JP2021512646A - 翻訳を上方調節するアンチセンスｒｎａ分子の構造ドメイン - Google Patents

翻訳を上方調節するアンチセンスｒｎａ分子の構造ドメイン Download PDF

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JP2021512646A
JP2021512646A JP2020563841A JP2020563841A JP2021512646A JP 2021512646 A JP2021512646 A JP 2021512646A JP 2020563841 A JP2020563841 A JP 2020563841A JP 2020563841 A JP2020563841 A JP 2020563841A JP 2021512646 A JP2021512646 A JP 2021512646A
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seq
sequence
nucleic acid
acid molecule
functional nucleic
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JPWO2019150346A5 (https=
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グスティンシチ ステファノ
グスティンシチ ステファノ
ズッチェルリ シルビア
ズッチェルリ シルビア
ポドベブセク ピーター
ポドベブセク ピーター
プラヴェク ジャネズ
プラヴェク ジャネズ
カルニンチ ピエロ
カルニンチ ピエロ
葉月 高橋
葉月 高橋
俊夫 山崎
俊夫 山崎
貴子 大山
貴子 大山
シャルマ ハルシタ
シャルマ ハルシタ
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スクオラ インターナジオナレ スペリオレ ディ ステュディ アバンザティ‐シッサ
スクオラ インターナジオナレ スペリオレ ディ ステュディ アバンザティ‐シッサ
トランシネ セラピューティクス リミテッド
トランシネ セラピューティクス リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/532—Closed or circular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids

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  • Wood Science & Technology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
JP2020563841A 2018-02-05 2019-02-05 翻訳を上方調節するアンチセンスｒｎａ分子の構造ドメイン Pending JP2021512646A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT102018000002411 2018-02-05
IT201800002411A IT201800002411A1 (it) 2018-02-05 2018-02-05 Domini strutturali di molecole di rna antisenso che aumentano la traduzione
PCT/IB2019/050914 WO2019150346A1 (en) 2018-02-05 2019-02-05 Structural domains of antisense rna molecules up-regulating translation

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JP2021512646A true JP2021512646A (ja) 2021-05-20
JP2021512646A5 JP2021512646A5 (https=) 2022-02-14
JPWO2019150346A5 JPWO2019150346A5 (https=) 2022-02-14

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US (1) US12134768B2 (https=)
EP (1) EP3749772A1 (https=)
JP (1) JP2021512646A (https=)
KR (1) KR20210005548A (https=)
CN (1) CN112236524A (https=)
CA (1) CA3090347A1 (https=)
IT (1) IT201800002411A1 (https=)
WO (1) WO2019150346A1 (https=)

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CN116322791A (zh) 2020-09-24 2023-06-23 意大利技术基金会 经修饰的功能性核酸分子
CA3196633A1 (en) * 2020-10-08 2022-04-14 Scuola Internazionale Superiore Di Studi Avanzati Functional nucleic acid molecules
EP3992289A1 (en) 2020-10-30 2022-05-04 Transine Therapeutics Limited Functional nucleic acid molecules incorporating protein binding domain
EP4063505A1 (en) 2021-03-22 2022-09-28 Fondazione Istituto Italiano di Tecnologia Functional nucleic acid molecules directed to targets for nervous system disorders
WO2022214635A1 (en) 2021-04-08 2022-10-13 Stichting Vu Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders
GB202205423D0 (en) 2022-04-12 2022-05-25 Transine Therapeutics Ltd Functional nucleic acid molecule
GB202207796D0 (en) 2022-05-26 2022-07-13 Fondazione St Italiano Tecnologia Functional nucleic acid molecule
GB202207795D0 (en) * 2022-05-26 2022-07-13 Fondazione St Italiano Tecnologia Functional nucleic acid molecule
CN115054612B (zh) * 2022-06-15 2023-07-21 北京航空航天大学 一种可用于促进骨形成的增强子及其应用
CN119040324B (zh) * 2024-08-30 2025-06-24 广州国家实验室 一种tns1基因增强子及其应用

Citations (1)

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Publication number Priority date Publication date Assignee Title
JP2014514921A (ja) * 2011-03-30 2014-06-26 独立行政法人理化学研究所 機能性核酸分子、及びその利用

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CN102586237B (zh) * 2012-02-17 2017-12-22 北京大学 一种多聚核酸分子及其应用
CN105624156B (zh) * 2014-11-04 2021-07-16 清华大学 含有反向sineb2重复序列的人工非编码rna及其在增强靶蛋白翻译中的用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014514921A (ja) * 2011-03-30 2014-06-26 独立行政法人理化学研究所 機能性核酸分子、及びその利用

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US12134768B2 (en) 2024-11-05
CA3090347A1 (en) 2019-08-08
KR20210005548A (ko) 2021-01-14
IT201800002411A1 (it) 2019-08-05
CN112236524A (zh) 2021-01-15
EP3749772A1 (en) 2020-12-16
US20210139898A1 (en) 2021-05-13
WO2019150346A1 (en) 2019-08-08

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