CN112236524A - 上调翻译的反义rna分子的结构域 - Google Patents

上调翻译的反义rna分子的结构域 Download PDF

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Publication number
CN112236524A
CN112236524A CN201980023671.0A CN201980023671A CN112236524A CN 112236524 A CN112236524 A CN 112236524A CN 201980023671 A CN201980023671 A CN 201980023671A CN 112236524 A CN112236524 A CN 112236524A
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seq
sequence
motif
nucleic acid
acid molecule
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CN201980023671.0A
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Chinese (zh)
Inventor
S·古斯丁奇
S·祖切利
P·波德韦塞克
J·普拉韦茨
P·卡尼奇
高桥绮月
山崎俊夫
大山高子
H·夏尔马
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Transnet Therapeutics Ltd
International Institute Of Advanced Studies
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Transnet Therapeutics Ltd
International Institute Of Advanced Studies
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Publication of CN112236524A publication Critical patent/CN112236524A/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/532—Closed or circular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids

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  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN201980023671.0A 2018-02-05 2019-02-05 上调翻译的反义rna分子的结构域 Withdrawn CN112236524A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT102018000002411 2018-02-05
IT201800002411A IT201800002411A1 (it) 2018-02-05 2018-02-05 Domini strutturali di molecole di rna antisenso che aumentano la traduzione
PCT/IB2019/050914 WO2019150346A1 (en) 2018-02-05 2019-02-05 Structural domains of antisense rna molecules up-regulating translation

Publications (1)

Publication Number Publication Date
CN112236524A true CN112236524A (zh) 2021-01-15

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CN201980023671.0A Withdrawn CN112236524A (zh) 2018-02-05 2019-02-05 上调翻译的反义rna分子的结构域

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US (1) US12134768B2 (https=)
EP (1) EP3749772A1 (https=)
JP (1) JP2021512646A (https=)
KR (1) KR20210005548A (https=)
CN (1) CN112236524A (https=)
CA (1) CA3090347A1 (https=)
IT (1) IT201800002411A1 (https=)
WO (1) WO2019150346A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115054612A (zh) * 2022-06-15 2022-09-16 北京航空航天大学 一种可用于促进骨形成的增强子及其应用
CN119040324A (zh) * 2024-08-30 2024-11-29 广州国家实验室 一种tns1基因增强子及其应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116322791A (zh) 2020-09-24 2023-06-23 意大利技术基金会 经修饰的功能性核酸分子
CA3196633A1 (en) * 2020-10-08 2022-04-14 Scuola Internazionale Superiore Di Studi Avanzati Functional nucleic acid molecules
EP3992289A1 (en) 2020-10-30 2022-05-04 Transine Therapeutics Limited Functional nucleic acid molecules incorporating protein binding domain
EP4063505A1 (en) 2021-03-22 2022-09-28 Fondazione Istituto Italiano di Tecnologia Functional nucleic acid molecules directed to targets for nervous system disorders
WO2022214635A1 (en) 2021-04-08 2022-10-13 Stichting Vu Nucleic acid molecules for compensation of stxbp1 haploinsufficiency and their use in the treatment of stxbp1-related disorders
GB202205423D0 (en) 2022-04-12 2022-05-25 Transine Therapeutics Ltd Functional nucleic acid molecule
GB202207796D0 (en) 2022-05-26 2022-07-13 Fondazione St Italiano Tecnologia Functional nucleic acid molecule
GB202207795D0 (en) * 2022-05-26 2022-07-13 Fondazione St Italiano Tecnologia Functional nucleic acid molecule

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102586237A (zh) * 2012-02-17 2012-07-18 北京大学 一种多聚核酸分子及其应用
US20140107187A1 (en) * 2011-03-30 2014-04-17 International School For Advanced Studies Functional nucleic acid molecule and use thereof
WO2016070853A1 (zh) * 2014-11-04 2016-05-12 清华大学 含有反向sineb2重复序列的人工非编码rna及其在增强靶蛋白翻译中的用途

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140107187A1 (en) * 2011-03-30 2014-04-17 International School For Advanced Studies Functional nucleic acid molecule and use thereof
CN102586237A (zh) * 2012-02-17 2012-07-18 北京大学 一种多聚核酸分子及其应用
WO2016070853A1 (zh) * 2014-11-04 2016-05-12 清华大学 含有反向sineb2重复序列的人工非编码rna及其在增强靶蛋白翻译中的用途
CN105624156A (zh) * 2014-11-04 2016-06-01 清华大学 含有反向sineb2重复序列的人工非编码rna及其在增强靶蛋白翻译中的用途

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CLAUDIA CARRIERI等: "Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat", LETTER, pages 1 - 6 *
JANICE M. DEMOOR等: "Antisense Nucleic Acids Targeted to the Thymidylate Synthase (TS) mRNA Translation Start Site Stimulate TS Gene Transcription", EXPERIMENTAL CELL RESEARCH, pages 11 - 21 *
PETER PODBEVŠEK等: "Structural determinants of the SINE B2 element embedded in the long non-coding RNA activator of translation AS Uchl1", SCIENTIFIC REPORTS, pages 1 - 13 *
SILVIA ZUCCHELLI等: "SINEUPs are modular antisense long non-coding RNAs that increase synthesis of target proteins in cells", FRONTIERS IN CELLULAR NEUROSCIENCE, pages 6 - 8 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115054612A (zh) * 2022-06-15 2022-09-16 北京航空航天大学 一种可用于促进骨形成的增强子及其应用
CN115054612B (zh) * 2022-06-15 2023-07-21 北京航空航天大学 一种可用于促进骨形成的增强子及其应用
CN119040324A (zh) * 2024-08-30 2024-11-29 广州国家实验室 一种tns1基因增强子及其应用

Also Published As

Publication number Publication date
US12134768B2 (en) 2024-11-05
CA3090347A1 (en) 2019-08-08
KR20210005548A (ko) 2021-01-14
IT201800002411A1 (it) 2019-08-05
JP2021512646A (ja) 2021-05-20
EP3749772A1 (en) 2020-12-16
US20210139898A1 (en) 2021-05-13
WO2019150346A1 (en) 2019-08-08

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