JPWO2019150346A5 - - Google Patents
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- Publication number
- JPWO2019150346A5 JPWO2019150346A5 JP2020563841A JP2020563841A JPWO2019150346A5 JP WO2019150346 A5 JPWO2019150346 A5 JP WO2019150346A5 JP 2020563841 A JP2020563841 A JP 2020563841A JP 2020563841 A JP2020563841 A JP 2020563841A JP WO2019150346 A5 JPWO2019150346 A5 JP WO2019150346A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- acid molecule
- functional nucleic
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004707 nucleic acids Proteins 0.000 description 35
- 102000039446 nucleic acids Human genes 0.000 description 35
- 150000007523 nucleic acids Chemical class 0.000 description 35
- 230000001105 regulatory effect Effects 0.000 description 20
- 239000002773 nucleotide Substances 0.000 description 12
- 125000003729 nucleotide group Chemical group 0.000 description 12
- 230000000295 complement effect Effects 0.000 description 8
- 108020004999 messenger RNA Proteins 0.000 description 8
- 230000014616 translation Effects 0.000 description 8
- 108020004394 Complementary RNA Proteins 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 239000003184 complementary RNA Substances 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000002411 | 2018-02-05 | ||
| IT201800002411A IT201800002411A1 (it) | 2018-02-05 | 2018-02-05 | Domini strutturali di molecole di rna antisenso che aumentano la traduzione |
| PCT/IB2019/050914 WO2019150346A1 (en) | 2018-02-05 | 2019-02-05 | Structural domains of antisense rna molecules up-regulating translation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021512646A JP2021512646A (ja) | 2021-05-20 |
| JP2021512646A5 JP2021512646A5 (https=) | 2022-02-14 |
| JPWO2019150346A5 true JPWO2019150346A5 (https=) | 2022-02-14 |
Family
ID=62044899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020563841A Pending JP2021512646A (ja) | 2018-02-05 | 2019-02-05 | 翻訳を上方調節するアンチセンスｒｎａ分子の構造ドメイン |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US12134768B2 (https=) |
| EP (1) | EP3749772A1 (https=) |
| JP (1) | JP2021512646A (https=) |
| KR (1) | KR20210005548A (https=) |
| CN (1) | CN112236524A (https=) |
| CA (1) | CA3090347A1 (https=) |
| IT (1) | IT201800002411A1 (https=) |
| WO (1) | WO2019150346A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116322791A (zh) | 2020-09-24 | 2023-06-23 | 意大利技术基金会 | 经修饰的功能性核酸分子 |
| CA3196633A1 (en) * | 2020-10-08 | 2022-04-14 | Scuola Internazionale Superiore Di Studi Avanzati | Functional nucleic acid molecules |
| EP3992289A1 (en) | 2020-10-30 | 2022-05-04 | Transine Therapeutics Limited | Functional nucleic acid molecules incorporating protein binding domain |
| EP4063505A1 (en) | 2021-03-22 | 2022-09-28 | Fondazione Istituto Italiano di Tecnologia | Functional nucleic acid molecules directed to targets for nervous system disorders |
| WO2022214635A1 (en) | 2021-04-08 | 2022-10-13 | Stichting Vu | Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders |
| GB202205423D0 (en) | 2022-04-12 | 2022-05-25 | Transine Therapeutics Ltd | Functional nucleic acid molecule |
| GB202207796D0 (en) | 2022-05-26 | 2022-07-13 | Fondazione St Italiano Tecnologia | Functional nucleic acid molecule |
| GB202207795D0 (en) * | 2022-05-26 | 2022-07-13 | Fondazione St Italiano Tecnologia | Functional nucleic acid molecule |
| CN115054612B (zh) * | 2022-06-15 | 2023-07-21 | 北京航空航天大学 | 一种可用于促进骨形成的增强子及其应用 |
| CN119040324B (zh) * | 2024-08-30 | 2025-06-24 | 广州国家实验室 | 一种tns1基因增强子及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3792359A1 (en) * | 2011-03-30 | 2021-03-17 | Transine Therapeutics Limited | Functional nucleic acid molecule and use thereof |
| CN102586237B (zh) * | 2012-02-17 | 2017-12-22 | 北京大学 | 一种多聚核酸分子及其应用 |
| CN105624156B (zh) * | 2014-11-04 | 2021-07-16 | 清华大学 | 含有反向sineb2重复序列的人工非编码rna及其在增强靶蛋白翻译中的用途 |
-
2018
- 2018-02-05 IT IT201800002411A patent/IT201800002411A1/it unknown
-
2019
- 2019-02-05 CA CA3090347A patent/CA3090347A1/en active Pending
- 2019-02-05 CN CN201980023671.0A patent/CN112236524A/zh not_active Withdrawn
- 2019-02-05 JP JP2020563841A patent/JP2021512646A/ja active Pending
- 2019-02-05 US US16/967,254 patent/US12134768B2/en active Active
- 2019-02-05 KR KR1020207025572A patent/KR20210005548A/ko not_active Withdrawn
- 2019-02-05 EP EP19708167.2A patent/EP3749772A1/en active Pending
- 2019-02-05 WO PCT/IB2019/050914 patent/WO2019150346A1/en not_active Ceased
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