CN114126591A - 连续制造有效成分颗粒的方法 - Google Patents

连续制造有效成分颗粒的方法 Download PDF

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Publication number
CN114126591A
CN114126591A CN202080042850.1A CN202080042850A CN114126591A CN 114126591 A CN114126591 A CN 114126591A CN 202080042850 A CN202080042850 A CN 202080042850A CN 114126591 A CN114126591 A CN 114126591A
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CN
China
Prior art keywords
active ingredient
particles
spray composition
liquid
spray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080042850.1A
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English (en)
Chinese (zh)
Inventor
R·诺瓦克
N·波林杰
A·格拉维
M·雅各布
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Ed Advanced Drug Delivery Technology Co ltd
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Ed Advanced Drug Delivery Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ed Advanced Drug Delivery Technology Co ltd filed Critical Ed Advanced Drug Delivery Technology Co ltd
Publication of CN114126591A publication Critical patent/CN114126591A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
CN202080042850.1A 2019-04-11 2020-04-09 连续制造有效成分颗粒的方法 Pending CN114126591A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19168673.2A EP3721870A1 (de) 2019-04-11 2019-04-11 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
EP19168673.2 2019-04-11
PCT/EP2020/060277 WO2020208201A1 (de) 2019-04-11 2020-04-09 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats

Publications (1)

Publication Number Publication Date
CN114126591A true CN114126591A (zh) 2022-03-01

Family

ID=66105201

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080042850.1A Pending CN114126591A (zh) 2019-04-11 2020-04-09 连续制造有效成分颗粒的方法

Country Status (10)

Country Link
US (1) US20220323361A1 (https=)
EP (2) EP3721870A1 (https=)
JP (1) JP7620565B2 (https=)
CN (1) CN114126591A (https=)
AU (1) AU2020272151B2 (https=)
BR (1) BR112021020320A2 (https=)
CA (1) CA3136529A1 (https=)
ES (1) ES3050631T3 (https=)
IL (1) IL287126B1 (https=)
WO (1) WO2020208201A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116422227A (zh) * 2022-12-09 2023-07-14 山东奥诺能源科技股份有限公司 一种流化床造粒机

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3721871A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
MX2023006016A (es) * 2020-11-24 2023-08-14 Nanoform Finland PLC Sistema, aparatos, dispositivos y metodos para producir particulas.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1182377A (zh) * 1995-04-21 1998-05-20 底古萨股份公司 通过流化床喷射成粒作用制造粒状物的方法和设备
US20100080849A1 (en) * 2007-03-13 2010-04-01 Add Advanced Drug Delivery Technologies Ltd. Pellets containing a pharmaceutical substance, method for the production thereof and use of the same
US20140163109A1 (en) * 2012-03-26 2014-06-12 Glatt Ag Taste-masked ibupropen granules
WO2015012365A1 (ja) * 2013-07-25 2015-01-29 株式会社 三和化学研究所 医薬製剤
WO2018034627A1 (en) * 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117451A (en) 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
DE10004939C1 (de) 2000-02-05 2001-08-23 Lothar Moerl Steuerbare Gasanströmeinrichtung für Strahlschichtapparate
ES2260345T3 (es) * 2001-03-07 2006-11-01 Dainippon Sumitomo Pharma Co., Ltd. Metodo para fabricar granulos de farmacos, los granulos de farmaco y preparacion farmaceutica que contiene los granulos de farmaco.
US6667054B2 (en) 2001-12-05 2003-12-23 Bernard Charles Sherman Metformin hydrochloride tablets
DE10322062A1 (de) 2003-05-15 2004-12-02 Glatt Ingenieurtechnik Gmbh Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates
ES2374191T3 (es) 2003-06-11 2012-02-14 Glatt Ingenieurtechnik Gmbh Procedimiento de preparación de granulados de enzimas y granulados de enzimas así obtenidos.
CA2572549A1 (en) * 2004-07-01 2006-01-12 Warner-Lambert Company Llc Preparation of pharmaceutical compositions containing nanoparticles
EP2590631B1 (en) * 2010-07-06 2016-10-26 Janssen Pharmaceutica NV Formulation for co-therapy treatment of diabetes
KR101642193B1 (ko) * 2014-10-13 2016-07-25 씨제이헬스케어 주식회사 메트포르민 서방성 제제 및 그의 제조방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1182377A (zh) * 1995-04-21 1998-05-20 底古萨股份公司 通过流化床喷射成粒作用制造粒状物的方法和设备
US20100080849A1 (en) * 2007-03-13 2010-04-01 Add Advanced Drug Delivery Technologies Ltd. Pellets containing a pharmaceutical substance, method for the production thereof and use of the same
US20140163109A1 (en) * 2012-03-26 2014-06-12 Glatt Ag Taste-masked ibupropen granules
WO2015012365A1 (ja) * 2013-07-25 2015-01-29 株式会社 三和化学研究所 医薬製剤
WO2018034627A1 (en) * 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
冯怡主编: "中药固体制剂技术理论与实践", vol. 1, 中国中医药出版社, pages: 22 - 26 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116422227A (zh) * 2022-12-09 2023-07-14 山东奥诺能源科技股份有限公司 一种流化床造粒机
CN116422227B (zh) * 2022-12-09 2024-01-30 山东奥诺能源科技股份有限公司 一种流化床造粒机

Also Published As

Publication number Publication date
EP3721870A1 (de) 2020-10-14
EP3952843B1 (de) 2025-08-06
IL287126B1 (en) 2026-01-01
CA3136529A1 (en) 2020-10-15
JP7620565B2 (ja) 2025-01-23
JP2022528570A (ja) 2022-06-14
US20220323361A1 (en) 2022-10-13
AU2020272151A1 (en) 2021-12-09
IL287126A (en) 2022-01-01
ES3050631T3 (en) 2025-12-22
EP3952843A1 (de) 2022-02-16
WO2020208201A1 (de) 2020-10-15
BR112021020320A2 (pt) 2021-12-14
AU2020272151B2 (en) 2025-07-03

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