JPWO2020208201A5 - - Google Patents
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- Publication number
- JPWO2020208201A5 JPWO2020208201A5 JP2021560695A JP2021560695A JPWO2020208201A5 JP WO2020208201 A5 JPWO2020208201 A5 JP WO2020208201A5 JP 2021560695 A JP2021560695 A JP 2021560695A JP 2021560695 A JP2021560695 A JP 2021560695A JP WO2020208201 A5 JPWO2020208201 A5 JP WO2020208201A5
- Authority
- JP
- Japan
- Prior art keywords
- active ingredient
- process space
- solid particles
- spray composition
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 50
- 239000004480 active ingredient Substances 0.000 claims description 26
- 239000002245 particle Substances 0.000 claims description 24
- 239000008187 granular material Substances 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 12
- 239000007787 solid Substances 0.000 claims description 12
- 239000007921 spray Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 11
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 210000001072 colon Anatomy 0.000 claims description 4
- 238000013270 controlled release Methods 0.000 claims description 4
- 210000003405 ileum Anatomy 0.000 claims description 4
- 229960003105 metformin Drugs 0.000 claims description 4
- 229960004329 metformin hydrochloride Drugs 0.000 claims description 3
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical group Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 238000010924 continuous production Methods 0.000 claims description 2
- 238000001704 evaporation Methods 0.000 claims description 2
- 238000000227 grinding Methods 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19168673.2A EP3721870A1 (de) | 2019-04-11 | 2019-04-11 | Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats |
| EP19168673.2 | 2019-04-11 | ||
| PCT/EP2020/060277 WO2020208201A1 (de) | 2019-04-11 | 2020-04-09 | Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022528570A JP2022528570A (ja) | 2022-06-14 |
| JPWO2020208201A5 true JPWO2020208201A5 (https=) | 2023-04-14 |
| JP2022528570A5 JP2022528570A5 (https=) | 2023-04-14 |
| JP7620565B2 JP7620565B2 (ja) | 2025-01-23 |
Family
ID=66105201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021560695A Active JP7620565B2 (ja) | 2019-04-11 | 2020-04-09 | 有効成分顆粒の連続製造のためのプロセス |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220323361A1 (https=) |
| EP (2) | EP3721870A1 (https=) |
| JP (1) | JP7620565B2 (https=) |
| CN (1) | CN114126591A (https=) |
| AU (1) | AU2020272151B2 (https=) |
| BR (1) | BR112021020320A2 (https=) |
| CA (1) | CA3136529A1 (https=) |
| ES (1) | ES3050631T3 (https=) |
| IL (1) | IL287126B1 (https=) |
| WO (1) | WO2020208201A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3721871A1 (de) * | 2019-04-11 | 2020-10-14 | ADD Advanced Drug Delivery Technologies, Ltd. | Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats |
| MX2023006016A (es) * | 2020-11-24 | 2023-08-14 | Nanoform Finland PLC | Sistema, aparatos, dispositivos y metodos para producir particulas. |
| CN116422227B (zh) * | 2022-12-09 | 2024-01-30 | 山东奥诺能源科技股份有限公司 | 一种流化床造粒机 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19514187C1 (de) * | 1995-04-21 | 1996-05-15 | Degussa | Verfahren und Vorrichtung zur Herstellung von Granulaten durch Wirbelschicht-Sprühgranulation |
| US6117451A (en) | 1998-08-25 | 2000-09-12 | Pharmalogix, Inc. | Direct compression metformin hydrochloride tablets |
| DE10004939C1 (de) | 2000-02-05 | 2001-08-23 | Lothar Moerl | Steuerbare Gasanströmeinrichtung für Strahlschichtapparate |
| ES2260345T3 (es) * | 2001-03-07 | 2006-11-01 | Dainippon Sumitomo Pharma Co., Ltd. | Metodo para fabricar granulos de farmacos, los granulos de farmaco y preparacion farmaceutica que contiene los granulos de farmaco. |
| US6667054B2 (en) | 2001-12-05 | 2003-12-23 | Bernard Charles Sherman | Metformin hydrochloride tablets |
| DE10322062A1 (de) | 2003-05-15 | 2004-12-02 | Glatt Ingenieurtechnik Gmbh | Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates |
| ES2374191T3 (es) | 2003-06-11 | 2012-02-14 | Glatt Ingenieurtechnik Gmbh | Procedimiento de preparación de granulados de enzimas y granulados de enzimas así obtenidos. |
| CA2572549A1 (en) * | 2004-07-01 | 2006-01-12 | Warner-Lambert Company Llc | Preparation of pharmaceutical compositions containing nanoparticles |
| DE102007012105A1 (de) * | 2007-03-13 | 2008-09-18 | Add Advanced Drug Delivery Technologies Ltd. | Pellets enthaltend pharmazeutische Substanz, Verfahren zu deren Herstellung und deren Verwendung |
| EP2590631B1 (en) * | 2010-07-06 | 2016-10-26 | Janssen Pharmaceutica NV | Formulation for co-therapy treatment of diabetes |
| WO2013143688A1 (en) * | 2012-03-26 | 2013-10-03 | Glatt Ag | Taste-masked ibuprofen granules |
| JP5922310B2 (ja) * | 2013-07-25 | 2016-05-24 | 株式会社三和化学研究所 | 医薬製剤 |
| KR101642193B1 (ko) * | 2014-10-13 | 2016-07-25 | 씨제이헬스케어 주식회사 | 메트포르민 서방성 제제 및 그의 제조방법 |
| WO2018034627A1 (en) * | 2016-08-18 | 2018-02-22 | İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi | Pharmaceutical composition of antidiabetic tablet |
-
2019
- 2019-04-11 EP EP19168673.2A patent/EP3721870A1/de not_active Withdrawn
-
2020
- 2020-04-09 CN CN202080042850.1A patent/CN114126591A/zh active Pending
- 2020-04-09 WO PCT/EP2020/060277 patent/WO2020208201A1/de not_active Ceased
- 2020-04-09 US US17/602,356 patent/US20220323361A1/en active Pending
- 2020-04-09 AU AU2020272151A patent/AU2020272151B2/en active Active
- 2020-04-09 CA CA3136529A patent/CA3136529A1/en active Pending
- 2020-04-09 BR BR112021020320A patent/BR112021020320A2/pt unknown
- 2020-04-09 EP EP20722226.6A patent/EP3952843B1/de active Active
- 2020-04-09 JP JP2021560695A patent/JP7620565B2/ja active Active
- 2020-04-09 ES ES20722226T patent/ES3050631T3/es active Active
-
2021
- 2021-10-10 IL IL287126A patent/IL287126B1/en unknown
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