JPWO2020095059A5 - - Google Patents
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- Publication number
- JPWO2020095059A5 JPWO2020095059A5 JP2021524452A JP2021524452A JPWO2020095059A5 JP WO2020095059 A5 JPWO2020095059 A5 JP WO2020095059A5 JP 2021524452 A JP2021524452 A JP 2021524452A JP 2021524452 A JP2021524452 A JP 2021524452A JP WO2020095059 A5 JPWO2020095059 A5 JP WO2020095059A5
- Authority
- JP
- Japan
- Prior art keywords
- tissue sample
- population
- hematopoietic tissue
- cells
- lymphocytes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 104
- 230000003394 haemopoietic effect Effects 0.000 claims description 65
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 46
- 210000004698 lymphocyte Anatomy 0.000 claims description 33
- 210000004027 cell Anatomy 0.000 claims description 15
- 238000012258 culturing Methods 0.000 claims description 15
- 102000003812 Interleukin-15 Human genes 0.000 claims description 13
- 108090000172 Interleukin-15 Proteins 0.000 claims description 13
- 108010002350 Interleukin-2 Proteins 0.000 claims description 13
- 102000000588 Interleukin-2 Human genes 0.000 claims description 13
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 claims description 10
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 claims description 10
- 102100027207 CD27 antigen Human genes 0.000 claims description 9
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims description 9
- 238000001574 biopsy Methods 0.000 claims description 9
- 238000007388 punch biopsy Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 230000002496 gastric effect Effects 0.000 claims description 3
- 101001055157 Homo sapiens Interleukin-15 Proteins 0.000 claims description 2
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims description 2
- 102000056003 human IL15 Human genes 0.000 claims description 2
- 210000000822 natural killer cell Anatomy 0.000 claims description 2
- 229910052715 tantalum Inorganic materials 0.000 claims description 2
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 description 4
- 239000002609 medium Substances 0.000 description 2
- 239000012679 serum free medium Substances 0.000 description 2
- 239000000556 agonist Substances 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 210000002536 stromal cell Anatomy 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025064036A JP2025106453A (ja) | 2018-11-08 | 2025-04-09 | 細胞を単離及び拡大する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1818243.6A GB201818243D0 (en) | 2018-11-08 | 2018-11-08 | Methods for isolating and expanding cells |
| GB1818243.6 | 2018-11-08 | ||
| PCT/GB2019/053166 WO2020095059A1 (en) | 2018-11-08 | 2019-11-08 | Methods for isolating and expanding cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025064036A Division JP2025106453A (ja) | 2018-11-08 | 2025-04-09 | 細胞を単離及び拡大する方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022506841A JP2022506841A (ja) | 2022-01-17 |
| JP2022506841A5 JP2022506841A5 (https=) | 2022-11-25 |
| JPWO2020095059A5 true JPWO2020095059A5 (https=) | 2022-11-25 |
| JP7665513B2 JP7665513B2 (ja) | 2025-04-21 |
Family
ID=64739360
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021524452A Active JP7665513B2 (ja) | 2018-11-08 | 2019-11-08 | 細胞を単離及び拡大する方法 |
| JP2025064036A Pending JP2025106453A (ja) | 2018-11-08 | 2025-04-09 | 細胞を単離及び拡大する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025064036A Pending JP2025106453A (ja) | 2018-11-08 | 2025-04-09 | 細胞を単離及び拡大する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US12460180B2 (https=) |
| EP (1) | EP3877510A1 (https=) |
| JP (2) | JP7665513B2 (https=) |
| KR (1) | KR20210111747A (https=) |
| CN (1) | CN113423821A (https=) |
| AU (1) | AU2019374489B2 (https=) |
| BR (1) | BR112021008166A2 (https=) |
| CA (1) | CA3117913A1 (https=) |
| EA (1) | EA202190864A1 (https=) |
| GB (1) | GB201818243D0 (https=) |
| IL (1) | IL282901A (https=) |
| MX (1) | MX2021005480A (https=) |
| PH (1) | PH12021551038A1 (https=) |
| WO (1) | WO2020095059A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
| CA3145523A1 (en) | 2019-08-16 | 2021-02-25 | GammaDelta Therapeutics Limited | Therapeutic uses of anti-tcr delta variable 1 antibodies |
| US20220290101A1 (en) | 2019-08-16 | 2022-09-15 | GammaDelta Therapeutics Limited | Ex vivo gamma delta t cell populations |
| GB202002581D0 (en) | 2020-02-24 | 2020-04-08 | Gammadelta Therapeutics Ltd | Novel antibodies |
| LT4269444T (lt) | 2020-08-14 | 2024-09-25 | GammaDelta Therapeutics Limited | Daugiaspecifiniai anti-tcr kintamos delta 1 antikūnai |
| TW202246338A (zh) | 2021-02-17 | 2022-12-01 | 英商適應生物治療有限公司 | 抗ＴＣＲδ可變1抗體 |
| GB202105113D0 (en) | 2021-04-09 | 2021-05-26 | Gammadelta Therapeutics Ltd | Novel method |
| KR20240040799A (ko) | 2021-08-03 | 2024-03-28 | 감마델타 테라퓨틱스 엘티디 | 감마 델타 t 세포 및 이의 조성물의 조작 |
| WO2023194915A1 (en) | 2022-04-04 | 2023-10-12 | Gammadelta Therapeutics Ltd | Novel gene armoring |
| GB202204926D0 (en) | 2022-04-04 | 2022-05-18 | Gammadelta Therapeutics Ltd | Method for expanding gammadelta T cells |
| WO2025017531A1 (en) * | 2023-07-20 | 2025-01-23 | Takeda Pharmaceutical Company Limited | Grid-free methods for making gamma delta t cells |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6028176A (en) | 1996-07-19 | 2000-02-22 | Bayer Corporation | High-affinity interleukin-4 muteins |
| US7078034B2 (en) | 1999-01-28 | 2006-07-18 | Palmetto Health Alliance | In vitro activated γ δ lymphocytes |
| CN101120083B (zh) | 2003-10-08 | 2013-03-27 | 威尔森沃尔夫制造公司 | 利用透气性材料进行细胞培养的方法及装置 |
| EP1777294A1 (en) | 2005-10-20 | 2007-04-25 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | IL-15Ralpha sushi domain as a selective and potent enhancer of IL-15 action through IL-15Rbeta/gamma, and hyperagonist (IL15Ralpha sushi -IL15) fusion proteins |
| AU2006340750B2 (en) | 2005-11-28 | 2013-03-07 | Zymogenetics, Inc. | IL-21 antagonists |
| JP4659785B2 (ja) * | 2007-06-15 | 2011-03-30 | トヨタ自動車株式会社 | 内燃機関の燃料噴射制御装置 |
| US8529883B2 (en) * | 2010-05-07 | 2013-09-10 | Fibrocell Technologies, Inc. | Dosage unit formulations of autologous dermal fibroblasts |
| US9428567B2 (en) | 2010-12-22 | 2016-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Antagonists of interleukin-2 receptor |
| CN103635573B (zh) | 2011-05-19 | 2016-05-11 | 分子医学研究所 | 包含γδT细胞的淋巴细胞系、其组合物及生产方法 |
| JP2016539929A (ja) | 2013-10-25 | 2016-12-22 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 免疫療法のためのポリクローナルγδＴ細胞 |
| AU2015273501B2 (en) | 2014-06-11 | 2021-01-21 | Polybiocept Gmbh | Expansion of lymphocytes with a cytokine composition for active cellular immunotherapy |
| WO2016081518A2 (en) | 2014-11-17 | 2016-05-26 | Adicet Bio, Inc. | Engineered gamma delta t-cells |
| AU2016274633B2 (en) | 2015-06-09 | 2022-04-21 | Gammadelta Therapeutics Ltd | Methods for the production of TCR gamma delta+ T cells |
| EP4148124A1 (en) * | 2015-10-30 | 2023-03-15 | Cancer Research Technology Limited | Expansion of non-haematopoietic tissue-resident gamma delta t cells and uses of these cells |
| US11401507B2 (en) * | 2016-11-17 | 2022-08-02 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| BR112019013940A2 (pt) | 2017-01-06 | 2020-02-11 | Iovance Biotherapeutics, Inc. | Método de tratar um câncer com uma população de linfócitos infiltrantes de tumor, processo para preparação de uma população de linfócitos infiltrantes de tumor, população de linfócitos infiltrantes de tumor, e, composição farmacêutica. |
| GB201707048D0 (en) | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| WO2018229163A1 (en) | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| KR20210111746A (ko) | 2018-11-08 | 2021-09-13 | 감마델타 테라퓨틱스 리미티드 | 세포를 단리 및 증식하는 방법 |
| GB201818243D0 (en) | 2018-11-08 | 2018-12-26 | Gammadelta Therapeutics Ltd | Methods for isolating and expanding cells |
-
2018
- 2018-11-08 GB GBGB1818243.6A patent/GB201818243D0/en not_active Ceased
-
2019
- 2019-11-08 KR KR1020217013912A patent/KR20210111747A/ko not_active Ceased
- 2019-11-08 JP JP2021524452A patent/JP7665513B2/ja active Active
- 2019-11-08 AU AU2019374489A patent/AU2019374489B2/en active Active
- 2019-11-08 MX MX2021005480A patent/MX2021005480A/es unknown
- 2019-11-08 WO PCT/GB2019/053166 patent/WO2020095059A1/en not_active Ceased
- 2019-11-08 CA CA3117913A patent/CA3117913A1/en active Pending
- 2019-11-08 US US17/292,411 patent/US12460180B2/en active Active
- 2019-11-08 EA EA202190864A patent/EA202190864A1/ru unknown
- 2019-11-08 CN CN201980088258.2A patent/CN113423821A/zh active Pending
- 2019-11-08 EP EP19804793.8A patent/EP3877510A1/en active Pending
- 2019-11-08 BR BR112021008166-6A patent/BR112021008166A2/pt unknown
-
2021
- 2021-05-03 IL IL282901A patent/IL282901A/en unknown
- 2021-05-05 PH PH12021551038A patent/PH12021551038A1/en unknown
-
2025
- 2025-04-09 JP JP2025064036A patent/JP2025106453A/ja active Pending
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