JPS6333393A - ジンセノサイド−Ｒｇ↓１の精製法 - Google Patents
ジンセノサイド−Ｒｇ↓１の精製法Info
- Publication number
- JPS6333393A JPS6333393A JP17647786A JP17647786A JPS6333393A JP S6333393 A JPS6333393 A JP S6333393A JP 17647786 A JP17647786 A JP 17647786A JP 17647786 A JP17647786 A JP 17647786A JP S6333393 A JPS6333393 A JP S6333393A
- Authority
- JP
- Japan
- Prior art keywords
- ginsenoside
- solution
- material containing
- aqueous solution
- column chromatography
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YURJSTAIMNSZAE-UHFFFAOYSA-N UNPD89172 Natural products C1CC(C2(CC(C3C(C)(C)C(O)CCC3(C)C2CC2O)OC3C(C(O)C(O)C(CO)O3)O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O YURJSTAIMNSZAE-UHFFFAOYSA-N 0.000 title claims abstract 7
- YURJSTAIMNSZAE-HHNZYBFYSA-N ginsenoside Rg1 Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YURJSTAIMNSZAE-HHNZYBFYSA-N 0.000 title claims abstract 7
- CBEHEBUBNAGGKC-UHFFFAOYSA-N ginsenoside Rg1 Natural products CC(=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5CC(OC6OC(CO)C(O)C(O)C6O)C34C)C CBEHEBUBNAGGKC-UHFFFAOYSA-N 0.000 title claims abstract 7
- 238000000746 purification Methods 0.000 title description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 12
- 239000007864 aqueous solution Substances 0.000 claims abstract description 9
- 239000012047 saturated solution Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 239000007787 solid Substances 0.000 claims description 11
- 238000004440 column chromatography Methods 0.000 abstract description 14
- 239000013078 crystal Substances 0.000 abstract description 12
- 239000000243 solution Substances 0.000 abstract description 8
- 240000004371 Panax ginseng Species 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 235000008434 ginseng Nutrition 0.000 abstract description 4
- 235000002789 Panax ginseng Nutrition 0.000 abstract description 3
- 239000002904 solvent Substances 0.000 abstract description 3
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract description 2
- 239000000284 extract Substances 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 230000004520 agglutination Effects 0.000 abstract 1
- 230000001276 controlling effect Effects 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 4
- 230000005526 G1 to G0 transition Effects 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000208343 Panax Species 0.000 description 1
- 235000002791 Panax Nutrition 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- ISGXZRIDYZBDFG-UHFFFAOYSA-N butan-1-ol;butan-2-one Chemical compound CCCCO.CCC(C)=O ISGXZRIDYZBDFG-UHFFFAOYSA-N 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- -1 ginsenoside-Rg Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
Landscapes
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17647786A JPS6333393A (ja) | 1986-07-26 | 1986-07-26 | ジンセノサイド−Ｒｇ↓１の精製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17647786A JPS6333393A (ja) | 1986-07-26 | 1986-07-26 | ジンセノサイド−Ｒｇ↓１の精製法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6333393A true JPS6333393A (ja) | 1988-02-13 |
| JPH0212960B2 JPH0212960B2 (enEXAMPLES) | 1990-03-30 |
Family
ID=16014354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17647786A Granted JPS6333393A (ja) | 1986-07-26 | 1986-07-26 | ジンセノサイド−Ｒｇ↓１の精製法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6333393A (enEXAMPLES) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102532234A (zh) * | 2010-12-10 | 2012-07-04 | 北京本草天源药物研究院 | 一种人参皂苷Rg1的提取纯化方法 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0575638U (ja) * | 1992-03-16 | 1993-10-15 | 山武ハネウエル株式会社 | 現場型計器 |
-
1986
- 1986-07-26 JP JP17647786A patent/JPS6333393A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102532234A (zh) * | 2010-12-10 | 2012-07-04 | 北京本草天源药物研究院 | 一种人参皂苷Rg1的提取纯化方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0212960B2 (enEXAMPLES) | 1990-03-30 |
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