US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
US5959177A
(en)
|
1989-10-27 |
1999-09-28 |
The Scripps Research Institute |
Transgenic plants expressing assembled secretory antibodies
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
SG48759A1
(en)
|
1990-01-12 |
2002-07-23 |
Abgenix Inc |
Generation of xenogenic antibodies
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
KR100272077B1
(ko)
|
1990-08-29 |
2000-11-15 |
젠팜인터내셔날,인코포레이티드 |
이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
ATE164395T1
(de)
|
1990-12-03 |
1998-04-15 |
Genentech Inc |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
JP4124480B2
(ja)
|
1991-06-14 |
2008-07-23 |
ジェネンテック・インコーポレーテッド |
免疫グロブリン変異体
|
GB9114948D0
(en)
|
1991-07-11 |
1991-08-28 |
Pfizer Ltd |
Process for preparing sertraline intermediates
|
EP0861893A3
(en)
|
1991-09-19 |
1999-11-10 |
Genentech, Inc. |
High level expression of immunoglobulin polypeptides
|
US5587458A
(en)
|
1991-10-07 |
1996-12-24 |
Aronex Pharmaceuticals, Inc. |
Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
US5766886A
(en)
|
1991-12-13 |
1998-06-16 |
Xoma Corporation |
Modified antibody variable domains
|
US5869619A
(en)
|
1991-12-13 |
1999-02-09 |
Xoma Corporation |
Modified antibody variable domains
|
DE69334255D1
(de)
|
1992-02-06 |
2009-02-12 |
Novartis Vaccines & Diagnostic |
Marker für Krebs und biosynthetisches Bindeprotein dafür
|
US5789199A
(en)
|
1994-11-03 |
1998-08-04 |
Genentech, Inc. |
Process for bacterial production of polypeptides
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US5840523A
(en)
|
1995-03-01 |
1998-11-24 |
Genetech, Inc. |
Methods and compositions for secretion of heterologous polypeptides
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
KR100654645B1
(ko)
|
1995-04-27 |
2007-04-04 |
아브게닉스, 인크. |
면역화된 제노마우스 유래의 인간 항체
|
CA2219486A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
AU7378096A
(en)
|
1995-09-28 |
1997-04-17 |
Alexion Pharmaceuticals, Inc. |
Porcine cell interaction proteins
|
KR20080059467A
(ko)
|
1996-12-03 |
2008-06-27 |
아브게닉스, 인크. |
복수의 vh 및 vk 부위를 함유하는 사람 면역글로불린유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된항체
|
US6133426A
(en)
|
1997-02-21 |
2000-10-17 |
Genentech, Inc. |
Humanized anti-IL-8 monoclonal antibodies
|
US6040498A
(en)
|
1998-08-11 |
2000-03-21 |
North Caroline State University |
Genetically engineered duckweed
|
US6610833B1
(en)
|
1997-11-24 |
2003-08-26 |
The Institute For Human Genetics And Biochemistry |
Monoclonal human natural antibodies
|
BR9813365A
(pt)
|
1997-12-05 |
2004-06-15 |
Scripps Research Inst |
Método para produção e humanização de um anticorpo monoclonal de rato
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
EP1048299A1
(en)
|
1999-04-28 |
2000-11-02 |
Faculteit der Geneeskunde van de Vrije Universiteit |
Method for inhibiting cell functioning for use in anti-inflammatory and anti-tumour therapies
|
KR100797667B1
(ko)
|
1999-10-04 |
2008-01-23 |
메디카고 인코포레이티드 |
외래 유전자의 전사를 조절하는 방법
|
US7125978B1
(en)
|
1999-10-04 |
2006-10-24 |
Medicago Inc. |
Promoter for regulating expression of foreign genes
|
AU1701001A
(en)
|
1999-11-30 |
2001-06-12 |
Eberhard-Karls-Universitat Tubingen Universitatsklinikum |
Antibodies against signal regulator proteins
|
US20020090674A1
(en)
*
|
2000-01-31 |
2002-07-11 |
Rosen Craig A. |
Nucleic acids, proteins, and antibodies
|
DK2857516T3
(en)
|
2000-04-11 |
2017-08-07 |
Genentech Inc |
Multivalent antibodies and uses thereof
|
US7064191B2
(en)
|
2000-10-06 |
2006-06-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Process for purifying antibody
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
KR100857943B1
(ko)
|
2000-11-30 |
2008-09-09 |
메다렉스, 인코포레이티드 |
인간 항체의 제조를 위한 형질전환 트랜스염색체 설치류
|
US7282556B2
(en)
|
2001-05-15 |
2007-10-16 |
Emory University |
Polynucleotides and polypeptides relating to the modulation of SIRPα-CD47
|
KR100988949B1
(ko)
|
2001-10-25 |
2010-10-20 |
제넨테크, 인크. |
당단백질 조성물
|
US20040093621A1
(en)
|
2001-12-25 |
2004-05-13 |
Kyowa Hakko Kogyo Co., Ltd |
Antibody composition which specifically binds to CD20
|
EP1500400A4
(en)
|
2002-04-09 |
2006-10-11 |
Kyowa Hakko Kogyo Kk |
MEDICAMENT WITH ANTIBODY COMPOSITION
|
PL373256A1
(en)
|
2002-04-09 |
2005-08-22 |
Kyowa Hakko Kogyo Co, Ltd. |
Cells with modified genome
|
EP1498490A4
(en)
|
2002-04-09 |
2006-11-29 |
Kyowa Hakko Kogyo Kk |
PROCESS FOR PREPARING ANTIBODY COMPOSITION
|
DE60336548D1
(de)
|
2002-04-09 |
2011-05-12 |
Kyowa Hakko Kirin Co Ltd |
Zelle mit erniedrigter oder deletierter aktivität eines am gdp-fucosetransport beteiligten proteins
|
US20040119010A1
(en)
|
2002-11-01 |
2004-06-24 |
The Regents Of The University Of Colorado |
Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
|
CN1961003B
(zh)
|
2004-03-31 |
2013-03-27 |
健泰科生物技术公司 |
人源化抗TGF-β抗体
|
EA200701211A1
(ru)
|
2004-12-31 |
2007-12-28 |
Дженентек, Инк. |
Полипептиды, которые связываются с br3, и их применение
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
BRPI0708909B8
(pt)
|
2006-03-15 |
2021-05-25 |
Alexion Pharma Inc |
uso de um anticorpo que se liga a c5 para tratar um paciente que sofre de hemoglobinúria paroxística noturna
|
JP2009536527A
(ja)
|
2006-05-09 |
2009-10-15 |
ジェネンテック・インコーポレーテッド |
最適化されたスキャフォールドを備えた結合ポリペプチド
|
EP2471816A1
(en)
|
2006-08-30 |
2012-07-04 |
Genentech, Inc. |
Multispecific antibodies
|
UY30776A1
(es)
|
2006-12-21 |
2008-07-03 |
Medarex Inc |
Anticuerpos cd44
|
CN100592373C
(zh)
|
2007-05-25 |
2010-02-24 |
群康科技(深圳)有限公司 |
液晶显示面板驱动装置及其驱动方法
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
CA2964398C
(en)
|
2007-09-14 |
2023-03-07 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
AU2008310263B2
(en)
|
2007-10-11 |
2014-09-11 |
University Health Network |
Modulation of SIRPALPHA - CD47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor
|
EP2235064B1
(en)
|
2008-01-07 |
2015-11-25 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
CA3054220C
(en)
|
2008-01-15 |
2022-10-11 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for manilpulating phagocytosis mediated by cd47
|
JP2011518313A
(ja)
|
2008-01-15 |
2011-06-23 |
ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ |
急性骨髄性白血病幹細胞のマーカー
|
EP2111869A1
(en)
|
2008-04-23 |
2009-10-28 |
Stichting Sanquin Bloedvoorziening |
Compositions and methods to enhance the immune system
|
FR2945538B1
(fr)
|
2009-05-12 |
2014-12-26 |
Sanofi Aventis |
Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide.
|
CA2983972C
(en)
|
2009-05-15 |
2023-05-02 |
University Health Network |
Compositions and methods for treating hematologic cancers targeting the sirp.alpha.-cd47 interaction
|
DK3336225T3
(da)
|
2010-07-16 |
2020-03-30 |
Adimab Llc |
Antistofbiblioteker
|
WO2012173153A1
(ja)
|
2011-06-15 |
2012-12-20 |
旭硝子株式会社 |
含フッ素共重合体の製造方法
|
LT2748201T
(lt)
|
2011-08-23 |
2018-02-26 |
Roche Glycart Ag |
Dvigubai specifinė t ląsteles aktyvinantį antigeną surišanti molekulė
|
US20140242095A1
(en)
|
2011-10-19 |
2014-08-28 |
University Health Network |
Antibodies and antibody fragments targeting sirp-alpha and their use in treating hematologic cancers
|
US8945214B2
(en)
|
2011-12-19 |
2015-02-03 |
Allergan, Inc. |
Intravitreal applicator
|
AU2013343099A1
(en)
*
|
2012-11-09 |
2015-05-14 |
Pfizer Inc. |
Platelet-derived growth factor B specific antibodies and compositions and uses thereof
|
ES2649165T3
(es)
|
2013-02-05 |
2018-01-10 |
The Board Of Trustees Of The Leland Stanford Junior University |
CD47 terapias dirigidas para el tratamiento de enfermedades infecciosas
|
SG11201506132PA
(en)
|
2013-02-06 |
2015-09-29 |
Inhibrx Llc |
Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof
|
WO2015138600A2
(en)
|
2014-03-11 |
2015-09-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Anti sirp-alpha antibodies and bi-specific macrophage enhancing antibodies
|
KR102419766B1
(ko)
|
2014-05-22 |
2022-07-13 |
비온디스 비.브이. |
항체에 대한 링커 약물의 부위 특이적 접합 및 그 결과로 얻어지는 adc
|
CA3090240A1
(en)
|
2014-08-08 |
2016-02-11 |
Alector Llc |
Anti-trem2 antibodies and methods of use thereof
|
EP3012271A1
(en)
|
2014-10-24 |
2016-04-27 |
Effimune |
Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases
|
WO2016205042A1
(en)
|
2015-06-16 |
2016-12-22 |
The Board Of Trustees Of The Leland Stanford Junior University |
SIRPα AGONIST ANTIBODY
|
US20180312600A1
(en)
|
2015-10-21 |
2018-11-01 |
Ose Immunotherapeutics |
Methods and compositions for modifying macrophage polarization into pro-inflammatory cells to treat cancer
|
EP3442541B1
(en)
|
2016-04-10 |
2021-11-17 |
Georgia State University Research Foundation, Inc. |
Composition for use in treating cancer
|
BR112018070823A2
(pt)
|
2016-04-14 |
2019-02-05 |
Ose Immunotherapeutics |
anticorpo sirpa anti-humano ou fragmento de ligação a antígeno do mesmo ou mimético de anticorpo de ligação a antígeno, composição farmacêutica, produto de combinação, molécula de ácido nucleico isolada, vetor, célula hospedeira isolada, polipeptídeo, métodos para fabricar um anticorpo, in vitro ou ex vivo para determinar células positivas para sirpa, de diagnóstico e para prever a resposta de um sujeito, e, uso de um anticorpo anti-sirpa ou um fragmento de ligação a antígeno do mesmo ou um mimético de ligação a anticorpo e in vitro ou ex vivo de pelo menos um anticorpo sirpa anti-humano ou fragmento de ligação a antígeno do mesmo ou mimético de anticorpo de ligação a antígeno.
|
US11649284B2
(en)
|
2016-04-18 |
2023-05-16 |
Baylor College Of Medicine |
Cancer gene therapy targeting CD47
|
WO2017197495A1
(en)
|
2016-05-19 |
2017-11-23 |
Adaerata, Limited Partnership |
Methods of preventing or treating slamf7 positive and slamf7 negative cancers
|
CA3031034A1
(en)
|
2016-08-03 |
2018-02-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Disrupting fc receptor engagement on macrophages enhances efficacy of anti-sirpalpha antibody therapy
|
JOP20190009A1
(ar)
*
|
2016-09-21 |
2019-01-27 |
Alx Oncology Inc |
أجسام مضادة ضد بروتين ألفا منظم للإشارات وطرق استخدامها
|
JP7173971B2
(ja)
*
|
2016-12-09 |
2022-11-16 |
アレクトル エルエルシー |
抗SIRP-α抗体及びその使用方法
|
CN110650976B
(zh)
|
2017-04-13 |
2024-04-19 |
赛罗帕私人有限公司 |
抗SIRPα抗体
|
CA3063622A1
(en)
|
2017-05-16 |
2018-11-22 |
Synthon Biopharmaceuticals B.V. |
Anti-sirp.alpha. antibodies
|
FI3658141T3
(fi)
|
2017-07-24 |
2023-03-02 |
|
Patologisten tilojen hoitaminen suoralla tai epäsuoralla siralfa-cd47-vuorovaikutukseen kohdentamisella
|
WO2019023347A1
(en)
|
2017-07-26 |
2019-01-31 |
Forty Seven, Inc. |
ANTI-SIRP-ALPHA ANTIBODIES AND ASSOCIATED METHODS
|
EP3765512A1
(en)
|
2018-03-13 |
2021-01-20 |
OSE Immunotherapeutics |
Use of anti-human sirpa v1 antibodies and method for producing anti-sirpa v1 antibodies
|
CR20200566A
(es)
|
2018-05-25 |
2021-02-19 |
Alector Llc |
Anticuerpos anti-sirpa y metodos de utilización de los mismos
|
BR112021005585A2
(pt)
|
2018-09-27 |
2021-06-29 |
Celgene Corporation |
proteínas de ligação a sirpa e métodos de uso das mesmas
|
KR20210093270A
(ko)
|
2018-11-15 |
2021-07-27 |
비온디스 비.브이. |
인간화 항-SIRPα 항체
|
JP2022514698A
(ja)
|
2018-12-21 |
2022-02-14 |
オーエスイー・イミュノセラピューティクス |
二機能性抗pd-1/sirpa分子
|