JPWO2020135674A5 - - Google Patents
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- JPWO2020135674A5 JPWO2020135674A5 JP2021537771A JP2021537771A JPWO2020135674A5 JP WO2020135674 A5 JPWO2020135674 A5 JP WO2020135674A5 JP 2021537771 A JP2021537771 A JP 2021537771A JP 2021537771 A JP2021537771 A JP 2021537771A JP WO2020135674 A5 JPWO2020135674 A5 JP WO2020135674A5
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- amino acid
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- Prior art date
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 954
- 150000001413 amino acids Chemical class 0.000 claims description 25
- 238000006467 substitution reaction Methods 0.000 claims description 16
- 102000002029 Claudin Human genes 0.000 claims description 4
- 108050009302 Claudin Proteins 0.000 claims description 4
- 241001529936 Murinae Species 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 description 7
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 4
- 210000002865 immune cell Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000004068 intracellular signaling Effects 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024103100A JP7724332B2 (ja) | 2018-12-28 | 2024-06-26 | クローディン１８．２結合部分およびその利用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018125052 | 2018-12-28 | ||
| CNPCT/CN2018/125052 | 2018-12-28 | ||
| CN2019095827 | 2019-07-12 | ||
| CNPCT/CN2019/095827 | 2019-07-12 | ||
| PCT/CN2019/129017 WO2020135674A1 (en) | 2018-12-28 | 2019-12-27 | Claudin18.2 binding moieties and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024103100A Division JP7724332B2 (ja) | 2018-12-28 | 2024-06-26 | クローディン１８．２結合部分およびその利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022515487A JP2022515487A (ja) | 2022-02-18 |
| JP2022515487A5 JP2022515487A5 (https=) | 2022-11-24 |
| JPWO2020135674A5 true JPWO2020135674A5 (https=) | 2022-11-24 |
Family
ID=71127698
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021537771A Pending JP2022515487A (ja) | 2018-12-28 | 2019-12-27 | クローディン１８．２結合部分およびその利用 |
| JP2024103100A Active JP7724332B2 (ja) | 2018-12-28 | 2024-06-26 | クローディン１８．２結合部分およびその利用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024103100A Active JP7724332B2 (ja) | 2018-12-28 | 2024-06-26 | クローディン１８．２結合部分およびその利用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12258418B2 (https=) |
| EP (1) | EP3902839A4 (https=) |
| JP (2) | JP2022515487A (https=) |
| KR (1) | KR20210110339A (https=) |
| CN (1) | CN113227146B (https=) |
| AU (1) | AU2019415848A1 (https=) |
| BR (1) | BR112021012608A2 (https=) |
| CA (1) | CA3125193A1 (https=) |
| IL (1) | IL284393A (https=) |
| MX (1) | MX2021007939A (https=) |
| SG (1) | SG11202106534RA (https=) |
| WO (1) | WO2020135674A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020228806A1 (zh) * | 2019-05-16 | 2020-11-19 | 齐鲁制药有限公司 | 针对密蛋白18a2的抗体及其应用 |
| BR112022008653A2 (pt) | 2019-11-05 | 2022-07-19 | Lanova Medicines Ltd | Conjugado anticorpo-fármaco, método para tratar câncer, e, uso do conjugado anticorpo-fármaco |
| CN114829408B (zh) | 2019-12-20 | 2024-01-26 | 山东博安生物技术股份有限公司 | 用于免疫治疗的t细胞双特异性抗体生产中的优化抗cd3臂 |
| CN113637082A (zh) * | 2020-04-27 | 2021-11-12 | 启愈生物技术(上海)有限公司 | 一种靶向人claudin和人PDL1蛋白的双特异抗体及其应用 |
| WO2022002112A1 (en) | 2020-07-01 | 2022-01-06 | Shandong Boan Biotechnology Co., Ltd. | Anti-gpc3 antibody, anti-gpc3 chimeric antigen receptor and gpc3/cd3 bispecific antibody |
| CN113929780A (zh) * | 2020-07-13 | 2022-01-14 | 北京凯因科技股份有限公司 | 一种结合密蛋白的用于治疗癌症的人源化抗体 |
| EP4217396A4 (en) * | 2020-09-28 | 2025-06-18 | Elpiscience (Suzhou) Biopharma, Ltd. | NEW ANTI-CLAUDIN18 ANTIBODIES |
| IL302402A (en) | 2020-11-08 | 2023-06-01 | Seagen Inc | Combined treatment |
| CN114560941B (zh) * | 2020-11-27 | 2024-01-16 | 广东东阳光药业股份有限公司 | Cldn18.2的抗体及其应用 |
| CN114539402B (zh) * | 2020-11-27 | 2025-06-13 | 南京北恒生物科技有限公司 | 靶向Claudin18.2的抗体及其用途 |
| WO2022122709A1 (en) | 2020-12-07 | 2022-06-16 | Sotio Biotech A.S. | Antibody-drug conjugates based on humanized cldn18.2 antibodies |
| CA3199830A1 (en) | 2020-12-23 | 2022-06-30 | Lukas BAMMERT | Tumor-specific claudin 18.2 antibody-drug conjugates |
| CN113321730B (zh) * | 2021-01-11 | 2023-10-10 | 上海莱馥医疗科技有限公司 | Cldn18.2抗体及其应用 |
| US20240117035A1 (en) * | 2021-02-08 | 2024-04-11 | Shandong Boan Biotechnology Co., Ltd. | Cldn18.2/cd3 bispecific antibodies for the therapy of cldn18.2-expressing solid tumors |
| CN115109154A (zh) * | 2021-03-17 | 2022-09-27 | 三优生物医药(上海)有限公司 | 一种靶向cldn18.2的抗体或其抗原结合片段及其应用 |
| EP4299593A4 (en) * | 2021-04-02 | 2025-12-10 | Oricell Therapeutics Co Ltd | CLDN18.2 ANTIGEN-BINDING PROTEIN AND ITS USE |
| CN117157105A (zh) * | 2021-05-08 | 2023-12-01 | 荣昌生物制药(烟台)股份有限公司 | 一种抗Claudin18.2抗体及其抗体药物偶联物 |
| EP4488290A1 (en) | 2022-03-04 | 2025-01-08 | ABTIS Co., Ltd. | Method for increasing production yield of antibody-drug conjugate by using thiol-reactive additive |
| WO2024096564A1 (ko) | 2022-11-01 | 2024-05-10 | 앱티스 주식회사 | 항-클라우딘18.2 항체를 포함하는 항체-약물 컨쥬게이트 및 이의 암에 대한 치료용도 |
| KR20250129814A (ko) | 2023-01-18 | 2025-08-29 | 타이리간드 바이오사이언스 (상하이) 리미티드 | 항체-약물 접합체 및 이의 용도 |
| CN116284224B (zh) * | 2023-05-12 | 2023-07-25 | 中国农业大学 | 一种结合Claudin 18.2的环肽及其应用 |
| WO2025038602A1 (en) * | 2023-08-14 | 2025-02-20 | Ginkgo Bioworks, Inc. | Immune cell stimulatory sequences |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
| WO2025072299A1 (en) * | 2023-09-25 | 2025-04-03 | Duke University | Compositions comprising hiv envelopes to induce hiv-1 antibodies |
| CN120829517A (zh) * | 2024-04-22 | 2025-10-24 | 鲁南新时代生物技术有限公司 | 抗cldn18.2/cd3双特异性抗体及用途 |
| WO2025251228A1 (en) | 2024-06-05 | 2025-12-11 | Nuwacell Biotechnologies Co., Ltd. | Cldn18.2-targeting chimeric antigen receptor and engineered cell |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| EP1997832A1 (en) * | 2007-05-29 | 2008-12-03 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against Claudin-18 for treatment of cancer |
| WO2013174404A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2013174403A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| WO2014127785A1 (en) | 2013-02-20 | 2014-08-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| CN120137055A (zh) * | 2014-07-17 | 2025-06-13 | 恺兴生命科技(上海)有限公司 | 靶向cld18a2的t淋巴细胞及其制备方法和应用 |
| WO2016165762A1 (en) * | 2015-04-15 | 2016-10-20 | Ganymed Pharmaceuticals Ag | Drug conjugates comprising antibodies against claudin 18.2 |
| WO2016180468A1 (en) * | 2015-05-11 | 2016-11-17 | Biontech Cell & Gene Therapies Gmbh | Claudin-18.2-specific immunoreceptors and t cell epitopes |
| AU2017294276B2 (en) * | 2016-07-08 | 2024-08-01 | Crage Medical Co., Limited | Antibody for anti-claudin 18A2 and use thereof |
| JP7398380B2 (ja) * | 2018-03-08 | 2023-12-14 | フェインズ セラピューティクス，インコーポレーテッド | 抗クローディン１８．２抗体及びその使用 |
| SG11202007074PA (en) * | 2018-05-18 | 2020-08-28 | Lanova Medicines Ltd Company | Anti-claudin 18.2 antibodies and uses thereof |
| CA3128502A1 (en) * | 2019-02-01 | 2020-08-06 | Novarock Biotherapeutics, Ltd. | Anti-claudin 18 antibodies and methods of use thereof |
| WO2021032157A1 (en) * | 2019-08-20 | 2021-02-25 | Mabspace Biosciences (Suzhou) Co., Limited | Novel anti-cldn18.2 antibodies |
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2019
- 2019-12-27 CN CN201980085449.3A patent/CN113227146B/zh active Active
- 2019-12-27 JP JP2021537771A patent/JP2022515487A/ja active Pending
- 2019-12-27 KR KR1020217023724A patent/KR20210110339A/ko active Pending
- 2019-12-27 EP EP19906510.3A patent/EP3902839A4/en active Pending
- 2019-12-27 CA CA3125193A patent/CA3125193A1/en active Pending
- 2019-12-27 SG SG11202106534RA patent/SG11202106534RA/en unknown
- 2019-12-27 MX MX2021007939A patent/MX2021007939A/es unknown
- 2019-12-27 US US17/419,203 patent/US12258418B2/en active Active
- 2019-12-27 BR BR112021012608-2A patent/BR112021012608A2/pt unknown
- 2019-12-27 AU AU2019415848A patent/AU2019415848A1/en active Pending
- 2019-12-27 WO PCT/CN2019/129017 patent/WO2020135674A1/en not_active Ceased
-
2021
- 2021-06-27 IL IL284393A patent/IL284393A/en unknown
-
2024
- 2024-06-26 JP JP2024103100A patent/JP7724332B2/ja active Active