JPWO2020089883A5 - - Google Patents
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- Publication number
- JPWO2020089883A5 JPWO2020089883A5 JP2021523733A JP2021523733A JPWO2020089883A5 JP WO2020089883 A5 JPWO2020089883 A5 JP WO2020089883A5 JP 2021523733 A JP2021523733 A JP 2021523733A JP 2021523733 A JP2021523733 A JP 2021523733A JP WO2020089883 A5 JPWO2020089883 A5 JP WO2020089883A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- glycerol
- group
- less
- temperature values
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 72
- 239000000203 mixture Substances 0.000 claims 39
- 229920002201 Oxidized cellulose Polymers 0.000 claims 34
- 229940107304 oxidized cellulose Drugs 0.000 claims 34
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 230000009969 flowable effect Effects 0.000 claims 5
- 230000000740 bleeding effect Effects 0.000 claims 4
- 230000035515 penetration Effects 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 230000036316 preload Effects 0.000 claims 2
- 239000004627 regenerated cellulose Substances 0.000 claims 2
- 239000000523 sample Substances 0.000 claims 2
- 210000004872 soft tissue Anatomy 0.000 claims 2
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 235000017281 sodium acetate Nutrition 0.000 claims 1
- 239000001632 sodium acetate Substances 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862753981P | 2018-11-01 | 2018-11-01 | |
| US62/753,981 | 2018-11-01 | ||
| IL262716A IL262716A (en) | 2018-11-01 | 2018-11-01 | Oxidized cellulose preparations |
| IL262716 | 2018-11-01 | ||
| PCT/IL2019/000003 WO2020089883A2 (en) | 2018-11-01 | 2019-10-30 | Compositions comprising oxidized cellulose |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022509912A JP2022509912A (ja) | 2022-01-25 |
| JP2022509912A5 JP2022509912A5 (https=) | 2022-10-25 |
| JPWO2020089883A5 true JPWO2020089883A5 (https=) | 2022-10-25 |
| JP7539878B2 JP7539878B2 (ja) | 2024-08-26 |
Family
ID=66624699
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021523733A Active JP7539878B2 (ja) | 2018-11-01 | 2019-10-30 | 酸化セルロースを含む組成物 |
| JP2022567307A Active JP7772381B2 (ja) | 2018-11-01 | 2021-05-03 | 酸化セルロースを含む組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022567307A Active JP7772381B2 (ja) | 2018-11-01 | 2021-05-03 | 酸化セルロースを含む組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20200139021A1 (https=) |
| EP (3) | EP4327840B1 (https=) |
| JP (2) | JP7539878B2 (https=) |
| KR (1) | KR102802704B1 (https=) |
| CN (2) | CN112969481A (https=) |
| AU (1) | AU2019373895B2 (https=) |
| BR (1) | BR112021008297A2 (https=) |
| CA (1) | CA3117353A1 (https=) |
| CO (1) | CO2021005679A2 (https=) |
| ES (1) | ES2967597T3 (https=) |
| IL (1) | IL262716A (https=) |
| MX (1) | MX2021005146A (https=) |
| WO (2) | WO2020089883A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11739166B2 (en) | 2020-07-02 | 2023-08-29 | Davol Inc. | Reactive polysaccharide-based hemostatic agent |
| US12161777B2 (en) | 2020-07-02 | 2024-12-10 | Davol Inc. | Flowable hemostatic suspension |
| EP4267210A1 (en) | 2020-12-28 | 2023-11-01 | Davol Inc. | Reactive dry powdered hemostatic materials comprising a protein and a multifunctionalized modified polyethylene glycol based crosslinking agent |
| US20240099804A1 (en) * | 2021-02-16 | 2024-03-28 | Cornell University | Polysaccharide-glycerol penetration-resistant compositions and surgical barriers made therefrom |
| EP4323027B1 (en) * | 2021-04-14 | 2025-11-12 | Guangzhou Bioseal Biotech Co., Ltd. | Flowable hemostatic paste |
| GB2636872A (en) * | 2023-12-29 | 2025-07-02 | Futamura Chemical Uk Ltd | Composition |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3122479A (en) * | 1957-11-14 | 1964-02-25 | David F Smith | Hemostatic surgical dressings |
| US3364200A (en) | 1960-03-28 | 1968-01-16 | Johnson & Johnson | Oxidized cellulose product and method for preparing the same |
| US4668224A (en) * | 1983-10-24 | 1987-05-26 | Warner-Lambert Company | Oxidized cellulose as a medical lubricant |
| US4626253A (en) | 1984-10-05 | 1986-12-02 | Johnson & Johnson Products, Inc. | Surgical hemostat comprising oxidized cellulose |
| US5007916A (en) | 1985-08-22 | 1991-04-16 | Johnson & Johnson Medical, Inc. | Method and material for prevention of surgical adhesions |
| US5002551A (en) | 1985-08-22 | 1991-03-26 | Johnson & Johnson Medical, Inc. | Method and material for prevention of surgical adhesions |
| US4696812A (en) * | 1985-10-28 | 1987-09-29 | Warner-Lambert Company | Thrombin preparations |
| US5134229A (en) * | 1990-01-12 | 1992-07-28 | Johnson & Johnson Medical, Inc. | Process for preparing a neutralized oxidized cellulose product and its method of use |
| US5180398A (en) | 1990-12-20 | 1993-01-19 | Johnson & Johnson Medical, Inc. | Cellulose oxidation by a perfluorinated hydrocarbon solution of nitrogen dioxide |
| CA2060223C (en) * | 1991-02-12 | 1999-07-20 | Clarence C. Lee | Injectable medical lubricating fluid composition and method of use |
| US5266624A (en) * | 1992-07-20 | 1993-11-30 | Isp Investments Inc. | High load polymer pastes as pharmaceutical adhesives |
| RU2136319C1 (ru) * | 1993-12-23 | 1999-09-10 | Джонсон энд Джонсон Медикал, Инк. | Биоабсорбируемое хирургическое гемостатическое средство и способ его получения (варианты) |
| US5696101A (en) * | 1996-04-16 | 1997-12-09 | Eastman Chemical Company | Oxidized cellulose and vitamin E blend for topical hemostatic applications |
| US20030073663A1 (en) * | 1997-06-25 | 2003-04-17 | David M Wiseman | Bioabsorbable medical devices from oxidized polysaccharides |
| US6627749B1 (en) * | 1999-11-12 | 2003-09-30 | University Of Iowa Research Foundation | Powdered oxidized cellulose |
| AU784607B2 (en) * | 2000-05-12 | 2006-05-11 | Systagenix Wound Management Ip Co. B.V. | Free radical scavenging compositions |
| JP2003024431A (ja) | 2001-07-18 | 2003-01-28 | Kuraray Co Ltd | 癒着防止材およびその製造方法 |
| WO2004080500A1 (en) * | 2003-03-10 | 2004-09-23 | Johnson & Johnson Medical Limited | Hydrocolloid materials for use in wound healing |
| US20040265371A1 (en) | 2003-06-25 | 2004-12-30 | Looney Dwayne Lee | Hemostatic devices and methods of making same |
| NZ545521A (en) * | 2003-09-23 | 2010-02-26 | Orthocon Inc | Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects |
| US7109163B2 (en) | 2004-01-30 | 2006-09-19 | Ethicon, Inc. | Hemostatic compositions and devices |
| WO2006006140A1 (en) | 2004-07-08 | 2006-01-19 | Alltracel Development Services Limited | A delivery system for control bleeding skin wounds |
| CA2645764C (en) * | 2006-03-13 | 2015-11-03 | Xylos Corporation | Oxidized microbial cellulose and use thereof |
| CN104888264B (zh) * | 2008-01-14 | 2018-01-09 | 北京环球利康科技有限公司 | 生物相容性止血、防粘连、促愈合、外科封闭的变性淀粉材料 |
| US9572907B2 (en) | 2010-10-01 | 2017-02-21 | Covidien Lp | Implantable polymeric films |
| US20130084324A1 (en) | 2011-09-30 | 2013-04-04 | Michel Gensini | Adhesion prevention fabric |
| ES2938566T3 (es) | 2011-10-11 | 2023-04-12 | Baxter Int | Composiciones hemostaticas |
| US8815832B2 (en) * | 2012-05-25 | 2014-08-26 | Ethicon, Inc. | Oxidized regenerated cellulose hemostatic powders and methods of making |
| US9447196B2 (en) | 2012-06-28 | 2016-09-20 | Covidien Lp | Dissolution of oxidized cellulose and particle preparation by solvent and non-solvent precipitation |
| JP6489485B2 (ja) * | 2013-12-11 | 2019-03-27 | フェロサン メディカル デバイシーズ エイ/エス | 押し出し増強因子を含んでいる乾燥組成物 |
| KR101588633B1 (ko) * | 2013-12-26 | 2016-01-26 | 주식회사 삼양바이오팜 | 지혈 또는 유착방지용 겔 형성용 조성물 및 키트 |
| TN2017000345A1 (en) | 2015-02-16 | 2019-01-16 | Ihor Volodymyrovych Gaiovych | Hemostatic composition and hemostatic device (variants) |
| US10172617B2 (en) * | 2015-03-25 | 2019-01-08 | Ethicon Llc | Malleable bioabsorbable polymer adhesive for releasably attaching a staple buttress to a surgical stapler |
| KR102576293B1 (ko) | 2015-11-06 | 2023-09-08 | 에디컨인코포레이티드 | 압밀된 지혈 셀룰로오스 집합체 |
| ES2886040T3 (es) | 2015-11-08 | 2021-12-16 | Omrix Biopharmaceuticals Ltd | Mezcla hemostática de fibras cortas y largas a base de celulosa |
| CN105536039A (zh) * | 2015-12-25 | 2016-05-04 | 北京大清生物技术有限公司 | 一种可吸收流体止血材料及其制备方法与应用 |
| WO2018049059A1 (en) * | 2016-09-07 | 2018-03-15 | Blood Brothers, LLC | Hemostatic paste with light-curable feature |
-
2018
- 2018-11-01 IL IL262716A patent/IL262716A/en unknown
-
2019
- 2019-10-30 EP EP23210952.0A patent/EP4327840B1/en active Active
- 2019-10-30 JP JP2021523733A patent/JP7539878B2/ja active Active
- 2019-10-30 AU AU2019373895A patent/AU2019373895B2/en active Active
- 2019-10-30 MX MX2021005146A patent/MX2021005146A/es unknown
- 2019-10-30 US US16/668,691 patent/US20200139021A1/en not_active Abandoned
- 2019-10-30 CN CN201980072743.0A patent/CN112969481A/zh active Pending
- 2019-10-30 BR BR112021008297-2A patent/BR112021008297A2/pt not_active Application Discontinuation
- 2019-10-30 CA CA3117353A patent/CA3117353A1/en active Pending
- 2019-10-30 ES ES19806061T patent/ES2967597T3/es active Active
- 2019-10-30 WO PCT/IL2019/000003 patent/WO2020089883A2/en not_active Ceased
- 2019-10-30 KR KR1020217016577A patent/KR102802704B1/ko active Active
- 2019-10-30 EP EP19806061.8A patent/EP3873548B1/en active Active
-
2020
- 2020-05-05 US US16/866,739 patent/US20200261492A1/en not_active Abandoned
-
2021
- 2021-04-29 CO CONC2021/0005679A patent/CO2021005679A2/es unknown
- 2021-05-03 EP EP21727946.2A patent/EP4146294A1/en active Pending
- 2021-05-03 WO PCT/IL2021/050513 patent/WO2021224919A1/en not_active Ceased
- 2021-05-03 JP JP2022567307A patent/JP7772381B2/ja active Active
- 2021-05-03 CN CN202180033290.8A patent/CN115515654A/zh active Pending
-
2024
- 2024-04-18 US US18/638,964 patent/US20240285834A1/en active Pending
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