JPWO2019138739A1 - ゲル状組成物およびその製造方法 - Google Patents
ゲル状組成物およびその製造方法 Download PDFInfo
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- JPWO2019138739A1 JPWO2019138739A1 JP2019564339A JP2019564339A JPWO2019138739A1 JP WO2019138739 A1 JPWO2019138739 A1 JP WO2019138739A1 JP 2019564339 A JP2019564339 A JP 2019564339A JP 2019564339 A JP2019564339 A JP 2019564339A JP WO2019138739 A1 JPWO2019138739 A1 JP WO2019138739A1
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- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 1
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- 229940093471 ethyl oleate Drugs 0.000 description 1
- GJQLBGWSDGMZKM-UHFFFAOYSA-N ethylhexyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(CC)CCCCC GJQLBGWSDGMZKM-UHFFFAOYSA-N 0.000 description 1
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- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
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- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
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- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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- 239000002453 shampoo Substances 0.000 description 1
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- 229920002545 silicone oil Polymers 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 230000000087 stabilizing effect Effects 0.000 description 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
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- 230000008719 thickening Effects 0.000 description 1
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Classifications
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Abstract
Description
以下、本発明を示す。
前記アルカリ性物質が、水酸基を含有するアミン化合物、アルカリ金属の水酸化物、塩基性アミノ酸から選ばれる1種以上であり、かつ
前記油性成分の濃度が50質量%以上、99質量%以下であることを特徴とするゲル状組成物。
前記ゲル状組成物が、バイオサーファクタント、水、アルカリ性物質、多価アルコール、および油性成分を含み、
前記アルカリ性物質が、水酸基を含有するアミン化合物、アルカリ金属の水酸化物、塩基性アミノ酸から選ばれる1種以上であり、かつ、
前記油性成分の濃度が50質量%以上、99質量%以下であり、
前記バイオサーファクタントおよび前記アルカリ性物質を、前記水の全量または一部に溶解して第一溶液を得る工程、
前記第一溶液に多価アルコールを混合して第二溶液を得る工程、および、
前記第二溶液に、前記油性成分、または前記水の残部および前記油性成分を添加する工程を含むことを特徴とする方法。
(A)サーファクチンナトリウム 0.67質量%
(B)トリエタノールアミン 0.0167質量%
(C)グリセリン 5質量%
(D)スクアラン 91.67質量%
(E)精製水 2.6433質量%
実施例1において(B)成分の量を0.067質量%、(E)成分の量を2.593質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりにジエタノールアミンを0.01質量%、(E)成分の量を2.65質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりにモノエタノールアミンを0.0033質量%、(E)成分の量を2.6567質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりにジイソプロパノールアミンを0.0083質量%、(E)成分の量を2.6517質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりにトリイソプロパノールアミンを0.0167質量%、(E)成分の量を2.6433質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりに2−アミノ−2−メチルプロパンジオールを0.0067質量%、(E)成分の量を2.6533質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりに2−アミノ−2―エチル−1,3−プロパンジオールを0.0067質量%、(E)成分の量を2.6533質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりに2−アミノ−2−ヒドロキシメチル−1,3−プロパンジオールを0.01質量%、(E)成分の量を2.65質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりにDL−1−アミノ−2−プロパノールを0.0067質量%、(E)成分の量を2.6533質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりにKOHを0.0033質量%、(E)成分の量を2.6567質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりにリシンを0.0267質量%、(E)成分の量を2.6333質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりにリシンを0.033質量%、(E)成分の量を2.627質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(B)成分としてトリエタノールアミンの代わりにヒスチジンを0.1167質量%、(E)成分の量を2.5433質量%とした以外は同様の方法によりゲル状組成物を調製した。
(A)サーファクチンナトリウム 0.67質量%
(C)グリセリン 5質量%
(D)スクアラン 91.67質量%
(E)精製水 2.66質量%
実施例1において(C)成分としてグリセリンの代わりにリン酸水素2ナトリウムを0.033質量%、(E)成分の量を2.627質量%とした以外は同様の方法によりゲル状組成物を調製した。
実施例1において(C)成分としてグリセリンの代わりにリン酸水素2ナトリウムを0.33質量%、(E)成分の量を2.33質量%とした以外は同様の方法によりゲル状組成物を調製した。
上記実施例1〜16、比較例1〜3のゲル状組成物を50℃にて最大20週間静置した後、以下の基準に基づいて外観を評価した。結果を表1、表2に示す。
良: 分離なしでゲル状組成物が維持
悪: 油が離奨してゲル状組成物が分離
Claims (14)
- バイオサーファクタント、水および/又は多価アルコール、油性成分、アルカリ性物質を含み、
前記アルカリ性物質が、水酸基を含有するアミン化合物、アルカリ金属の水酸化物、塩基性アミノ酸から選ばれる1種以上であり、かつ
前記油性成分の濃度が50質量%以上、99質量%以下であることを特徴とするゲル状組成物。 - 前記水酸基を有するアミン化合物が、トリエタノールアミン、ジエタノールアミン、モノエタノールアミン、ジイソプロパノールアミン、トリイソプロパノールアミン、2−アミノ−2−メチルプロパノール、2−アミノ−2−メチルプロパンジオール、2−アミノ−2−エチル−1,3−プロパンジオール、2−アミノ−2−ヒドロキシメチル−1,3−プロパンジオール、DL−1−アミノ−2−プロパノールから選ばれる1種以上である請求項1に記載のゲル状組成物。
- 上記アルカリ金属の水酸化物が、NaOH、KOHから選ばれる1種以上である請求項1または2に記載のゲル状組成物。
- 前記バイオサーファクタントがサーファクチン、アルスロファクチン、イチュリン、およびそれらの塩の群から選ばれる1種以上である請求項1〜3のいずれかに記載のゲル状組成物。
- 前記多価アルコールがグリセリン、ソルビトール、キシリトール、ジグリセリン、ポリエチレングリコールのいずれか1種以上である請求項1〜4のいずれかに記載のゲル状組成物。
- 前記ゲル状組成物のpHが7.0以上、11.0以下である請求項1〜5のいずれかに記載のゲル状組成物。
- 請求項1〜6のいずれかに記載のゲル状組成物を含む皮膚用外用剤。
- 請求項1〜6のいずれかに記載のゲル状組成物を含む化粧料。
- ゲル状組成物を製造するための方法であって、
前記ゲル状組成物が、バイオサーファクタント、水、アルカリ性物質、多価アルコール、および油性成分を含み、
前記アルカリ性物質が、水酸基を含有するアミン化合物、アルカリ金属の水酸化物、塩基性アミノ酸から選ばれる1種以上であり、かつ、
前記油性成分の濃度が50質量%以上、99質量%以下であり、
前記バイオサーファクタントおよび前記アルカリ性物質を、前記水の全量または一部に溶解して第一溶液を得る工程、
前記第一溶液に多価アルコールを混合して第二溶液を得る工程、および、
前記第二溶液に、前記油性成分、または前記水の残部および前記油性成分を添加する工程を含むことを特徴とする方法。 - 前記水酸基を有するアミン化合物が、トリエタノールアミン、ジエタノールアミン、モノエタノールアミン、ジイソプロパノールアミン、トリイソプロパノールアミン、2−アミノ−2−メチルプロパノール、2−アミノ−2−メチルプロパンジオール、2−アミノ−2−エチル−1,3−プロパンジオール、2−アミノ−2−ヒドロキシメチル−1,3−プロパンジオール、DL−1−アミノ−2−プロパノールから選ばれる1種以上である請求項9に記載の方法。
- 上記アルカリ金属の水酸化物が、NaOH、KOHから選ばれる1種以上である請求項9または10に記載の方法。
- 前記バイオサーファクタントがサーファクチン塩、アルスロファクチン塩、およびイチュリン塩から選ばれる1種以上である請求項9〜11のいずれかに記載の方法。
- 前記多価アルコールがグリセリン、ソルビトール、キシリトール、ジグリセリン、およびポリエチレングリコールから選ばれる1種以上である請求項9〜12のいずれかに記載の方法。
- 前記ゲル状組成物のpHが7.0以上、11.0以下である請求項9〜13のいずれかに記載の方法。
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JPS6230546A (ja) * | 1985-07-31 | 1987-02-09 | Agency Of Ind Science & Technol | 多塩基酸型バイオサ−フアクタント系乳化組成物 |
JP2000087006A (ja) * | 1998-09-14 | 2000-03-28 | Agency Of Ind Science & Technol | ゲル化剤 |
JP2003176211A (ja) * | 2001-08-10 | 2003-06-24 | Showa Denko Kk | 油性増粘ゲル状組成物、該組成物を用いた乳化組成物及びその調製法 |
JP2003212750A (ja) * | 2002-01-23 | 2003-07-30 | Nonogawa Shoji Kk | ゲル組成物および乳化組成物 |
JP2006265153A (ja) * | 2005-03-23 | 2006-10-05 | Noevir Co Ltd | ゲル組成物 |
WO2018052084A1 (ja) * | 2016-09-14 | 2018-03-22 | 株式会社カネカ | ゲル状組成物、並びにそれを用いた皮膚外用剤及び化粧料 |
WO2018079620A1 (ja) * | 2016-10-28 | 2018-05-03 | 株式会社カネカ | ゲル状組成物 |
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JP2004067647A (ja) | 2002-08-09 | 2004-03-04 | Showa Denko Kk | 皮膚外用剤 |
JP3835392B2 (ja) | 2002-10-10 | 2006-10-18 | 昭和電工株式会社 | 発熱性組成物および温感化粧料 |
KR20060121848A (ko) * | 2003-08-28 | 2006-11-29 | 쇼와 덴코 가부시키가이샤 | 화장품 |
JP2005162741A (ja) * | 2003-11-10 | 2005-06-23 | Showa Denko Kk | 油性増粘ゲル状組成物の製造方法及び化粧料 |
KR20060130215A (ko) * | 2004-03-24 | 2006-12-18 | 쇼와 덴코 가부시키가이샤 | 수중유형 유화조성물, 및 상기 조성물을 사용한 피부외용제 및 화장품 |
US20070103076A1 (en) * | 2005-11-07 | 2007-05-10 | Kim Ki-Dong | Plasma display panel |
JP6738671B2 (ja) | 2016-07-01 | 2020-08-12 | 日鉄ステンレス株式会社 | ステンレス鋼板 |
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- 2018-12-05 CN CN201880085430.4A patent/CN111565702B/zh active Active
- 2018-12-05 EP EP18899914.8A patent/EP3738576A4/en active Pending
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JPS6230546A (ja) * | 1985-07-31 | 1987-02-09 | Agency Of Ind Science & Technol | 多塩基酸型バイオサ−フアクタント系乳化組成物 |
JP2000087006A (ja) * | 1998-09-14 | 2000-03-28 | Agency Of Ind Science & Technol | ゲル化剤 |
JP2003176211A (ja) * | 2001-08-10 | 2003-06-24 | Showa Denko Kk | 油性増粘ゲル状組成物、該組成物を用いた乳化組成物及びその調製法 |
JP2003212750A (ja) * | 2002-01-23 | 2003-07-30 | Nonogawa Shoji Kk | ゲル組成物および乳化組成物 |
JP2006265153A (ja) * | 2005-03-23 | 2006-10-05 | Noevir Co Ltd | ゲル組成物 |
WO2018052084A1 (ja) * | 2016-09-14 | 2018-03-22 | 株式会社カネカ | ゲル状組成物、並びにそれを用いた皮膚外用剤及び化粧料 |
WO2018079620A1 (ja) * | 2016-10-28 | 2018-05-03 | 株式会社カネカ | ゲル状組成物 |
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JP7212634B2 (ja) | 2023-01-25 |
WO2019138739A1 (ja) | 2019-07-18 |
US20200345594A1 (en) | 2020-11-05 |
CN111565702B (zh) | 2023-01-31 |
CN111565702A (zh) | 2020-08-21 |
EP3738576A1 (en) | 2020-11-18 |
EP3738576A4 (en) | 2021-11-03 |
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