JPWO2019213489A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019213489A5 JPWO2019213489A5 JP2021510286A JP2021510286A JPWO2019213489A5 JP WO2019213489 A5 JPWO2019213489 A5 JP WO2019213489A5 JP 2021510286 A JP2021510286 A JP 2021510286A JP 2021510286 A JP2021510286 A JP 2021510286A JP WO2019213489 A5 JPWO2019213489 A5 JP WO2019213489A5
- Authority
- JP
- Japan
- Prior art keywords
- dimethylphenol
- catalyst
- concentration
- acetaminophen
- aminophenol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 30
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical compound NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 claims 26
- NKTOLZVEWDHZMU-UHFFFAOYSA-N p-cumyl phenol Natural products CC1=CC=C(C)C(O)=C1 NKTOLZVEWDHZMU-UHFFFAOYSA-N 0.000 claims 22
- 239000003054 catalyst Substances 0.000 claims 16
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 15
- 229960005489 paracetamol Drugs 0.000 claims 15
- 150000003739 xylenols Chemical class 0.000 claims 15
- 238000003556 assay Methods 0.000 claims 14
- 238000004040 coloring Methods 0.000 claims 12
- 239000000243 solution Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- QWBBPBRQALCEIZ-UHFFFAOYSA-N 2,3-dimethylphenol Chemical compound CC1=CC=CC(O)=C1C QWBBPBRQALCEIZ-UHFFFAOYSA-N 0.000 claims 7
- 108010000519 Aryl-acylamidase Proteins 0.000 claims 7
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims 7
- 229960004308 acetylcysteine Drugs 0.000 claims 7
- NXXYKOUNUYWIHA-UHFFFAOYSA-N 2,6-Dimethylphenol Chemical compound CC1=CC=CC(C)=C1O NXXYKOUNUYWIHA-UHFFFAOYSA-N 0.000 claims 6
- 238000005859 coupling reaction Methods 0.000 claims 6
- 238000006460 hydrolysis reaction Methods 0.000 claims 6
- 230000003647 oxidation Effects 0.000 claims 6
- 238000007254 oxidation reaction Methods 0.000 claims 6
- 238000005691 oxidative coupling reaction Methods 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 125000001257 2,5-xylenyl group Chemical group [H]C1=C([H])C(=C(O*)C([H])=C1C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108010024636 Glutathione Proteins 0.000 claims 4
- 238000002835 absorbance Methods 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 239000003755 preservative agent Substances 0.000 claims 4
- 239000003381 stabilizer Substances 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 230000008878 coupling Effects 0.000 claims 3
- 238000010168 coupling process Methods 0.000 claims 3
- 150000004683 dihydrates Chemical class 0.000 claims 3
- 230000003301 hydrolyzing effect Effects 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 239000007800 oxidant agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 229940124272 protein stabilizer Drugs 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- ZLVSYODPTJZFMK-UHFFFAOYSA-M sodium 4-hydroxybenzoate Chemical compound [Na+].OC1=CC=C(C([O-])=O)C=C1 ZLVSYODPTJZFMK-UHFFFAOYSA-M 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 102000001554 Hemoglobins Human genes 0.000 claims 1
- 108010054147 Hemoglobins Proteins 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000008367 deionised water Substances 0.000 claims 1
- 229910021641 deionized water Inorganic materials 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 229940028435 intralipid Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- -1 pH regulators Substances 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862666282P | 2018-05-03 | 2018-05-03 | |
| US62/666,282 | 2018-05-03 | ||
| PCT/US2019/030558 WO2019213489A1 (fr) | 2018-05-03 | 2019-05-03 | Dosage d'acétaminophène |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021523383A JP2021523383A (ja) | 2021-09-02 |
| JPWO2019213489A5 true JPWO2019213489A5 (fr) | 2022-05-11 |
| JP7465257B2 JP7465257B2 (ja) | 2024-04-10 |
Family
ID=68383705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021510286A Active JP7465257B2 (ja) | 2018-05-03 | 2019-05-03 | アセトアミノフェンアッセイ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20190338337A1 (fr) |
| EP (1) | EP3813812A4 (fr) |
| JP (1) | JP7465257B2 (fr) |
| CN (1) | CN112702996A (fr) |
| BR (1) | BR112020022414A2 (fr) |
| CA (1) | CA3099277C (fr) |
| MX (1) | MX2020011631A (fr) |
| WO (1) | WO2019213489A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102018100426A1 (de) * | 2018-01-10 | 2019-07-11 | Diasys Diagnostic Systems Gmbh | Quantitative Acetaminophen-Analytik |
| CN112255395B (zh) * | 2020-12-23 | 2021-06-18 | 中生北控生物科技股份有限公司 | 一种消除脂血样本中乳糜干扰的方法和免疫浊度法试剂盒及应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US415929A (en) * | 1889-11-26 | Richard walsh | ||
| US4154929A (en) * | 1976-08-16 | 1979-05-15 | American Monitor Corporation | 9-(2-Pyridyl)-acenaphtho[1,2-e]-as-triazines |
| US4224034A (en) * | 1978-09-07 | 1980-09-23 | American Monitor Corporation | Assay of iron and iron binding protein reagents and methods |
| US5151370A (en) * | 1990-10-11 | 1992-09-29 | Synermed, Inc. | Reagent and method for serum iron assay |
| CA2178048C (fr) * | 1995-06-22 | 2009-08-11 | Thomas C. Arter | Element analytique sec pour la detection de l'acetaminophene |
| JP4345956B2 (ja) * | 2003-01-15 | 2009-10-14 | 国立大学法人 宮崎大学 | 農園芸用抗菌溶液およびその製造方法 |
| BRPI0911578B8 (pt) * | 2008-04-28 | 2021-07-27 | Genzyme Corp | método e conjunto para determinação da concentração de acetaminofeno em uma amostra |
-
2019
- 2019-05-03 MX MX2020011631A patent/MX2020011631A/es unknown
- 2019-05-03 WO PCT/US2019/030558 patent/WO2019213489A1/fr unknown
- 2019-05-03 EP EP19797109.6A patent/EP3813812A4/fr active Pending
- 2019-05-03 BR BR112020022414-6A patent/BR112020022414A2/pt unknown
- 2019-05-03 US US16/402,547 patent/US20190338337A1/en active Pending
- 2019-05-03 JP JP2021510286A patent/JP7465257B2/ja active Active
- 2019-05-03 CN CN201980044477.0A patent/CN112702996A/zh active Pending
- 2019-05-03 CA CA3099277A patent/CA3099277C/fr active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Barham et al. | An improved colour reagent for the determination of blood glucose by the oxidase system | |
| EP0823943B1 (fr) | Determination de la presence de proteines glycosylees | |
| ES2263476T3 (es) | Procedimiento de pretratamiento de una muestra para cuantificar el colesterol y procedimiento para cuantificar el colesterol en lipoproteinas especificas usando dicho procedimiento. | |
| JP2011521622A5 (fr) | ||
| WO2012085497A1 (fr) | Méthode de dosage | |
| JPWO2019213489A5 (fr) | ||
| JPS62220199A (ja) | 体液の試料中の総−ビリルビンの測定のための方法および試薬 | |
| JPH0372280B2 (fr) | ||
| JPH07155196A (ja) | 生体成分の測定法 | |
| JP4217815B2 (ja) | グルコースデヒドロゲナーゼによるグルコースの定量方法およびグルコース定量用試薬 | |
| JPH03187400A (ja) | ビリルビンの光学的測定法および測定用試薬 | |
| JP2880209B2 (ja) | 総ビリルビンの定量法及びそれに用いる試薬 | |
| JP4220765B2 (ja) | Ｄ−アミノ酸オキシダーゼの安定化方法 | |
| JP3727392B2 (ja) | 抱合ビリルビン測定試薬 | |
| JP3428073B2 (ja) | １，５−アンヒドログルシトールの定量法 | |
| JP2001116756A (ja) | 液状試薬および保存方法 | |
| JPH0772157A (ja) | 糖化蛋白の定量方法およびその定量用キット | |
| JPH0225752A (ja) | 血清中の鉄を定量する方法および複合試薬 | |
| JP3227486B2 (ja) | 銅の測定方法 | |
| JPH052942B2 (fr) | ||
| JPH0244396B2 (ja) | Birirubinteiryoho | |
| JP2823901B2 (ja) | セルロプラスミン活性の測定法 | |
| WO2018221446A1 (fr) | Procédé de mesure de l'hémoglobine glyquée | |
| Aguilera‐Tejero et al. | Quantification of plasma bile acids in the dog with a direct spectrophotometric method | |
| Uete et al. | A fluorometric assay of the acetylcholinesterase activity in blood |