JPWO2012141316A1 - 栄養組成物 - Google Patents
栄養組成物 Download PDFInfo
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- JPWO2012141316A1 JPWO2012141316A1 JP2013509995A JP2013509995A JPWO2012141316A1 JP WO2012141316 A1 JPWO2012141316 A1 JP WO2012141316A1 JP 2013509995 A JP2013509995 A JP 2013509995A JP 2013509995 A JP2013509995 A JP 2013509995A JP WO2012141316 A1 JPWO2012141316 A1 JP WO2012141316A1
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Abstract
遊離リジン、リジンを含むジペプチド及びリジン塩類よりなる群から選ばれる1種以上と、n−3系脂肪酸を含有する栄養組成物であって、
遊離リジン、リジンを含むジペプチド及びリジン塩類よりなる群から選ばれる1種以上の含有量が組成物100kcalあたり総量で0.1g〜10.0gであり、
n−3系脂肪酸の含有量が組成物100kcalあたり総量で0.17g〜5.00gである、栄養組成物。
Description
[1]遊離リジン、リジンを含むジペプチド及びリジン塩類よりなる群から選ばれる1種以上と、n−3系脂肪酸を含有する栄養組成物であって、
遊離リジン、リジンを含むジペプチド及びリジン塩類よりなる群から選ばれる1種以上の含有量が組成物100kcalあたり総量で0.1g〜10.0gであり、
n−3系脂肪酸の含有量が組成物100kcalあたり総量で0.17g〜5.00gである、栄養組成物。
[2]さらにバリン、ロイシンおよびイソロシンよりなる群から選ばれる1種以上の分岐鎖アミノ酸を含有する、上記[1]記載の栄養組成物。
[3]バリン、ロイシンおよびイソロシンよりなる群から選ばれる1種以上の分岐鎖アミノ酸の含有量が、組成物100kcalあたり総量で1.0g〜20gである、上記[2]に記載の栄養組成物。
[4]バリン、ロイシンおよびイソロシンよりなる群から選ばれる1種以上の、遊離の形態の分岐鎖アミノ酸の含有量が、組成物100kcalあたり総量で0.1g〜15gである、上記[2]又は[3]に記載の栄養組成物。
[5]n−3系脂肪酸が、エイコサペンタエン酸、ドコサペンタエン酸及びドコサヘキサエン酸よりなる群から選ばれる1種以上を含有する、上記[1]〜[4]のいずれか1つに記載の栄養組成物。
[6]エイコサペンタエン酸を組成物100kcalあたり10mg〜3000mg含有する、上記[5]に記載の栄養組成物。
[7]組成物100kcalあたり0.2mg〜20.0mgのビタミンB1、
組成物100kcalあたり0.25mg〜20.0mgのビタミンB2、
組成物100kcalあたり0.3mg〜20.0mgのビタミンB6、及び、
組成物100kcalあたり0.3μg〜20.0μgのビタミンB12よりなる群から選ばれる1種以上を含有する、上記[1]〜[6]のいずれか1つに記載の栄養組成物。
[8]組成物100kcalあたり50μgレチノール当量〜2500μgレチノール当量のビタミンA、
組成物100kcalあたり10mg〜700mgのビタミンC、及び、
組成物100kcalあたりα−トコフェロール換算量で1mg〜50mgのビタミンEよりなる群から選ばれる1種以上を含有する、上記[1]〜[7]のいずれか1つに記載の栄養組成物。
[9]組成物100kcalあたり1mg〜50mgの亜鉛及び/又は組成物100kcalあたり1.0μg〜50.0μgのセレンを含有する、上記[1]〜[8]のいずれか1つに記載の栄養組成物。
[10]中鎖脂肪酸油を含有し、中鎖脂肪酸油の含有量が、脂質の総量に対して10重量%〜65重量%である、上記[1]〜[9]のいずれか1つに記載の栄養組成物。
[11]筋肉量の増加及び/又は筋肉量の低下抑制用である、上記[1]〜[10]のいずれか1つに記載の栄養組成物。
[12]内臓脂肪低下用、又はエネルギー消費量増加用である、上記[1]〜[10]のいずれか1つに記載の栄養組成物。
[13]筋力低下症の予防及び/又は改善、筋力回復のためのリハビリテーションの効果促進、内臓脂肪増加に伴う脂質代謝異常の予防及び/又は改善、内臓脂肪増加に伴う高血糖の予防及び/又は改善、内臓脂肪増加に伴う脂肪肝の予防及び/又は改善、内臓脂肪増加に伴う肝臓機能低下の予防及び/又は改善、基礎エネルギー消費量の低下の予防及び/又は改善、基礎体温の低下の予防及び/又は改善、炎症性サイトカインの上昇を伴わない筋肉量低下の予防及び/又は改善、低栄養状態の改善、運動器低下の改善、ロコモティブシンドロームの予防及び/又は改善、転倒の防止、並びにスポーツにおける筋肉量の増加からなる群より選ばれる少なくとも1種の用途用である、上記[1]〜[10]のいずれか1つに記載の栄養組成物。
[14]上記[1]〜[10]のいずれか1つに記載の組成物を有効量投与することを特徴とする筋肉量の増加及び/又は筋肉量の低下抑制方法。
[15]上記[1]〜[10]のいずれか1つに記載の組成物を有効量投与することを特徴とする内臓脂肪低下方法、又はエネルギー消費量増加方法。
[16]上記[1]〜[10]のいずれか1つに記載の組成物を有効量投与することを特徴とする、筋力低下症の予防及び/又は改善方法、筋力回復のためのリハビリテーションの効果促進方法、内臓脂肪増加に伴う脂質代謝異常の予防及び/又は改善方法、内臓脂肪増加に伴う高血糖の予防及び/又は改善方法、内臓脂肪増加に伴う脂肪肝の予防及び/又は改善方法、内臓脂肪増加に伴う肝臓機能低下の予防及び/又は改善方法、基礎エネルギー消費量の低下の予防及び/又は改善方法、基礎体温の低下の予防及び/又は改善方法、炎症性サイトカインの上昇を伴わない筋肉量低下の予防及び/又は改善方法、低栄養状態の改善方法、運動器低下の改善方法、ロコモティブシンドロームの予防及び/又は改善方法、転倒の防止方法、並びに、スポーツにおける筋肉量の増加方法からなる群より選ばれる少なくとも1種の方法。
[17]筋肉量の増加及び/又は筋肉量の低下抑制剤を製造するための上記[1]〜[10]のいずれか1つに記載の組成物の使用。
[18]内臓脂肪低下剤、又はエネルギー消費量増加剤を製造するための上記[1]〜[10]のいずれか1つに記載の組成物の使用。
[19]筋力低下症の予防及び/又は改善剤、筋力回復のためのリハビリテーションの効果促進剤、内臓脂肪増加に伴う脂質代謝異常の予防及び/又は改善剤、内臓脂肪増加に伴う高血糖の予防及び/又は改善剤、内臓脂肪増加に伴う脂肪肝の予防及び/又は改善剤、内臓脂肪増加に伴う肝臓機能低下の予防及び/又は改善剤、基礎エネルギー消費量の低下の予防及び/又は改善剤、基礎体温の低下の予防及び/又は改善剤、炎症性サイトカインの上昇を伴わない筋肉量低下の予防及び/又は改善剤、低栄養状態の改善剤、運動器低下の改善剤、ロコモティブシンドロームの予防及び/又は改善剤、転倒の防止剤、並びに、スポーツにおける筋肉量の増加剤からなる群より選ばれる少なくとも1種を製造するための上記[1]〜[10]のいずれか1つに記載の組成物の使用。
また、リジンの1日あたりの摂取量は、年齢、性別、体重、食事の状況などにより個別に定められるが、アミノ酸栄養バランスの観点から、ヒトの体重1kgあたり20mg〜400mgが好ましく、40mg〜200mgがより好ましい。リジンの1日あたりの最大許容摂取量は明確になっていないが、ヒトの体重1kgあたり20gより多い場合、単一のアミノ酸を多量に摂取することになり、アミノ酸バランスの点からあまり好ましくない。
なお、本明細書において、分岐鎖アミノ酸の量は遊離形態換算量である。
なお、本発明に係る栄養組成物が、タンパク質の形態の分岐鎖アミノ酸を含有する場合、当該タンパク質の量も含んだ、本発明に係る栄養組成物におけるタンパク源の総含有量は、本発明に係る組成物100kcalあたり2〜20gであることが好ましいが、特に、本発明に係る栄養組成物において用いる分岐鎖アミノ酸が、遊離の形態の分岐鎖アミノ酸のみからなる場合には、本発明に係る栄養組成物におけるタンパク源の含有量は、本発明に係る組成物100kcalあたり総量で1.0〜15gであることが好ましい。
高齢者に対する最適栄養効果を熟考し、表1に示す栄養組成物を調製した。これを具現化するための液状物の原料配合量を表2に示す。各成分と乳化剤を水に添加して混合し、高圧乳化機にて、500〜1,000kg/cm2の加圧下にて複数回乳化工程を繰り返し、乳化組成物を得た。アミノ酸組成は、組成物100kcalあたりL−ロイシン0.38g、L−バリン0.19g、L−イソロイシン0.23g、L−リジン0.32gを添加した。この場合、タンパク質由来のものも含んだ分岐鎖アミノ酸(ロイシン、バリン、イソロイシン)の総量として組成物100kcalあたり1.46gを含有することになる。この乳化組成物を、通常の充填機にてアルミ製の袋に充填し、レトルト殺菌機にて通常の条件下に滅菌した。本実施例に係る栄養組成物は、1年後においても全成分は安定に存在し、25℃における粘度は9mPa・sであった。また、この調整液に増粘剤を添加し、とろみ調整栄養組成物(1,000〜7,000mPa・s)あるいはゼリーを製造することができた。更に、添加するアミノ酸の量を2倍量にした場合も同様に製造することができた。この栄養組成物のカロリー密度は、1.0kcal/mlであった。
実施例1と同様に、表3に示す栄養組成物を調製した。実施例1と同様に、各成分と乳化剤を水に添加して混合し、高圧乳化機にて50〜500kg/cm2の加圧下、数回乳化工程を繰り返し、乳化組成物を得た。アミノ酸組成は、組成物100kcalあたりL−ロイシン0.28g、L−バリン0.14g、L−イソロイシン0.14g、L−リジン0.28gを添加した。この場合、タンパク質由来のものも含んだ分岐鎖アミノ酸(ロイシン、バリン、イソロイシン)の総量として組成物100kcalあたり1.30gを含有することになる。この乳化組成物を、通常の充填機にてアルミ製の袋に充填し、レトルト殺菌機にて通常の条件下に滅菌した。本実施例に係る栄養組成物は、1年後においても全成分は安定に存在し、25℃における粘度は4,000mPa・sであった。また、この調整液に適量の増粘剤を添加して更に粘度をつけ、とろみ調整栄養組成物(1,000〜7,000mPa・s)あるいはゼリーを製造することができた。この栄養組成物のカロリー密度は、2.0kcal/mlであった。
表4に示す粉末タイプの栄養組成物を調製した。これを具現化するための液状物の原料配合量を表5に示す。各成分と乳化剤を適量の水に添加して混合し、乳化機にて2〜50kg/cm2の加圧下、数回乳化工程を繰り返し、乳化組成物を得た。この乳化組成物を噴霧乾燥し、粉末栄養組成物とした。アミノ酸組成は、組成物100kcalあたりL−ロイシン3.9g、L−バリン2.4g、L−イソロイシン2.0g、L−リジン4.1gであった。この粉末栄養組成物を、通常の充填機にてアルミ製の袋に充填した。本実施例に係る粉末栄養組成物は、1年後においても全成分は安定に存在した。また、この粉末栄養組成物は、温水に溶解し栄養剤に混合しても、使用することができた。
本発明に係る栄養組成物において、アミノ酸とn−3系脂肪酸の内臓脂肪増加や筋肉量低下の改善効果を、以下の実験により検討した。すなわち、10週齢のC57BL/6J雄性マウスに表6に示す1B群と同じ高脂肪食を摂取させ、内臓脂肪増加モデルを作製後、3群に分け(各群N=5−9)、それぞれ表6に示す組成の実験食を2週間摂取させた。1B群には飽和脂肪酸の豊富な牛脂を多く含む高脂肪食を継続して、摂取させた。1C群には標準的な組成の実験食を摂取させた。1D群には強化した組成として、タンパク、脂肪の総量を変えずにリジン、BCAA(ロイシン、バリン、イソロイシンからなる3種の分岐鎖アミノ酸)、魚油をそれぞれ実験食100kcalあたり0.32g、0.8g、0.24g置換した実験食を摂取させた。この場合、1D群においてはタンパク質由来も含んだBCAAの総量として実験食100kcalあたり1.46g、n−3系脂肪酸の総量として0.24g、エイコサペンタエン酸(EPA)として67mgを含有することになる。1A群には正常対照群として、高脂肪食を摂取させずに、試験期間を通じて標準的な組成の実験食を摂取させた。実験食摂取2週後に16時間絶食させ、腸間膜脂肪重量及び被覆筋重量を測定した。結果を図1に示す。
試験例1の結果、腸間膜脂肪重量低下及び被覆筋重量増加作用を示すのに、本発明で用いるアミノ酸とn−3系脂肪酸の強化が必要であることが明らかとなったが、それぞれの成分が単独でこのような効果を示すかどうかは明確ではない。そこで、本発明で用いるアミノ酸及びn−3系脂肪酸をそれぞれ単独で強化および併用強化した、以下の検討を行った。すなわち、試験例1と同様に内臓脂肪増加モデルを作製後、4群に分け(各群N=5〜9)、それぞれ表7に示す組成の実験食を2週間摂取させた。2A群には標準的な組成の実験食を摂取させた。2D群には強化した組成として、タンパク質、脂肪の総量を変えずにリジン、BCAA、魚油をそれぞれ100kcalあたり0.32g、0.8g、0.24g置換した実験食を摂取させた。この場合、2D群においてはタンパク質由来も含んだBCAAの総量として実験食100kcalあたり1.46g、n−3系脂肪酸の総量として0.24g、エイコサペンタエン酸(EPA)として67mgを含有することになる。更に、本発明で用いるアミノ酸、n−3系脂肪酸のそれぞれを単独で強化した実験食を摂取させた群として、2B群、2C群を設けた。各実験食を摂取2週後に16時間絶食させ、腸間膜脂肪重量及び被覆筋重量を測定した。結果を図2に示す。
次いで、本発明に係るアミノ酸及びn−3系脂肪酸を強化した栄養組成物が、呼気ガス代謝測定装置を用いたエネルギー代謝測定へ及ぼす影響を検討した。すなわち、試験例1と同様に作製した内臓脂肪増加モデルにおいて、表8に示すように標準的な組成の実験食(3A群)または強化した組成の実験食(3B群)を摂取させ、評価を実施した。摂餌量安定のため1週間の実験食馴化期間を設け、その後2週間内に各ケージに一匹ずつ入れ、酸素消費量(ml/min)および二酸化炭素産生量(ml/min)を測定した(小動物用代謝計測システムMK−5000 RQ、室町機械)。測定時の餌は実験食を給与し、摂餌量を測定した。呼吸商は二酸化炭素産生量÷酸素消費量で算出し、エネルギー消費量はWeirの式[エネルギー消費量(kcal/min)=3.9(kcal)×酸素消費量(ml/min)+1.1(kcal)×二酸化炭素産生量(ml/min)]を用いて算出した。結果を図3に示す。
Claims (19)
- 遊離リジン、リジンを含むジペプチド及びリジン塩類よりなる群から選ばれる1種以上と、n−3系脂肪酸を含有する栄養組成物であって、
遊離リジン、リジンを含むジペプチド及びリジン塩類よりなる群から選ばれる1種以上の含有量が組成物100kcalあたり総量で0.1g〜10.0gであり、
n−3系脂肪酸の含有量が組成物100kcalあたり総量で0.17g〜5.00gである、栄養組成物。 - さらにバリン、ロイシンおよびイソロシンよりなる群から選ばれる1種以上の分岐鎖アミノ酸を含有する、請求項1記載の栄養組成物。
- バリン、ロイシンおよびイソロシンよりなる群から選ばれる1種以上の分岐鎖アミノ酸の含有量が、組成物100kcalあたり総量で1.0g〜20gである、請求項2に記載の栄養組成物。
- バリン、ロイシンおよびイソロシンよりなる群から選ばれる1種以上の、遊離の形態の分岐鎖アミノ酸の含有量が、組成物100kcalあたり総量で0.1g〜15gである、請求項2又は3に記載の栄養組成物。
- n−3系脂肪酸が、エイコサペンタエン酸、ドコサペンタエン酸及びドコサヘキサエン酸よりなる群から選ばれる1種以上を含有する、請求項1〜4のいずれか1項に記載の栄養組成物。
- エイコサペンタエン酸を組成物100kcalあたり10mg〜3000mg含有する、請求項5に記載の栄養組成物。
- 組成物100kcalあたり0.2mg〜20.0mgのビタミンB1、
組成物100kcalあたり0.25mg〜20.0mgのビタミンB2、
組成物100kcalあたり0.3mg〜20.0mgのビタミンB6、及び、
組成物100kcalあたり0.3μg〜20.0μgのビタミンB12よりなる群から選ばれる1種以上を含有する、請求項1〜6のいずれか1項に記載の栄養組成物。 - 組成物100kcalあたり50μgレチノール当量〜2500μgレチノール当量のビタミンA、
組成物100kcalあたり10mg〜700mgのビタミンC、及び、
組成物100kcalあたりα−トコフェロール換算量で1mg〜50mgのビタミンEよりなる群から選ばれる1種以上を含有する、請求項1〜7のいずれか1項に記載の栄養組成物。 - 組成物100kcalあたり1mg〜50mgの亜鉛及び/又は組成物100kcalあたり1.0μg〜50.0μgのセレンを含有する、請求項1〜8のいずれか1項に記載の栄養組成物。
- 中鎖脂肪酸油を含有し、中鎖脂肪酸油の含有量が、脂質の総量に対して10重量%〜65重量%である、請求項1〜9のいずれか1項に記載の栄養組成物。
- 筋肉量の増加及び/又は筋肉量の低下抑制用である、請求項1〜10のいずれか1項に記載の栄養組成物。
- 内臓脂肪低下用、又はエネルギー消費量増加用である、請求項1〜10のいずれか1項に記載の栄養組成物。
- 筋力低下症の予防及び/又は改善、筋力回復のためのリハビリテーションの効果促進、内臓脂肪増加に伴う脂質代謝異常の予防及び/又は改善、内臓脂肪増加に伴う高血糖の予防及び/又は改善、内臓脂肪増加に伴う脂肪肝の予防及び/又は改善、内臓脂肪増加に伴う肝臓機能低下の予防及び/又は改善、基礎エネルギー消費量の低下の予防及び/又は改善、基礎体温の低下の予防及び/又は改善、炎症性サイトカインの上昇を伴わない筋肉量低下の予防及び/又は改善、低栄養状態の改善、運動器低下の改善、ロコモティブシンドロームの予防及び/又は改善、転倒の防止、並びにスポーツにおける筋肉量の増加からなる群より選ばれる少なくとも1種の用途用である、請求項1〜10のいずれか1項に記載の栄養組成物。
- 請求項1〜10のいずれか1項に記載の組成物を有効量投与することを特徴とする筋肉量の増加及び/又は筋肉量の低下抑制方法。
- 請求項1〜10のいずれか1項に記載の組成物を有効量投与することを特徴とする内臓脂肪低下方法、又はエネルギー消費量増加方法。
- 請求項1〜10のいずれか1項に記載の組成物を有効量投与することを特徴とする、筋力低下症の予防及び/又は改善方法、筋力回復のためのリハビリテーションの効果促進方法、内臓脂肪増加に伴う脂質代謝異常の予防及び/又は改善方法、内臓脂肪増加に伴う高血糖の予防及び/又は改善方法、内臓脂肪増加に伴う脂肪肝の予防及び/又は改善方法、内臓脂肪増加に伴う肝臓機能低下の予防及び/又は改善方法、基礎エネルギー消費量の低下の予防及び/又は改善方法、基礎体温の低下の予防及び/又は改善方法、炎症性サイトカインの上昇を伴わない筋肉量低下の予防及び/又は改善方法、低栄養状態の改善方法、運動器低下の改善方法、ロコモティブシンドロームの予防及び/又は改善方法、転倒の防止方法、並びに、スポーツにおける筋肉量の増加方法からなる群より選ばれる少なくとも1種の方法。
- 筋肉量の増加及び/又は筋肉量の低下抑制剤を製造するための請求項1〜10のいずれか1項に記載の組成物の使用。
- 内臓脂肪低下剤、又はエネルギー消費量増加剤を製造するための請求項1〜10のいずれか1項に記載の組成物の使用。
- 筋力低下症の予防及び/又は改善剤、筋力回復のためのリハビリテーションの効果促進剤、内臓脂肪増加に伴う脂質代謝異常の予防及び/又は改善剤、内臓脂肪増加に伴う高血糖の予防及び/又は改善剤、内臓脂肪増加に伴う脂肪肝の予防及び/又は改善剤、内臓脂肪増加に伴う肝臓機能低下の予防及び/又は改善剤、基礎エネルギー消費量の低下の予防及び/又は改善剤、基礎体温の低下の予防及び/又は改善剤、炎症性サイトカインの上昇を伴わない筋肉量低下の予防及び/又は改善剤、低栄養状態の改善剤、運動器低下の改善剤、ロコモティブシンドロームの予防及び/又は改善剤、転倒の防止剤、並びに、スポーツにおける筋肉量の増加剤からなる群より選ばれる少なくとも1種を製造するための請求項1〜10のいずれか1項に記載の組成物の使用。
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JP5983601B2 (ja) | 2016-08-31 |
KR102100091B1 (ko) | 2020-04-14 |
EP2705844B1 (en) | 2019-05-22 |
EP2705844A1 (en) | 2014-03-12 |
US10136669B2 (en) | 2018-11-27 |
US20160374381A1 (en) | 2016-12-29 |
KR20140022888A (ko) | 2014-02-25 |
WO2012141316A1 (ja) | 2012-10-18 |
EP2705844A4 (en) | 2015-04-01 |
US20140044828A1 (en) | 2014-02-13 |
CN103458891A (zh) | 2013-12-18 |
KR20180100455A (ko) | 2018-09-10 |
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