CA3136529A1 - Process for the continuous production of an active ingredient granulate - Google Patents

Process for the continuous production of an active ingredient granulate Download PDF

Info

Publication number
CA3136529A1
CA3136529A1 CA3136529A CA3136529A CA3136529A1 CA 3136529 A1 CA3136529 A1 CA 3136529A1 CA 3136529 A CA3136529 A CA 3136529A CA 3136529 A CA3136529 A CA 3136529A CA 3136529 A1 CA3136529 A1 CA 3136529A1
Authority
CA
Canada
Prior art keywords
active ingredient
particles
process space
solid particles
granulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3136529A
Other languages
English (en)
French (fr)
Inventor
Reinhard Nowak
Norbert Pollinger
Annette Grave
Michael Jacob
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADD Advanced Drug Delivery Technologies AG
Original Assignee
ADD Advanced Drug Delivery Technologies AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADD Advanced Drug Delivery Technologies AG filed Critical ADD Advanced Drug Delivery Technologies AG
Publication of CA3136529A1 publication Critical patent/CA3136529A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
CA3136529A 2019-04-11 2020-04-09 Process for the continuous production of an active ingredient granulate Pending CA3136529A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19168673.2A EP3721870A1 (de) 2019-04-11 2019-04-11 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
EP19168673.2 2019-04-11
PCT/EP2020/060277 WO2020208201A1 (de) 2019-04-11 2020-04-09 Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats

Publications (1)

Publication Number Publication Date
CA3136529A1 true CA3136529A1 (en) 2020-10-15

Family

ID=66105201

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3136529A Pending CA3136529A1 (en) 2019-04-11 2020-04-09 Process for the continuous production of an active ingredient granulate

Country Status (10)

Country Link
US (1) US20220323361A1 (https=)
EP (2) EP3721870A1 (https=)
JP (1) JP7620565B2 (https=)
CN (1) CN114126591A (https=)
AU (1) AU2020272151B2 (https=)
BR (1) BR112021020320A2 (https=)
CA (1) CA3136529A1 (https=)
ES (1) ES3050631T3 (https=)
IL (1) IL287126B1 (https=)
WO (1) WO2020208201A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3721871A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
MX2023006016A (es) * 2020-11-24 2023-08-14 Nanoform Finland PLC Sistema, aparatos, dispositivos y metodos para producir particulas.
CN116422227B (zh) * 2022-12-09 2024-01-30 山东奥诺能源科技股份有限公司 一种流化床造粒机

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19514187C1 (de) * 1995-04-21 1996-05-15 Degussa Verfahren und Vorrichtung zur Herstellung von Granulaten durch Wirbelschicht-Sprühgranulation
US6117451A (en) 1998-08-25 2000-09-12 Pharmalogix, Inc. Direct compression metformin hydrochloride tablets
DE10004939C1 (de) 2000-02-05 2001-08-23 Lothar Moerl Steuerbare Gasanströmeinrichtung für Strahlschichtapparate
ES2260345T3 (es) * 2001-03-07 2006-11-01 Dainippon Sumitomo Pharma Co., Ltd. Metodo para fabricar granulos de farmacos, los granulos de farmaco y preparacion farmaceutica que contiene los granulos de farmaco.
US6667054B2 (en) 2001-12-05 2003-12-23 Bernard Charles Sherman Metformin hydrochloride tablets
DE10322062A1 (de) 2003-05-15 2004-12-02 Glatt Ingenieurtechnik Gmbh Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates
ES2374191T3 (es) 2003-06-11 2012-02-14 Glatt Ingenieurtechnik Gmbh Procedimiento de preparación de granulados de enzimas y granulados de enzimas así obtenidos.
CA2572549A1 (en) * 2004-07-01 2006-01-12 Warner-Lambert Company Llc Preparation of pharmaceutical compositions containing nanoparticles
DE102007012105A1 (de) * 2007-03-13 2008-09-18 Add Advanced Drug Delivery Technologies Ltd. Pellets enthaltend pharmazeutische Substanz, Verfahren zu deren Herstellung und deren Verwendung
EP2590631B1 (en) * 2010-07-06 2016-10-26 Janssen Pharmaceutica NV Formulation for co-therapy treatment of diabetes
WO2013143688A1 (en) * 2012-03-26 2013-10-03 Glatt Ag Taste-masked ibuprofen granules
JP5922310B2 (ja) * 2013-07-25 2016-05-24 株式会社三和化学研究所 医薬製剤
KR101642193B1 (ko) * 2014-10-13 2016-07-25 씨제이헬스케어 주식회사 메트포르민 서방성 제제 및 그의 제조방법
WO2018034627A1 (en) * 2016-08-18 2018-02-22 İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi Pharmaceutical composition of antidiabetic tablet

Also Published As

Publication number Publication date
EP3721870A1 (de) 2020-10-14
EP3952843B1 (de) 2025-08-06
CN114126591A (zh) 2022-03-01
IL287126B1 (en) 2026-01-01
JP7620565B2 (ja) 2025-01-23
JP2022528570A (ja) 2022-06-14
US20220323361A1 (en) 2022-10-13
AU2020272151A1 (en) 2021-12-09
IL287126A (en) 2022-01-01
ES3050631T3 (en) 2025-12-22
EP3952843A1 (de) 2022-02-16
WO2020208201A1 (de) 2020-10-15
BR112021020320A2 (pt) 2021-12-14
AU2020272151B2 (en) 2025-07-03

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