JPWO2014077135A1 - 血中アセトアルデヒド低減剤 - Google Patents
血中アセトアルデヒド低減剤 Download PDFInfo
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- JPWO2014077135A1 JPWO2014077135A1 JP2014546935A JP2014546935A JPWO2014077135A1 JP WO2014077135 A1 JPWO2014077135 A1 JP WO2014077135A1 JP 2014546935 A JP2014546935 A JP 2014546935A JP 2014546935 A JP2014546935 A JP 2014546935A JP WO2014077135 A1 JPWO2014077135 A1 JP WO2014077135A1
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- Japan
- Prior art keywords
- acid
- blood acetaldehyde
- citric
- ascorbic
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000008280 blood Substances 0.000 title claims abstract description 56
- 210000004369 blood Anatomy 0.000 title claims abstract description 56
- 239000003638 chemical reducing agent Substances 0.000 title claims abstract description 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical class C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 148
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 90
- 235000015165 citric acid Nutrition 0.000 claims abstract description 62
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 54
- 150000000996 L-ascorbic acids Chemical class 0.000 claims abstract description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 82
- 239000011668 ascorbic acid Substances 0.000 claims description 40
- 229960005070 ascorbic acid Drugs 0.000 claims description 39
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- 239000004260 Potassium ascorbate Substances 0.000 claims description 3
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- 229910052623 talc Inorganic materials 0.000 description 1
- 229940074410 trehalose Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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Abstract
Description
7週齢以上の雄性BALB/cマウスに、有効成分であるアスコルビン酸又はクエン酸のいずれか一方を5%(v/v)エタノール含有水に溶解した被験液を調製し、体重を基準にして8.45ml/kgの量で強制胃内投与した。各被験液は、アスコルビン酸又はクエン酸の投与量が表1及び表2に示す値になるように濃度を調節した。例えば、投与量が0.5g/kgである場合、被験液のアスコルビン酸濃度又はクエン酸濃度は5.9重量%とした。なお、5%(v/v)エタノール含有水のみを投与する群をコントロールとした。
有効成分であるアスコルビン酸及びクエン酸の投与量が表3に示す値になるように濃度調節した被験液を使用すること以外は参考例と同様にして、各被験液について血中アセトアルデヒド濃度抑制率を測定した。
有効成分であるアスコルビン酸及びクエン酸の投与量が表4に示す値になるように濃度調節した被験液を使用すること以外は参考例と同様にして、各被験液について血中アセトアルデヒド濃度抑制率を測定した。また、上記と同様にして血中アセトアルデヒド濃度抑制率の理論値を計算した。
7週齢以上の雄性BALB/cマウスに、有効成分である酢酸を5%(v/v)エタノール含有水に溶解した被験液を調製し、体重を基準にして8.45ml/kgの量で強制胃内投与した。各被験液は、酢酸の投与量が表1に示す値になるように濃度を調節した。
有効成分であるアスコルビン酸、クエン酸及び酢酸の投与量が表6に示す値になるように濃度調節した被験液を使用すること以外は参考例と同様にして、各被験液について血中アセトアルデヒド濃度抑制率を測定した。また、上記と同様にして血中アセトアルデヒド濃度抑制率の理論値を計算した。
Claims (12)
- 血中アセトアルデヒド低減剤における、アスコルビン酸類[A]及び酢酸[C]から成る群から選択される少なくとも一種と、クエン酸類[B]との使用。
- 血中アセトアルデヒド低減剤における、アスコルビン酸類[A]とクエン酸類[B]との使用。
- アスコルビン酸類[A]とクエン酸類[B]との重量比[A/B]が0.33を超えて1.33未満である請求項2に記載の使用。
- アスコルビン酸類[A]とクエン酸類[B]との重量比[A/B]が0.5〜1である請求項2に記載の使用。
- アスコルビン酸類[A]及びクエン酸類[B]の投与量が体重を基準にして0.05g/kg以上である請求項1〜4のいずれか一項に記載の使用。
- 更に酢酸[C]を使用する請求項2〜5のいずれか一項に記載の使用。
- 血中アセトアルデヒド低減剤における、酢酸[C]とクエン酸類[B]との使用。
- 酢酸[C]とクエン酸類[B]との重量比[C/B]が0.01〜5である請求項6又は7に記載の使用。
- アスコルビン酸類[A]及びクエン酸類[B]の投与量が体重を基準にして0.01g/kg以上であり、酢酸[C]の投与量が0.1g/kg以下である請求項6〜8のいずれか一項に記載の使用。
- 前記アスコルビン酸類が、アスコルビン酸、アスコルビン酸ナトリウム、アスコルビン酸カルシウム及びアスコルビン酸カリウムからなる群から選択される少なくとも一種である請求項1〜9のいずれか一項に記載の使用。
- 前記クエン酸類が、クエン酸、クエン酸ナトリウム及びクエン酸カリウムからなる群から選択される少なくとも一種である請求項1〜10のいずれか一項に記載の使用。
- アスコルビン酸類[A]及び酢酸[C]から成る群から選択される少なくとも一種と、クエン酸類[B]とを含む血中アセトアルデヒド低減剤。
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS62143678A (ja) * | 1985-12-17 | 1987-06-26 | Nakano Vinegar Co Ltd | 深酔い防止アルコ−ル飲料の製造法 |
JPS63169974A (ja) * | 1985-06-24 | 1988-07-13 | マンフレ−ト・バンネス | フルクト−ス・ビタミンc、キニン及び/又はこれらの代替物を含有する飲料 |
WO2006064550A1 (ja) * | 2004-12-14 | 2006-06-22 | Toyo Shinyaku Co.,Ltd. | アルコール代謝向上剤及びアルコール飲料 |
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JPS63169974A (ja) * | 1985-06-24 | 1988-07-13 | マンフレ−ト・バンネス | フルクト−ス・ビタミンc、キニン及び/又はこれらの代替物を含有する飲料 |
JPS62143678A (ja) * | 1985-12-17 | 1987-06-26 | Nakano Vinegar Co Ltd | 深酔い防止アルコ−ル飲料の製造法 |
WO2006064550A1 (ja) * | 2004-12-14 | 2006-06-22 | Toyo Shinyaku Co.,Ltd. | アルコール代謝向上剤及びアルコール飲料 |
Non-Patent Citations (1)
Title |
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J.P.BONJOUR: "Vitamins and alcoholism", INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, vol. 49(4), JPN6014001117, 1979, pages 434 - 441, ISSN: 0003496030 * |
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