlink Genetics Imidazole derivatives as ido inhibitors
NZ599516A (en) 2009-12-10 2013-11-29 Hoffmann La Roche Antibodies binding preferentially human csf1r extracellular domain 4 and their use
MX345232B (es) 2010-03-04 2017-01-20 Macrogenics Inc Anticuerpos reactivos con b7-h3, fragmentos inmunologicamente activos de los mismos y sus usos.
CN102918060B (zh) 2010-03-05 2016-04-06 霍夫曼-拉罗奇有限公司 抗人csf-1r抗体及其用途
JP5989547B2 (ja) 2010-03-05 2016-09-07 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト ヒトcsf−1rに対する抗体及びその使用
TR201900368T4 (tr) 2010-05-04 2019-02-21 Five Prime Therapeutics Inc Csf1r'ye bağlanan antikorlar.
NZ714128A (en) 2010-09-09 2017-10-27 Pfizer 4-1bb binding molecules
NO2694640T3 (he) 2011-04-15 2018-03-17
EP2699264B1 (en) 2011-04-20 2018-03-14 Medlmmune, LLC Antibodies and other molecules that bind b7-h1 and pd-1
PT2785375T (pt) 2011-11-28 2020-10-29 Merck Patent Gmbh Anticorpos anti-pd-l1 e usos destes
WO2013087699A1 (en) 2011-12-15 2013-06-20 F. Hoffmann-La Roche Ag Antibodies against human csf-1r and uses thereof
EP2812355A4 (en) 2012-02-06 2016-03-02 Hoffmann La Roche COMPOSITIONS AND METHODS OF USE OF CSF1R INHIBITORS
AR090263A1 (es) 2012-03-08 2014-10-29 Hoffmann La Roche Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma
RU2670743C9 (ru) 2012-05-11 2018-12-19 Файв Прайм Терапьютикс, Инк. Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r)
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
WO2014036357A1 (en) 2012-08-31 2014-03-06 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
WO2015107196A1 (en) 2014-01-20 2015-07-23 Institut Curie Use of thalidomide or analogs thereof for preventing neurologic disorders induced by brain irradiation
US9499514B2 (en) * 2014-07-11 2016-11-22 Celgene Corporation Antiproliferative compounds and methods of use thereof
KR102055491B1 (ko) 2015-05-22 2019-12-12 바이오테릭스, 인코포레이티드 단백질을 표적하는 화합물, 조성물, 방법, 및 그의 용도
JP6873433B2 (ja) 2015-06-04 2021-05-19 アルヴィナス・オペレーションズ・インコーポレイテッド タンパク質分解のイミド系修飾因子および関連の使用方法
GB201516243D0 (en) 2015-09-14 2015-10-28 Glaxosmithkline Ip Dev Ltd Novel compounds
WO2017117118A1 (en) 2015-12-28 2017-07-06 Celgene Corporation Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases
CN109153644B (zh) 2016-03-16 2022-10-21 H·李·莫菲特癌症中心研究有限公司 用以增强效应t细胞功能的针对cereblon的小分子
CN109415336B (zh) 2016-04-06 2023-08-29 密执安大学评议会 Mdm2蛋白质降解剂
WO2017185034A1 (en) 2016-04-22 2017-10-26 Dana-Farber Cancer Institute, Inc. Degradation of cyclin-dependent kinase 8 (cdk8) by conjugation of cdk8 inhibitors with e3 ligase ligand and methods of use
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR THE DEGRADATION OF TARGET PROTEINS
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
WO2017197056A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Bromodomain targeting degronimers for target protein degradation
US10646488B2 (en) 2016-07-13 2020-05-12 Araxes Pharma Llc Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
AU2017326171B2 (en) 2016-09-13 2021-12-09 The Regents Of The University Of Michigan Fused 1,4-oxazepines as BET protein degraders
KR102173463B1 (ko) 2016-10-11 2020-11-04 아비나스 오퍼레이션스, 인코포레이티드 안드로겐 수용체의 표적 분해용 화합물 및 방법
CA3042260C (en) 2016-11-01 2023-10-03 Arvinas, Inc. Tau-protein targeting protacs and associated methods of use
BR112019011200B1 (pt) 2016-12-01 2021-12-28 Arvinas Operations, Inc Derivados de tetrahidronaftaleno e tetrahidroisoquinolina como degradadores do receptor de estrogênio
JP2020504711A (ja) 2016-12-21 2020-02-13 バイオセリックス, インコーポレイテッド タンパク質を標的とすることにおいて使用するための、チエノピロール誘導体、その組成物、方法、および使用
JP2020504741A (ja) 2016-12-23 2020-02-13 アルビナス・オペレーションズ・インコーポレイテッドArvinas Operations, Inc. Raf(急速進行性線維肉腫)ポリペプチドの標的分解のための化合物および方法
US10806737B2 (en) 2016-12-23 2020-10-20 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
EP3559002A4 (en) 2016-12-23 2021-02-17 Arvinas Operations, Inc. CHEMERICAL MOLECULES TARGETING EGFR PROTEOLYSIS AND RELATED METHODS OF USE
TWI793151B (zh) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
EP3697436A1 (en) * 2017-10-18 2020-08-26 Novartis AG Compositions and methods for selective protein degradation
WO2019148055A1 (en) 2018-01-26 2019-08-01 Yale University Imide-based modulators of proteolysis and methods of use
WO2019191112A1 (en) 2018-03-26 2019-10-03 C4 Therapeutics, Inc. Cereblon binders for the degradation of ikaros
EP3807283A1 (en) 2018-06-13 2021-04-21 Biotheryx, Inc. Fused thiophene compounds
JOP20210001A1 (ar) 2018-07-10 2021-01-05 Novartis Ag مشتقات 3-(5- هيدروكسي -1- أوكسو أيزو إندولين -2- يل) بيبريدين -2، 6- دايون واستخدامها لمعالجة أمراض مرتبطة ببروتين ذات أصبع الزنك من عائلة (ikaros 2 (ikzf2
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
AU2019381688A1 (en) 2018-11-13 2021-06-03 Biotheryx, Inc. Substituted isoindolinones
JP2022514315A (ja) 2018-12-20 2022-02-10 ノバルティス アーゲー 3-(1-オキソイソインドリン-2-イル)ピペリジン-2,6-ジオン誘導体を含む投与計画及び薬剤組み合わせ
AU2020374957A1 (en) 2019-10-30 2022-04-28 Dana-Farber Cancer Institute, Inc. Small molecule degraders of Helios and methods of use

Similar Documents

Publication Publication Date Title
JPWO2021101919A5 (he)
JP2019525941A5 (he)
RU2462464C2 (ru) Замещенные сульфамидные производные
US8153625B2 (en) Nitrogen-containing heterocyclic compounds and medicinal use thereof
AU2004226165B2 (en) Pyrimidin-4-one derivatives and their use as p38 kinase modulators
ES2374451T3 (es) Bencimidazoles sustituidos como inhibidores de quinasa.
JP5487214B2 (ja) キナーゼ阻害剤として有用なカルバゾールカルボキシアミド化合物
JP4958772B2 (ja) 脈管形成に関連する高増殖性疾患および疾患を処置するために有用なピロロトリアジン誘導体
AU732863B2 (en) Indole derivatives having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity
JP2015503529A5 (he)
US7795271B2 (en) Substituted pyrimidinones
JP2012529535A (ja) キナーゼモジュレーターとして有用なニコチンアミド化合物
JP2009524589A5 (ja) 置換されたイソキノリン−1,3(2h,4h)−ジオン、1−チオキソ−1,4−ジヒドロ−2h−イソキノリン−3−オン、および1,4−ジヒドロ−3(2h)−イソキノロン、ならびにキナーゼインヒビターとしてのそれらの使用
JP2011518836A5 (he)
EP1747206A1 (en) Amino-tetrazoles analogues and methods of use
RU2479578C2 (ru) Производное тетрагидроизохинолин-1-она или его фармацевтически приемлемая соль, полезные в качестве антагониста вв2
JP2013503846A (ja) ベンズイミダゾール誘導体
JPH04253976A (ja) 新規インドール誘導体
PT2207773E (pt) Composto heterocíclico e composição farmacêutica que contém o mencionado composto
FI3356344T3 (fi) Mdm2-p53-vuorovaikutuksen isoindolinoniestäjiä, joilla on syövänvastaista aktiivisuutta
JP2022553832A (ja) メラノコルチンサブタイプ-2受容体(mc2r)アンタゴニストおよびその使用
CN1351595A (zh) 可用于选择性抑制凝血级联的取代的多环芳基与杂芳基吡嗪酮
JPWO2020165833A5 (he)
JP2006503033A5 (he)
RU2008139079A (ru) Замещенные 3-цианопиридины в качестве ингибиторов протеинкиназы