KR20210005548A - 번역을 상향-조절하는 안티센스 rna 분자의 구조 도메인 - Google Patents

번역을 상향-조절하는 안티센스 rna 분자의 구조 도메인 Download PDF

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KR20210005548A
KR20210005548A KR1020207025572A KR20207025572A KR20210005548A KR 20210005548 A KR20210005548 A KR 20210005548A KR 1020207025572 A KR1020207025572 A KR 1020207025572A KR 20207025572 A KR20207025572 A KR 20207025572A KR 20210005548 A KR20210005548 A KR 20210005548A
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seq
sequence
sineup
rna
motif
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스테파노 구스틴치크
실비아 추켈리
페테르 포드베브세크
자네즈 플라베크
피에로 카르닌치
하즈키 다카하시
도시오 야마자키
다카코 오야마
하르시타 샤르마
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스쿠오라 인타나찌오나레 수페리오레 디 스투디 아반짜티-에스.아이.에스.에스.에이
트랜사인 테라퓨틱스 리미티드
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/532—Closed or circular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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KR1020207025572A 2018-02-05 2019-02-05 번역을 상향-조절하는 안티센스 rna 분자의 구조 도메인 Withdrawn KR20210005548A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT102018000002411 2018-02-05
IT201800002411A IT201800002411A1 (it) 2018-02-05 2018-02-05 Domini strutturali di molecole di rna antisenso che aumentano la traduzione
PCT/IB2019/050914 WO2019150346A1 (en) 2018-02-05 2019-02-05 Structural domains of antisense rna molecules up-regulating translation

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KR20210005548A true KR20210005548A (ko) 2021-01-14

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KR1020207025572A Withdrawn KR20210005548A (ko) 2018-02-05 2019-02-05 번역을 상향-조절하는 안티센스 rna 분자의 구조 도메인

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Country Link
US (1) US12134768B2 (https=)
EP (1) EP3749772A1 (https=)
JP (1) JP2021512646A (https=)
KR (1) KR20210005548A (https=)
CN (1) CN112236524A (https=)
CA (1) CA3090347A1 (https=)
IT (1) IT201800002411A1 (https=)
WO (1) WO2019150346A1 (https=)

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CN116322791A (zh) 2020-09-24 2023-06-23 意大利技术基金会 经修饰的功能性核酸分子
CA3196633A1 (en) * 2020-10-08 2022-04-14 Scuola Internazionale Superiore Di Studi Avanzati Functional nucleic acid molecules
EP3992289A1 (en) 2020-10-30 2022-05-04 Transine Therapeutics Limited Functional nucleic acid molecules incorporating protein binding domain
EP4063505A1 (en) 2021-03-22 2022-09-28 Fondazione Istituto Italiano di Tecnologia Functional nucleic acid molecules directed to targets for nervous system disorders
WO2022214635A1 (en) 2021-04-08 2022-10-13 Stichting Vu Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders
GB202205423D0 (en) 2022-04-12 2022-05-25 Transine Therapeutics Ltd Functional nucleic acid molecule
GB202207796D0 (en) 2022-05-26 2022-07-13 Fondazione St Italiano Tecnologia Functional nucleic acid molecule
GB202207795D0 (en) * 2022-05-26 2022-07-13 Fondazione St Italiano Tecnologia Functional nucleic acid molecule
CN115054612B (zh) * 2022-06-15 2023-07-21 北京航空航天大学 一种可用于促进骨形成的增强子及其应用
CN119040324B (zh) * 2024-08-30 2025-06-24 广州国家实验室 一种tns1基因增强子及其应用

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* Cited by examiner, † Cited by third party
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EP3792359A1 (en) * 2011-03-30 2021-03-17 Transine Therapeutics Limited Functional nucleic acid molecule and use thereof
CN102586237B (zh) * 2012-02-17 2017-12-22 北京大学 一种多聚核酸分子及其应用
CN105624156B (zh) * 2014-11-04 2021-07-16 清华大学 含有反向sineb2重复序列的人工非编码rna及其在增强靶蛋白翻译中的用途

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US12134768B2 (en) 2024-11-05
CA3090347A1 (en) 2019-08-08
IT201800002411A1 (it) 2019-08-05
CN112236524A (zh) 2021-01-15
JP2021512646A (ja) 2021-05-20
EP3749772A1 (en) 2020-12-16
US20210139898A1 (en) 2021-05-13
WO2019150346A1 (en) 2019-08-08

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